FB2025_01 , released February 20, 2025
Aberration: Dmel\Df(2L)esc10
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General Information
Symbol
Df(2L)esc10
Species
D. melanogaster
Name
FlyBase ID
FBab0001811
Feature type
chromosomal_deletion
Also Known As
Df(2L)esc10, Dfesc10, esc10
Computed Breakpoints include

33A1;33B2

Features within 33A1--33B2
Sequence coordinates
Member of large scale dataset(s)
Nature of Aberration
Cytological Order
Progenitor
Mutagen
gamma ray
Class of aberration (relative to wild type)
chromosomal_deletion
(FlyBase, 2007)
Class of aberration (relative to progenitor)
chromosomal_deletion
(D'Avino and Thummel, 1998, Harbecke and Lengyel, 1995, Kania et al., 1995, Pauli et al., 1995)
Breakpoints

33A8-33B1;33B2-33B3

(Harbecke and Lengyel, 1995, Kania et al., 1995, Pauli et al., 1995)

33A1;33B2

(D'Avino and Thummel, 1998)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data

sala << bk1 << crol << esc << bk2 << prd

Genetic mapping information
Comments

Breakpoint(s) molecularly mapped

(Frei et al., 1988, Kilchherr et al., 1986, Frei et al., 1985, Frei et al., 1985)

380 kb deletion Embryos deficient for esc show indiscriminate expression of segment-specific homeotic genes (Struhl and Akam, 1985, EMBO J. 4: 3259-64). Distal breakpoint mapped to the DNA at about -310 to -290 kb and proximal breakpoint mapped at about +70 kb ('-' values to right, '+' values to left) in the F walk of Frei et al., 1985.

Comments on Cytology

Ref: Lindsley and Zimm, 1992

(Kania et al., 1995)

380kb deletion including esc sequences.

(Simon et al., 1995)

Limits of break 1 from polytene analysis (FBrf0102633) Left limit of break 2 from polytene analysis (FBrf0080145) Right limit of break 2 from polytene analysis (FBrf0102633)

Sequence Crossreferences
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
Gene Deletion and Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted
crol
(D'Avino and Thummel, 1998)
esc
(Simon et al., 1995, Jurgens, 1988, Struhl and Akam, 1985)
mir-bft
(Hardiman et al., 2002)
Partially deleted / disrupted
Molecular Data
Completely deleted
Partially deleted
Genes NOT Deleted / Disrupted
Genes Duplicated
Complementation Data
Completely duplicated
Partially duplicated
Molecular Data
Completely duplicated
Partially duplicated
Genes NOT Duplicated
Complementation Data
 
Molecular Data
 
Affected Genes Inferred by Location (0)
    If no genes are listed here, it may be because the affected region is very large. The JBrowse insert above may show an error for the same reason, and other FlyBase tools such as CytoSearch may also fail for large regions. You can contact FlyBase for more help.
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    Phenotypic Data
    In combination with other aberrations

    Df(2L)esc10 is semi-lethal in combination with Df(2L)prd1.7. Surviving males and females are fertile.

    (Levine et al., 2007)

    Df(2L)esc10/Df(2L)prd1.7 adult survivors lack almost all interommatidial bristles.

    (Hardiman et al., 2002)
    NOT in combination with other aberrations

    The Df(2L)esc10 chromosome does not act as a dominant suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{wvar}KR3-2", a stable "brown-red" variant of the P{3'WP-2,wvar}2Lt insertion).

    (Mason et al., 2004)

    Heterozygosity for Df(2L)esc10 results in 0.0% X chromosome nondisjunction and 0.2% fourth chromosome nondisjunction in In(1)FM7/X ; svspa-pol females.

    (Harris et al., 2003)

    Shows no maternal enhancement of dpphr4.

    (Nicholls and Gelbart, 1998)

    Deficient embryos show a variably penetrant mutant midgut phenotype: incomplete constriction formation.

    (Bilder and Scott, 1995)

    Heterozygosity for this deletion has no effect on the mutant ovarian phenotype of ovoD2.

    (Pauli et al., 1995)

    Heterozygotes with esc2 are embryonic lethal due to transformation of most body segments into ectopic eighth abdominal segments. Complete lethality is seen if a 2 hour heat shock of eschs.PS is administered after 4 hours of embryogenesis. Rescue to first instar larval viability is seen if heat shock is induced prior to 4 hours of embryogenesis. Only 10% of rescued larvae reach adulthood. Of these adults half are normal and half exhibit segmental transformations.

    (Simon et al., 1995)

    Homozygotes viable and extreme esc when mother esc+/esc-, but lethal in first larval instar with homoeotic transformation of segments when mother esc-/esc-. Heterozygotes with esc2, esc4, esc5, esc6, esc8, or esc9 show same extreme phenotypes as homozygotes.

    Stocks (2)
    Notes on Origin
    Discoverer

    Struhl.

     
    Balancer / Genotype Variants of the Aberration
     
    Separable Components
     
    Other Comments
     

    Does not suppress the nos mutant phenotype.

    (Pelegri and Lehmann, 1994)

    Expression of en in the embryo not derepressed, as it is for other Pc group genes, but all stripes resemble A8.

    (Moazed and O'Farrell, 1992)

    Embryos initially have normal abd-A expression pattern.

    (Simon et al., 1992)
    Synonyms and Secondary IDs (7)
    References (41)