Aberration Dmel\Df(2R)M41A8

General Information
Symbol	Dmel\Df(2R)M41A8	Species	D. melanogaster
Name	Deficiency (2R) Minute 41A	FlyBase ID	FBab0001995
Feature type	chromosomal_deletion

Computed Breakpoints include	h44-h46;h46-41A3
Deleted segment	h44--41A3
Sequence coordinates
Recent Updates
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FB2012_01
FB2011_10
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Nature of the Aberration
Cytological Order
Progenitor
Mutagen	X ray
Class of aberration (relative to progenitor)	chromosomal_deletion (Pauli et al., 1995, Koryakov and Zhimulev, 1996)
Breakpoints	41A;41A (Pauli et al., 1995) 41C;41F8-41F9 (Koryakov and Zhimulev, 1996)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data	uex << bk1 << l(2)IR4 << stw << bk2 << ap
Genetic mapping information
Comments
Comments on Cytology
	Left limit of break 1 from non-inclusion of uex (FBrf0042654) Right limit of break 1 from inclusion of l(2)41Ae (FBrf0027524) Left limit of break 2 from inclusion of RpL38 (FBrf0027524) Right limit of break 2 from polytene analysis (FBrf0080317)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	CG17683 (Myster et al., 2004) CG40127 (Myster et al., 2004) IntS3 (Marygold et al., 2005, Myster et al., 2004, Dimitri et al., 1997) kune (Gambetta and Mueller, 2009.8.18) l(2)41Ae (Rollins et al., 1999, Hilliker and Holm, 1975, Sharp et al., 1985, Koryakov and Zhimulev, 1996, Dimitri et al., 1997) l(2)IR4 (Dimitri et al., 1997) l(2)IR24 (Dimitri et al., 1997) l(2)IR30 (Dimitri et al., 1997) l(2)NC12 (Myster et al., 2004) l(2)NC14 (Myster et al., 2004) l(2)NC30 (Myster et al., 2004) l(2)NC45 (Myster et al., 2004) l(2)NC47 (Myster et al., 2004) l(2)NC83 (Myster et al., 2004) l(2)NC85 (Myster et al., 2004) l(2)NC114 (Myster et al., 2004) l(2)NC133 (Myster et al., 2004) l(2)NC136 (Myster et al., 2004, Gambetta and Mueller, 2009.8.18) l(2)NC139 (Myster et al., 2004) l(2)NC148 (Myster et al., 2004) l(2)NC192 (Myster et al., 2004) l(2)NC204 (Myster et al., 2004, Marygold et al., 2005) laccase2 (Gambetta and Mueller, 2009.8.18) Nipped-A (Rollins et al., 1999, Myster et al., 2004, Koryakov and Zhimulev, 1996, Gambetta and Mueller, 2009.8.18) Nipped-B (Rollins et al., 1999, Myster et al., 2004, Gambetta and Mueller, 2009.8.18) p120ctn (Myster et al., 2004) RpL38 (Rollins et al., 1999, Myster et al., 2004, Marygold et al., 2005, Hilliker and Holm, 1975, Cicchetti and Loverre, 1989, Dimitri et al., 1997, Gambetta and Mueller, 2009.8.18) stw (Hilliker and Holm, 1975, Sharp et al., 1985, Cicchetti and Loverre, 1989, Koryakov and Zhimulev, 1996) sxc (Myster et al., 2004, Sinclair et al., 2009, Gambetta and Mueller, 2009.8.18, Gambetta et al., 2009) uex (Hilliker and Holm, 1975, Myster et al., 2004, Dimitri et al., 1997, Marygold et al., 2005) vlc (Myster et al., 2004)
Molecular Data
Completely deleted	Atf6 (Myster et al., 2004) CG3107 (Myster et al., 2004) CG12547 (Myster et al., 2004) CG14464 (Myster et al., 2004) CG17082 (Myster et al., 2004) CG17486 (Myster et al., 2004) CG17528 (Myster et al., 2004) CR41440 (Myster et al., 2004) d4 (Myster et al., 2004) gus (Myster et al., 2004) l(2)NC136 (Myster et al., 2004) Nipped-A (Myster et al., 2004) Nipped-B (Myster et al., 2004) p120ctn (Myster et al., 2004) Stlk (Myster et al., 2004) sxc (Myster et al., 2004) TpnC41C (Myster et al., 2004) vlc (Myster et al., 2004)
Genes NOT Deleted / Disrupted
Complementation Data
	ap (Hilliker and Holm, 1975, Sharp et al., 1985, Cicchetti and Loverre, 1989, Koryakov and Zhimulev, 1996, Gambetta and Mueller, 2009.8.18) Bl (Cicchetti and Loverre, 1989) BubR1 (Myster et al., 2004) cn (Cicchetti and Loverre, 1989) crc (Hilliker and Holm, 1975) l(2)40Fa (Hilliker and Holm, 1975) l(2)40Fg (Hilliker and Holm, 1975) l(2)09851 (Gambetta and Mueller, 2009.8.18) l(2)Co (Cicchetti and Loverre, 1989) lt (Hilliker and Holm, 1975, Cicchetti and Loverre, 1989) mle (Cicchetti and Loverre, 1989) pk (Cicchetti and Loverre, 1989) pr (Cicchetti and Loverre, 1989) rl (Myster et al., 2004, Hilliker and Holm, 1975) st (Cicchetti and Loverre, 1989) tri (Hilliker and Holm, 1975) uex (Sharp et al., 1985) vlc (Gambetta and Mueller, 2009.8.18)
Molecular Data
	BubR1 (Myster et al., 2004) rl (Myster et al., 2004)
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations	The z¹ In(1)w^is eye colour phenotype is enhanced by Df(2R)M41A8. (Rasmuson-Lestander et al., 1993) Lethal in combination with Df(2R)M41A4 or Df(2R)M41A10. (Hilliker and Holm, 1975) Lethal in combination with Df(2R)M41A10. (Curry, 1939)
NOT in combination with other aberrations	Strongly (over 4-fold) enhances the ct^53d cut wing phenotype. (Rollins et al., 1999) Does not cause unconditional lethality in hybrid females when heterozygous with D.simulans chromosome. (Coyne et al., 1998) Heterozygosity for this deletion enhances the mutant ovarian phenotype of ovo^D2. (Pauli et al., 1995) Heterozygotes show a Minute phenotype. Homozygous lethal. (Hilliker and Holm, 1975) homozygous lethal Long-bristled Minute; readily classifiable. Pale body color. Eyes often deformed; postscutellar bristles may be erect or absent.
Stocks ( 3 )
Bloomington	740 Df(2R)M41A8/SM1
Kyoto	106056 Df(2R)M41A8/SM1 101447 Df(2R)M41A8 / SM1, al² Cy¹ cn² sp²
Notes on Origin
Discoverer

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments
	The Df(2R)M41A8 chromosome acts as a dominant moderate suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{w^var}KR3-2", a stable "brown-red" variant of the P{3'WP-2,w^var}2Lt insertion), but this is assumed to be a false positive result (the suppressor may not be within the bounds of the deficient region) because the 2L TAS array on the chromosome is missing (as assayed by in situ hybridization) and it has previously been shown (FBrf0137248, FBrf0158986) that partial or complete deficiency of the 2L TAS array on the homologue suppresses silencing of brown-red variants of P{3'WP-2,w^var}2Lt. In addition, the deficiency chromosome fails to complement lethal mutations of l(2)gl and deficiencies that are mutant for l(2)gl are often also deficient for the 2L TAS array (FBrf0137248). (Mason et al., 2004)
Synonyms & Secondary IDs ( 13 )
Reported As
Symbol Synonym	41A8 (Dimitri et al., 2005) Df(2)M-S8 (Curry, 1939) Df(2R)M41 (Coyne et al., 1998) Df(2R)M41A8 (Myster et al., 2004, Gambetta et al., 2009, Gambetta and Mueller, 2009.8.18, Sinclair et al., 2009) Df(2R)MS2-8 (Cicchetti and Loverre, 1989) Df(2R)M-S2-8 Df(2R)MS2⁸ (Koryakov and Zhimulev, 1996) Df(2R)M-S8 (Sharp et al., 1985) Df(2Rh)M-S2⁸ (Dimitri et al., 1997) M(2)S2⁸ MS2-8 (Hilliker and Holm, 1975) M-S2⁸ (Rasmuson-Lestander et al., 1993)
Name Synonym	Deficiency (2R) Minute 41A
Secondary FlyBase IDs

References ( 25 )

Generate a list of	All references relating to this aberration ( 25 )

List References by type	Research paper ( 19 ) Supplementary material ( 2 ) Review ( 1 ) Personal communication to FlyBase ( 1 ) FlyBase analysis ( 1 ) Book ( 1 )
Recent research papers (0)
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Recent reviews (0)
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