Aberration Dmel\Df(2R)Egfr3

General Information
Symbol	Dmel\Df(2R)Egfr3	Species	D. melanogaster
Name	Deficiency (2R) Epidermal growth factor	FlyBase ID	FBab0001959
Feature type	chromosomal_deletion
Also Known As	egfr^3F18, flb^3F18, DER^3F18

Computed Breakpoints include	57E1;57F5-57F10
Deleted segment	57E1--57F10
Sequence coordinates
Member of large scale dataset(s)
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Aberration
Cytological Order
Progenitor
Mutagen	ethyl methanesulfonate
Class of aberration (relative to progenitor)	chromosomal_deletion (Price et al., 1989, Clifford and Schupbach, 1989)
Breakpoints	57D8-57E1;57F5-57F10 (Clifford and Schupbach, 1989) 57E1;57F5-57F11 (Price et al., 1989)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data	bk1 << l(2)57Eb << bk2
Genetic mapping information
Comments
Comments on Cytology
	Ref: Price et al., 1989, Cell 56: 1085--1092 (Clifford and Schupbach, 1989) Limits of break 1 from polytene analysis (FBrf0049331) Left limit of break 2 from polytene analysis (FBrf0049331) Right limit of break 2 from polytene analysis (FBrf0049928)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	comr (Jiang and White-Cooper, 2003) Egfr (Simcox, 1997)
Molecular Data
Completely deleted	CG4363 (Jiang and White-Cooper, 2003) CG4372 (Jiang and White-Cooper, 2003) CG4377 (Jiang and White-Cooper, 2003) CG9294 (Jiang and White-Cooper, 2003) CG13492 (Jiang and White-Cooper, 2003) comr (Jiang and White-Cooper, 2003)
Genes NOT Deleted / Disrupted
Complementation Data
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations	Egfr^f3/Df(2R)Egfr3 embryos exhibit no ventral cuticle and the anterior has a large hole. No Egfr^f3/Df(2R)Egfr3 mutant discs could be in vivo cultured. (Simcox, 1997) Homozygotes and hemizygotes display a severe 'flb' phenotype. (Clifford and Schupbach, 1989) Abdominal denticle belts and head skeleton are almost absent. Germ band has not retracted and the cuticle size is much reduced. (Price et al., 1989) Severe lethal phenotype: anterior structures deteriorate, ventral denticle bands are missing, germ band does not retract and the CNS shows a collapse of commissure and midline pattern. (Schejter and Shilo, 1989)
Stocks ( 2 )
Bloomington	6276 Df(2R)Egfr3, cn¹ bw¹ sp¹/CyO
Kyoto	108710 Df(2R)Egfr3, cn¹ bw¹ sp¹/CyO
Notes on Origin
Discoverer

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

Synonyms & Secondary IDs ( 13 )
Reported As
Symbol Synonym	DER^3F18 (Simcox, 1997, Schnepp et al., 1996) Df(2R)Egfr3 Df(2R)Egfr3F18 Df(2R)egfr^3F18 (Alvarado et al., 2004) Df(2R)top^3F18 (Clifford and Schupbach, 1989) egfr^3F18 (Alvarado et al., 2004) Egfr^3F18 (Butchar et al., 2012, Rawlings et al., 2004) Egfr^Df (Schnorr et al., 2001) Egf-r<up>Df F18</up> (Sturtevant et al., 1993) flb^3F18 (Kraut and Campos-Ortega, 1996, Baker and Rubin, 1992, Schejter and Shilo, 1989, ) flb^3F (O'Keefe et al., 1997) top^3F18 (Price et al., 1989)
Name Synonym	Deficiency (2R) Epidermal growth factor
Secondary FlyBase IDs

References ( 17 )
Research paper	Butchar et al., 2012, Genetics 191(4): 1213--1226 New negative feedback regulators of egfr signaling in Drosophila. [FBrf0219175] Alvarado et al., 2004, Genetics 167(1): 187--202 Bipartite inhibition of Drosophila epidermal growth factor receptor by the extracellular and transmembrane domains of Kekkon1. [FBrf0178972] Alvarado et al., 2004, Genetics 166(1): 201--211 Knockouts of Kekkon1 define sequence elements essential for Drosophila epidermal growth factor receptor inhibition. [FBrf0174701] Rawlings et al., 2004, BMC Cell Biol. 5(1): 38 Two Drosophila suppressors of cytokine signaling (SOCS) differentially regulate JAK and EGFR pathway activities. [FBrf0179958] Jiang and White-Cooper, 2003, Development 130(3): 563--573 Transcriptional activation in Drosophila spermatogenesis involves the mutually dependent function of aly and a novel meiotic arrest gene cookie monster. [FBrf0155716] Schnorr et al., 2001, Genetics 159(2): 609--622 Ras1 interacts with multiple new signaling and cytoskeletal loci in Drosophila eggshell patterning and morphogenesis. [FBrf0139680] O'Keefe et al., 1997, Development 124(23): 4837--4845 Spitz and Wingless, emanating from distinct borders, cooperate to establish cell fate across the Engrailed domain in the Drosophila epidermis. [FBrf0099888] Simcox, 1997, Mech. Dev. 62(1): 41--50 Differential requirement for EGF-like ligands in Drosophila wing development. [FBrf0093212] Kraut and Campos-Ortega, 1996, Dev. Biol. 174(1): 65--81 Inscuteable, a neural precursor gene of Drosophila, encodes a candidate for a cytoskeleton adaptor protein. [FBrf0086502] Schnepp et al., 1996, Genes Dev. 10(18): 2302--2313 Vein is a novel component in the Drosophila epidermal growth factor receptor pathway with similarity to the neuregulins. [FBrf0090788] Sturtevant et al., 1993, Genes Dev. 7(6): 961--973 The Drosophila rhomboid gene mediates the localized formation of wing veins and interacts genetically with components of the EGF-R signaling pathway. [FBrf0058540] Baker and Rubin, 1992, Dev. Biol. 150: 381--396 Ellipse mutations in the Drosophila homologue of the EGF receptor affect pattern formation, cell division, and cell death in eye imaginal discs. [FBrf0055813] Clifford and Schupbach, 1989, Genetics 123: 771--787 Coordinately and differentially mutable activities of torpedo, the Drosophila melanogaster homolog of the vertebrate EGF receptor gene. [FBrf0049928] Price et al., 1989, Cell 56: 1085--1092 The maternal ventralizing locus torpedo is allelic to faint little ball, an embryonic lethal, and encodes the Drosophila EGF receptor homolog. [FBrf0049331] Schejter and Shilo, 1989, Cell 56: 1093--1104 The Drosophila EGF receptor homolog (DER) gene is allelic to faint little ball, a locus essential for embryonic development. [FBrf0049332]
FlyBase analysis	FlyBase, 2007, En masse symbol-based assigment of Aberration Class with respect to wild type. En masse symbol-based assigment of Aberration Class with respect to wild type. [FBrf0191808]
Book	Lindsley and Zimm, 1992, The Genome of Drosophila melanogaster. The Genome of Drosophila melanogaster. [FBrf0066905]