Aberration Dmel\Df(2L)el28

General Information
Symbol	Dmel\Df(2L)el28	Species	D. melanogaster
Name	Deficiency (2L) elbow	FlyBase ID	FBab0001800
Feature type	chromosomal_deletion

Computed Breakpoints include	[35A4--35B1];[35D5--35E1]
Deleted segment	35A4--35E1
Sequence coordinates
Member of large scale dataset(s)
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Aberration
Cytological Order
Progenitor
Mutagen	gamma ray (Davis et al., 1997)
Class of aberration (relative to progenitor)	chromosomal_deletion (Davis et al., 1990, Gubb et al., 1990, Ashburner et al., 1990, Furukawa et al., 1992, Roote et al., 1996, Davis et al., 1997)
Breakpoints	35B3;35D4 (Davis et al., 1990, Gubb et al., 1990, Ashburner et al., 1990, Furukawa et al., 1992, Roote et al., 1996, Davis et al., 1997)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data	pu << bk1 << elA << fs(2)35Ec << bk2 << ms(2)35Eb
Genetic mapping information
Comments
Comments on Cytology
	Left limit of break 1 from non-inclusion of elB (FBrf0051916) Right limit of break 1 from inclusion of elA (FBrf0091422) Left limit of break 2 from inclusion of wek (FBrf0091422) Right limit of break 2 from non-inclusion of BicC (FBrf0051973)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	Adh (Furukawa et al., 1992) ck (Ashburner et al., 1990, Furukawa et al., 1992) dyn-p25 (Furukawa et al., 1992) elA (Roote et al., 1996, Davis et al., 1997) fs(2)35Ec (Roote, 1997.6.6) l(2)35Bc (Furukawa et al., 1992) l(2)35Bd (Furukawa et al., 1992) l(2)35Be (Furukawa et al., 1992) l(2)35Bg (Furukawa et al., 1992) l(2)35Cc (Ashburner et al., 1990, Furukawa et al., 1992) mol (Furukawa et al., 1992) noc (Davis et al., 1990, Davis et al., 1997) rd (Ashburner et al., 1990, Furukawa et al., 1992) stc (Ashburner et al., 1990, Furukawa et al., 1992) Su(H) (Ashburner et al., 1990, Furukawa et al., 1992) TfIIS (Ashburner et al., 1990, Furukawa et al., 1992) vas (Furukawa et al., 1992, Ashburner et al., 1990) wek (Roote et al., 1996)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	BicC (Ashburner et al., 1990) cact (Ashburner et al., 1990) Ca-α1D (Ashburner et al., 1990) chif (Ashburner et al., 1990) cni (Ashburner et al., 1990) crp (Ashburner et al., 1990) Cul-3 (Ashburner et al., 1990, Furukawa et al., 1992) CycE (Ashburner et al., 1990, Furukawa et al., 1992) Cyp303a1 (Ashburner et al., 1990) dac (Ashburner et al., 1990) elA (Davis et al., 1990) elB (Davis et al., 1990, Davis et al., 1997) esg (Ashburner et al., 1990, Furukawa et al., 1992) fzy (Ashburner et al., 1990) Gli (Ashburner et al., 1990) heix (Ashburner et al., 1990) l(2)34Fd (Davis et al., 1990) l(2)35De (Ashburner et al., 1990, Furukawa et al., 1992) l(2)35Df (Ashburner et al., 1990, Furukawa et al., 1992) l(2)35Di (Ashburner et al., 1990) l(2)36Aa (Ashburner et al., 1990) l(2)36Ab (Ashburner et al., 1990) l(2)36Ac (Ashburner et al., 1990) l(2)36Ad (Ashburner et al., 1990) lace (Ashburner et al., 1990, Furukawa et al., 1992) mRpL4 (Ashburner et al., 1990) ms(2)34Fe (Davis et al., 1990) ms(2)35Eb (Ashburner et al., 1990) pburs (Davis et al., 1990, Davis et al., 1997) Pgant35A (Davis et al., 1990) plo (Ashburner et al., 1990) sna (Ashburner et al., 1990, Furukawa et al., 1992) Syx5 (Ashburner et al., 1990) wek (Ashburner et al., 1990) wor (Ashburner et al., 1990, Furukawa et al., 1992)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations	Df(2L)el28/Df(2L)b83d29a adults have a weak "elbow" phenotype. Df(2L)el28/Df(2L)b84a2 animals often do not survive to adulthood, those that do have an "elbow" phenotype. (Davis et al., 1997) Heterozygotes with Df(2L)RA5 exhibit a leaky female sterile phenotype (uncovering fs(2)35Ec). (Roote, 1997.6.6) Weakly suppresses the zeste phenotype in a z¹ w^11E4; Tp(1;2)TE35B homologue. (Gubb et al., 1990)
NOT in combination with other aberrations	Chromosome acts as a weak trans-suppressor of a physical interaction between tandemly duplicated copies of w⁺, an interaction that is required for the suppression of genes by z¹. (Gubb et al., 1990)
Stocks ( 0 )

Notes on Origin
Discoverer

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	Df(2L)el28 el28 (Furukawa et al., 1992)
Name Synonym	Deficiency (2L) elbow
Secondary FlyBase IDs

References ( 9 )
Research paper	Davis et al., 1997, Hereditas 126(1): 67--75 Genetic and phenotypic analysis of the genes of the elbow-no-ocelli region of chromosome 2L of Drosophila melanogaster. [FBrf0093413] Roote et al., 1996, D. I. S. 77: 55--65 Aberrations in the l(2)34Fc - l(2)35Bb region of chromosome arm 2L. [FBrf0091422] Furukawa et al., 1992, Cell 69: 1191--1197 The Drosophila homolog of the immunoglobulin recombination signal-binding protein regulates peripheral nervous system development. [FBrf0055544] Ashburner et al., 1990, Genetics 126: 679--694 The genetics of a small autosomal region of Drosophila melanogaster containing the structural gene for alcohol dehydrogenase. [FBrf0051973] Davis et al., 1990, Genetics 126: 105--119 The molecular analysis of the el-noc complex of Drosophila melanogaster. [FBrf0051916] Gubb et al., 1990, Genetics 126: 167--176 A novel transvection phenomenon affecting the white gene of Drosophila melanogaster. [FBrf0051930]
Personal communication to FlyBase	Roote, 1997.6.6, Alleles and aberrations update. Alleles and aberrations update. [FBrf0093866]
FlyBase analysis	FlyBase, 2007, En masse symbol-based assigment of Aberration Class with respect to wild type. En masse symbol-based assigment of Aberration Class with respect to wild type. [FBrf0191808]
Book	Lindsley and Zimm, 1992, The Genome of Drosophila melanogaster. The Genome of Drosophila melanogaster. [FBrf0066905]