FB2025_01 , released February 20, 2025
Aberration: Dmel\Df(2R)PC4
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General Information
Symbol
Df(2R)PC4
Species
D. melanogaster
Name
FlyBase ID
FBab0002014
Feature type
chromosomal_deletion
Also Known As
Df(2)PC4, Df(PC4)
Computed Breakpoints include

55A1;55F1-55F2

Features within 55A1--55F2
Sequence coordinates
Member of large scale dataset(s)
Nature of Aberration
Cytological Order
Progenitor
Mutagen
Class of aberration (relative to wild type)
chromosomal_deletion
(FlyBase, 2007)
Class of aberration (relative to progenitor)
chromosomal_deletion
(Moore, 1999.4.29, Boube et al., 1997, Brodsky and Steller, 1996, Corbo and Levine, 1996, Duffy et al., 1996, Tearle, 1996.5.14, Harbecke and Lengyel, 1995, Kania et al., 1995, Lemaitre et al., 1995, Pauli et al., 1995, Roseman et al., 1995, Lindsley and Zimm, 1992, Doane and Dumapias, 1987)
Breakpoints

55A;55F

(Boube et al., 1997, Brodsky and Steller, 1996, Corbo and Levine, 1996, Duffy et al., 1996, Harbecke and Lengyel, 1995, Kania et al., 1995, Lemaitre et al., 1995, Pauli et al., 1995, Roseman et al., 1995, Lindsley and Zimm, 1992, Doane and Dumapias, 1987)

54D3-54E10;55D3-55E11

(Moore, 1999.4.29)

55A;55C

(Tearle, 1996.5.14)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data

bk1 << E(var)55 << bk2 << l(2)08717

Genetic mapping information
Comments

This deletion removes a single ribosomal protein-coding gene (though other genes are also removed).

(Marygold et al., 2007)
Comments on Cytology

Ref: Lindsley and Zimm, 1992

(Kania et al., 1995)

Left limit of break 1 from polytene analysis (FBrf0080145) Right limit of break 1 from inclusion of grh (FBrf0041708) Left limit of break 2 from polytene analysis (FBrf0080145) Right limit of break 2 from non-inclusion of l(2)08717 (FBrf0067338)

Sequence Crossreferences
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
Gene Deletion and Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted
adp
(Doane, 1999, Doane, 1996, Doane and Dumapias, 1987)
Dp1
(Huertas et al., 2004)
E(var)55
(Wustmann et al., 1989)
eay
(Doane, 1996, Tearle, 1996.5.14, Schupbach and Wieschaus, 1991, Schupbach and Wieschaus, 1989)
edl
(Baker et al., 2001, BDGP Project Members, 1994-1999)
ena
(Cox et al., 2000)
fj
(Zeidler et al., 1999, Brodsky and Steller, 1996, Villano and Katz, 1995, Deng and Rizki, 1988)
fs(2)lto4
(Schupbach and Wieschaus, 1991)
fs(2)PC4-U
(Tearle, 1996.5.14)
grh
(Tearle, 1996.5.14, Tearle and Nusslein-Volhard, 1987, Nusslein-Volhard et al., 1984)
hall
(Castrillon et al., 1993)
Hsf
(Spradling et al., 1999, BDGP Project Members, 1994-1999)
imd
(Corbo and Levine, 1996)
l(2)55BCa
(Roseman et al., 1995)
l(2)55Da
(Roseman et al., 1995)
l(2)55Db
(Roseman et al., 1995)
l(2)k03117
(BDGP Project Members, 1994-1999)
l(2)PC4-51
(Tearle, 1996.5.14)
l(2)PC4-427
(Tearle, 1996.5.14)
l(2)PC4-A
(Tearle, 1996.5.14)
l(2)PC4-B
(Tearle, 1996.5.14)
l(2)PC4-C
(Tearle, 1996.5.14)
l(2)PC4-D
(Tearle, 1996.5.14)
l(2)PC4-E
(Tearle, 1996.5.14)
l(2)PC4-F
(Tearle, 1996.5.14)
l(2)PC4-G
(Tearle, 1996.5.14)
l(2)PC4-H
(Tearle, 1996.5.14)
l(2)PC4-K
(Tearle, 1996.5.14)
l(2)PC4-M
(Tearle, 1996.5.14)
l(2)PC4-N
(Tearle, 1996.5.14)
l(2)PC4-P
(Tearle, 1996.5.14)
l(2)PC4-Q
(Tearle, 1996.5.14)
l(2)PC4-R
(Tearle, 1996.5.14)
l(2)PC4-S
(Tearle, 1996.5.14)
lolal
(BDGP Project Members, 1994-1999)
lup-4
(Ceprani et al., 2008)
mama
(Doane, 1999, Tearle, 1996.5.14)
nopo
(Merkle et al., 2009)
oho55DE
(BDGP Project Members, 1994-1999)
Ote
(Jiang et al., 2008, Doane, 1996, Tearle, 1996.5.14, Schupbach and Wieschaus, 1991)
pAbp
(BDGP Project Members, 1994-1999)
Pcl
(Tearle, 1996.5.14, Harbecke and Lengyel, 1995, BDGP Project Members, 1994-1999, Lonie et al., 1994, Jurgens, 1985)
PPO1
(Corbo and Levine, 1996, Lemaitre et al., 1995, Asada et al., 1993)
Prp19
(Spradling et al., 1999, BDGP Project Members, 1994-1999)
Rst(2)Lb
(Hita et al., 1999)
sbb
(Haecker et al., 2007, LaJeunesse et al., 2001, Senti et al., 2000, Shaver et al., 2000, Yang et al., 2000, Spradling et al., 1999, BDGP Project Members, 1994-1999)
Sec6
(Beronja et al., 2005)
stau
(Doane, 1996, Tearle, 1996.5.14, Schupbach and Wieschaus, 1989, Jurgens, 1985)
sub
(Giunta et al., 2002, Doane, 1996, Tearle, 1996.5.14, Moore et al., 1994, Schupbach and Wieschaus, 1991, Schupbach and Wieschaus, 1989)
thr
(Tearle, 1996.5.14, Harbecke and Lengyel, 1995, BDGP Project Members, 1994-1999, Lonie et al., 1994, Tearle and Nusslein-Volhard, 1987, Jurgens, 1985)
Ttd14
(BDGP Project Members, 1994-1999)
wt
(Deng and Rizki, 1988)
Partially deleted / disrupted
Molecular Data
Completely deleted
mRpS28
(Marygold et al., 2007)
Partially deleted
Genes NOT Deleted / Disrupted
Genes Duplicated
Complementation Data
Completely duplicated
Partially duplicated
Molecular Data
Completely duplicated
Partially duplicated
Genes NOT Duplicated
Complementation Data
 
Molecular Data
 
Affected Genes Inferred by Location (0)
    If no genes are listed here, it may be because the affected region is very large. The JBrowse insert above may show an error for the same reason, and other FlyBase tools such as CytoSearch may also fail for large regions. You can contact FlyBase for more help.
    In these cases, there will be no "Export to Hitlist" button to the left.
    Phenotypic Data
    In combination with other aberrations

    Inferred to overlap with: Df(2R)BSC399.

    (Christensen et al., 2007.10.29)

    Fails to complement Df(2R)PclXM82, Df(2R)Pcl7B, Df(2R)Pcl11B, Df(2R)PC29, Df(2R)P34 and Df(2R)PC66.

    (Tearle, 1996.5.14)

    Enhancer of In(1)wm4h position-effect variegation.

    (Wustmann et al., 1989)
    NOT in combination with other aberrations

    Flies heterozygous for the deletion do not show a Minute bristle phenotype.

    (Marygold et al., 2007)

    The Df(2R)PC4 chromosome does not act as a dominant suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{wvar}KR3-2", a stable "brown-red" variant of the P{3'WP-2,wvar}2Lt insertion).

    (Mason et al., 2004)

    Heterozygosity for Df(2R)PC4 results in 4.8% X chromosome nondisjunction and 5.8% fourth chromosome nondisjunction in In(1)FM7/X ; svspa-pol females.

    (Harris et al., 2003)

    Homozygous embryos have abnormal gut morphology.

    (Merabet et al., 2002)

    Does not cause unconditional lethality in hybrid females when heterozygous with D.simulans chromosome.

    (Coyne et al., 1998)

    Weak second site non-complementing phenotype with zipEbr (though not zipmhc-c6.1 : malformed phenotype penetrance 10-24%.

    (Halsell and Kiehart, 1998)

    Shows no maternal enhancement of dpphr4.

    (Nicholls and Gelbart, 1998)

    Shows a dose-sensitive interaction with pbhs.PB.

    (Boube et al., 1997)

    Uncovers Dsim\jba in D.melanogaster/D.simulans hybrids. Does not uncover Dsim\pm in D.melanogaster/D.simulans hybrids.

    (Yamamoto et al., 1997)

    Dominantly causes tergite defects in less than 50% of run3 heterozygotes.

    (Duffy et al., 1996)

    Deficient embryos show a variably penetrant mutant midgut phenotype: variable constrictions absent.

    (Bilder and Scott, 1995)

    Homozygous embryos are very abnormal compared to wild-type and tracheae are not completely connected. Midgut constrictions do not form and Malpighian tubules are poorly differentiated.

    (Harbecke and Lengyel, 1995)

    Heterozygosity for this deletion enhances the mutant ovarian phenotype of ovoD2.

    (Pauli et al., 1995)

    Semiviable over subDub. Transheterozygotes tend to die during the pupal phase or only eclose halfway. Escapers show rough eyes, etched tergites and blistered or nicked wings. Males and females are sterile.

    (Moore et al., 1994)

    Fewer larger nuclei.

    (Smith et al., 1993)
    Stocks (3)
    Notes on Origin
    Discoverer
     
    Balancer / Genotype Variants of the Aberration
     
    Separable Components
     
    Other Comments
     
    Synonyms and Secondary IDs (8)
    References (106)