A Database of Drosophila Genes & Genomes

FB2008_07, released August 8, 2008
 

Aberration Dmel\Df(2R)PC4

General Information
SymbolDmel\Df(2R)PC4SpeciesD. melanogaster
NameFlyBase IDFBab0002014
Feature typechromosomal_deletionCreated / Updated2006-08-22/2006-08-22
Formalized genetic data bk1 << E(var)55 << bk2 << l(2)08717
Sequence coordinates
Deleted segment55A1--55F2
Duplicated segment
Computed Breakpoints include 55A1;55F1-55F2
Breakpoints Inherited  
hide Nature of the Aberration
Cytological Order
Progenitor
Mutagen
Class of aberration (relative to progenitor)
chromosomal_deletion
(Lindsley and Zimm, 1992, Doane and Dumapias, 1987, Kania et al., 1995, Pauli et al., 1995, Roseman et al., 1995, Tearle, 1996.5.14, Lemaitre et al., 1995, Brodsky and Steller, 1996, Duffy et al., 1996, Corbo and Levine, 1996, Harbecke and Lengyel, 1995, Boube et al., 1997, Moore, 1999.4.29)
Breakpoints
55A;55F
(Doane and Dumapias, 1987, Lindsley and Zimm, 1992, Kania et al., 1995, Pauli et al., 1995, Harbecke and Lengyel, 1995, Lemaitre et al., 1995, Roseman et al., 1995, Brodsky and Steller, 1996, Duffy et al., 1996, Corbo and Levine, 1996, Boube et al., 1997)
55A;55C
(Tearle, 1996.5.14)
54D3-54E10;55D3-55E11
(Moore, 1999.4.29)
Causes alleles
Carries alleles
Transposon Insertions
Genetic mapping information
Comments
hide Comments on Cytology
Left limit of break 1 from polytene analysis (FBrf0080145) Right limit of break 1 from inclusion of grh (FBrf0041708) Left limit of break 2 from polytene analysis (FBrf0080145) Right limit of break 2 from non-inclusion of l(2)08717 (FBrf0067338)
 
Ref: Lindsley and Zimm, 1992
(Kania et al., 1995)
hide Molecularly Mapped Breakpoints
 
hide Sequence Crossreferences
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
hide Gene Deletion & Duplication Data
hide Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted
edl
(BDGP Project Members, 1994-1999, Baker et al., 2001)
Dp1
(Huertas et al., 2004)
sec6
(Beronja et al., 2005)
imd
(Corbo and Levine, 1996)
Pcl
(Jurgens, 1985, BDGP Project Members, 1994-1999, Lonie et al., 1994, Harbecke and Lengyel, 1995, Tearle, 1996.5.14)
pAbp
(BDGP Project Members, 1994-1999)
adp
(Doane and Dumapias, 1987, Doane, 1996, Doane, 1999)
fj
(Deng and Rizki, 1988, Villano and Katz, 1995, Brodsky and Steller, 1996, Zeidler et al., 1999)
sbb
(BDGP Project Members, 1994-1999, Spradling et al., 1999, Senti et al., 2000, Yang et al., 2000, LaJeunesse et al., 2001)
lolal
(BDGP Project Members, 1994-1999)
Hsf
(BDGP Project Members, 1994-1999, Spradling et al., 1999)
stau
(Jurgens, 1985, Schupbach and Wieschaus, 1989, Tearle, 1996.5.14, Doane, 1996)
Bc
(Asada et al., 1993, Deng and Rizki, 1988, Lemaitre et al., 1995, Corbo and Levine, 1996)
sub
(Schupbach and Wieschaus, 1989, Schupbach and Wieschaus, 1991, Moore et al., 1994, Tearle, 1996.5.14, Doane, 1996, Giunta et al., 2002)
thr
(Jurgens, 1985, Tearle and Nusslein-Volhard, 1987, BDGP Project Members, 1994-1999, Lonie et al., 1994, Harbecke and Lengyel, 1995, Tearle, 1996.5.14)
ena
(Cox et al., 2000)
oho55DE
(BDGP Project Members, 1994-1999)
hall
(Castrillon et al., 1993)
Prp19
(BDGP Project Members, 1994-1999, Spradling et al., 1999)
l(2)08770
(BDGP Project Members, 1994-1999)
l(2)55BCa
(Roseman et al., 1995)
l(2)55Da
(Roseman et al., 1995)
l(2)55Db
(Roseman et al., 1995)
l(2)PC4-P
(Tearle, 1996.5.14)
l(2)k03117
(BDGP Project Members, 1994-1999)
l(2)PC4-H
(Tearle, 1996.5.14)
eay
(Schupbach and Wieschaus, 1989, Schupbach and Wieschaus, 1991, Tearle, 1996.5.14, Doane, 1996)
lup-4
(Ceprani et al., 2008)
l(2)PC4-E
(Tearle, 1996.5.14)
l(2)PC4-F
(Tearle, 1996.5.14)
fs(2)PC4-U
(Tearle, 1996.5.14)
l(2)PC4-S
(Tearle, 1996.5.14)
l(2)PC4-M
(Tearle, 1996.5.14)
l(2)PC4-G
(Tearle, 1996.5.14)
l(2)PC4-N
(Tearle, 1996.5.14)
l(2)PC4-K
(Tearle, 1996.5.14)
l(2)PC4-D
(Tearle, 1996.5.14)
Rst(2)Lb
(Hita et al., 1999)
l(2)PC4-R
(Tearle, 1996.5.14)
l(2)PC4-51
(Tearle, 1996.5.14)
mama
(Tearle, 1996.5.14, Doane, 1999)
l(2)PC4-Q
(Tearle, 1996.5.14)
hal
(Schupbach and Wieschaus, 1991, Tearle, 1996.5.14, Doane, 1996)
l(2)PC4-427
(Tearle, 1996.5.14)
l(2)PC4-C
(Tearle, 1996.5.14)
fs(2)lto4
(Schupbach and Wieschaus, 1991)
wt
(Deng and Rizki, 1988)
E(var)55
(Wustmann et al., 1989)
l(2)PC4-B
(Tearle, 1996.5.14)
l(2)PC4-A
(Tearle, 1996.5.14)
grh
(Nusslein-Volhard et al., 1984, Tearle and Nusslein-Volhard, 1987, Tearle, 1996.5.14)
Molecular Data
hide Genes NOT Deleted / Disrupted
Complementation Data
l(2)05510
(BDGP Project Members, 1994-1999)
wbl
(Konsolaki and Schupbach, 1998)
l(2)03709
(BDGP Project Members, 1994-1999, Spradling et al., 1999)
l(2)08717
(BDGP Project Members, 1994-1999, Spradling et al., 1999)
olf186-F
(BDGP Project Members, 1994-1999, Spradling et al., 1999)
l(2)k09021
(BDGP Project Members, 1994-1999)
l(2)k08931
(BDGP Project Members, 1994-1999)
l(2)04548
(BDGP Project Members, 1994-1999)
l(2)k06106
(BDGP Project Members, 1994-1999)
l(2)s1864
(BDGP Project Members, 1994-1999)
RpL30
(BDGP Project Members, 1994-1999)
Molecular Data
hide Genes Duplicated
Complementation Data
Molecular Data
hide Genes NOT Duplicated
Complementation Data
Molecular Data
hide Related Comments
hide Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations
Deficient embryos show a variably penetrant mutant midgut phenotype: variable constrictions absent.
(Bilder and Scott, 1995)
Does not cause unconditional lethality in hybrid females when heterozygous with D.simulans chromosome.
(Coyne et al., 1998)
Dominantly causes tergite defects in less than 50% of run3 heterozygotes.
(Duffy et al., 1996)
Fewer larger nuclei.
(Smith et al., 1993)
Heterozygosity for Df(2R)PC4 results in 4.8% X chromosome nondisjunction and 5.8% fourth chromosome nondisjunction in In(1)FM7/X ; svspa-pol females.
(Harris et al., 2003)
Heterozygosity for this deletion enhances the mutant ovarian phenotype of ovoD2.
(Pauli et al., 1995)
Homozygous embryos are very abnormal compared to wild-type and tracheae are not completely connected. Midgut constrictions do not form and Malpighian tubules are poorly differentiated.
(Harbecke and Lengyel, 1995)
Homozygous embryos have abnormal gut morphology.
(Merabet et al., 2002)
Semiviable over subDub. Transheterozygotes tend to die during the pupal phase or only eclose halfway. Escapers show rough eyes, etched tergites and blistered or nicked wings. Males and females are sterile.
(Moore et al., 1994)
Shows a dose-sensitive interaction with pbhs.PB.
(Boube et al., 1997)
Shows no maternal enhancement of dpphr4.
(Nicholls and Gelbart, 1998)
The Df(2R)PC4 chromosome does not act as a dominant suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{wvar}KR3-2", a stable "brown-red" variant of the P{3\'WP-2,wvar}2Lt insertion).
(Mason et al., 2004)
Uncovers Dsim\jba in D.melanogaster/D.simulans hybrids. Does not uncover Dsim\pm in D.melanogaster/D.simulans hybrids.
(Yamamoto et al., 1997)
Weak second site non-complementing phenotype with zipEbr (though not zipmhc-c6.1: malformed phenotype penetrance 10-24%.
(Halsell and Kiehart, 1998)
hide Position Effect Variegation Data
  
hide Stocks ( 3 )
Bloomington
1547
Df(2R)PC4/CyO
Kyoto
106715
Df(2R)PC4/CyO
103259
CyO, Cy1 dplv1 pr1 cn2 / Df(2R)PC4
hide Notes on Origin
Discoverer
hide Balancer / Genotype Variants of the Aberration
    hide Separable Components
      hide Other Comments
      hide Synonyms & Secondary IDs ( 6 )
      Reported As
      Symbol Synonym
      Df(2)PC4
      (Doane, 2000, Jurgens, 1985)
      Df(2L)PC4
      (Wehn and Campbell, 2006)
      Df(2R)PC4
      (Munro et al., 2006, Beronja et al., 2005, Crest et al., 2007, Christensen et al., 2007.10.29, Ceprani et al., 2008)
      Df(2R)Pc4
      (Abrell et al., 2000, Yang et al., 2000, Hita et al., 1999, Yamamoto et al., 1997, Nicholls and Gelbart, 1998, Wustmann et al., 1989, Konsolaki and Schupbach, 1998, Pauli et al., 1995, Smith et al., 1993, Castrillon et al., 1993)
      Df(2R)Pc4
      (Clark et al., 1994)
      Pcl4
      (Brodsky and Steller, 1996)
      Name Synonym
      Secondary FlyBase IDs
        hide References ( 82 )
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        hide Recent research papers ( 4 )
        Ceprani et al., 2008, BMC Genet. 9: 32
        Autosomal mutations affecting Y chromosome loops in Drosophila melanogaster. [FBrf0204958]
        Crest et al., 2007, Genetics 175(2): 567--584
        Onset of the DNA replication checkpoint in the early Drosophila embryo. [FBrf0194644]
        Munro et al., 2006, J. Cell Biol. 172(4): 577--588
        A repeated IMP-binding motif controls oskar mRNA translation and anchoring independently of Drosophila melanogaster IMP. [FBrf0190940]
        Wehn and Campbell, 2006, Genetics 173(2): 849--861
        Genetic interactions among scribbler, Atrophin and groucho in Drosophila uncover links in transcriptional repression. [FBrf0193648]
        Show all research papers ...