Aberration Dmel\Df(2R)Px2

General Information
Symbol	Dmel\Df(2R)Px2	Species	D. melanogaster
Name	Deficiency (2R) Plexate	FlyBase ID	FBab0002027
Feature type	chromosomal_deletion
Also Known As	Df(2R)Px²

Computed Breakpoints include	60C6;60D9-60D10
Deleted segment	60C6--60D9 (Estimated cytology)
Map ( GBrowse )	Untitled Document
Sequence coordinates	2R:20,155,881..20,193,551 (Df(2R)Px2:bk1) (Cook et al., 2010.2.12) 2R:20,492,825..20,500,415 (Df(2R)Px2:bk2) (Cook et al., 2010.2.12)
Member of large scale dataset(s)
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Aberration
Cytological Order
Progenitor
Mutagen	X ray (Gotwals and Fristrom, 1991)
Class of aberration (relative to progenitor)	chromosomal_deletion (Montell et al., 1992, Pauli et al., 1995, Duffy et al., 1996, Dettman et al., 1996, Sunkel and Whittle, 1987, Harbecke and Lengyel, 1995, Prout et al., 1997)
Breakpoints	60C5-60C6;60D9-60D10 (Schupbach and Wieschaus, 1989, Montell et al., 1992, Pauli et al., 1995, Harbecke and Lengyel, 1995, Duffy et al., 1996, Dettman et al., 1996, Prout et al., 1997) 60C6;60D11 (Sunkel and Whittle, 1987)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data	sp Nop60B << bk1 <<βTub60D << God << bk2 << Dll
Genetic mapping information
Comments
Comments on Cytology
	The left Df(2R)Px2 breakpoint lies within CG13577 or βTub60D or in the region between them, and lies in the range 2R:20155881..20193551 (R5) (predicted cytology: 60C4-60C6). (Cook et al., 2010.2.12) The right Df(2R)Px2 breakpoint lies within CG4707 or CG42360 and CG42361 or in the region between them, and lies in the range 2R:20492825..20500415 (R5) (predicted cytology: 60D9). (Cook et al., 2010.2.12) Left limit of break 1 from polytene analysis (FBrf0047276) Right limit of break 1 from inclusion of slbo (FBrf0055567) Limits of break 2 from polytene analysis (FBrf0049878)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	bs (Walsh and Brown, 1998, Spradling et al., 1999, LaJeunesse et al., 2001, Bridges, 1937, Kimble et al., 1990, Diaz-Benjumea and Garcia-Bellido, 1990, Gotwals and Fristrom, 1991, BDGP Project Members, 1994-1999, Affolter et al., 1994, Fristrom et al., 1994, Guillemin et al., 1996, Montagne et al., 1996) CG3511 (Edgar et al., 2005) God (Ruden and Jaeckle, 1995) kis (BDGP Project Members, 1994-1999) l(2)60Ca (Kimble et al., 1990) l(2)60Cb (Kimble et al., 1990) l(2)60Cc (Kimble et al., 1990) l(2)60Cd (Kimble et al., 1990) l(2)60Da (Kimble et al., 1990) l(2)60Db (Kimble et al., 1990) l(2)60Dc (Kimble et al., 1990) l(2)60Dd (Kimble et al., 1990) l(2)60De (Kimble et al., 1990) l(2)60Df (Kimble et al., 1990) l(2)60Dg (Kimble et al., 1990) milou (Galloni and Edgar, 1999) Mod(Prat:bw)2-5 (Malmanche and Clark, 2003) Nurf-38 (Spradling et al., 1999, BDGP Project Members, 1994-1999) pio (Jazwinska et al., 2003, Prout et al., 1997) slbo (Montell et al., 1992, Rorth and Montell, 1992) βTub60D (Dettman et al., 2001, Kimble et al., 1990, Dettman et al., 1996)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	Dll (Spradling et al., 1999, Sunkel and Whittle, 1987, BDGP Project Members, 1994-1999) eIF-5A (Spradling et al., 1999, BDGP Project Members, 1994-1999) ifm(2)RU3 (Nongthomba and Ramachandra, 1999) Kr (Kimble et al., 1990) l(2)04012a (Spradling et al., 1999, BDGP Project Members, 1994-1999) l(2)k00808 (Spradling et al., 1999, BDGP Project Members, 1994-1999) Mmp1 (Spradling et al., 1999, BDGP Project Members, 1994-1999) Nop60B (Spradling et al., 1999, Kauffman et al., 2003, BDGP Project Members, 1994-1999) Peb (Ludwig et al., 1991) sp (Bridges, 1937, Kimble et al., 1990) spag (Spradling et al., 1999, BDGP Project Members, 1994-1999) tsr (Spradling et al., 1999, BDGP Project Members, 1994-1999) Zfrp8 (Spradling et al., 1999, BDGP Project Members, 1994-1999) zip (Gotwals and Fristrom, 1991)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations	No effect on In(1)w^m4h position-effect variegation. (Wustmann et al., 1989) Lethal in combination with Df(2R)Px5. (Thompson, 1963) Df(2R)Px1/Df(2R)Px2 lethal Df(2R)Px2/Df(2R)Px5 lethal
NOT in combination with other aberrations	Homozygotes show lethality at late stages of embryogenesis. The body wall muscles develop correctly in the mutant embryos and attach to the epidermis as in wild type. (Rudolf et al., 2012) The Df(2R)Px2 chromosome does not act as a dominant suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{w^var}KR3-2", a stable "brown-red" variant of the P{3'WP-2,w^var}2Lt insertion). (Mason et al., 2004) Heterozygosity for Df(2R)Px2 results in 0.8% X chromosome nondisjunction and 0.6% fourth chromosome nondisjunction in In(1)FM7/X ; sv^spa-pol females. (Harris et al., 2003) Heterozygotes show an extra wing vein phenotype. (LaJeunesse et al., 2001) Heterozygotes have a blistered wing and ectopic vein phenotype. (Firth et al., 2000) No defects in targeting are seen in individual axons in Df(2R)Px2 heterozygotes. However the R7,8 axon array is mispositioned in 13% of optic lobes in pupal brains. (Hoyle et al., 2000) Heterozygotes have ectopic wing veins. (Palsson and Gibson, 2000) Does not cause unconditional lethality in hybrid females when heterozygous with D.simulans chromosome. (Coyne et al., 1998) No second site non-complementing phenotype with zip^Ebr and zip^mhc-c6.1. (Halsell and Kiehart, 1998) Shows no maternal enhancement of dpp^hr4. (Nicholls and Gelbart, 1998) Transheterozygotes with βTub60D^P126 are semi-lethal and survivors are sterile, remaining combinations with βTub60D alleles are lethal. Myogenesis and sarcomere integrity are normal in mutant larvae and embryos. (Dettman et al., 1996) Dominantly causes tergite defects in less than 50% of run³ heterozygotes. (Duffy et al., 1996) The tracheal phenotypes previously reported for this deficiency in FBrf0051997 and FBrf0072461, where the primary branches are disrupted and discontinuous, are due to the deletion of a gene other than bs, or more than one gene in the region. (Guillemin et al., 1996) Shows a haploinsufficient ectopic wing vein phenotype. (Montagne et al., 1996) Deficient embryos show a variably penetrant mutant midgut phenotype: central constriction forms posterior to normal site. (Bilder and Scott, 1995) Homozygous embryos have a defective tracheal system. (Harbecke and Lengyel, 1995) Heterozygosity for this deletion has no effect on the mutant ovarian phenotype of ovo^D2. (Pauli et al., 1995) Heterozygotes with T(2;3)God¹ are inviable. (Ruden and Jaeckle, 1995) Progeny of the genotype zip/Df(zip) exhibit the mlf phenotype (malformed syndrome), wing malformations and leg defects, at a penetrance of 14--35%. (Gotwals and Fristrom, 1991) Heterozygotes have smaller and narrower wings, slight plexates between all longitudinal veins. Veins are thickened at irregular intervals (Diaz-Benjumea and Garcia-Bellido, 1990) cell lethal (Ripoll and Garcia-Bellido, 1979). Wing veins of heterozygote with plexuslike or δlike thickenings, most often near posterior crossvein and free fragments of vein, most often in third posterior cell; L4 vein bent near margin. Wings smaller and narrower than wild type and dusky textured. Closely resembles bs. Expression more extreme in female; enhanced by cold (19^o). embryonic lethal as homozygote
Stocks ( 3 )
Bloomington	2604 Df(2R)Px2/CyO, P{sevRas1.V12}FK1
Kyoto	107424 Df(2R)Px2/SM5 103283 Df(2R)Px2, bw¹ sp¹ / SM1, al² Cy¹ cn² sp²
Notes on Origin
Discoverer	Schultz, 1st Dec. 1932.

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments
	Complementation tests reported for Df(2R)Px1 may have used a Df(2R)Px2 stock. The Mid-America Stock Center stock 1779 and the Bloomington Stock Center stock 750, which were labeled Df(2R)Px1, were in fact Df(2R)Px2 stocks. The mix-up predates 1991. (Bloomington Drosophila Stock Center, 2003.8.1)
Synonyms & Secondary IDs ( 10 )
Reported As
Symbol Synonym	BL-2604 (Edgar et al., 2005) Def-(2R) Px2 (Giang et al., 2011) Def (2R) Px2 (Giang et al., 2011) Df(2L)Px² (Terriente-Félix and de Celis, 2009) Df(2R)PX2 (Halsell and Kiehart, 1998) Df(2R)Px2 (Crest et al., 2007, Kirchner et al., 2008, Barbash and Lorigan, 2007, Matsuo et al., 2007, Cook et al., 2010.2.12) Df(2R)Px² (Abrell et al., 2000, Dettman et al., 2001, Hoyle et al., 2000, Galloni and Edgar, 1999, Wustmann et al., 1989, Sunkel and Whittle, 1987, Montagne et al., 1996, Dettman et al., 1996, Affolter et al., 1994, Germeraad et al., 1992, Rorth and Montell, 1992, Montell et al., 1992, Schupbach and Wieschaus, 1991, Ludwig et al., 1991, Schupbach and Wieschaus, 1989, Rudolf et al., 2012) Df(2R)px² (Bokel et al., 2005) Px² (Thompson, 1963)
Name Synonym	Deficiency (2R) Plexate
Secondary FlyBase IDs

References ( 71 )

Generate a list of	All references relating to this aberration ( 71 )

List References by type	Research paper ( 66 ) Personal communication to FlyBase ( 3 ) FlyBase analysis ( 1 ) Book ( 1 )
Recent research papers ( 2 )
	Rudolf et al., 2012, Europ. J. Cell Biol. 91(3): 192--203 The syncytial visceral and somatic musculature develops independently of β3-Tubulin during Drosophila embryogenesis, while maternally supplied β1-Tubulin is stable until the early steps of myoblast fusion. [FBrf0217503] Giang et al., 2011, J. Neurogenet. 25(1-2): 17--26 The Serotonin Transporter Expression in Drosophila melanogaster. [FBrf0213697] Show all research papers ...