Aberration Dmel\Df(2R)Pcl7B

General Information
Symbol	Dmel\Df(2R)Pcl7B	Species	D. melanogaster
Name	Deficiency (2R) Polycomblike	FlyBase ID	FBab0002023
Feature type	chromosomal_deletion
Also Known As	Df(2R)Pcl-7B, Df(2R)Pc17B, Df(2R)Pcl^7B, Df(2R)7B, grh^Df

Computed Breakpoints include	54E8-54F1;55B9-55C1
Deleted segment	54E8--55C1
Sequence coordinates
Member of large scale dataset(s)
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Aberration
Cytological Order
Progenitor
Mutagen	X ray (Duncan, 1982)
Class of aberration (relative to progenitor)	chromosomal_deletion (Pauli et al., 1995, Lemaitre et al., 1995, Duffy et al., 1996, Duncan, 1982)
Breakpoints	54E8-54F1;55B9-55C1 (Duncan, 1982, Pauli et al., 1995, Lemaitre et al., 1995, Duffy et al., 1996)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data	bk1 << grh << E(dpp)55A << bk2 << sbb
Genetic mapping information
Comments
Comments on Cytology
	All limits from polytene analysis (FBrf0038059)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	adp (Doane, 1999) Bc (Lemaitre et al., 1995) E(dpp)55A (Nicholls and Gelbart, 1998) eay (Tearle, 1996.5.14) fab1 (Rusten et al., 2006) grh (Spradling et al., 1999, BDGP Project Members, 1994-1999, Tearle, 1996.5.14, Almeida and Bray, 2005) Hsf (Spradling et al., 1999, BDGP Project Members, 1994-1999) l(2)PC4-A (Tearle, 1996.5.14) l(2)PC4-B (Tearle, 1996.5.14) l(2)PC4-C (Tearle, 1996.5.14) l(2)PC4-D (Tearle, 1996.5.14) lolal (Spradling et al., 1999, BDGP Project Members, 1994-1999) mama (Doane, 1999) nopo (Merkle et al., 2009) pAbp (Spradling et al., 1999, BDGP Project Members, 1994-1999, Sigrist et al., 2000, Blagden et al., 2009) Pcl (Spradling et al., 1999, Duncan, 1982, Sato et al., 1983, Tearle and Nusslein-Volhard, 1987, BDGP Project Members, 1994-1999, Soto et al., 1995, Tearle, 1996.5.14) sbb (BDGP Project Members, 1994-1999) stau (Tearle and Nusslein-Volhard, 1987, Tearle, 1996.5.14) thr (Spradling et al., 1999, Philp et al., 1993, BDGP Project Members, 1994-1999, Tearle, 1996.5.14)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	fs(2)PC4-U (Tearle, 1996.5.14) hal (Tearle, 1996.5.14) imd (Lemaitre et al., 1995) l(2)04548 (BDGP Project Members, 1994-1999) l(2)k08931 (BDGP Project Members, 1994-1999) l(2)PC4-51 (Tearle, 1996.5.14) l(2)PC4-427 (Tearle, 1996.5.14) l(2)PC4-E (Tearle, 1996.5.14) l(2)PC4-F (Tearle, 1996.5.14) l(2)PC4-G (Tearle, 1996.5.14) l(2)PC4-H (Tearle, 1996.5.14) l(2)PC4-K (Tearle, 1996.5.14) l(2)PC4-M (Tearle, 1996.5.14) l(2)PC4-N (Tearle, 1996.5.14) l(2)PC4-P (Tearle, 1996.5.14) l(2)PC4-Q (Tearle, 1996.5.14) l(2)PC4-R (Tearle, 1996.5.14) l(2)PC4-S (Tearle, 1996.5.14) mama (Tearle, 1996.5.14) olf186-F (Spradling et al., 1999, BDGP Project Members, 1994-1999) qsm (BDGP Project Members, 1994-1999) Rst(2)Lb (Hita et al., 1999) sbb (Spradling et al., 1999) sub (Giunta et al., 2002, Tearle, 1996.5.14) tef (Tomkiel et al., 2001)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations	Fails to complement: Df(2R)14H10W-35. (Mohr and Gelbart, 2002) Fails to complement Df(2R)PC4, Df(2R)Pcl^XM82 and Df(2R)Pcl11B, complements Df(2R)PC29, Df(2R)P34 and Df(2R)PC66. (Tearle, 1996.5.14)
NOT in combination with other aberrations	Homozygotes die as wandering third instar larvae. (Rusten et al., 2006) The Df(2R)Pcl7B chromosome does not act as a dominant suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{w^var}KR3-2", a stable "brown-red" variant of the P{3'WP-2,w^var}2Lt insertion). (Mason et al., 2004) Heterozygosity for Df(2R)Pcl7B results in 1.4% X chromosome nondisjunction and 1.4% fourth chromosome nondisjunction in In(1)FM7/X ; sv^spa-pol females. (Harris et al., 2003) No second site non-complementing phenotype with zip^Ebr and zip^mhc-c6.1. (Halsell and Kiehart, 1998) Shows maternal enhancement of dpp^hr4, dpp^hr56 and dpp^hr27, measured as reduction in recovery of doubly heterozygous progeny. (Nicholls and Gelbart, 1998) Uncovers Dsim\jba in D.melanogaster/D.simulans hybrids. Does not uncover Dsim\pm in D.melanogaster/D.simulans hybrids. (Yamamoto et al., 1997) Dominantly causes tergite defects in less than 50% of run³ heterozygotes. (Duffy et al., 1996) Heterozygosity for this deletion enhances the mutant ovarian phenotype of ovo^D2. (Pauli et al., 1995) When heterozygous with wild type, flies carrying the Pcl deficiency show transformation of second and third legs to first legs. Enhances Pcl³
Stocks ( 3 )
Bloomington	3064 Df(2R)Pcl7B/CyO
Kyoto	106815 Df(2R)Pcl7B/CyO 103282 Df(2R)Pcl7B / CyO
Notes on Origin
Discoverer	E. B. Lewis.

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

Synonyms & Secondary IDs ( 11 )
Reported As
Symbol Synonym	Df(2R)7B (Duncan, 1982, Soto et al., 1995, ) Df(2R)Pc17B (Merabet et al., 2002, Ashton et al., 2001, Halsell and Kiehart, 1998, Crest et al., 2007) df(2R)pcl7b (Reiff et al., 2002) Df(2R)Pcl-7B (Nicholls and Gelbart, 1998, Tearle and Nusslein-Volhard, 1987, Lemaitre et al., 1995, Tearle, 1996.5.14, Merkle et al., 2009) Df(2R)Pcl7B (Almeida and Bray, 2005, Benito-Sipos et al., 2011, Blagden et al., 2009, Baumgardt et al., 2009, Garcia and Stathopoulos, 2011, Vazquez-Pianzola et al., 2011) Df(2R)Pcl17B (Kania et al., 1995) Df(2R)Pcl^7B (Uv et al., 1997, Bray and Kafatos, 1991) Df(2R)Pcl^7b (Rusten et al., 2006) Df(2R)PcP7B (Harris et al., 2003) grh^Df (Benito-Sipos et al., 2011, Baumgardt et al., 2009)
Name Synonym	Deficiency (2R) Polycomblike
Secondary FlyBase IDs

References ( 53 )

Generate a list of	All references relating to this aberration ( 53 )

List References by type	Research paper ( 46 ) Personal communication to FlyBase ( 2 ) FlyBase analysis ( 1 ) Stock list ( 1 ) Letter ( 1 ) Book ( 1 ) Thesis ( 1 )
Recent research papers ( 3 )
	Benito-Sipos et al., 2011, Development 138(24): 5311--5320 Seven up acts as a temporal factor during two different stages of neuroblast 5-6 development. [FBrf0216799] Garcia and Stathopoulos, 2011, PLoS ONE 6(12): e29172 Lateral gene expression in Drosophila early embryos is supported by grainyhead-mediated activation and tiers of dorsally-localized repression. [FBrf0217082] Vazquez-Pianzola et al., 2011, Dev. Biol. 357(2): 404--418 Pabp binds to the osk 3'UTR and specifically contributes to osk mRNA stability and oocyte accumulation. [FBrf0214798] Show all research papers ...