Aberration Dmel\Df(2L)dp-h25

General Information
Symbol	Dmel\Df(2L)dp-h25	Species	D. melanogaster
Name	Deficiency (2L) dumpy	FlyBase ID	FBab0001771
Feature type	chromosomal_deletion
Also Known As	Df(2L)dp^h25

Computed Breakpoints include	24E4;25B2
Deleted segment	24E4--25B2
Sequence coordinates
Member of large scale dataset(s)
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Aberration
Cytological Order
Progenitor
Mutagen	X ray
Class of aberration (relative to progenitor)	chromosomal_deletion (Semeshin and Szidonya, 1985, Szidonya and Reuter, 1988, Szidonya and Reuter, 1988, Bryant et al., 1988, Pauli et al., 1995, Duffy et al., 1996, Rodriguez et al., 1996, Harbecke and Lengyel, 1995)
Breakpoints	24E2-24E4;25B2-25B5 (Szidonya and Reuter, 1988, Bryant et al., 1988, Szidonya and Reuter, 1988, Pauli et al., 1995, Harbecke and Lengyel, 1995, Rodriguez et al., 1996) 24E4-24F2;25B2-25B3 (Semeshin and Szidonya, 1985) 24E4;25B2 (Duffy et al., 1996)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data	tutl << bk1 << dw-24E << l(2)25Ba << bk2 << l(2)25Bc
Genetic mapping information
Comments
Comments on Cytology
	Left limit of break 1 from polytene analysis (FBrf0042240) Right limit of break 1 from polytene analysis (FBrf0047784) Left limit of break 2 from polytene analysis (FBrf0042240) Right limit of break 2 from polytene analysis (FBrf0086390)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	CG15429 (Mathew et al., 2009) dp (Szidonya and Reuter, 1988, Bryant et al., 1988, Szidonya and Reuter, 1988, Mathew et al., 2009) dw-24E (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) l(2)24Fa (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) l(2)24Fc (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) l(2)25Ab (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) l(2)25Ba (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) l(2)25Bb (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) morgue (Wing et al., 2002) Psf2 (Mathew et al., 2009) RpL27A (Szidonya and Reuter, 1988, Bryant et al., 1988, Szidonya and Reuter, 1988, Mathew et al., 2009) slf (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988, Harbecke and Lengyel, 1995) Su(var)2-8 (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) Tps1 (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)
Molecular Data
Completely deleted	CG3225 (Mathew et al., 2009) CG3652 (Mathew et al., 2009) CG11929 (Mathew et al., 2009) CG12677 (Mathew et al., 2009) CG15436 (Mathew et al., 2009) CG15631 (Mathew et al., 2009) dp (Mathew et al., 2009) Traf4 (Mathew et al., 2009)
Genes NOT Deleted / Disrupted
Complementation Data
	bcn92 (Mathew et al., 2009) Cg25C (Rodriguez et al., 1996) cl (Bryant et al., 1988) ed (Szidonya and Reuter, 1988, Bryant et al., 1988, Szidonya and Reuter, 1988) ft (Szidonya and Reuter, 1988, Bryant et al., 1988, Szidonya and Reuter, 1988, Mathew et al., 2009) l(2)24Dc (Szidonya and Reuter, 1988, Bryant et al., 1988, Szidonya and Reuter, 1988) l(2)24Dd (Szidonya and Reuter, 1988, Bryant et al., 1988, Szidonya and Reuter, 1988) l(2)24De (Szidonya and Reuter, 1988, Bryant et al., 1988, Szidonya and Reuter, 1988) l(2)25Bc (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) l(2)25Bd (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) l(2)25Be (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) l(2)25Bf (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) l(2)25Bg (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) l(2)25Ca (Bryant et al., 1988) M(2)24D (Szidonya and Reuter, 1988, Bryant et al., 1988, Szidonya and Reuter, 1988) mRpS2 (Mathew et al., 2009) RpL37A (Bryant et al., 1988) tkv (Bryant et al., 1988) Tps1 (Mathew et al., 2009) tutl (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988, Mathew et al., 2009)
Molecular Data
	Atet (Mathew et al., 2009) CG15429 (Mathew et al., 2009) CG15634 (Mathew et al., 2009) Tps1 (Mathew et al., 2009)
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations	The Df(2L)dp-h25 chromosome does not act as a dominant suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{w^var}KR3-2", a stable "brown-red" variant of the P{3'WP-2,w^var}2Lt insertion). (Mason et al., 2004) Acts as a dosage sensitive maternal modifier of run: causes tergite defects in greater than 50% of run³ heterozygotes. (Duffy et al., 1996) Homozygous embryos have disconnected tracheae. (Harbecke and Lengyel, 1995) Heterozygosity for this deletion has no effect on the mutant ovarian phenotype of ovo^D2. (Pauli et al., 1995) olv class of dp phenotype. Reduced viability and fertility. (Szidonya and Reuter, 1988)
Stocks ( 2 )
Bloomington	3081 Df(2L)dp-h25/In(2L)Cy^Lt^R, In(2R)Cy, amos^Roi-1
Kyoto	106827 Df(2L)dp-h25/In(2L)Cy^Lt^R, In(2R)Cy, amos^Roi-1
Notes on Origin
Discoverer
	Isolated over Dp(2;2)B3 = Dp(2;2)23E2-3;26E2-F1
Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	Df(2L)dp^h25 (Bryant et al., 1988, Szidonya and Reuter, 1988, Szidonya and Reuter, 1988, Semeshin and Szidonya, 1985) Df(2L)dp-h25 (Crest et al., 2007, Mahoney et al., 2006, Mukai et al., 2007, Mathew et al., 2009) dp-h25 (Hirose et al., 2001)
Name Synonym	Deficiency (2L) dumpy
Secondary FlyBase IDs

References ( 19 )
Research paper	Mathew et al., 2009, PLoS ONE 4(10): e7437 A small genomic region containing several loci required for gastrulation in Drosophila. [FBrf0208913] Crest et al., 2007, Genetics 175(2): 567--584 Onset of the DNA replication checkpoint in the early Drosophila embryo. [FBrf0194644] Mukai et al., 2007, Mech. Dev. 124(7-8): 570--583 MAMO, a maternal BTB/POZ-Zn-finger protein enriched in germline progenitors is required for the production of functional eggs in Drosophila. [FBrf0202210] Mahoney et al., 2006, Genetics 172(4): 2309--2324 Presenilin-based genetic screens in Drosophila melanogaster identify novel Notch pathway modifiers. [FBrf0190744] Mason et al., 2004, Genetics 168(3): 1353--1370 A deficiency screen for dominant suppressors of telomeric silencing in Drosophila. [FBrf0180277] Kuranaga et al., 2002, Nat. Cell Biol. 4(9): 705--710 Reaper-mediated inhibition of DIAP1-induced DTRAF1 degradation results in activation of JNK in Drosophila. [FBrf0152246] Wing et al., 2002, Nat. Cell Biol. 4(6): 451--456 Drosophila Morgue is an F box/ubiquitin conjugase domain protein important for grim-reaper mediated apoptosis. [FBrf0149135] Hirose et al., 2001, Mol. Cell. Biol. 21(21): 7231--7242 Ectopic expression of DREF induces DNA synthesis, apoptosis, and unusual morphogenesis in the Drosophila eye imaginal disc: possible interaction with Polycomb and Trithorax group proteins. [FBrf0139759] Duffy et al., 1996, Genetics 142(3): 839--852 Dosage-sensitive maternal modifiers of the Drosophila segmentation gene runt. [FBrf0086390] Rodriguez et al., 1996, Genetics 143(2): 929--940 Identification of immune system and responses genes, and novel mutations causing melanotic tumor formation in Drosophila melanogaster. [FBrf0087676] Harbecke and Lengyel, 1995, Rouxs Arch. Dev. Biol. 204(5): 308--329 Genes controlling posterior gut development in the Drosophila embryo. [FBrf0082073] Pauli et al., 1995, Genetics 139(2): 713--732 Identification of regions interacting with ovo^D mutations: Potential new genes involved in germline sex determination or differentiation in Drosophila melanogaster. [FBrf0080317] Pauli et al., 1995, D. I. S. 76: 107--124 Dose dependent enhancers and suppressors of ovoD2. [FBrf0082455] Bryant et al., 1988, Dev. Biol. 129: 541--554 Mutations at the fat locus interfere with cell proliferation control and epithelial morphogenesis in Drosophila. [FBrf0047838] Szidonya and Reuter, 1988, Genet. Res. (Camb.) 51(3): 197--208 Cytogenetic analysis of the echinoid (ed), dumpy (dp) and clot (cl) region in Drosophila melanogaster. [FBrf0048137] Szidonya and Reuter, 1988, D. I. S. 67: 77--79 Cytogenetics of the 24D4-25F2 region of the Drosophila melanogaster 2L chromosome. [FBrf0047784] Semeshin and Szidonya, 1985, D. I. S. 61: 148--154 EM mapping of rearrangements in the 24-25 sections of Drosophila melanogaster 2L chromosomes. [FBrf0042240]
FlyBase analysis	FlyBase, 2007, En masse symbol-based assigment of Aberration Class with respect to wild type. En masse symbol-based assigment of Aberration Class with respect to wild type. [FBrf0191808]
Book	Lindsley and Zimm, 1992, The Genome of Drosophila melanogaster. The Genome of Drosophila melanogaster. [FBrf0066905]