Aberration Dmel\Df(2L)b87e25

General Information
Symbol	Dmel\Df(2L)b87e25	Species	D. melanogaster
Name	Deficiency (2L) black	FlyBase ID	FBab0001747
Feature type	chromosomal_deletion	Created / Updated	2006-08-22/2006-08-22

Formalized genetic data	bk1 << kuz << vas << bk2 << stc
Sequence coordinates
Deleted segment	34C1--35C1
Duplicated segment
Computed Breakpoints include	34C1;35C1
Breakpoints Inherited
Nature of the Aberration
Cytological Order
Progenitor
Mutagen	γ ray (Alexandrova et al., 1996, Alexandrov and Alexandrova, 1991, Roote, 1995.3.27) irradiation (The Moscow Regional Drosophila melanogaster Stock Center, Dubna) spontaneous (The Moscow Regional Drosophila melanogaster Stock Center, Dubna)
Class of aberration (relative to progenitor)	chromosomal_deletion (Alexandrova et al., 1996, Alexandrov and Alexandrova, 1991, Kania et al., 1995, Roote, 1995.3.27, Harbecke and Lengyel, 1995, The Moscow Regional Drosophila melanogaster Stock Center, Dubna, Tinker et al., 1998)
Breakpoints	34C1;35C1-35C2 (Alexandrov and Alexandrova, 1991, Roote, 1995.3.27) 34B12-34C1;35B10-35C1 (Kania et al., 1995, Harbecke and Lengyel, 1995) 34D3;35B10 (Alexandrova et al., 1996) 34C1;35B10 (The Moscow Regional Drosophila melanogaster Stock Center, Dubna) 34C1-34C2;35B10-35C1 (Tinker et al., 1998)
Causes alleles
Carries alleles
Transposon Insertions
Genetic mapping information
Comments
Comments on Cytology
	Limits of break 1 from polytene analysis (FBrf0053558) Left limit of break 2 from inclusion of vas (FBrf0077941) Right limit of break 2 from polytene analysis (FBrf0080145) Ref: Lindsley and Zimm, 1992 (Kania et al., 1995)
Molecularly Mapped Breakpoints

Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	p38b (Paricio et al., 1999, Weber et al., 2000) rk (Eriksen et al., 2000) Su(H) (Alexandrova et al., 1996) vas (Roote, 1995.3.27, Roote, 1996.8, Tinker et al., 1998, Ashraf et al., 1999, Iyengar et al., 1999) CG15270 (Ashburner et al., 1999.10.12) kuz (Roote, 1995.3.27, Roote, 1996.8, Ashraf et al., 1999, Iyengar et al., 1999, Thibault et al., 2004) b (Alexandrov and Alexandrova, 1991) l(2)34Db (Alexandrova et al., 1996)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	stc (Zhu et al., 2005, Roote, 1996.8) esg (Kania et al., 1995) gft (Zhu et al., 2005)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations	Df(2L)b87e25 in combination with a pair of introgressions from D.simulans spanning 30F1-31E7 to 35D7-36A14 Dsim\Int(2L)S and 21A1 to 22D1--23A2 Dsim\Int(2L)D produces semi-sterile male flies. These flies are female sterile. (Sawamura et al., 2000) Deficient embryos show an uninterpretable mutant midgut phenotype. (Bilder and Scott, 1995) Homozygous embryos are very abnormal compared to wild-type. (Harbecke and Lengyel, 1995) Lethal in combination with: Df(2L)BSC147. Inferred to overlap with: Df(2L)BSC147. (Christensen and Cook, 2006.3.8) No second site non-complementing phenotype with zip^Ebr and zip^mhc-c6.1. (Halsell and Kiehart, 1998) Shows no maternal enhancement of dpp^hr4. (Nicholls and Gelbart, 1998) Suppresses the ommatidial polarity phenotype of dsh^hs.sev.B. Suppresses the ommatidial polarity phenotype of msn^EP549 when driven by Scer\GAL4^hs.2sev. (Paricio et al., 1999)
Position Effect Variegation Data

Stocks ( 3 )
Bloomington	3138 Df(2L)b87e25/CyO
Kyoto	106874 Df(2L)b87e25/CyO 103263 Df(2L)b87e25 / In(2L)NS, (Cu^*)
Notes on Origin
Discoverer

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments
	"irradiation" was stated as tentative. "spontaneous" was stated as tentative. (The Moscow Regional Drosophila melanogaster Stock Center, Dubna) The Df(2L)b87e25 chromosome acts as a dominant weak suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{w^var}KR3-2", a stable "brown-red" variant of the P{3'WP-2,w^var}2Lt insertion), but this is a false positive result (the suppressor is not within the bounds of the deficient region) because the suppressor maps to the tip of 2L rather than to the site of the deficiency. In addition, the deficiency chromosome fails to complement lethal mutations of l(2)gl. (Mason et al., 2004)
Synonyms & Secondary IDs ( 9 )
Reported As
Symbol Synonym	3138 (Eriksen et al., 2000) b87e25 (Ashburner et al., 1999.10.12, Alexandrova et al., 1996) b^87e25 (The Moscow Regional Drosophila melanogaster Stock Center, Dubna) Df(2L)87e25 (Alexandrov and Alexandrova, 1991) Df(2L)b80e25 (Paricio et al., 1999) Df(2L)b87E25 Df(2L)b87e25 (Crest et al., 2007, Wittwer et al., 2005, Christensen et al., 2007.10.29, Zhu et al., 2005) Df(2L)b87e35 (Weber et al., 2000)
Name Synonym	Deficiency (2L) black
Secondary FlyBase IDs

References ( 34 )

Generate a list of	All references relating to this aberration ( 34 )

List References by type	Research paper ( 26 ) Personal communication to FlyBase ( 5 ) FlyBase analysis ( 1 ) Stock list ( 1 ) Book ( 1 )
Recent research papers ( 1 )
	Crest et al., 2007, Genetics 175(2): 567--584 Onset of the DNA replication checkpoint in the early Drosophila embryo. [FBrf0194644] Show all research papers ...