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General Information
Symbol
Df(2R)Jp8
Species
D. melanogaster
Name
FlyBase ID
FBab0001974
Feature type
Computed Breakpoints include

52F5-52F9;53A1

Sequence coordinates
2R:16,059,113..16,100,060 (Df(2R)Jp8:bk1)
2R:16,324,513..16,336,565 (Df(2R)Jp8:bk2)
Member of large scale dataset(s)
Nature of Aberration
Cytological Order
Mutagen
Class of aberration (relative to wild type)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data

bk1 << l(2)52Fe << Rho1 << bk2 << veg

Genetic mapping information
Comments
Comments on Cytology

The left Df(2R)Jp8 breakpoint lies within CG8405 or CG8414 or in the region between them, and lies in the range 2R:11946618..11987565 (R5) (predicted cytology: 52E1-52E4).

The right Df(2R)Jp8 breakpoint lies within CG4282 or Vha44 or in the region between them, and lies in the range 2R:12212018..12224070 (R5) (predicted cytology: 53B5-53C1).

Breakpoints reported for Df(2R)Jp8 (52F5--9;53A1) are under question as Df(2R)Jp8 appears to delete Rho1 (52E5).

Ref: Saxton et al., 1991, Cell 64: 1093--1102

Limits of break 1 from polytene analysis (FBrf0080145) Left limit of break 2 from inclusion of Khc (FBrf0102325) Right limit of break 2 from polytene analysis (FBrf0080145)

Sequence Crossreferences
DNA sequence
Protein sequence
Gene Deletion and Duplication Data
Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations

Heterozygosity for Df(2R)Jp8 results in 0.7% X chromosome nondisjunction and 1.4% fourth chromosome nondisjunction in In(1)FM7/X ; svspa-pol females.

Df(2R)Jp7/Df(2R)Jp8 embryos retain a grossly normal number of sense organs. However, neuronal disruption is observed, most noticeable in the chordotonal organs. The dendrites of chordotonal organs are consistently malformed, appearing longer and often thicker than their wild-type equivalents. The dendrite tips occasionally appear enlarged around a non-staining "hole" at the point where the dendrite enters the scolopale. The scolopale itself is disorganised, and the arrangement of the neurons are also disorganised with their characteristic dendritic orientations often awry. The single exception to the observation that this combination of deficiencies is a duplication of v'ch1 chordotonal neurons.

Strong second site non-complementing phenotype with zipEbr and zipmhc-c6.1 : malformed phenotype penetrance >75%.

Shows no maternal enhancement of dpphr4.

Midgut development of mutant embryos is wild type.

Homozygous embryos have smaller heads than normal.

Heterozygosity for this deletion suppresses the mutant ovarian phenotype of ovoD2.

Stocks (2)
Notes on Origin
Discoverer
 
Balancer / Genotype Variants of the Aberration
 
Separable Components
 
Other Comments
 
Synonyms and Secondary IDs (4)
References (43)