A Database of Drosophila Genes & Genomes

FB2012_01, released January 20th, 2012
 

Aberration Dmel\Df(2R)M41A10

General Information
SymbolDmel\Df(2R)M41A10SpeciesD. melanogaster
NameDeficiency (2R) Minute 41AFlyBase IDFBab0001992
Feature typechromosomal_deletion
Computed Breakpoints include h38R;h46
Deleted segmenth38R--h46
Sequence coordinates
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Description
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FB2012_01
FB2011_10
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hide Nature of the Aberration
Cytological Order
Progenitor
Mutagen
X ray
 
Class of aberration (relative to progenitor)
chromosomal_deletion
(Dimitri, 1991, Belyaeva and Zhimulev, 1991, Pauli et al., 1995, Duffy et al., 1996, Cicchetti and Loverre, 1989, Koryakov and Zhimulev, 1996)
Breakpoints
41A;41A
(Pauli et al., 1995, Duffy et al., 1996)
41A;h38R-h46
(Cicchetti and Loverre, 1989)
h38R;41A
(Belyaeva and Zhimulev, 1991)
h38R;41E1-41E2
(Koryakov and Zhimulev, 1996)
h38R;h46
(Dimitri, 1991)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data l(2)40Fg << bk1 << Rsp << l(2)IR23 << bk2 << stw
Genetic mapping information
Comments
hide Comments on Cytology
Lacks 2R heterochromatin.
(Sinclair et al., 1992)
Most of the centric heterochromatin on 2R is deleted.
(Ganetzky, 1977)
Mitotic prophase preparations of Df(2R)M41A10 clearly show that the proximal 2R heterochromatin is missing
(Hilliker and Holm, 1975)
Limits of break 1 from polytene analysis (FBrf0053437) Left limit of break 2 from inclusion of RpL38 (FBrf0027524) Right limit of break 2 from polytene analysis (FBrf0049871)
 
hide Sequence Crossreferences
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
hide Gene Deletion & Duplication Data
hide Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted
CG17486
(Myster et al., 2004)
CG17683
(Myster et al., 2004)
CG40127
(Myster et al., 2004)
IntS3
(Marygold et al., 2005, Myster et al., 2004, Dimitri et al., 1997)
l(2)41Aa
(Hilliker and Holm, 1975, Hilliker, 1976, Ganetzky, 1977, Lyttle, 1989, Eberl et al., 1993)
l(2)41Ab
(Ganetzky, 1977, Eberl et al., 1993, Hilliker, 1976, Hilliker and Holm, 1975)
l(2)41Ae
(Rollins et al., 1999, Hilliker and Holm, 1975, Hilliker, 1976, Ganetzky, 1977, Eberl et al., 1993, Duffy et al., 1996, Koryakov and Zhimulev, 1996)
l(2)309
(Myster et al., 2004)
l(2)IR4
(Dimitri et al., 1997)
l(2)IR24
(Dimitri et al., 1997)
l(2)IR30
(Dimitri et al., 1997)
l(2)NC30
(Myster et al., 2004)
l(2)NC83
(Myster et al., 2004)
l(2)NC85
(Myster et al., 2004)
l(2)NC133
(Myster et al., 2004)
l(2)NC192
(Myster et al., 2004)
l(2)NC204
(Myster et al., 2004, Marygold et al., 2005)
Nipped-A
(Rollins et al., 1999, Myster et al., 2004, Hilliker, 1976, Ganetzky, 1977, Sharp et al., 1985, Eberl et al., 1993, Duffy et al., 1996, Koryakov and Zhimulev, 1996, Gambetta and Mueller, 2009.8.18)
Nipped-B
(Rollins et al., 1999, Corradini et al., 2003, Myster et al., 2004, Gambetta and Mueller, 2009.8.18)
p120ctn
(Myster et al., 2004)
rl
(Zhang et al., 1999, Corradini et al., 2003, Myster et al., 2004, Hilliker and Holm, 1975, Hilliker, 1976, Ganetzky, 1977, Lyttle, 1989, Morgan et al., 1941, Eberl et al., 1993, Curry, 1939)
RpL38
(Rollins et al., 1999, Myster et al., 2004, Marygold et al., 2005, Hilliker and Holm, 1975, Hilliker, 1976, Ganetzky, 1977, Cicchetti and Loverre, 1989, Lyttle, 1989, Eberl et al., 1993, Duffy et al., 1996, Gambetta and Mueller, 2009.8.18)
st
(Cicchetti and Loverre, 1989)
Stlk
(Myster et al., 2004)
uex
(Hilliker, 1976, Hilliker and Holm, 1975, Ganetzky, 1977, Eberl et al., 1993, Lyttle, 1989, Myster et al., 2004, Dimitri et al., 1997, Marygold et al., 2005)
Molecular Data
Completely deleted
Atf6
(Myster et al., 2004)
CG3107
(Myster et al., 2004)
CG12547
(Myster et al., 2004)
CG14464
(Myster et al., 2004)
CG17082
(Myster et al., 2004)
CG17486
(Myster et al., 2004)
CG17528
(Myster et al., 2004)
CR41440
(Myster et al., 2004)
gus
(Myster et al., 2004)
Nipped-A
(Myster et al., 2004)
Nipped-B
(Myster et al., 2004)
p120ctn
(Myster et al., 2004)
rl
(Myster et al., 2004)
Stlk
(Myster et al., 2004)
TpnC41C
(Myster et al., 2004)
hide Genes NOT Deleted / Disrupted
Complementation Data
ap
(Hilliker and Holm, 1975, Ganetzky, 1977, Cicchetti and Loverre, 1989, Eberl et al., 1993, Koryakov and Zhimulev, 1996, Gambetta and Mueller, 2009.8.18)
Bl
(Cicchetti and Loverre, 1989)
BubR1
(Myster et al., 2004)
cn
(Cicchetti and Loverre, 1989)
crc
(Hilliker and Holm, 1975)
kune
(Gambetta and Mueller, 2009.8.18)
l(2)40Fa
(Hilliker and Holm, 1975)
l(2)40Fg
(Hilliker and Holm, 1975)
l(2)309
(Coulthard et al., 2010, Coulthard et al., 2010)
l(2)09851
(Corradini et al., 2003, Gambetta and Mueller, 2009.8.18)
l(2)Co
(Cicchetti and Loverre, 1989)
l(2)IR4
(Coulthard et al., 2010)
l(2)k03002a
(Corradini et al., 2003)
l(2)k07312b
(Corradini et al., 2003)
l(2)L10
(Coulthard et al., 2010)
l(2)NC12
(Myster et al., 2004)
l(2)NC14
(Myster et al., 2004)
l(2)NC30
(Coulthard et al., 2010, Coulthard et al., 2010)
l(2)NC45
(Myster et al., 2004)
l(2)NC47
(Myster et al., 2004)
l(2)NC83
(Coulthard et al., 2010, Coulthard et al., 2010)
l(2)NC114
(Myster et al., 2004)
l(2)NC136
(Myster et al., 2004, Gambetta and Mueller, 2009.8.18)
l(2)NC139
(Myster et al., 2004)
l(2)NC148
(Myster et al., 2004)
l(2)NC195
(Coulthard et al., 2010)
laccase2
(Gambetta and Mueller, 2009.8.18)
lt
(Hilliker and Holm, 1975, Cicchetti and Loverre, 1989)
mle
(Cicchetti and Loverre, 1989)
pk
(Cicchetti and Loverre, 1989)
pr
(Cicchetti and Loverre, 1989)
ptc
(Sturtevant, 1948)
Rsp
(Eberl et al., 1993)
stw
(Hilliker and Holm, 1975, Ganetzky, 1977, Sharp et al., 1985, Cicchetti and Loverre, 1989, Eberl et al., 1993, Curry, 1939, Koryakov and Zhimulev, 1996)
sxc
(Sinclair et al., 2009, Gambetta and Mueller, 2009.8.18, Gambetta et al., 2009, Myster et al., 2004)
tri
(Hilliker and Holm, 1975)
vlc
(Corradini et al., 2003, Myster et al., 2004, Gambetta and Mueller, 2009.8.18)
Molecular Data
BubR1
(Myster et al., 2004)
d4
(Myster et al., 2004)
l(2)NC136
(Myster et al., 2004)
sxc
(Myster et al., 2004)
vlc
(Myster et al., 2004)
hide Genes Duplicated
Complementation Data
Molecular Data
hide Genes NOT Duplicated
Complementation Data
Molecular Data
hide Related Comments
hide Phenotypic Data
In combination with other aberrations
Partially sensitive to segregation distortion by In(2R)SD5.
(Ganetzky, 1977)
Lethal in combination with Df(2R)M41A50j.
(Arvelighetsinstitutten, University)
Lethal in combination with Df(2R)M41A, Df(2R)M41A4, Df(2R)M41A8 or Df(2R)M41A-vg11.
(Curry, 1939)
NOT in combination with other aberrations
Does not cause unconditional lethality in hybrid females when heterozygous with D.simulans chromosome.
(Coyne et al., 1998)
Acts as a dosage sensitive maternal modifier of run: causes tergite defects in greater than 64% of run3 heterozygotes.
(Duffy et al., 1996)
Heterozygosity for this deletion has no effect on the mutant ovarian phenotype of ovoD2.
(Pauli et al., 1995)
Heterozygotes have shorter bristles than wild type flies. Eclosion is delayed by 13 hours.
(Ferrus, 1975)
Heterozygotes show a thin bristled Minute phenotype. Homozygotes do not survive.
(Hilliker and Holm, 1975)
Dominant enhancer of variegation.
(Lindsley et al., 1960)
homozygous lethal Long-bristled Minute; readily classifiable. Enhances variegation of white mottleds and brown Variegateds to same extent as removal of a Y chromosome. Causes abnormal development of hybrids with D.simulans (e.g., melanotic tumors, extra organs, missing organs, death).
 
hide Stocks ( 3 )
Bloomington
741
Df(2R)M41A10/SM1
Kyoto
106057
Df(2R)M41A10/SM1
101448
Df(2R)M41A10 / SM1, al2 Cy1 cn2 sp2
hide Notes on Origin
Discoverer
hide Balancer / Genotype Variants of the Aberration
hide Separable Components
hide Other Comments
The Df(2R)M41A10 chromosome may act as a dominant suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{wvar}KR3-2", a stable "brown-red" variant of the P{3'WP-2,wvar}2Lt insertion), but the eye colour phenotype in the presence of Df(2R)M41A10 overlaps the eye colour phenotype in a wild-type background so it cannot be unequivocally demonstrated that the deficiency chromosome uncovers a suppressor of telomeric silencing.
(Mason et al., 2004)
"Deletes or disrupts l(2)41Ae" was stated as revision. "Deletes or disrupts Nipped-A" was stated as revision. "Does not delete or disrupt stw" was stated as revision. "Does not delete or disrupt ap" was stated as revision.
(Koryakov and Zhimulev, 1996)
Used to enhance variegation.
(Belyaeva and Zhimulev, 1991)
hide Synonyms & Secondary IDs ( 23 )
Reported As
Symbol Synonym
41A10
(Dimitri et al., 2005)
Df(2)M-S10
(Curry, 1939)
Df(2R)A10
(Gambetta and Mueller, 2009.8.18)
Df(2R)M41
(Coyne et al., 1998)
Df(2R)m41A10
(Sage and Csink, 2003)
Df(2R)M41A10
(Myster et al., 2004, Gambetta et al., 2009, Sinclair et al., 2009, Coulthard et al., 2010, Coulthard et al., 2010)
Df(2R)MS2-10
(Chadov et al., 1995, Cicchetti and Loverre, 1989)
Df(2R)M-S2-10
(Chadov et al., 1994, Lyttle, 1989, )
Df(2R)MS210
(Zhang et al., 1999, Koryakov and Zhimulev, 1996, Eberl et al., 1993, Pokholkova et al., 1993, Sinclair et al., 1992, Belyaeva and Zhimulev, 1991)
Df(2R)M-S210
(Dimitri et al., 1997, Duffy et al., 1996, Ganetzky, 1977, Hilliker, 1976)
Df(2R)M-S10
(Sharp et al., 1985, Reuter et al., 1983)
Df(2R)MS41A10
(Corradini et al., 2003)
Df(2Rh)41A10
(Corradini et al., 2005)
Df(2Rh)M-S210
(Caizzi et al., 1993)
DfMS10
(Sturtevant, 1948)
M(2)S210
 
M(2)S10
(Arvelighetsinstitutten, University, Lindsley et al., 1960, Hilliker, 1976)
M(2R)S210
(Ferrus, 1975)
MS2-10
(Artemova and Chadov, 1995, Hilliker and Holm, 1975)
MS210
(Koryakov et al., 1996)
M-S210
(Dimitri, 1991)
Name Synonym
Deficiency (2R) Minute 41A
 
Df(2)Minute-Schultz 10
(Curry, 1939)
Secondary FlyBase IDs
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hide Recent research papers ( 1 )
Coulthard et al., 2010, Genetics 185(2): 479--495
Essential loci in centromeric heterochromatin of Drosophila melanogaster. I: the right arm of chromosome 2. [FBrf0211235]
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