Aberration Dmel\Df(2L)prd1.7

General Information
Symbol	Dmel\Df(2L)prd1.7	Species	D. melanogaster
Name		FlyBase ID	FBab0001902
Feature type	chromosomal_deletion
Also Known As	Df(2L)prd^1.7

Computed Breakpoints include	33B3;34A1-34A2
Deleted segment	33B3--34A2
Sequence coordinates
Member of large scale dataset(s)
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Aberration
Cytological Order
Progenitor
Mutagen
Class of aberration (relative to progenitor)	chromosomal_deletion (Kania et al., 1995, Pauli et al., 1995, Verheyen et al., 1996, Harbecke and Lengyel, 1995, Landecker et al., 1994)
Breakpoints	33B2-33B3;34A1-34A2 (Landecker et al., 1994, Kania et al., 1995, Harbecke and Lengyel, 1995, Verheyen et al., 1996) 33B3-33B7;34A1-34A2 (Schupbach and Wieschaus, 1989, Pauli et al., 1995)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data	esc << bk1 << E(var)33AD << pdm2 << bk2
Genetic mapping information
Comments	Breakpoint(s) molecularly mapped (Frei et al., 1985, Frei et al., 1985, Kilchherr et al., 1986) Distal breakpoint mapped to the DNA (Frei et al., 1985).
Comments on Cytology
	Ref: Lindsley and Zimm, 1992 (Kania et al., 1995) Left limit of break 1 from polytene analysis (FBrf0049878) Right limit of break 1 from polytene analysis (FBrf0076124) Limits of break 2 from polytene analysis (FBrf0049878)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	Aats-thr (Spradling et al., 1999, BDGP Project Members, 1994-1999) aret (Schupbach and Wieschaus, 1991) bft (Hardiman et al., 2002) bun (BDGP Project Members, 1994-1999, Gluderer et al., 2008) E(var)33AD (Wustmann et al., 1989) Elf (Chao et al., 2003) l(2)10333 (BDGP Project Members, 1994-1999) l(2)rK639 (Spradling et al., 1999, BDGP Project Members, 1994-1999) nub (Yeo et al., 1995, Ng et al., 1995, Bhat and Schedl, 1994) pdm2 (Bhat and Schedl, 1994, Yeo et al., 1995) Pkd2 (Gao et al., 2004) prd (Jurgens, 1988, Harbecke and Lengyel, 1995, Yeo et al., 1995) Rab6 (Spradling et al., 1999, BDGP Project Members, 1994-1999, Verheyen et al., 1996) Vha68-2 (Spradling et al., 1999, BDGP Project Members, 1994-1999) zuc (Schupbach and Wieschaus, 1991)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	bun (Kania et al., 1995) Elf (BDGP Project Members, 1994-1999) esc (Jurgens, 1988) l(2)k05448 (BDGP Project Members, 1994-1999) l(2)k07015 (BDGP Project Members, 1994-1999) l(2)k07332 (BDGP Project Members, 1994-1999) l(2)k09035 (BDGP Project Members, 1994-1999) l(2)k10105 (Spradling et al., 1999, BDGP Project Members, 1994-1999) l(2)k11328 (Spradling et al., 1999, BDGP Project Members, 1994-1999) nAcRα-30D (Watson et al., 2010) salm (Tearle and Nusslein-Volhard, 1987, Jurgens, 1988)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations	Df(2L)esc10 is semi-lethal in combination with Df(2L)prd1.7. Surviving males and females are fertile. (Levine et al., 2007) Df(2L)esc10/Df(2L)prd1.7 adult survivors lack almost all interommatidial bristles. (Hardiman et al., 2002) No effect on In(1)w^m4h position-effect variegation. (Wustmann et al., 1989)
NOT in combination with other aberrations	Heterozygous Df(2L)prd1.7 larvae show a reduction in food ingestion rate of about 35% compared to wild-type larvae. Waste excretion rates of heterozygous Df(2L)prd1.7 larvae are reduced compared to wild type. (Gao et al., 2004) The Df(2L)prd1.7 chromosome does not act as a dominant suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{w^var}KR3-2", a stable "brown-red" variant of the P{3'WP-2,w^var}2Lt insertion). (Mason et al., 2004) Df(2L)prd1.7 in combination with a pair of introgressions from D.simulans spanning 30F1-31E7 to 35D7-36A14 Dsim\Int(2L)S and 21A1 to 22D1--23A2 Dsim\Int(2L)D produces sterile male flies. These flies are female sterile. (Sawamura et al., 2000) Does not cause unconditional lethality in hybrid females when heterozygous with D.simulans chromosome. (Coyne et al., 1998) No second site non-complementing phenotype with zip^Ebr and zip^mhc-c6.1. (Halsell and Kiehart, 1998) Shows no maternal enhancement of dpp^hr4. (Nicholls and Gelbart, 1998) 100% of homozygotes lack cells from the RP2/sib lineage in all remaining hemisegments. Heterozygotes show a weak haploinsufficient phenotype, with approximately 6.5% of embryos having an RP2 lineage defect. All Df(2L)prd1.7/Df(2L)Prl embryos have hemisegments which show RP2/sib lineage defects. (Bhat et al., 1995) Deficient embryos show an uninterpretable mutant midgut phenotype. (Bilder and Scott, 1995) Homozygous embryos do not complete head involution and tracheae are disconnected. The midgut does not constrict and the midgut epithelium shows variable degrees of degeneration. (Harbecke and Lengyel, 1995) Heterozygosity for this deletion has no effect on the mutant ovarian phenotype of ovo^D2. (Pauli et al., 1995) eve-positive RP2/sib GMCs are not observed in 7.5hr deficiency embryos. (Bhat and Schedl, 1994) prd⁴/Df(2L)prd1.7 transheterozygotes only survive to adulthood in the presence of a copy of P{prd-SN20}. These adults give rise to fertile offspring. (Gutjahr et al., 1994)
Stocks ( 3 )
Bloomington	3344 Df(2L)prd1.7, b¹ Adhⁿ² pr¹ cn¹ sca¹/CyO, P{elav-lacZ.H}YH2
Kyoto	106992 Df(2L)prd1.7, b¹ Adhⁿ² pr¹ cn¹ sca¹/CyO, P{elav-lacZ.H}YH2 103257 CyO, Cy¹ dp^lv1 pr¹ cn² / Df(2L)prd1.7, b¹ pr¹ cn¹ sca¹
Notes on Origin
Discoverer	Nusslein-Volhard.

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

Synonyms & Secondary IDs ( 8 )
Reported As
Symbol Synonym	Df(2L)prd-1.7 (Tearle and Nusslein-Volhard, 1987) Df(2L)prd1.7 (Gluderer et al., 2008, Watson et al., 2010, Yang et al., 2011, Turchyn et al., 2011) Df(2L)Prd1.7 (Pane et al., 2007) Df(2L)PRD1.7 (Levine et al., 2007) Df(2L)prd.1.7 (Cifuentes and Garcia-Bellido, 1997) Df(2L)prd^1.7.20 (Kilchherr et al., 1986) Df(2L)prd^1.7 (Abrell et al., 2000, Wustmann et al., 1989, Klingler and Gergen, 1993, Gutjahr et al., 1994, Jurgens, 1988, Gutjahr et al., 1993) Df(2R)prdl,7 (Shamloula et al., 2002)
Name Synonym
Secondary FlyBase IDs

References ( 54 )

Generate a list of	All references relating to this aberration ( 54 )

List References by type	Research paper ( 50 ) Personal communication to FlyBase ( 1 ) FlyBase analysis ( 1 ) Stock list ( 1 ) Book ( 1 )
Recent research papers ( 2 )
	Turchyn et al., 2011, Dev. Biol. 357(1): 83--95 Evolution of nubbin function in hemimetabolous and holometabolous insect appendages. [FBrf0214671] Yang et al., 2011, Mol. Biol. Cell 22(7): 976--987 Regulation of flagellar motility by the conserved flagellar protein CG34110/Ccdc135/FAP50. [FBrf0214073] Show all research papers ...