Aberration Dmel\Df(2L)fn2

General Information
Symbol	Dmel\Df(2L)fn2	Species	D. melanogaster
Name	Deficiency (2L) formaldehyde induced	FlyBase ID	FBab0001815
Feature type	chromosomal_deletion

Computed Breakpoints include	35A4-35B1;35B2
Deleted segment	35A4--35B2
Sequence coordinates
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2012_01
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Aberration
Cytological Order
Progenitor
Mutagen	formaldehyde (O'Donnell et al., 1977, Woodruff and Ashburner, 1979, McNabb et al., 1996, Grau et al., 1984)
Class of aberration (relative to progenitor)	chromosomal_deletion (Gubb et al., 1990, O'Donnell et al., 1977, Woodruff and Ashburner, 1979, Ashburner et al., 1982, Ashburner et al., 1983, Gubb et al., 1986, McNabb et al., 1996, Roote et al., 1996, Gubb et al., 1997)
Breakpoints	35A1-35A2;35B6-35B7 (O'Donnell et al., 1977) 35A3;35B2 (Gubb et al., 1990, McNabb et al., 1996, Roote et al., 1996, Gubb et al., 1997) 35A3;35B2-35B4 (Woodruff and Ashburner, 1979, Ashburner et al., 1982, Ashburner et al., 1983, Gubb et al., 1986)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data	pu << bk1 << l(2)35Ab << Adh << bk2 << mol
Genetic mapping information
Comments
Comments on Cytology
	Left limit of break 1 from non-inclusion of elB (FBrf0091422) Right limit of break 1 from inclusion of elA (FBrf0030161) Left limit of break 2 from inclusion of Adh (FBrf0030161) Right limit of break 2 from polytene analysis (FBrf0051930)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	Adh (Roote, 2002.1.15, O'Donnell et al., 1977, Woodruff and Ashburner, 1979, Woodruff and Ashburner, 1979, Ashburner et al., 1982, Ashburner et al., 1982, Grau et al., 1984, McNabb et al., 1996, Roote et al., 1996, Roote, 1996.8) elA (O'Donnell et al., 1977, Woodruff and Ashburner, 1979, Woodruff and Ashburner, 1979, Ashburner et al., 1982, Ashburner et al., 1982, Roote et al., 1996, Davis et al., 1997) elB (Dorfman et al., 2002) l(2)35Ab (Roote, 1994.12.19) mol (McNabb et al., 1996) noc (O'Donnell et al., 1977, Woodruff and Ashburner, 1979, Ashburner et al., 1982, Ashburner et al., 1982, Grau et al., 1984, McNabb et al., 1996, Roote et al., 1996, Davis et al., 1997) osp (Woodruff and Ashburner, 1979, Woodruff and Ashburner, 1979, Ashburner et al., 1982, Ashburner et al., 1982, Grau et al., 1984, McNabb et al., 1996, Roote et al., 1996, Roote, 1996.8)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	Ance (Ashburner et al., 1982) b (O'Donnell et al., 1977, Woodruff and Ashburner, 1979, Woodruff and Ashburner, 1979, Ashburner et al., 1982) BicC (Grau et al., 1984) ck (O'Donnell et al., 1977, Woodruff and Ashburner, 1979, Ashburner et al., 1982, Ashburner et al., 1982, Grau et al., 1984) Cul-3 (Ashburner et al., 1982, Ashburner et al., 1982) CycE (Ashburner et al., 1982, Ashburner et al., 1982, Grau et al., 1984) DNApol-γ35 (Woodruff and Ashburner, 1979, Ashburner et al., 1982) dyn-p25 (O'Donnell et al., 1977, Woodruff and Ashburner, 1979, Ashburner et al., 1982) elB (Roote et al., 1996, Davis et al., 1997) l(2)34Db (Ashburner et al., 1982) l(2)34Fc (Roote et al., 1996, O'Donnell et al., 1977, Ashburner et al., 1982, Woodruff and Ashburner, 1979, Ashburner et al., 1982) l(2)34Fd (Woodruff and Ashburner, 1979, Ashburner et al., 1982, O'Donnell et al., 1977, Roote et al., 1996) l(2)35Bc (O'Donnell et al., 1977, Ashburner et al., 1982, Woodruff and Ashburner, 1979) l(2)35Bd (O'Donnell et al., 1977, Woodruff and Ashburner, 1979, Ashburner et al., 1982) l(2)35Be (Woodruff and Ashburner, 1979, Ashburner et al., 1982, O'Donnell et al., 1977) l(2)35Bg (O'Donnell et al., 1977, Woodruff and Ashburner, 1979, Ashburner et al., 1982, Ashburner et al., 1982) lace (Ashburner et al., 1982, Ashburner et al., 1982, Grau et al., 1984) mol (O'Donnell et al., 1977, Woodruff and Ashburner, 1979, Ashburner et al., 1982, Ashburner et al., 1982, Grau et al., 1984, Roote et al., 1996, Roote, 1996.8) ms(2)34Fe (Roote et al., 1996) nimA (Woodruff and Ashburner, 1979, Ashburner et al., 1982, O'Donnell et al., 1977, Woodruff and Ashburner, 1979) nimC3 (Ashburner et al., 1982) Pgant35A (O'Donnell et al., 1977, Woodruff and Ashburner, 1979, Ashburner et al., 1982, Ashburner et al., 1982, Roote et al., 1996) pu (O'Donnell et al., 1977, Woodruff and Ashburner, 1979, Woodruff and Ashburner, 1979, Ashburner et al., 1982, Ashburner et al., 1982, Grau et al., 1984, Roote et al., 1996, Davis et al., 1997) rd (O'Donnell et al., 1977, Woodruff and Ashburner, 1979, Woodruff and Ashburner, 1979, Ashburner et al., 1982, Ashburner et al., 1982, Grau et al., 1984) rk (O'Donnell et al., 1977, Woodruff and Ashburner, 1979, Woodruff and Ashburner, 1979, Ashburner et al., 1982) RpII33 (Woodruff and Ashburner, 1979, Ashburner et al., 1982) sna (Ashburner et al., 1982, Ashburner et al., 1982, Grau et al., 1984) Sop2 (Woodruff and Ashburner, 1979, Ashburner et al., 1982) Sos (Woodruff and Ashburner, 1979, Ashburner et al., 1982) stc (Ashburner et al., 1982, Ashburner et al., 1982, Grau et al., 1984) Su(H) (O'Donnell et al., 1977, Woodruff and Ashburner, 1979, Woodruff and Ashburner, 1979, Ashburner et al., 1982, Grau et al., 1984) tam (Woodruff and Ashburner, 1979, Ashburner et al., 1982) wb (Woodruff and Ashburner, 1979, O'Donnell et al., 1977, Ashburner et al., 1982) wor (Ashburner et al., 1982, Ashburner et al., 1982, Grau et al., 1984)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations	Df(2L)fn2/Df(2L)b83d29a adults have a weak crippled legs phenotype. Df(2L)fn2/Df(2L)b84a2 animals usually die as pharate adults, rare escapers have crippled legs and show an "elbow" phenotype. (Davis et al., 1997) Viable in combination with In(2L)TE35B-1, T(2;3)TE35B-3, In(2L)TE35B-8, In(2L)TE35B-11, In(2LR)TE35B-15, In(2L)TE35B-16, T(2;3)TE35B-25, T(2;3)TE35B-26, In(2L)TE35B-27, T(2;3)TE35B-28, T(2;4)TE35B-50, In(2L)TE35B-53, Tp(2;2)TE35B-54, In(2L)TE35B-55, In(2L)TE35B-56, T(2;3)TE35B-58, T(2;3)TE35B-200, T(Y;2)TE35B-201, In(2LR)TE35B-205, T(Y;2)TE35B-206, T(2;3)TE35B-207, T(2;3)TE35B-208, T(2;3)TE35B-209, In(2L)TE35B-210, T(Y;2)TE35B-211, T(2;3)TE35B-212, T(Y;2)TE35B-213, T(2;4)TE35B-214, T(2;3)TE35B-215, T(2;3)TE35B-216, T(1;2)TE35B-217, T(2;3)TE35B-218, In(2)TE35B-219, In(2L)TE35B-220, In(2LR)TE35B-222, In(2LR)TE35B-223, T(2;3)TE35B-224, In(2L)TE35B-225, In(2LR)TE35B-226, In(2L)TE35B-227 and T(2;3)TE35B-230, producing flies with a noc phenotype. (Gubb et al., 1997) Strongly suppresses the zeste phenotype in a z¹ w^11E4; Tp(1;2)TE35B homologue. (Gubb et al., 1990)
NOT in combination with other aberrations	Chromosome acts as a strong trans-suppressor of a physical interaction between tandemly duplicated copies of w⁺, an interaction that is required for the suppression of genes by z¹. (Gubb et al., 1990) Homozygous embryos gastrulate normally and usually appear morphologically normal at the end of embryogenesis (a few show weak pigmentation). (Grau et al., 1984)
Stocks ( 2 )
Bloomington	3583 Df(2L)fn2/CyO, Adh^nB
Kyoto	107110 Df(2L)fn2/CyO, Adh^nB
Notes on Origin
Discoverer	Sofer.
	Selected as ADH null on 1-penten-3-ol.
Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments
	The Df(2L)fn2 chromosome may act as a dominant suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{w^var}KR3-2", a stable "brown-red" variant of the P{3'WP-2,w^var}2Lt insertion), but the eye colour phenotype in the presence of Df(2L)fn2 overlaps the eye colour phenotype in a wild-type background so it cannot be unequivocally demonstrated that the deficiency chromosome uncovers a suppressor of telomeric silencing. In addition, any suppression is a false positive result (the suppressor is not within the bounds of the deficient region) because the region of the deficiency is covered by one or more nonsuppressing deficiencies. (Mason et al., 2004) Reported to delete Adhr in error; see FBrf0141768 for correction. (Roote et al., 1996)
Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	Df(2L)Adh^fn2 (O'Donnell et al., 1977) Df(2L)fn2
Name Synonym	Deficiency (2L) formaldehyde induced
Secondary FlyBase IDs

References ( 21 )

Generate a list of	All references relating to this aberration ( 21 )

List References by type	Research paper ( 15 ) Personal communication to FlyBase ( 4 ) FlyBase analysis ( 1 ) Book ( 1 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2010 Show research papers ...