A Database of Drosophila Genes & Genomes

FB2013_03, released May 7th, 2013
 

Aberration Dmel\Df(2R)PC4

General Information
SymbolDmel\Df(2R)PC4SpeciesD. melanogaster
NameFlyBase IDFBab0002014
Feature typechromosomal_deletion
Also Known AsDf(2)PC4, Df(PC4)
Computed Breakpoints include 55A1;55F1-55F2
Deleted segment55A1--55F2
Sequence coordinates
Member of large scale dataset(s)
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Description
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FB2013_03
FB2013_02
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hide Nature of the Aberration
Cytological Order
Progenitor
Mutagen
Class of aberration (relative to progenitor)
chromosomal_deletion
(Lindsley and Zimm, 1992, Doane and Dumapias, 1987, Kania et al., 1995, Pauli et al., 1995, Roseman et al., 1995, Tearle, 1996.5.14, Lemaitre et al., 1995, Brodsky and Steller, 1996, Duffy et al., 1996, Corbo and Levine, 1996, Harbecke and Lengyel, 1995, Boube et al., 1997, Moore, 1999.4.29)
Breakpoints
54D3-54E10;55D3-55E11
(Moore, 1999.4.29)
55A;55C
(Tearle, 1996.5.14)
55A;55F
(Doane and Dumapias, 1987, Lindsley and Zimm, 1992, Kania et al., 1995, Pauli et al., 1995, Harbecke and Lengyel, 1995, Lemaitre et al., 1995, Roseman et al., 1995, Brodsky and Steller, 1996, Duffy et al., 1996, Corbo and Levine, 1996, Boube et al., 1997)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data bk1 << E(var)55 << bk2 << l(2)08717
Genetic mapping information
Comments
hide Comments on Cytology
Ref: Lindsley and Zimm, 1992
(Kania et al., 1995)
Left limit of break 1 from polytene analysis (FBrf0080145) Right limit of break 1 from inclusion of grh (FBrf0041708) Left limit of break 2 from polytene analysis (FBrf0080145) Right limit of break 2 from non-inclusion of l(2)08717 (FBrf0067338)
 
hide Sequence Crossreferences
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
hide Gene Deletion & Duplication Data
hide Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted
adp
(Doane, 1999, Doane and Dumapias, 1987, Doane, 1996)
Bc
(Lemaitre et al., 1995, Corbo and Levine, 1996)
Dp1
(Huertas et al., 2004)
E(var)55
(Wustmann et al., 1989)
eay
(Schupbach and Wieschaus, 1989, Schupbach and Wieschaus, 1991, Tearle, 1996.5.14, Doane, 1996)
edl
(Baker et al., 2001, BDGP Project Members, 1994-1999)
ena
(Cox et al., 2000)
fj
(Zeidler et al., 1999, Deng and Rizki, 1988, Villano and Katz, 1995, Brodsky and Steller, 1996)
fs(2)lto4
(Schupbach and Wieschaus, 1991)
fs(2)PC4-U
(Tearle, 1996.5.14)
grh
(Nusslein-Volhard et al., 1984, Tearle and Nusslein-Volhard, 1987, Tearle, 1996.5.14)
hal
(Schupbach and Wieschaus, 1991, Tearle, 1996.5.14, Doane, 1996)
hall
(Castrillon et al., 1993)
Hsf
(Spradling et al., 1999, BDGP Project Members, 1994-1999)
imd
(Corbo and Levine, 1996)
l(2)55BCa
(Roseman et al., 1995)
l(2)55Da
(Roseman et al., 1995)
l(2)55Db
(Roseman et al., 1995)
l(2)08770
(BDGP Project Members, 1994-1999)
l(2)k03117
(BDGP Project Members, 1994-1999)
l(2)PC4-51
(Tearle, 1996.5.14)
l(2)PC4-427
(Tearle, 1996.5.14)
l(2)PC4-A
(Tearle, 1996.5.14)
l(2)PC4-B
(Tearle, 1996.5.14)
l(2)PC4-C
(Tearle, 1996.5.14)
l(2)PC4-D
(Tearle, 1996.5.14)
l(2)PC4-E
(Tearle, 1996.5.14)
l(2)PC4-F
(Tearle, 1996.5.14)
l(2)PC4-G
(Tearle, 1996.5.14)
l(2)PC4-H
(Tearle, 1996.5.14)
l(2)PC4-K
(Tearle, 1996.5.14)
l(2)PC4-M
(Tearle, 1996.5.14)
l(2)PC4-N
(Tearle, 1996.5.14)
l(2)PC4-P
(Tearle, 1996.5.14)
l(2)PC4-Q
(Tearle, 1996.5.14)
l(2)PC4-R
(Tearle, 1996.5.14)
l(2)PC4-S
(Tearle, 1996.5.14)
lolal
(BDGP Project Members, 1994-1999)
lup-4
(Ceprani et al., 2008)
mama
(Doane, 1999, Tearle, 1996.5.14)
nopo
(Merkle et al., 2009)
oho55DE
(BDGP Project Members, 1994-1999)
Ote
(Jiang et al., 2008)
pAbp
(BDGP Project Members, 1994-1999)
Pcl
(Jurgens, 1985, BDGP Project Members, 1994-1999, Lonie et al., 1994, Harbecke and Lengyel, 1995, Tearle, 1996.5.14)
proPO-A1
(Asada et al., 1993)
Prp19
(Spradling et al., 1999, BDGP Project Members, 1994-1999)
Rst(2)Lb
(Hita et al., 1999)
sbb
(Spradling et al., 1999, Senti et al., 2000, Yang et al., 2000, LaJeunesse et al., 2001, BDGP Project Members, 1994-1999, Haecker et al., 2007, Shaver et al., 2000)
sec6
(Beronja et al., 2005)
stau
(Jurgens, 1985, Schupbach and Wieschaus, 1989, Tearle, 1996.5.14, Doane, 1996)
sub
(Giunta et al., 2002, Schupbach and Wieschaus, 1989, Schupbach and Wieschaus, 1991, Moore et al., 1994, Tearle, 1996.5.14, Doane, 1996)
thr
(Jurgens, 1985, Tearle and Nusslein-Volhard, 1987, BDGP Project Members, 1994-1999, Lonie et al., 1994, Harbecke and Lengyel, 1995, Tearle, 1996.5.14)
wt
(Deng and Rizki, 1988)
Molecular Data
hide Genes NOT Deleted / Disrupted
Complementation Data
l(2)03709
(Spradling et al., 1999, BDGP Project Members, 1994-1999)
l(2)04548
(BDGP Project Members, 1994-1999)
l(2)08717
(Spradling et al., 1999, BDGP Project Members, 1994-1999)
l(2)k06106
(BDGP Project Members, 1994-1999)
l(2)k08931
(BDGP Project Members, 1994-1999)
l(2)k09021
(BDGP Project Members, 1994-1999)
l(2)s1864
(BDGP Project Members, 1994-1999)
olf186-F
(Spradling et al., 1999, BDGP Project Members, 1994-1999)
qsm
(BDGP Project Members, 1994-1999)
RpL30
(BDGP Project Members, 1994-1999)
wbl
(Konsolaki and Schupbach, 1998)
Molecular Data
hide Genes Duplicated
Complementation Data
Molecular Data
hide Genes NOT Duplicated
Complementation Data
Molecular Data
hide Related Comments
hide Phenotypic Data
In combination with other aberrations
Inferred to overlap with: Df(2R)BSC399.
(Christensen et al., 2007.10.29)
Fails to complement Df(2R)PclXM82, Df(2R)Pcl7B, Df(2R)Pcl11B, Df(2R)PC29, Df(2R)P34 and Df(2R)PC66.
(Tearle, 1996.5.14)
Enhancer of In(1)wm4h position-effect variegation.
(Wustmann et al., 1989)
NOT in combination with other aberrations
The Df(2R)PC4 chromosome does not act as a dominant suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{wvar}KR3-2", a stable "brown-red" variant of the P{3'WP-2,wvar}2Lt insertion).
(Mason et al., 2004)
Heterozygosity for Df(2R)PC4 results in 4.8% X chromosome nondisjunction and 5.8% fourth chromosome nondisjunction in In(1)FM7/X ; svspa-pol females.
(Harris et al., 2003)
Homozygous embryos have abnormal gut morphology.
(Merabet et al., 2002)
Does not cause unconditional lethality in hybrid females when heterozygous with D.simulans chromosome.
(Coyne et al., 1998)
Weak second site non-complementing phenotype with zipEbr (though not zipmhc-c6.1: malformed phenotype penetrance 10-24%.
(Halsell and Kiehart, 1998)
Shows no maternal enhancement of dpphr4.
(Nicholls and Gelbart, 1998)
Shows a dose-sensitive interaction with pbhs.PB.
(Boube et al., 1997)
Uncovers Dsim\jba in D.melanogaster/D.simulans hybrids. Does not uncover Dsim\pm in D.melanogaster/D.simulans hybrids.
(Yamamoto et al., 1997)
Dominantly causes tergite defects in less than 50% of run3 heterozygotes.
(Duffy et al., 1996)
Deficient embryos show a variably penetrant mutant midgut phenotype: variable constrictions absent.
(Bilder and Scott, 1995)
Homozygous embryos are very abnormal compared to wild-type and tracheae are not completely connected. Midgut constrictions do not form and Malpighian tubules are poorly differentiated.
(Harbecke and Lengyel, 1995)
Heterozygosity for this deletion enhances the mutant ovarian phenotype of ovoD2.
(Pauli et al., 1995)
Semiviable over subDub. Transheterozygotes tend to die during the pupal phase or only eclose halfway. Escapers show rough eyes, etched tergites and blistered or nicked wings. Males and females are sterile.
(Moore et al., 1994)
Fewer larger nuclei.
(Smith et al., 1993)
hide Stocks ( 3 )
Bloomington
1547
Df(2R)PC4/CyO
Kyoto
106715
Df(2R)PC4/CyO
103259
CyO, Cy1 dplv1 pr1 cn2 / Df(2R)PC4
hide Notes on Origin
Discoverer
hide Balancer / Genotype Variants of the Aberration
hide Separable Components
hide Other Comments
hide Synonyms & Secondary IDs ( 8 )
Reported As
Symbol Synonym
Df(2)PC4
(Doane, 2000, Jurgens, 1985)
Df(2L)PC4
(Wehn and Campbell, 2006)
Df(2R)PC4
(Munro et al., 2006, Beronja et al., 2005, Crest et al., 2007, Haecker et al., 2007, Christensen et al., 2007.10.29, Ceprani et al., 2008, Murthy et al., 2005, Casso et al., 2008, Asada et al., 1993, Merkle et al., 2009, Matsuo et al., 2007, Jiang et al., 2008, Snee et al., 2007, Gonsalvez et al., 2010, Sanghavi et al., 2012)
Df(2R)Pc4
(Abrell et al., 2000, Yang et al., 2000, Hita et al., 1999, Yamamoto et al., 1997, Nicholls and Gelbart, 1998, Wustmann et al., 1989, Konsolaki and Schupbach, 1998, Pauli et al., 1995, Smith et al., 1993, Castrillon et al., 1993, Shaver et al., 2000)
Df(2R)Pc4
(Clark et al., 1994)
Df(PC4)
(Vazquez-Pianzola et al., 2011, Ratnaparkhi et al., 2008)
PC4
(Hirose et al., 2001)
Pcl4
(Brodsky and Steller, 1996)
Name Synonym
Secondary FlyBase IDs
hide References ( 95 )
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hide Recent research papers ( 2 )
Sanghavi et al., 2012, Dev. Biol. 367(1): 66--77
A functional link between localized Oskar, dynamic microtubules, and endocytosis. [FBrf0218511]
Vazquez-Pianzola et al., 2011, Dev. Biol. 357(2): 404--418
Pabp binds to the osk 3'UTR and specifically contributes to osk mRNA stability and oocyte accumulation. [FBrf0214798]
Show all research papers ...