A Database of Drosophila Genes & Genomes

FB2008_07, released August 8, 2008
 

Aberration Dmel\Df(2R)PC4

General Information
SymbolDmel\Df(2R)PC4SpeciesD. melanogaster
NameFlyBase IDFBab0002014
Feature typechromosomal_deletionCreated / Updated2006-08-22/2006-08-22
Formalized genetic data bk1 << E(var)55 << bk2 << l(2)08717
Sequence coordinates
Deleted segment55A1--55F2
Duplicated segment
Computed Breakpoints include 55A1;55F1-55F2
Breakpoints Inherited  
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Cytological Order
Progenitor
Mutagen
Class of aberration (relative to progenitor)
Breakpoints
54D3-54E10;55D3-55E11
Causes alleles
Carries alleles
Transposon Insertions
Genetic mapping information
Comments
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Left limit of break 1 from polytene analysis (FBrf0080145) Right limit of break 1 from inclusion of grh (FBrf0041708) Left limit of break 2 from polytene analysis (FBrf0080145) Right limit of break 2 from non-inclusion of l(2)08717 (FBrf0067338)
 
Ref: Lindsley and Zimm, 1992
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DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
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Complementation Data
Completely deleted / disrupted
Molecular Data
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Complementation Data
Molecular Data
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Complementation Data
Molecular Data
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Complementation Data
Molecular Data
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In combination with other aberrations
NOT in combination with other aberrations
Deficient embryos show a variably penetrant mutant midgut phenotype: variable constrictions absent.
Does not cause unconditional lethality in hybrid females when heterozygous with D.simulans chromosome.
Dominantly causes tergite defects in less than 50% of run3 heterozygotes.
Fewer larger nuclei.
Heterozygosity for Df(2R)PC4 results in 4.8% X chromosome nondisjunction and 5.8% fourth chromosome nondisjunction in In(1)FM7/X ; svspa-pol females.
Heterozygosity for this deletion enhances the mutant ovarian phenotype of ovoD2.
Homozygous embryos are very abnormal compared to wild-type and tracheae are not completely connected. Midgut constrictions do not form and Malpighian tubules are poorly differentiated.
Homozygous embryos have abnormal gut morphology.
Semiviable over subDub. Transheterozygotes tend to die during the pupal phase or only eclose halfway. Escapers show rough eyes, etched tergites and blistered or nicked wings. Males and females are sterile.
Shows a dose-sensitive interaction with pbhs.PB.
Shows no maternal enhancement of dpphr4.
The Df(2R)PC4 chromosome does not act as a dominant suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{wvar}KR3-2", a stable "brown-red" variant of the P{3\'WP-2,wvar}2Lt insertion).
Uncovers Dsim\jba in D.melanogaster/D.simulans hybrids. Does not uncover Dsim\pm in D.melanogaster/D.simulans hybrids.
Weak second site non-complementing phenotype with zipEbr (though not zipmhc-c6.1: malformed phenotype penetrance 10-24%.
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hide Stocks ( 3 )
Bloomington
Kyoto
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Discoverer
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      hide Synonyms & Secondary IDs ( 6 )
      Reported As
      Symbol Synonym
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      Secondary FlyBase IDs
        hide References ( 82 )
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        hide Recent research papers ( 4 )
        Ceprani et al., 2008, BMC Genet. 9: 32
        Autosomal mutations affecting Y chromosome loops in Drosophila melanogaster. [FBrf0204958]
        Crest et al., 2007, Genetics 175(2): 567--584
        Onset of the DNA replication checkpoint in the early Drosophila embryo. [FBrf0194644]
        Munro et al., 2006, J. Cell Biol. 172(4): 577--588
        A repeated IMP-binding motif controls oskar mRNA translation and anchoring independently of Drosophila melanogaster IMP. [FBrf0190940]
        Wehn and Campbell, 2006, Genetics 173(2): 849--861
        Genetic interactions among scribbler, Atrophin and groucho in Drosophila uncover links in transcriptional repression. [FBrf0193648]