25D2-25D4;25D6-25E1
25D2-25D5;25D6-25E1
25D2-25D4;25D6-25E1
Msp-300 << bk1 << tkv << nompC << bk2 << cl
Heterozygotes with Df(2L)tkv3 are lethal and with Df(2L)M24F11, Df(2L)M24F-B, Df(2L)ed1 or Df(2L)ed2 are viable.
Homozygous embryos exhibit no dorsal closure and head involution resulting in in the absence of dorsal epidermis. Homozygous embryos and transheterozygous embryos with Df(2L)tkv2 carrying tkvUbi-p63E.PB die and possess a vri phenotype. vri3/Df(2L)tkv2 transheterozygotes exhibit shortening of wing vein L2 and L5. Weak dominant enhancer of ea161.13 embryonic lethal phenotype.
P{tkvBrk25D1} has suboptimal levels of expression sufficient to rescue the lethality of tkv7/Df(2L)tkv2 through embryonic and larval development. Rescued adults display defects in the wing (cleft in the notum and reduction/deletion of the scutellum) and leg (duplication of ventral structures and loss of dorsal and distal structures) patterning.
Heterozygosity for this deletion suppresses the mutant ovarian phenotype of ovoD2.
Homozygous embryonic lethal, embryos display dorsally open cuticle, severe defective head and contracted epidermis giving the cuticle a rounded appearance. Female transheterozygotes with tkv1 and tkv6 are viable and display a wing phenotype, wing veins are very thick and short along the proximal distal axis. Adult Df(2L)tkv3/tkv6 females lay eggs, some of the embryos from these females crossed to wild type males die showing a weakly ventralised phenotype.
Szidonya.
Ref: Reuter and Szidonya, 1983, Chromosoma 88: 277--285
Left limit of break 1 from polytene analysis (FBrf0039034) Right limit of break 1 from polytene analysis (FBrf0047784) Left limit of break 2 from inclusion of cype (FBrf0094777) Right limit of break 2 from polytene analysis (FBrf0039034)