Aberration Dmel\Df(2L)pr-A14

General Information
Symbol	Dmel\Df(2L)pr-A14	Species	D. melanogaster
Name	Deficiency (2L) purple	FlyBase ID	FBab0001867
Feature type	chromosomal_deletion
Also Known As	Df(2L)A14

Computed Breakpoints include	37D2-37D5;39A4-39A7
Deleted segment	37D2--39A7
Sequence coordinates
Member of large scale dataset(s)
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Aberration
Cytological Order
Progenitor
Mutagen	X ray (Ganetzky, 1977)
Class of aberration (relative to progenitor)	chromosomal_deletion (Kania et al., 1995, Stathakis et al., 1995, Semeshin et al., 1999)
Breakpoints	37C6-37D1;39A4-39A7 (Stathakis et al., 1995) 37D2-37D7;39A4-39A7 (Kania et al., 1995) 37D;39B2 (Semeshin et al., 1999)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data	l(2)37Da << bk1 << l(2)37Db <<βInt-ν << bk2 << crc
Genetic mapping information
Comments
Comments on Cytology
	Ref: Lindsley and Zimm, 1992 (Kania et al., 1995) Ref: FBrf0030142. (Stathakis et al., 1995) Left limit of break 1 from polytene analysis (FBrf0080145) Right limit of break 1 from inclusion of RanGap (FBrf0030142) Limits of break 2 from polytene analysis (FBrf0080145)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	Acon (BDGP Project Members, 1994-1999) barr (BDGP Project Members, 1994-1999, Kania et al., 1995) Itgβν (Reuter et al., 1993) l(2)01528 (BDGP Project Members, 1994-1999) l(2)05287 (BDGP Project Members, 1994-1999) l(2)k07215 (BDGP Project Members, 1994-1999) neb (BDGP Project Members, 1994-1999) P{lacW}snRNA:U4:39B^k09414 (BDGP Project Members, 1994-1999) pr (Ganetzky, 1977) RanGAP (Ganetzky, 1977) spi (Tio et al., 1994) tadr (Ni et al., 2008)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	amos (Ganetzky, 1977) bur (BDGP Project Members, 1994-1999) crc (Ganetzky, 1977) l(2)k11241 (BDGP Project Members, 1994-1999) Low (Bhadra et al., 1997) lt (Ganetzky, 1977) P{lacW}snRNA:U4:39B^k06410 (BDGP Project Members, 1994-1999) tup (Roote, 1996.9.11)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations	Analysis of two-cell mutant clones in the sensory organ precursors of the leg indicates that bract induction is normal when the inner (sheath and neuron) cells are mutant, and that bracts are not induced when the outer cells (shaft and socket) are mutant. Most single-cell mutant clones fail to induce bract cells, while single-cell mutant clones in the shaft cell have no effect on bract cell induction. (Peng et al., 2012) Shows no maternal enhancement of dpp^hr4. (Nicholls and Gelbart, 1998)
Stocks ( 2 )
Bloomington	3632 Df(2L)pr-A14, cn¹ bw¹/SM5
Kyoto	107141 Df(2L)pr-A14, cn¹ bw¹/SM5
Notes on Origin
Discoverer

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments
	The Df(2L)pr-A14 chromosome acts as a dominant weak suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{w^var}KR3-2", a stable "brown-red" variant of the P{3'WP-2,w^var}2Lt insertion), but this is a false positive result (the suppressor is not within the bounds of the deficient region) because the region of the deficiency is covered by one or more nonsuppressing deficiencies. (Mason et al., 2004)
Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	A14 (Ganetzky, 1977) Df(2)prA14 (Semeshin et al., 1999) Df(2L)A14 (Bhadra et al., 1997, Tio et al., 1994, ) Df(2L)prA-14 (Frolov et al., 2001) Df(2L)pr-A14 (Crest et al., 2007, Casso et al., 2008, Ni et al., 2008)
Name Synonym	Deficiency (2L) purple
Secondary FlyBase IDs

References ( 20 )
Research paper	Peng et al., 2012, Dev. Cell 23(3): 507--518 Planar Polarized Protrusions Break the Symmetry of EGFR Signaling during Drosophila Bract Cell Fate Induction. [FBrf0219458] Casso et al., 2008, Genetics 178(3): 1399--1413 A screen for modifiers of hedgehog signaling in Drosophila melanogaster identifies swm and mts. [FBrf0205418] Ni et al., 2008, J. Neurosci. 28(50): 13478--13487 Mutation of a TADR protein leads to rhodopsin and Gq-dependent retinal degeneration in Drosophila. [FBrf0206556] Crest et al., 2007, Genetics 175(2): 567--584 Onset of the DNA replication checkpoint in the early Drosophila embryo. [FBrf0194644] Mason et al., 2004, Genetics 168(3): 1353--1370 A deficiency screen for dominant suppressors of telomeric silencing in Drosophila. [FBrf0180277] Ward et al., 2003, Genetics 165(3): 1397--1415 Genetic modifier screens in Drosophila demonstrate a role for Rho1 signaling in ecdysone-triggered imaginal disc morphogenesis. [FBrf0167639] Frolov et al., 2001, Genes Dev. 15(16): 2146--2160 Functional antagonism between E2F family members. [FBrf0138394] Semeshin et al., 1999, D. I. S. 82: 63--65 Cytological localization of Drosophila melanogaster Dhr38 gene. [FBrf0112033] Nicholls and Gelbart, 1998, Genetics 149(1): 203--215 Identification of chromosomal regions involved in decapentaplegic function in Drosophila. [FBrf0102843] Bhadra et al., 1997, Genetics 146(3): 903--917 A sex-influenced modifier in Drosophila that affects a broad spectrum of target loci including the histone repeats. [FBrf0094158] Kania et al., 1995, Genetics 139(4): 1663--1678 P-element mutations affecting embryonic peripheral nervous system development in Drosophila melanogaster. [FBrf0080145] Stathakis et al., 1995, Genetics 141(2): 629--655 The genetic and molecular organization of the Dopa decarboxylase gene cluster of Drosophila melanogaster. [FBrf0084402] Tio et al., 1994, Mech. Dev. 48(1): 13--23 spitz, a Drosophila homolog of transforming growth factor-, is required in the founding photoreceptor cells of the compound eye facets. [FBrf0079521] Gay and Contamine, 1993, Mol. Gen. Genet. 239(3): 361--370 Study of the ref(2)P locus of Drosophila melanogaster. [FBrf0059083] Reuter et al., 1993, Development 119(4): 1135--1145 A role for the mesoderm in endodermal migration and morphogenesis in Drosophila. [FBrf0068651] Ganetzky, 1977, Genetics 86: 321--355 On the components of Segregation Distortion in Drosophila melanogaster. [FBrf0030142]
Personal communication to FlyBase	Roote, 1996.9.11, tup<up>1</up>. tup¹. [FBrf0089933] BDGP Project Members, 1994-1999, BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project. (Computer file) BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project. (Computer file) [FBrf0067338]
FlyBase analysis	FlyBase, 2007, En masse symbol-based assigment of Aberration Class with respect to wild type. En masse symbol-based assigment of Aberration Class with respect to wild type. [FBrf0191808]
Book	Lindsley and Zimm, 1992, The Genome of Drosophila melanogaster. The Genome of Drosophila melanogaster. [FBrf0066905]