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General Information
Symbol
Df(2R)M41A8
Species
D. melanogaster
Name
Deficiency (2R) Minute 41A
FlyBase ID
FBab0001995
Feature type
Computed Breakpoints include

h44-h46;h46-41A3

Deleted Segment
Sequence coordinates
Member of large scale dataset(s)
Nature of Aberration
Cytological Order
Progenitor
Mutagen
Class of aberration (relative to wild type)
Class of aberration (relative to progenitor)
Breakpoints
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data

uex << bk1 << l(2)IR4 << stw << bk2 << ap

Genetic mapping information
Comments

This deletion removes a single ribosomal protein-coding gene (though other genes are also removed).

Comments on Cytology

Left limit of break 1 from non-inclusion of uex (FBrf0042654) Right limit of break 1 from inclusion of l(2)41Ae (FBrf0027524) Left limit of break 2 from inclusion of RpL38 (FBrf0027524) Right limit of break 2 from polytene analysis (FBrf0080317)

Sequence Crossreferences
DNA sequence
Protein sequence
Gene Deletion and Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted
Partially deleted / disrupted
Molecular Data
Partially deleted
Genes NOT Deleted / Disrupted
Genes Duplicated
Complementation Data
Completely duplicated
Partially duplicated
Molecular Data
Completely duplicated
Partially duplicated
Genes NOT Duplicated
Complementation Data
 
Molecular Data
 
Phenotypic Data
In combination with other aberrations

The z1 In(1)wis eye colour phenotype is enhanced by Df(2R)M41A8.

Lethal in combination with Df(2R)M41A4 or Df(2R)M41A10.

Lethal in combination with Df(2R)M41A10.

NOT in combination with other aberrations

Flies heterozygous for the deletion show a Minute bristle phenotype.

Strongly (over 4-fold) enhances the ct53d cut wing phenotype.

Does not cause unconditional lethality in hybrid females when heterozygous with D.simulans chromosome.

Heterozygosity for this deletion enhances the mutant ovarian phenotype of ovoD2.

Heterozygotes show a Minute phenotype. Homozygous lethal.

homozygous lethal Long-bristled Minute; readily classifiable. Pale body color. Eyes often deformed; postscutellar bristles may be erect or absent.

Stocks (3)
Notes on Origin
Discoverer
 
Balancer / Genotype Variants of the Aberration
 
Separable Components
 
Other Comments
 

The Df(2R)M41A8 chromosome acts as a dominant moderate suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{wvar}KR3-2", a stable "brown-red" variant of the P{3'WP-2,wvar}2Lt insertion), but this is assumed to be a false positive result (the suppressor may not be within the bounds of the deficient region) because the 2L TAS array on the chromosome is missing (as assayed by in situ hybridization) and it has previously been shown (FBrf0137248, FBrf0158986) that partial or complete deficiency of the 2L TAS array on the homologue suppresses silencing of brown-red variants of P{3'WP-2,wvar}2Lt. In addition, the deficiency chromosome fails to complement lethal mutations of l(2)gl and deficiencies that are mutant for l(2)gl are often also deficient for the 2L TAS array (FBrf0137248).

Synonyms and Secondary IDs (13)
Reported As
Name Synonyms
Deficiency (2R) Minute 41A
Secondary FlyBase IDs
    References (26)