Aberration Dmel\Df(2R)Dll-MP

General Information
Symbol	Dmel\Df(2R)Dll-MP	Species	D. melanogaster
Name		FlyBase ID	FBab0001942
Feature type	chromosomal_deletion
Also Known As	Dll^MP, Df(2R)Dll^MP, Df(2R)Ba-MP, Df(2R)Ba

Computed Breakpoints include	60E1-60E2;60E6
Deleted segment	60E1--60E6
Sequence coordinates
Member of large scale dataset(s)
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Aberration
Cytological Order
Progenitor
Mutagen	gamma ray (Sunkel and Whittle, 1987) X ray
Class of aberration (relative to progenitor)	chromosomal_deletion (Germeraad et al., 1992, Pauli et al., 1995)
Breakpoints	60E1-60E2;60E5-60E6 (Germeraad et al., 1992, Pauli et al., 1995)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data	E(w<up>a</up>) << bk1 << Dll << bk2 << RpL19
Genetic mapping information
Comments	Deletion removing entire Dll transcription unit. (Cohen et al., 1993) entire putative transcription unit deleted. Deleted for the region from approximately coordinate 90 kb through 180 kb and beyond on the molecular map of Cohen et al. Deletion removes the entire Dll coding region <up>Cohen, Bronner, Kuttner, Jurgens and Jackle, 1989, Nature (London), 338: 432-34</up>.
Comments on Cytology
	Ref: Cohen et al., 1989, Nature 338: 432--434 (Germeraad et al., 1992) Cytologically normal. (Sunkel and Whittle, 1987) Limits of break 1 from polytene analysis (FBrf0056560) Left limit of break 2 from polytene analysis (citation unavailable) Right limit of break 2 from polytene analysis (FBrf0056560)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	Dll (Gindhart and Kaufman, 1995, Castelli-Gair and Akam, 1995) egg (Clough et al., 2007) Eps-15 (Koh et al., 2007) key (Rutschmann et al., 2000) rsh (Elrod-Erickson et al., 2000)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	l(2)gl (Mason et al., 2004) RpL19 (Hart et al., 1993)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations	Df(3R)sbd45 dominantly enhances the transformation of arista to leg phenotype seen in Df(2R)Dll-MP heterozygotes. Df(2L)al dominantly enhances the transformation of arista to leg phenotype seen in Df(2R)Dll-MP heterozygotes. Df(2R)M60E dominantly enhances the transformation of arista to leg phenotype seen in Df(2R)Dll-MP heterozygotes. (Fauvarque et al., 2001)
NOT in combination with other aberrations	Df(2R)Dll-MP mutant embryos have fewer neurons and fewer support cells in the dorsal organ (DO) and terminal organ than wild type animals. No cell death is seen (TUNEL staining) and the remaining neurons exhibit aberrant morphologies. The DO dendrites are loosely associated rather than tightly bundled and the axons of the remaining DO neurons form a single fascicle projected towards the subesophageal ganglion. No fascicles target the larval antennal lobe (LAL). Df(2R)Dll-MP mutants also exhibit loss of a primary axon bundle that emanates from the mushroom bodies and projects along the dorsal and ventral tracts of the supraesophageal commissure. In Df(2R)Dll-MP mutant embryos the brain commissures are defective and the microtubule-associated Futsch protein is consistently mislocalised. One of the three supraesophageal commissures seen in wild type is missing in Df(2R)Dll-MP mutants. Both of the primary axon tracts that make up the subesophageal commissure are also missing. (Plavicki et al., 2012) Heterozygotes show a partial transformation of the arista to leg. (Fauvarque et al., 2001) No effect on the eye pigment phenotype of w^T81. (Netter et al., 1998) Mutation does not affect the level of w expression in ph-p^lac+3 flies. (Fauvarque et al., 1995) Heterozygosity for this deletion has no effect on the mutant ovarian phenotype of ovo^D2. (Pauli et al., 1995) Recessive lethal. Heterozygote shows partial transformation of aristae to tarsal segments. Dominant phenotype suppressed in either Pcl¹⁰ or Df(2R)en28 heterozygotes. Df(2R)Dll/+ shows almost complete suppression of the extra-sex combs phenotypes of Pc⁴/+, Pc^T7/+, Pcl¹⁰/+, Pcl¹¹/+, Antp^Scx/+, Msc/+, and Msc^T3/+.
Stocks ( 2 )
Bloomington	1465 Df(2R)Dll-MP/SM6a
Kyoto	106326 Df(2R)Dll-MP/SM6a
Notes on Origin
Discoverer	Moscoso del Prado.

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments
	The Df(2R)Dll-MP chromosome acts as a dominant weak suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{w^var}KR3-2", a stable "brown-red" variant of the P{3'WP-2,w^var}2Lt insertion), but this is assumed to be a false positive result (the suppressor may not be within the bounds of the deficient region) because the 2L TAS array on the chromosome is missing (as assayed by in situ hybridization) and it has previously been shown (FBrf0137248, FBrf0158986) that partial or complete deficiency of the 2L TAS array on the homologue suppresses silencing of brown-red variants of P{3'WP-2,w^var}2Lt. (Mason et al., 2004)
Synonyms & Secondary IDs ( 13 )
Reported As
Symbol Synonym	Art² (Sunkel and Whittle, 1987, ) Ba^MP (Fauvarque et al., 1995, ) Df(2R)Ba (Gindhart and Kaufman, 1995, Kassis, 1994, ) Df(2R)Ba-MP (Netter et al., 1998, Hart et al., 1993, ) Df(2R)Bra-MP Df(2R)D11-MP (Harbison et al., 2004) Df(2R)DII-MP (Tang et al., 2005) Df(2R)Dll^MP (Gorfinkiel et al., 1999, Gorfinkiel et al., 1997, Castelli-Gair and Akam, 1995, Germeraad et al., 1992, Cohen et al., 1989) Df(2R)Dll-Mp (Clough et al., 2006, Clough and Hazelrigg, 2007, Clough et al., 2007, Koryakov et al., 2011) Df(2R)Dll-MP (Koh et al., 2007, Brower-Toland et al., 2009) Dll^MP (Kubota et al., 2003, Fauvarque et al., 2001, Rusch and Kaufman, 2000, Moreno and Morata, 1999, Gonzalez-Crespo et al., 1998, ) dll^MP (Plavicki et al., 2012) Scnp^A1
Name Synonym
Secondary FlyBase IDs
	FBab0025540 FBal0029050
References ( 33 )

Generate a list of	All references relating to this aberration ( 33 )

List References by type	Research paper ( 29 ) Abstract ( 2 ) FlyBase analysis ( 1 ) Letter ( 1 )
Recent research papers ( 2 )
	Plavicki et al., 2012, Proc. Natl. Acad. Sci. U.S.A. 109(5): 1578--1583 Homeobox gene distal-less is required for neuronal differentiation and neurite outgrowth in the Drosophila olfactory system. [FBrf0217395] Koryakov et al., 2011, Chromosome Res. 19(2): 235--249 The SUUR protein is involved in binding of SU(VAR)3-9 and methylation of H3K9 and H3K27 in chromosomes of Drosophila melanogaster. [FBrf0213472] Show all research papers ...