FlyBase Aberration Report: Dmel\Df(2L)net-PMF

General Information

Symbol

Df(2L)net-PMF

Species

D. melanogaster

Name

FlyBase ID

FBab0001854

Feature type

chromosomal_deletion

Also Known As

Df(2L)PMF

Computed Breakpoints include

21A1;21B7-21B8

Features within 21A1--21B8

Sequence coordinates

Member of large scale dataset(s)

Nature of Aberration

Cytological Order

Progenitor

Mutagen

Class of aberration (relative to wild type)

chromosomal_deletion

(FlyBase, 2007)

Class of aberration (relative to progenitor)

chromosomal_deletion

(Boube et al., 1997, Dickson et al., 1996, Kania et al., 1995)

Breakpoints

21A1;21B7-21B8

(Kania et al., 1995)

21A;21B7-21B8

(Dickson et al., 1996)

[];21B7--8

(Alcedo et al., 1996)

21A1-21A3;21B7-21B8

(Boube et al., 1997)

Causes alleles

Carries alleles

Transposon Insertions

Formalized genetic data

bk1 << spen << l(2)21Be << bk2 << smo

Genetic mapping information

Comments

Comments on Cytology

Ref: Lindsley and Zimm, 1992

(Kania et al., 1995)

Limits of break 1 from polytene analysis (FBrf0080145) Left limit of break 2 from inclusion of kis (FBrf0067338) Right limit of break 2 from polytene analysis (FBrf0080145)

Sequence Crossreferences

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

Gene Deletion and Duplication Data

Genes Deleted / Disrupted

Complementation Data

Completely deleted / disrupted

cass

(BDGP Project Members, 1994-1999)

CG3164

(Caggese et al., 1994)

gl(2L)159-23

(Luschnig et al., 2004)

Gs1

(Caggese et al., 1994)

ifm(2)RU5

(Nongthomba and Ramachandra, 1999)

kis

(Therrien et al., 2000, Daubresse et al., 1999, Spradling et al., 1999, Netter et al., 1998, BDGP Project Members, 1994-1999)

l(2)21Ba1

(Caggese et al., 1994)

l(2)21Bb

(Caggese et al., 1994)

l(2)21Bd

(Caggese et al., 1994)

l(2)21Be

(Caggese et al., 1994)

l(2)04207a

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

l(2)gl

(Brumby et al., 2004, Mason et al., 2004, Caggese et al., 1994)

mbm

(Albert et al., 1995)

net

(Caggese et al., 1994)

Rpp30

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

spen

(Eun et al., 2007, Therrien et al., 2000, Spradling et al., 1999, Staehling-Hampton et al., 1999, Dickson et al., 1996, BDGP Project Members, 1994-1999)

Partially deleted / disrupted

Molecular Data

Completely deleted

Partially deleted

Genes NOT Deleted / Disrupted

Complementation Data

Molecular Data

Genes Duplicated

Complementation Data

Completely duplicated

Partially duplicated

Molecular Data

Completely duplicated

Partially duplicated

Genes NOT Duplicated

Complementation Data

Molecular Data

Affected Genes Inferred by Location (0)

If no genes are listed here, it may be because the affected region is very large. The JBrowse insert above may show an error for the same reason, and other FlyBase tools such as CytoSearch may also fail for large regions. You can contact FlyBase for more help.
In these cases, there will be no "Export to Hitlist" button to the left.

Related Comments

Phenotypic Data

In combination with other aberrations

NOT in combination with other aberrations

Heterozygosity for Df(2L)net-PMF results in 0.4% X chromosome nondisjunction and 0.0% fourth chromosome nondisjunction in In(1)FM7/X ; sv^spa-pol females.

(Harris et al., 2003)

Df(2L)net-PMF in combination with a pair of introgressions from D.simulans spanning 30F1-31E7 to 35D7-36A14 Dsim\Int(2L)S and 21A1 to 22D1--23A2 Dsim\Int(2L)D produces fertile male flies. These flies are female sterile.

(Sawamura et al., 2000)

Does not cause unconditional lethality in hybrid females when heterozygous with D.simulans chromosome.

(Coyne et al., 1998)

No second site non-complementing phenotype with zip^Ebr and zip^mhc-c6.1.

(Halsell and Kiehart, 1998)

No effect on the eye pigment phenotype of w^T81.

(Netter et al., 1998)

Shows no maternal enhancement of dpp^hr4.

(Nicholls and Gelbart, 1998)

Shows a dose-sensitive interaction with pb^hs.PB.

(Boube et al., 1997)

Hemizygosity weakly enhances the phl::tor^12D.hs.sev phenotype.

(Dickson et al., 1996)

Midgut development of mutant embryos is wild type.

(Bilder and Scott, 1995)

Mutation changes the level of w expression in ph-p^lac+3 flies; eye colour is darker.

(Fauvarque et al., 1995)

Stocks (3)

3638

107147

103270

Df(2L)net-PMF / SM6a, al² Duox^Cy dpy^lv1 cn² speck²

Notes on Origin

Discoverer

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

The Df(2L)net-PMF chromosome may act as a dominant suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{w^var}KR3-2", a stable "brown-red" variant of the P{3'WP-2,w^var}2Lt insertion), although the eye colour phenotype in the presence of Df(2L)net-PMF overlaps the eye colour phenotype in a wild-type background so it cannot be unequivocally demonstrated that the deficiency chromosome uncovers a suppressor of telomeric silencing. In addition, any suppression is assumed to be a false positive result (the suppressor may not be within the bounds of the deficient region) because the 2L TAS array on the chromosome is missing or reduced (as assayed by in situ hybridization) and it has previously been shown (FBrf0137248, FBrf0158986) that partial or complete deficiency of the 2L TAS array on the homologue suppresses silencing of brown-red variants of P{3'WP-2,w^var}2Lt. In addition, the deficiency chromosome fails to complement lethal mutations of l(2)gl and deficiencies that are mutant for l(2)gl are often also deficient for the 2L TAS array (FBrf0137248).

(Mason et al., 2004)

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Df(2L)PMF

(Harris et al., 2003, Tran and Berg, 2003, Abrell et al., 2000, Nongthomba and Ramachandra, 1999, Staehling-Hampton et al., 1999, Boube et al., 1997, Alcedo et al., 1996, Dickson et al., 1996, van den Heuvel and Ingham, 1996, Bilder and Scott, 1995, Fauvarque et al., 1995, Kania et al., 1995, Caggese et al., 1988)

Df(2L)net-PMF

(Ribot et al., 2022, Clough et al., 2014, Lee, 2012, Fernandes and Rao, 2011, Terriente-Félix et al., 2011, Crest et al., 2007, Eun et al., 2007, Secombe et al., 2007, Raabe et al., 2004, Zelhof et al., 2003)

Df(2L)netPMF

(Albert et al., 1997, Albert et al., 1995)

DfnetPMF

(Caggese et al., 1994)

Name Synonyms

Secondary FlyBase IDs

References (51)

Report Sections

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