Aberration Dmel\Df(2R)M41A4

General Information
Symbol	Dmel\Df(2R)M41A4	Species	D. melanogaster
Name	Deficiency (2R) Minute 41A	FlyBase ID	FBab0001993
Feature type	chromosomal_deletion

Computed Breakpoints include	h44-h46;42A1-42A2
Deleted segment	h44--42A2
Sequence coordinates
Recent Updates
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FB2012_01
FB2011_10
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Nature of the Aberration
Cytological Order
Progenitor
Mutagen	X ray
Class of aberration (relative to progenitor)	chromosomal_deletion (Dimitri, 1991, Pauli et al., 1995, Duffy et al., 1996, Koryakov and Zhimulev, 1996, Koryakov et al., 1996)
Breakpoints	41A;41A (Pauli et al., 1995, Duffy et al., 1996) 41A;[] (Harbecke and Lengyel, 1995) 41C;42A1-42A2 (Koryakov and Zhimulev, 1996) [];42A1--2 (Koryakov et al., 1996) [];h46 (Dimitri, 1991)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data	uex << bk1 << RpL38 << ap << bk2 << mle
Genetic mapping information
Comments
Comments on Cytology
	Euchromatic breakpoint not reported. (Dimitri, 1991) Left limit of break 1 from non-inclusion of uex (FBrf0028786) Right limit of break 1 from inclusion of l(2)41Ae (FBrf0027524) Limits of break 2 from polytene analysis (FBrf0091444)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	ap (Hilliker and Holm, 1975, Ganetzky, 1977, Sharp et al., 1985, Cicchetti and Loverre, 1989, Dimitri, 1991, Eberl et al., 1993, Koryakov and Zhimulev, 1996) IntS3 (Marygold et al., 2005) l(2)41Ae (Hilliker and Holm, 1975, Hilliker, 1976, Ganetzky, 1977, Sharp et al., 1985, Eberl et al., 1993, Duffy et al., 1996, Koryakov and Zhimulev, 1996) l(2)NC204 (Marygold et al., 2005) Nipped-A (Hilliker, 1976, Ganetzky, 1977, Eberl et al., 1993, Duffy et al., 1996, Koryakov and Zhimulev, 1996) Nipped-B (Spradling et al., 1999, BDGP Project Members, 1994-1999) p120ctn (Myster et al., 2004) RpL38 (Marygold et al., 2005, Hilliker and Holm, 1975, Hilliker, 1976, Ganetzky, 1977, Cicchetti and Loverre, 1989, Eberl et al., 1993, Duffy et al., 1996) stw (Hilliker and Holm, 1975, Ganetzky, 1977, Cicchetti and Loverre, 1989, Dimitri, 1991, Eberl et al., 1993, Koryakov and Zhimulev, 1996) sxc (Sinclair et al., 2009) uex (Hilliker and Holm, 1975, Marygold et al., 2005) vlc (Spradling et al., 1999, Gates and Thummel, 2000, BDGP Project Members, 1994-1999)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	Bl (Cicchetti and Loverre, 1989) BubR1 (Spradling et al., 1999, BDGP Project Members, 1994-1999) cn (Cicchetti and Loverre, 1989) crc (Hilliker and Holm, 1975) EcR (BDGP Project Members, 1994-1999) l(2)40Fa (Hilliker and Holm, 1975) l(2)40Fg (Hilliker and Holm, 1975) l(2)41Aa (Hilliker, 1976, Ganetzky, 1977, Eberl et al., 1993) l(2)41Ab (Ganetzky, 1977, Eberl et al., 1993, Hilliker, 1976) l(2)42Aa (Roote and Ashburner, 2005.6) l(2)42Ab (Roote and Ashburner, 2005.6) l(2)42Ac (Roote and Ashburner, 2005.6) l(2)05315 (BDGP Project Members, 1994-1999) l(2)09851 (Spradling et al., 1999) l(2)Co (Cicchetti and Loverre, 1989) l(2)gl (Mason et al., 2004) l(2)k03002a (Spradling et al., 1999, BDGP Project Members, 1994-1999) l(2)k07312b (BDGP Project Members, 1994-1999) lt (Hilliker and Holm, 1975, Cicchetti and Loverre, 1989) mle (Cicchetti and Loverre, 1989) pk (Cicchetti and Loverre, 1989) pr (Cicchetti and Loverre, 1989) ptc (Sturtevant, 1948) rl (Hilliker and Holm, 1975, Hilliker, 1976, Ganetzky, 1977, Eberl et al., 1993) Rsp (Eberl et al., 1993) S(CycE^JP)2.10 (Brumby et al., 2004) Src42A (Spradling et al., 1999, BDGP Project Members, 1994-1999) st (Cicchetti and Loverre, 1989) ta (Bien-Willner et al., 1997) tri (Hilliker and Holm, 1975) uex (Eberl et al., 1993, Hilliker, 1976, Sharp et al., 1985, Ganetzky, 1977)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations	The z¹ In(1)w^is eye colour phenotype is enhanced by Df(2R)M41A4. (Rasmuson-Lestander et al., 1993) Lethal in combination with Df(2R)M41A10. (Curry, 1939, Hilliker and Holm, 1975)
NOT in combination with other aberrations	Has no effect on viability of Asx¹² or Asx¹⁴, and homeotic transformations in double mutants are mild. Anterior transformations of A5 to A4 do occur, similar to those seen in trx-G group mutants. (Milne et al., 1999) Does not cause unconditional lethality in hybrid females when heterozygous with D.simulans chromosome. (Coyne et al., 1998) Weak second site non-complementing phenotype with zip^Ebr and zip^mhc-c6.1: malformed phenotype penetrance 10-24%. (Halsell and Kiehart, 1998) Shows no maternal enhancement of dpp^hr4. (Nicholls and Gelbart, 1998) Acts as a dosage sensitive maternal modifier of run: causes tergite defects in greater than 64% of run³ heterozygotes. (Duffy et al., 1996) Midgut development of mutant embryos is wild type. (Bilder and Scott, 1995) Homozygous embryos are very abnormal compared to wild-type. Formation of the gut is variable. (Harbecke and Lengyel, 1995) Heterozygosity for this deletion has no effect on the mutant ovarian phenotype of ovo^D2. (Pauli et al., 1995) Heterozygotes show a Minute phenotype. Homozygous lethal. (Hilliker and Holm, 1975) homozygous lethal Medium Minute bristles. Large pale body with heavy, malformed, bloated abdomen. Female fertility low.
Stocks ( 3 )
Bloomington	739 Df(2R)M41A4/SM1
Kyoto	108912 Df(2R)M41A4/SM5 103281 Df(2R)M41A4 / SM1, al² Cy¹ cn² sp²
Notes on Origin
Discoverer

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments
	The Df(2R)M41A4 chromosome acts as a dominant weak suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{w^var}KR3-2", a stable "brown-red" variant of the P{3'WP-2,w^var}2Lt insertion), but this is assumed to be a false positive result (the suppressor may not be within the bounds of the deficient region) because the 2L TAS array on the chromosome is reduced (as assayed by in situ hybridization) and it has previously been shown (FBrf0137248, FBrf0158986) that partial or complete deficiency of the 2L TAS array on the homologue suppresses silencing of brown-red variants of P{3'WP-2,w^var}2Lt. (Mason et al., 2004)
Synonyms & Secondary IDs ( 21 )
Reported As
Symbol Synonym	41A4 (Dimitri et al., 2005) Df(2)M-S4 (Curry, 1939) Df(2R)M41 (Coyne et al., 1998) Df(2R)m41A4 (Gildea et al., 2000) Df(2R)M41A4 (Sinclair et al., 2009) Df(2R)M-S2-4 (Harbecke and Lengyel, 1995, ) Df(2R)MS2-4 (Cicchetti and Loverre, 1989) Df(2R)M-S2⁴ (Abrell et al., 2000, Duffy et al., 1996, Ganetzky, 1977, Hilliker, 1976, Collett, 2008.2.16) Df(2R)MS2⁴ (Milne et al., 1999, Koryakov et al., 1996, Koryakov and Zhimulev, 1996, Eberl et al., 1993) Df(2R)M-S4 (Sharp et al., 1985) Df(2R)MS24 (Koryakov and Zhimulev, 1996) DfMS4 (Sturtevant, 1948) M41 A4 (Yamaguchi et al., 2001, Yamaguchi et al., 1999) M41A4 (Hirose et al., 2001) M(2)S2⁴ M(2)S4 (Ganetzky, 1977) M(2)S-4 (Hilliker, 1976) M(2R)S24 (Rasmuson-Lestander et al., 1993) MS2-4 (Hilliker and Holm, 1975) M-S2⁴ (Dimitri, 1991)
Name Synonym	Deficiency (2R) Minute 41A
Secondary FlyBase IDs

References ( 56 )

Generate a list of	All references relating to this aberration ( 56 )

List References by type	Research paper ( 49 ) Supplementary material ( 1 ) Review ( 1 ) Personal communication to FlyBase ( 2 ) FlyBase analysis ( 1 ) Computer file ( 1 ) Book ( 1 )
Recent research papers (0)
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