Aberration Dmel\Df(2L)pr2b

General Information
Symbol	Dmel\Df(2L)pr2b	Species	D. melanogaster
Name	Deficiency (2L) purple	FlyBase ID	FBab0001892
Feature type	chromosomal_deletion

Computed Breakpoints include	38B5;38D2-38E1
Deleted segment	38B5--38E1
Sequence coordinates
Member of large scale dataset(s)
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Aberration
Cytological Order
Progenitor
Mutagen	X ray (Wustmann et al., 1989)
Class of aberration (relative to progenitor)	chromosomal_deletion (Wustmann et al., 1989)
Breakpoints	38B5-38C1;38D2-38E1 (Wustmann et al., 1989)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data	bk1 << pr << bk2
Genetic mapping information
Comments
Comments on Cytology
	Left limit of break 1 from polytene analysis (FBrf0050576) Right limit of break 1 from inclusion of pr (citation unavailable) Limits of break 2 from polytene analysis (FBrf0050576)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	barr (Butler et al., 2001) bru (Giansanti et al., 2004, Robinett et al., 2009) l(2)38Aa (Butler et al., 2001) l(2)38Ab (Butler et al., 2001) l(2)38Db (Butler et al., 2001) l(2)38DEa (Butler et al., 2001) neb (Butler et al., 2001, BDGP Project Members, 1994-1999) pr (Butler et al., 2001) spir (Butler et al., 2001) vls (Butler et al., 2001)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	Bl (Butler et al., 2001) cad (Butler et al., 2001) dia (Butler et al., 2001) fs(2)38ABa (Butler et al., 2001) Fs(2)Ket (Butler et al., 2001) fs(2)ltoPP43 (Butler et al., 2001, BDGP Project Members, 1994-1999) Hr38 (Butler et al., 2001, BDGP Project Members, 1994-1999) ik2 (Butler et al., 2001) l(2)38ABa (Butler et al., 2001) l(2)38ABb (Butler et al., 2001) l(2)38EFd (Butler et al., 2001, BDGP Project Members, 1994-1999) l(2)01528 (Butler et al., 2001, BDGP Project Members, 1994-1999) l(2)k02501 (BDGP Project Members, 1994-1999) l(2)k09314b (BDGP Project Members, 1994-1999) l(2)k16703 (BDGP Project Members, 1994-1999) ms(2)38ABa (Butler et al., 2001) scw (Butler et al., 2001)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations	Embryos derived from lok null mothers (Df(2L)pr2b/Df(2L)be408 females carrying P{CG10728^+tMa} to rescue vls function and P{barr^+tMa} to rescue barr function) have an average of 24.5 pole cells/embryo compared to the wild-type number of 37.3 pole cells/embryo. The progeny of the lok null flies are viable and fertile, they show no increase in the rate of X chromosome nondisjunction compared to controls and females show no defects in meiotic recombination frequency. lok null larvae are not more sensitive to methyl methanesulfonate or hydroxyurea than control larvae. Irradiation does not result in a delay of entry into mitosis in lok null embryos, in contrast to wild-type embryos. (Masrouha et al., 2003) Viable and fertile in combination with Df(2L)TW50. Viable and fertile in combination with Df(2L)Sd37. Semilethal and female sterile in combination with Df(2L)DS5. Semilethal and female sterile in combination with Df(2L)DS9. (Butler et al., 2001) Dominant suppressor of In(1)w^m4h position-effect variegation. (Wustmann et al., 1989)
NOT in combination with other aberrations
Stocks ( 0 )

Notes on Origin
Discoverer

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	Df(2L)2b (Wustmann et al., 1989, ) Df(2L)pr2b (Robinett et al., 2009)
Name Synonym	Deficiency (2L) purple
Secondary FlyBase IDs

References ( 10 )
Research paper	Robinett et al., 2009, J. Cell Sci. 122(24): 4526--4534 TRAPPII is required for cleavage furrow ingression and localization of Rab11 in dividing male meiotic cells of Drosophila. [FBrf0209478] Cavey et al., 2005, Development 132(3): 459--468 Drosophila valois encodes a divergent WD protein that is required for Vasa localization and Oskar protein accumulation. [FBrf0183934] Giansanti et al., 2004, Mol. Biol. Cell 15(5): 2509--2522 Genetic dissection of meiotic cytokinesis in Drosophila males. [FBrf0174933] Masrouha et al., 2003, Genetics 163(3): 973--982 The Drosophila chk2 gene loki is essential for embryonic dna double-strand-break checkpoints induced in S phase or G2. [FBrf0158989] Staeva-Vieira et al., 2003, EMBO J. 22(21): 5863--5874 An essential role of DmRad51/SpnA in DNA repair and meiotic checkpoint control. [FBrf0167550] Butler et al., 2001, Genetics 158(4): 1597--1614 Map position and expression of the genes in the 38 region of Drosophila. [FBrf0138405] Wustmann et al., 1989, Mol. Gen. Genet. 217: 520--527 The genetics of position-effect variegation modifying loci in Drosophila melanogaster. [FBrf0050576]
Personal communication to FlyBase	BDGP Project Members, 1994-1999, BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project. (Computer file) BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project. (Computer file) [FBrf0067338]
FlyBase analysis	FlyBase, 2007, En masse symbol-based assigment of Aberration Class with respect to wild type. En masse symbol-based assigment of Aberration Class with respect to wild type. [FBrf0191808]
Book	Lindsley and Zimm, 1992, The Genome of Drosophila melanogaster. The Genome of Drosophila melanogaster. [FBrf0066905]