FB2020_06, released Dec 22, 2020

Aberration: Dmel\Df(2L)tkv2

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General Information
Symbol
Df(2L)tkv2
Species
D. melanogaster
Name
Deficiency (2L) thick veins
FlyBase ID
FBab0001918
Feature type
chromosomal_deletion
Also Known As
Df(2L)tkvSz2, Df(2L)tkv2, Df(2L)tkvSz-2
Computed Breakpoints include

25D2-25D4;25D6-25E1

Features within 25D2--25E1
Sequence coordinates
Member of large scale dataset(s)
Nature of Aberration
Cytological Order
Progenitor
Mutagen
X ray
Class of aberration (relative to wild type)
chromosomal_deletion
(FlyBase, 2007)
Class of aberration (relative to progenitor)
chromosomal_deletion
(George and Terracol, 1997, Pauli et al., 1995, Szidonya and Reuter, 1988, Reuter and Szidonya, 1983)
Breakpoints

25D2-25D5;25D6-25E1

(Reuter and Szidonya, 1983)

25D2-25D4;25D6-25E1

(George and Terracol, 1997, Pauli et al., 1995, Szidonya and Reuter, 1988)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data

Msp-300 << bk1 << tkv << nompC << bk2 << cl

Genetic mapping information
Comments
Comments on Cytology

Ref: Reuter and Szidonya, 1983, Chromosoma 88: 277--285

(Terracol and Lengyel, 1994)

Left limit of break 1 from polytene analysis (FBrf0039034) Right limit of break 1 from polytene analysis (FBrf0047784) Left limit of break 2 from inclusion of cype (FBrf0094777) Right limit of break 2 from polytene analysis (FBrf0039034)

Sequence Crossreferences
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
Gene Deletion and Duplication Data
Genes Deleted / Disrupted
Genes NOT Deleted / Disrupted
Complementation Data
 
cl
(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988, Reuter and Szidonya, 1983)
Col4a1
(Spradling et al., 1999, BDGP Project Members, 1994-1999)
dpy
(Reuter and Szidonya, 1983)
dw-24E
(Reuter and Szidonya, 1983)
E(var)25F
(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)
ed
(Reuter and Szidonya, 1983)
eIF3h
(Spradling et al., 1999, BDGP Project Members, 1994-1999)
ft
(Reuter and Szidonya, 1983)
garz
(Reuter and Szidonya, 1983)
Hel25E
(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)
l(2)25Ca
(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988, Reuter and Szidonya, 1983)
l(2)25Cc
(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)
l(2)25Cd
(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)
l(2)25Ce
(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)
l(2)25Cf
(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)
l(2)25Cg
(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)
l(2)25Ea
(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)
l(2)25Ed
(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)
l(2)25Ee
(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)
l(2)25Ef
(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)
l(2)25Fa
(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)
l(2)04884
(BDGP Project Members, 1994-1999)
Lam
(Spradling et al., 1999, BDGP Project Members, 1994-1999, Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)
M(2)24D
(Reuter and Szidonya, 1983)
mid
(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)
Msp300
(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)
RpL27A
(Reuter and Szidonya, 1983)
RpL37A
(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988, Reuter and Szidonya, 1983)
Su(var)2-4
(Reuter and Szidonya, 1983)
Su(var)2-8
(Reuter and Szidonya, 1983)
Su(var)25F26B
(Reuter and Szidonya, 1983)
thr
(Liu et al., 1999)
vkg
(Spradling et al., 1999, BDGP Project Members, 1994-1999)
Molecular Data
 
Genes Duplicated
Complementation Data
Completely duplicated
Partially duplicated
Molecular Data
Completely duplicated
Partially duplicated
Genes NOT Duplicated
Complementation Data
 
Molecular Data
 
Affected Genes Inferred by Location
    Phenotypic Data
    In combination with other aberrations

    Heterozygotes with Df(2L)tkv3 are lethal and with Df(2L)M24F11, Df(2L)M24F-B, Df(2L)ed1 or Df(2L)ed2 are viable.

    (Reuter and Szidonya, 1983)
    NOT in combination with other aberrations

    Homozygous embryos exhibit no dorsal closure and head involution resulting in in the absence of dorsal epidermis. Homozygous embryos and transheterozygous embryos with Df(2L)tkv2 carrying tkvUbi-p63E.PB die and possess a vri phenotype. vri3/Df(2L)tkv2 transheterozygotes exhibit shortening of wing vein L2 and L5. Weak dominant enhancer of ea161.13 embryonic lethal phenotype.

    (George and Terracol, 1997)

    P{tkvBrk25D1} has suboptimal levels of expression sufficient to rescue the lethality of tkv7/Df(2L)tkv2 through embryonic and larval development. Rescued adults display defects in the wing (cleft in the notum and reduction/deletion of the scutellum) and leg (duplication of ventral structures and loss of dorsal and distal structures) patterning.

    (Morimura et al., 1996)

    Heterozygosity for this deletion suppresses the mutant ovarian phenotype of ovoD2.

    (Pauli et al., 1995)

    Homozygous embryonic lethal, embryos display dorsally open cuticle, severe defective head and contracted epidermis giving the cuticle a rounded appearance. Female transheterozygotes with tkv1 and tkv6 are viable and display a wing phenotype, wing veins are very thick and short along the proximal distal axis. Adult Df(2L)tkv3/tkv6 females lay eggs, some of the embryos from these females crossed to wild type males die showing a weakly ventralised phenotype.

    (Terracol and Lengyel, 1994)

    Homozygous lethal. Chromosome does not have a suppressor effect on w variegation of In(1)wm4h.

    (Reuter and Szidonya, 1983)
    Stocks (2)
    Notes on Origin
    Discoverer

    Szidonya.

     
    Balancer / Genotype Variants of the Aberration
     
    Separable Components
     
    Other Comments
     
    Synonyms and Secondary IDs (9)
    Reported As
    Symbol Synonym
    Df tkv2
    (de Navas et al., 2006)
    Df(2L)tkv-Sz2
    Df(2L)tkv2
    (Leal et al., 2009)
    Df(2L)tkv2
    (Walker et al., 2000, Liu et al., 1999)
    Df(2L)tkvSz-2
    (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)
    Df(2L)tkvSz2
    (Szuplewski et al., 2003, Szuplewski and Terracol, 2001, George and Terracol, 1997, Affolter et al., 1994, Terracol and Lengyel, 1994, Reuter and Szidonya, 1983)
    Df(2L)tkvSz-2
    (Pauli et al., 1995)
    Df(2l)tkv2
    (McCabe et al., 2004)
    Name Synonyms
    Deficiency (2L) thick veins
    Secondary FlyBase IDs
      References (25)