Aberration Dmel\Df(2L)tkv3

General Information
Symbol	Dmel\Df(2L)tkv3	Species	D. melanogaster
Name		FlyBase ID	FBab0001919
Feature type	chromosomal_deletion
Also Known As	Df(2L)tkv^sz-3, Df(2L)tkv^Sz3

Computed Breakpoints include
Deleted segment	25A4--25D5
Sequence coordinates
Member of large scale dataset(s)
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Aberration
Cytological Order
Progenitor	Tp(2;3)tkv
Mutagen	segregation
Class of aberration (relative to progenitor)
Breakpoints
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data
Genetic mapping information
Comments
Comments on Cytology

Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	l(2)25Ab (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) l(2)25Ba (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) l(2)25Bb (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) l(2)25Bc (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) l(2)25Bd (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) l(2)25Be (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) l(2)25Bf (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) l(2)25Bg (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) l(2)25Ca (Reuter and Szidonya, 1983, Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) l(2)25Cc (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) l(2)25Cd (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) l(2)25Ce (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) l(2)25Cf (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) l(2)25Cg (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) Msp-300 (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) RpL37A (Reuter and Szidonya, 1983, Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) slf (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) tkv (Reuter and Szidonya, 1983, Szidonya and Reuter, 1988, Szidonya and Reuter, 1988, BDGP Project Members, 1994-1999, Nellen et al., 1994, George and Terracol, 1997) vri (George and Terracol, 1997)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	cl (Reuter and Szidonya, 1983, Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) cype (BDGP Project Members, 1994-1999) dp (Reuter and Szidonya, 1983, Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) dw-24E (Reuter and Szidonya, 1983, Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) E(var)25F (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) ed (Reuter and Szidonya, 1983, Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) ft (Reuter and Szidonya, 1983, Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) garz (Reuter and Szidonya, 1983) Hel25E (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) l(2)24Dc (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) l(2)24Dd (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) l(2)24De (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) l(2)24Fa (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) l(2)24Fc (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) l(2)25Ca (Reuter and Szidonya, 1983) l(2)25Ea (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) l(2)25Ed (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) l(2)25Ee (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) l(2)25Ef (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) l(2)25Fa (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) l(2)04884 (BDGP Project Members, 1994-1999) l(2)05714 (BDGP Project Members, 1994-1999) Lam (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988, BDGP Project Members, 1994-1999) M(2)24D (Reuter and Szidonya, 1983, Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) mid (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) nompC (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) RpL27A (Szidonya and Reuter, 1988, Reuter and Szidonya, 1983, Szidonya and Reuter, 1988) Su(var)2-4 (Reuter and Szidonya, 1983) Su(var)2-8 (Reuter and Szidonya, 1983, Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) Su(var)25F26B (Reuter and Szidonya, 1983) Tps1 (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) tutl (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) vkg (BDGP Project Members, 1994-1999) vri (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations	No effect on In(1)w^m4h position-effect variegation. (Wustmann et al., 1989) Heterozygotes with Df(2L)M24F11, Df(2L)M24F-B, Df(2L)tkv2 are lethal and with Df(2L)ed1 or Df(2L)ed2 are viable. (Reuter and Szidonya, 1983)
NOT in combination with other aberrations	Transheterozygous embryos with Df(2L)tkv2 carrying tkv^Ubi-p63E.PB die and possess a vri phenotype. (George and Terracol, 1997) Dominantly causes tergite defects in less than 50% of run³ heterozygotes. (Duffy et al., 1996) Minute phenotype and haplo sterile. Weak head defects, wrinkled dorsal epidermis and internalised and often disorganised filzkorper. Female transheterozygotes with tkv¹ are viable and display a wing vein phenotype, some wing vein thickening. Transheterozygotes with tkv⁴, tkv⁵ and tkv⁷ display extremely thickened veins and heterozygotes with tkv⁶ display wing veins that are very thick and short along the proximal distal axis. Adult Df(2L)tkv3/tkv⁸ females are very weak, possess atrophic ovaries and do not lay eggs in the few days they survive beyond eclosion. Adult Df(2L)tkv3/tkv⁷ females lay eggs, embryos from these females crossed to wild type males die showing a moderately ventralised phenotype. Adult Df(2L)tkv3/tkv⁶ females lay eggs, some of the embryos from these females crossed to wild type males die showing a weakly ventralised phenotype. (Terracol and Lengyel, 1994) Sterile and reduced viability. (Szidonya and Reuter, 1988) Homozygous lethal, shows a strong Minute phenotype. Dominant female sterility and males are not completely sterile. Chromosome does not have a suppressor effect on w variegation of In(1)w^m4h. (Reuter and Szidonya, 1983) Females sterile; males semisterile.
Stocks ( 2 )
Bloomington	1164 Df(2L)tkv3, al¹ b¹/SM1; Dp(2;3)tkv3/TM3, Sb¹
Kyoto	106235 Df(2L)tkv3, al¹ b¹/SM1; Dp(2;3)tkv3/TM3, Sb¹
Notes on Origin
Discoverer

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	Df(2L)tkv3 Df(2L)tkv^sz-3 (Wustmann et al., 1989, Nellen et al., 1994) Df(2L)tkv^Sz3 (George and Terracol, 1997, Terracol and Lengyel, 1994, Reuter and Szidonya, 1983) Df(2L)tkv^Sz-3 (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) Df(2L)tkvSz-3 (Duffy et al., 1996) Df(2L)tkv-Sz3
Name Synonym
Secondary FlyBase IDs

References ( 11 )
Research paper	Kuranaga et al., 2002, Nat. Cell Biol. 4(9): 705--710 Reaper-mediated inhibition of DIAP1-induced DTRAF1 degradation results in activation of JNK in Drosophila. [FBrf0152246] George and Terracol, 1997, Genetics 146(4): 1345--1363 The vrille gene of Drosophila is a maternal enhancer of decapentaplegic and encodes a new member of the bZIP family of transcription factors. [FBrf0094777] Duffy et al., 1996, Genetics 142(3): 839--852 Dosage-sensitive maternal modifiers of the Drosophila segmentation gene runt. [FBrf0086390] Nellen et al., 1994, Cell 78(2): 225--237 Receptor serine/threonine kinases implicated in the control of Drosophila body pattern by decapentaplegic. [FBrf0074016] Terracol and Lengyel, 1994, Genetics 138(1): 165--178 The thick veins gene of Drosophila is required for dorsoventral polarity of the embryo. [FBrf0076541] Wustmann et al., 1989, Mol. Gen. Genet. 217: 520--527 The genetics of position-effect variegation modifying loci in Drosophila melanogaster. [FBrf0050576] Szidonya and Reuter, 1988, Genet. Res. (Camb.) 51(3): 197--208 Cytogenetic analysis of the echinoid (ed), dumpy (dp) and clot (cl) region in Drosophila melanogaster. [FBrf0048137] Szidonya and Reuter, 1988, D. I. S. 67: 77--79 Cytogenetics of the 24D4-25F2 region of the Drosophila melanogaster 2L chromosome. [FBrf0047784] Reuter and Szidonya, 1983, Chromosoma 88: 277--285 Cytogenetic analysis of variegation suppressors and a dominant temperature-sensitive lethal in region 23-26 of chromosome arm 2L in Drosophila melanogaster. [FBrf0039034]
Personal communication to FlyBase	BDGP Project Members, 1994-1999, BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project. (Computer file) BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project. (Computer file) [FBrf0067338]
Book	Lindsley and Zimm, 1992, The Genome of Drosophila melanogaster. The Genome of Drosophila melanogaster. [FBrf0066905]