Aberration Dmel\Df(2R)42

General Information
Symbol	Dmel\Df(2R)42	Species	D. melanogaster
Name		FlyBase ID	FBab0001928
Feature type	chromosomal_deletion

Computed Breakpoints include	42C2;42D2-42D3
Deleted segment	42C2--42D3
Sequence coordinates
Member of large scale dataset(s)
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Aberration
Cytological Order
Progenitor
Mutagen	X ray
Class of aberration (relative to progenitor)	chromosomal_deletion (Chandrashekaran and Sarla, 1993)
Breakpoints	42C3;42D2 (Chandrashekaran and Sarla, 1993)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data	bk1 << Adf1 << l(2)01289 << bk2 << l(2)43Bd
Genetic mapping information
Comments
Comments on Cytology
	Left limit of break 1 from non-inclusion of Adf1 (FBrf0067338) Right limit of break 1 from inclusion of l(2)10521 (FBrf0067338) Limits of break 2 from polytene analysis (citation unavailable)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	Adf1 (DeZazzo et al., 2000, BDGP Project Members, 1994-1999) l(2)01289 (Spradling et al., 1999, BDGP Project Members, 1994-1999) l(2)03055 (Spradling et al., 1999, BDGP Project Members, 1994-1999) l(2)10521 (BDGP Project Members, 1994-1999) Tdc1 (Cole et al., 2005) Tdc2 (Cole et al., 2005) ubl (Spradling et al., 1999, BDGP Project Members, 1994-1999)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	Adf1 (BDGP Project Members, 1994-1999) geminin (Spradling et al., 1999, BDGP Project Members, 1994-1999) jing (Spradling et al., 1999, BDGP Project Members, 1994-1999) l(2)43Bd (BDGP Project Members, 1994-1999) l(2)00329 (BDGP Project Members, 1994-1999) l(2)Co (Cicchetti and Loverre, 1989) l(2)k02520 (BDGP Project Members, 1994-1999) l(2)k03204 (Spradling et al., 1999, BDGP Project Members, 1994-1999) l(2)k10613 (BDGP Project Members, 1994-1999) mbl (BDGP Project Members, 1994-1999) mle (Cicchetti and Loverre, 1989) ms(2)42D (Spradling et al., 1999, BDGP Project Members, 1994-1999) stmA (Chandrashekaran and Sarla, 1993) tai (BDGP Project Members, 1994-1999)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations	Homozygous embryonic lethal. (Schulte et al., 2010) The Df(2R)42 chromosome does not act as a dominant suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{w^var}KR3-2", a stable "brown-red" variant of the P{3'WP-2,w^var}2Lt insertion). (Mason et al., 2004)
Stocks ( 3 )
Bloomington	3367 Df(2R)42, cn¹/SM5
Kyoto	107011 Df(2R)42, cn¹/SM5 101433 Df(2R)42, en¹ / SM1, al² Cy¹ cn² sp²
Notes on Origin
Discoverer	Bridges, Feb. 1936.
	on vg^S
Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments
	"X ray" was stated as tentative.
Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	Df(2R)42 (He et al., 2005, Schulte et al., 2010)
Name Synonym
Secondary FlyBase IDs

References ( 13 )
Research paper	Schulte et al., 2010, J. Neurosci. 30(15): 5189--5203 DMob4/Phocein regulates synapse formation, axonal transport, and microtubule organization. [FBrf0210612] Cole et al., 2005, J. Biol. Chem. 280(15): 14948--14955 Two functional but noncomplementing Drosophila tyrosine decarboxylase genes. [FBrf0187786] He et al., 2005, Mol. Biol. Cell 16(9): 4139--4152 Drosophila mob family proteins interact with the related tricornered (trc) and warts (wts) kinases. [FBrf0188034] Mason et al., 2004, Genetics 168(3): 1353--1370 A deficiency screen for dominant suppressors of telomeric silencing in Drosophila. [FBrf0180277] DeZazzo et al., 2000, Neuron 27(1): 145--158 nalyot, a mutation of the Drosophila myb-related Adf1 transcription factor, disrupts synapse formation and olfactory memory. [FBrf0129787] Spradling et al., 1999, Genetics 153(1): 135--177 The Berkeley Drosophila genome project gene disruption project. Single P-element insertions mutating 25% of vital Drosophila genes. [FBrf0111489] Chandrashekaran and Sarla, 1993, Genetica 90(1): 61--71 Phenotypes of lethal alleles of the recessive temperature sensitive paralytic mutant stambh A of Drosophila melanogaster suggest its neurogenic function. [FBrf0065355] Sullivan et al., 1993, Development 118(4): 1245--1254 Mutations affecting the cytoskeletal organization of syncytial Drosophila embryos. [FBrf0065586] Cicchetti and Loverre, 1989, Genetica 78(3): 159--167 Analysis of an SD second chromosome from a natural population of Drosophila melanogaster. [FBrf0049871] Morgan et al., 1938, Yb. Carnegie Instn, Wash. 37: 304--309 Constitution of the germinal material in relation to heredity. [FBrf0064035]
Personal communication to FlyBase	BDGP Project Members, 1994-1999, BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project. (Computer file) BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project. (Computer file) [FBrf0067338]
FlyBase analysis	FlyBase, 2007, En masse symbol-based assigment of Aberration Class with respect to wild type. En masse symbol-based assigment of Aberration Class with respect to wild type. [FBrf0191808]
Book	Lindsley and Zimm, 1992, The Genome of Drosophila melanogaster. The Genome of Drosophila melanogaster. [FBrf0066905]