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General Information
D. melanogaster
Deficiency (2R) Plexate
FlyBase ID
Feature type
Also Known As
Computed Breakpoints include
Sequence coordinates
2R:24,268,358..24,306,028 (Df(2R)Px2:bk1)
2R:24,605,302..24,612,892 (Df(2R)Px2:bk2)
Member of large scale dataset(s)
Nature of Aberration
Cytological Order
Class of aberration (relative to wild type)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data

sp Nop60B << bk1 << βTub60D << God << bk2 << Dll

Genetic mapping information
Comments on Cytology

The left Df(2R)Px2 breakpoint lies within CG13577 or βTub60D or in the region between them, and lies in the range 2R:20155881..20193551 (R5) (predicted cytology: 60C4-60C6).

The right Df(2R)Px2 breakpoint lies within CG4707 or CG42360 and CG42361 or in the region between them, and lies in the range 2R:20492825..20500415 (R5) (predicted cytology: 60D9).

Left limit of break 1 from polytene analysis (FBrf0047276) Right limit of break 1 from inclusion of slbo (FBrf0055567) Limits of break 2 from polytene analysis (FBrf0049878)

Sequence Crossreferences
DNA sequence
Protein sequence
Gene Deletion and Duplication Data
Genes Deleted / Disrupted
Genes NOT Deleted / Disrupted
Genes Duplicated
Complementation Data
Completely duplicated
Partially duplicated
Molecular Data
Completely duplicated
Partially duplicated
Genes NOT Duplicated
Complementation Data
Molecular Data
Affected Genes Inferred by Location
Phenotypic Data
In combination with other aberrations

No effect on In(1)wm4h position-effect variegation.

Lethal in combination with Df(2R)Px5.

Df(2R)Px1/Df(2R)Px2 lethal Df(2R)Px2/Df(2R)Px5 lethal

NOT in combination with other aberrations

Homozygotes show lethality at late stages of embryogenesis. The body wall muscles develop correctly in the mutant embryos and attach to the epidermis as in wild type.

The Df(2R)Px2 chromosome does not act as a dominant suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{wvar}KR3-2", a stable "brown-red" variant of the P{3'WP-2,wvar}2Lt insertion).

Heterozygosity for Df(2R)Px2 results in 0.8% X chromosome nondisjunction and 0.6% fourth chromosome nondisjunction in In(1)FM7/X ; svspa-pol females.

Heterozygotes show an extra wing vein phenotype.

Heterozygotes have a blistered wing and ectopic vein phenotype.

No defects in targeting are seen in individual axons in Df(2R)Px2 heterozygotes. However the R7,8 axon array is mispositioned in 13% of optic lobes in pupal brains.

Heterozygotes have ectopic wing veins.

Does not cause unconditional lethality in hybrid females when heterozygous with D.simulans chromosome.

No second site non-complementing phenotype with zipEbr and zipmhc-c6.1.

Shows no maternal enhancement of dpphr4.

Transheterozygotes with βTub60DP126 are semi-lethal and survivors are sterile, remaining combinations with βTub60D alleles are lethal. Myogenesis and sarcomere integrity are normal in mutant larvae and embryos.

Dominantly causes tergite defects in less than 50% of run3 heterozygotes.

The tracheal phenotypes previously reported for this deficiency in FBrf0051997 and FBrf0072461, where the primary branches are disrupted and discontinuous, are due to the deletion of a gene other than bs, or more than one gene in the region.

Shows a haploinsufficient ectopic wing vein phenotype.

Deficient embryos show a variably penetrant mutant midgut phenotype: central constriction forms posterior to normal site.

Homozygous embryos have a defective tracheal system.

Heterozygosity for this deletion has no effect on the mutant ovarian phenotype of ovoD2.

Heterozygotes with T(2;3)God1 are inviable.

Progeny of the genotype zip/Df(zip) exhibit the mlf phenotype (malformed syndrome), wing malformations and leg defects, at a penetrance of 14--35%.

Heterozygotes have smaller and narrower wings, slight plexates between all longitudinal veins. Veins are thickened at irregular intervals

cell lethal (Ripoll and Garcia-Bellido, 1979). Wing veins of heterozygote with plexuslike or δlike thickenings, most often near posterior crossvein and free fragments of vein, most often in third posterior cell; L4 vein bent near margin. Wings smaller and narrower than wild type and dusky textured. Closely resembles bs. Expression more extreme in female; enhanced by cold (19o). embryonic lethal as homozygote

Stocks (3)
Notes on Origin

Schultz, 1st Dec. 1932.

Balancer / Genotype Variants of the Aberration
Separable Components
Other Comments

Complementation tests reported for Df(2R)Px1 may have used a Df(2R)Px2 stock. The Mid-America Stock Center stock 1779 and the Bloomington Stock Center stock 750, which were labeled Df(2R)Px1, were in fact Df(2R)Px2 stocks. The mix-up predates 1991.

Synonyms and Secondary IDs (10)
References (73)