Aberration Dmel\Df(2L)esc10

General Information
Symbol	Dmel\Df(2L)esc10	Species	D. melanogaster
Name		FlyBase ID	FBab0001811
Feature type	chromosomal_deletion
Also Known As	Df(2L)esc¹⁰, Dfesc¹⁰, esc¹⁰

Computed Breakpoints include	33A1;33B2
Deleted segment	33A1--33B2
Sequence coordinates
Member of large scale dataset(s)
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Aberration
Cytological Order
Progenitor
Mutagen	gamma ray
Class of aberration (relative to progenitor)	chromosomal_deletion (Kania et al., 1995, Pauli et al., 1995, Harbecke and Lengyel, 1995, D'Avino and Thummel, 1998)
Breakpoints	33A1;33B2 (D'Avino and Thummel, 1998) 33A8-33B1;33B2-33B3 (Kania et al., 1995, Pauli et al., 1995, Harbecke and Lengyel, 1995)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data	sala << bk1 << crol << esc << bk2 << prd
Genetic mapping information
Comments	Breakpoint(s) molecularly mapped (Frei et al., 1988, Frei et al., 1985, Frei et al., 1985, Kilchherr et al., 1986) 380 kb deletion Embryos deficient for esc show indiscriminate expression of segment-specific homeotic genes (Struhl and Akam, 1985, EMBO J. 4: 3259-64). Distal breakpoint mapped to the DNA at about -310 to -290 kb and proximal breakpoint mapped at about +70 kb ('-' values to right, '+' values to left) in the F walk of Frei et al., 1985.
Comments on Cytology
	Ref: Lindsley and Zimm, 1992 (Kania et al., 1995) 380kb deletion including esc sequences. (Simon et al., 1995) Limits of break 1 from polytene analysis (FBrf0102633) Left limit of break 2 from polytene analysis (FBrf0080145) Right limit of break 2 from polytene analysis (FBrf0102633)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	bft (Hardiman et al., 2002) crol (D'Avino and Thummel, 1998) esc (Struhl and Akam, 1985, Jurgens, 1988, Simon et al., 1995)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	Agi (Parker and Roberts, 1996) bun (BDGP Project Members, 1994-1999, Kania et al., 1995) prd (Jurgens, 1988) sala (Frei et al., 1988) salm (Frei et al., 1988, Jurgens, 1988)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations	Df(2L)esc10 is semi-lethal in combination with Df(2L)prd1.7. Surviving males and females are fertile. (Levine et al., 2007) Df(2L)esc10/Df(2L)prd1.7 adult survivors lack almost all interommatidial bristles. (Hardiman et al., 2002)
NOT in combination with other aberrations	The Df(2L)esc10 chromosome does not act as a dominant suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{w^var}KR3-2", a stable "brown-red" variant of the P{3'WP-2,w^var}2Lt insertion). (Mason et al., 2004) Heterozygosity for Df(2L)esc10 results in 0.0% X chromosome nondisjunction and 0.2% fourth chromosome nondisjunction in In(1)FM7/X ; sv^spa-pol females. (Harris et al., 2003) Shows no maternal enhancement of dpp^hr4. (Nicholls and Gelbart, 1998) Deficient embryos show a variably penetrant mutant midgut phenotype: incomplete constriction formation. (Bilder and Scott, 1995) Heterozygosity for this deletion has no effect on the mutant ovarian phenotype of ovo^D2. (Pauli et al., 1995) Heterozygotes with esc² are embryonic lethal due to transformation of most body segments into ectopic eighth abdominal segments. Complete lethality is seen if a 2 hour heat shock of esc^hs.PS is administered after 4 hours of embryogenesis. Rescue to first instar larval viability is seen if heat shock is induced prior to 4 hours of embryogenesis. Only 10% of rescued larvae reach adulthood. Of these adults half are normal and half exhibit segmental transformations. (Simon et al., 1995) Homozygotes viable and extreme esc when mother esc⁺/esc^-, but lethal in first larval instar with homoeotic transformation of segments when mother esc^-/esc^-. Heterozygotes with esc², esc⁴, esc⁵, esc⁶, esc⁸, or esc⁹ show same extreme phenotypes as homozygotes.
Stocks ( 2 )
Bloomington	3129 Df(2L)esc10, b¹ pr¹/CyO
Kyoto	106868 Df(2L)esc10, b¹ pr¹/CyO
Notes on Origin
Discoverer	Struhl.

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments
	Does not suppress the nos mutant phenotype. (Pelegri and Lehmann, 1994) Expression of en in the embryo not derepressed, as it is for other Pc group genes, but all stripes resemble A8. (Moazed and O'Farrell, 1992) Embryos initially have normal abd-A expression pattern. (Simon et al., 1992)
Synonyms & Secondary IDs ( 7 )
Reported As
Symbol Synonym	Df(2L)esc Df(2L)esc10 (Crest et al., 2007, Pane et al., 2007) Df(2L)esc 10 (Levine et al., 2007) Df(2L)esc¹⁰ (D'Avino and Thummel, 2000, D'Avino and Thummel, 1998, McKeon et al., 1994, Jurgens, 1988, Kilchherr et al., 1986, Frei et al., 1988) Dfesc¹⁰ (Ng et al., 1997, Simon et al., 1995) E10 (McKeon et al., 1994) esc¹⁰ (Simon et al., 1995, Ketel et al., 2005)
Name Synonym
Secondary FlyBase IDs
	FBal0003830
References ( 41 )

Generate a list of	All references relating to this aberration ( 41 )

List References by type	Research paper ( 38 ) Personal communication to FlyBase ( 1 ) FlyBase analysis ( 1 ) Book ( 1 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2011 Show research papers ...