FlyBase Aberration Report: Dmel\Df(2R)M60E

General Information

Symbol

Df(2R)M60E

Species

D. melanogaster

Name

FlyBase ID

FBab0001997

Feature type

chromosomal_deletion

Also Known As

Df(2R)M-c33a, Df(2R)M-c^33a, M(2)60E

Computed Breakpoints include

60E6-60E9;60E11

Features within 60E6--60E11

Genomic Maps

JBrowse

Sequence coordinates

2R:24,835,667..24,921,677 (Df(2R)M60E:bk1)

(Cook, 2016.2.8)

2R:24,976,456..25,061,964 (Df(2R)M60E:bk2)

(Cook, 2016.2.8)

Member of large scale dataset(s)

Nature of Aberration

Cytological Order

Progenitor

Mutagen

X ray

Class of aberration (relative to wild type)

chromosomal_deletion

(FlyBase, 2007)

Class of aberration (relative to progenitor)

chromosomal_deletion

(Duffy et al., 1996, Harbecke and Lengyel, 1995, Pauli et al., 1995, Landecker et al., 1994, Stern et al., 1990, Okamoto et al., 1987, Sunkel and Whittle, 1987)

Breakpoints

60E2-60E3;60E11-60E12

(Duffy et al., 1996, Harbecke and Lengyel, 1995, Pauli et al., 1995, Landecker et al., 1994, Okamoto et al., 1987, Sunkel and Whittle, 1987)

60E2;60E11

(Stern et al., 1990)

Causes alleles

Carries alleles

Transposon Insertions

Formalized genetic data

Dll << bk1 << NaCP60E << RpL19 << bk2 << gsb

Genetic mapping information

Comments

The 2R:24835667..24921677 release 6 coordinates of the left breakpoint are estimates. The left extent corresponds to the right end of Dll, which published results say is not deleted. The right extent corresponds to the right end of NaCP60E, which published results say is deleted.

(Cook, 2016.2.8)

The 2R:24976456..25061964 release 6 coordinates of the right breakpoint are estimates. The left extent corresponds to the left end of emp. Tests at the Bloomington Stock Center showed PCR primers within emp were not amplified from Df(2R)M60E. The right extent corresponds to the left end of gsb, which published results say is not deleted.

(Cook, 2016.2.8)

This deletion removes multiple ribosomal protein-coding genes (in addition to other genes).

(Marygold et al., 2007)

Comments on Cytology

Left limit of break 1 from non-inclusion of Dll (FBrf0047276) Right limit of break 1 from inclusion of RpL19 (FBrf0068519) Left limit of break 2 from polytene analysis (FBrf0047207) Right limit of break 2 from polytene analysis (FBrf0051924)

Sequence Crossreferences

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

Gene Deletion and Duplication Data

Genes Deleted / Disrupted

Complementation Data

Completely deleted / disrupted

hedera

(Riede, 1996)

l(2)k11118

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

NaCP60E

(Stern et al., 1990)

RpL19

(Hart et al., 1993)

S(CycE^JP)2.7

(Brumby et al., 2004)

S(CycE^JP)2.13

(Brumby et al., 2004)

Partially deleted / disrupted

Molecular Data

Completely deleted

RpL19

(Marygold et al., 2007)

RpL41

(Marygold et al., 2007)

Partially deleted

Genes NOT Deleted / Disrupted

Complementation Data

Molecular Data

Genes Duplicated

Complementation Data

Completely duplicated

Partially duplicated

Molecular Data

Completely duplicated

Partially duplicated

Genes NOT Duplicated

Complementation Data

Molecular Data

Affected Genes Inferred by Location (38)

Related Comments

Phenotypic Data

In combination with other aberrations

Df(2R)M60E dominantly enhances the transformation of arista to leg phenotype seen in Df(2R)Dll-MP heterozygotes.

(Fauvarque et al., 2001)

Df(2R)M60E/In(2LR)bw^V32g good viability (Campos-Ortega and Waitz, 1978).

NOT in combination with other aberrations

Flies heterozygous for the deletion show a Minute bristle phenotype.

(Marygold et al., 2007)

The Df(2R)M60E chromosome does not act as a dominant suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{w^var}KR3-2", a stable "brown-red" variant of the P{3'WP-2,w^var}2Lt insertion).

(Mason et al., 2004)

Heterozygosity for Df(2R)M60E results in 0.5% X chromosome nondisjunction and 0.0% fourth chromosome nondisjunction in In(1)FM7/X ; sv^spa-pol females.

(Harris et al., 2003)

Shows no maternal enhancement of dpp^hr4.

(Nicholls and Gelbart, 1998)

Dominantly causes tergite defects in less than 50% of run³ heterozygotes.

(Duffy et al., 1996)

Minute mutations, which slow the rate of cell division, partially restore a transvection effect that is disrupted by an inversion breakpoint.

(Golic and Golic, 1996)

Deficient embryos show an uninterpretable mutant midgut phenotype.

(Bilder and Scott, 1995)

Homozygous embryos are very abnormal compared to wild-type.

(Harbecke and Lengyel, 1995)

Heterozygosity for this deletion has no effect on the mutant ovarian phenotype of ovo^D2.

(Pauli et al., 1995)

Homozygotes lack a putative sodium channel at the 60E region. Homozygotes exhibit normal neurotoxin sensitivity suggesting other sodium channels are present in the embryonic neuron of homozygotes.

(Sakai et al., 1989)

Minute phenotype is not suppressed by RpL32^+t3.3.

(Kongsuwan et al., 1985)

Heterozygotes have shorter bristles than wild type flies. Eclosion is delayed by 49 hours.

(Ferrus, 1975)

Fairly strong Minute; slow development; good viability and fertility. Eclosion of Df(2R)M60E/+ delayed 49 hours (Ferrus, 1975).

Stocks (3)

Bloomington

2471

Df(2R)M60E/In(2LR)bw^V32g, bw^V32g

Kyoto

103279

Df(2R)M60E / In(2LR)bw^V32g

107354

Df(2R)M60E/In(2LR)bw^V32g, bw^V32g

Notes on Origin

Discoverer

Schultz, 7th Jan. 1933.

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

Synonyms and Secondary IDs (14)

Reported As

Symbol Synonym

BL-2471

(Edgar et al., 2005)

Df(2)M-33a

Df(2R) M60E

(Fiehler and Wolff, 2008)

Df(2R)M(2)c^33a

(Germeraad et al., 1992)

Df(2R)M-c33a

(Matsuo et al., 2007, Jackson and Berg, 1999, Nicholls and Gelbart, 1998, Duffy et al., 1996, Riede, 1996, Bilder and Scott, 1995, Harbecke and Lengyel, 1995, Pauli et al., 1995, Ludwig et al., 1991, Schupbach and Wieschaus, 1991, Sakai et al., 1989, Schupbach and Wieschaus, 1989)

Df(2R)M-c^33a

(Abrell et al., 2000, Stern et al., 1990, Okamoto et al., 1987, Sunkel and Whittle, 1987)

Df(2R)M60E

(Li et al., 2020, Sawyer et al., 2020, Baillon et al., 2018, Kale et al., 2018, Clough et al., 2014, Galindo et al., 2014, Talsma et al., 2014, Fernandes and Rao, 2011, Stork et al., 2008)

Df(2R)Mc^33a

(Golic and Golic, 1996)

Df(RpL19)

(Kale et al., 2018)

DfM(2)c³³a

(Kongsuwan et al., 1985)

M(2)115

M(2)60E

(Fauvarque et al., 2001, Csink and Henikoff, 1998)

M(2)c^33a

(Raghavan et al., 1996)

M(2R)c^33a

(Ferrus, 1975)

Name Synonyms

Secondary FlyBase IDs

References (55)

Report Sections

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