Aberration Dmel\Df(2R)ST1

General Information
Symbol	Dmel\Df(2R)ST1	Species	D. melanogaster
Name		FlyBase ID	FBab0002037
Feature type	chromosomal_deletion
Also Known As	Df(2R)ST1, noc³, Df(2R)1888

Computed Breakpoints include	42B3-42B4;43E18
Deleted segment	42B3--43E18
Sequence coordinates
Member of large scale dataset(s)
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Aberration
Cytological Order
Progenitor
Mutagen	gamma ray (Ashburner et al., 1981)
Class of aberration (relative to progenitor)	chromosomal_deletion (Gubb et al., 1985, Ashburner et al., 1981, Heitzler et al., 1993, Schupbach and Wieschaus, 1991, Pauli et al., 1995, Cheyette et al., 1994, Feger et al., 1995, Rodriguez et al., 1996, Grau and Simpson, 1987, Chandrashekaran and Sarla, 1993, Landecker et al., 1994, Holmes et al., 1998)
Breakpoints	42B3-42B4;43E18 (Feger et al., 1995) 42B3-42B5;43E15-43E18 (Heitzler et al., 1993) 43B3-43B4;43E18 (Landecker et al., 1994, Rodriguez et al., 1996) 43B3-43B5;43E1-43E8 (Grau and Simpson, 1987, Schupbach and Wieschaus, 1989, Schupbach and Wieschaus, 1991, Cheyette et al., 1994, Pauli et al., 1995) 43B3-43B5;43E15-43E18 (Holmes et al., 1998) 43B3-43B5;43E18 (Ashburner et al., 1981, Gubb et al., 1985) 43B3;43E18 (Chandrashekaran and Sarla, 1993)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data	stmA << bk1 << rambl << bk2
Genetic mapping information
Comments
Comments on Cytology
	Ref: Bloomington Stock Centre. (Cheyette et al., 1994) Ref: Ashburner et al., 1981, D. I. S. 56: 186--191. (Heitzler et al., 1993) Ref: Lindsley and Zimm, 1987, D. I. S. 65: 1--224 (Schupbach and Wieschaus, 1991) Left limit of break 1 from polytene analysis (FBrf0058613) Right limit of break 1 from polytene analysis (FBrf0085022) Limits of break 2 from polytene analysis (FBrf0036112)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	Aldh-III (Spradling et al., 1999, BDGP Project Members, 1994-1999) Bap170 (Rendina et al., 2010) blow (Eeken et al., 2001) boca (Eeken et al., 2001) CanB2 (Gajewski et al., 2003) CG3267 (BDGP Project Members, 1994-1999) cn (Eeken et al., 2001, Ashburner et al., 1981) cos (Spradling et al., 1999, Grau and Simpson, 1987, BDGP Project Members, 1994-1999) Cyt-b5 (Spradling et al., 1999, Kimbrell, 1996.4.28, BDGP Project Members, 1994-1999, Rodriguez et al., 1996) Dscam (Spradling et al., 1999, BDGP Project Members, 1994-1999) Eb1 (Spradling et al., 1999, Brumby et al., 2004) Egfr (Eeken et al., 2001) fs(2)43Ei (Eeken et al., 2001) fs(2)ltoRN73 (Schupbach and Wieschaus, 1991) geminin (Quinn et al., 2001) jing (Liu and Montell, 2001, Sedaghat et al., 2002) l(2)43Bb (Spradling et al., 1999, BDGP Project Members, 1994-1999) l(2)43Ef (Eeken et al., 2001) l(2)43Eg (Eeken et al., 2001) l(2)43Eh (Eeken et al., 2001) l(2)08492 (Spradling et al., 1999, BDGP Project Members, 1994-1999) pk (Ashburner et al., 1981) rambl (Holmes et al., 1998) Rpt1 (Eeken et al., 2001, BDGP Project Members, 1994-1999) sat (Schupbach and Wieschaus, 1991) scra (Eeken et al., 2001, Schupbach and Wieschaus, 1991, BDGP Project Members, 1994-1999, Spradling et al., 1999, Schupbach and Wieschaus, 1989) so (Ashburner et al., 1981) Tdc1 (Cole et al., 2005) Tdc2 (Cole et al., 2005) tor (Schupbach and Wieschaus, 1989, Schupbach and Wieschaus, 1991) U2A (Eeken et al., 2001)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	a (BDGP Project Members, 1994-1999) Cyt-b5 (BDGP Project Members, 1994-1999) hrg (Spradling et al., 1999, BDGP Project Members, 1994-1999) l(2)42Aa (Roote and Ashburner, 2005.6) l(2)42Ab (Roote and Ashburner, 2005.6) l(2)42Ac (Roote and Ashburner, 2005.6) l(2)k08625 (BDGP Project Members, 1994-1999) lin19 (Spradling et al., 1999, BDGP Project Members, 1994-1999) mus205 (Eeken et al., 2001) rnh1 (Spradling et al., 1999, BDGP Project Members, 1994-1999) sax (Twombly et al., 2009) stmA (Chandrashekaran and Sarla, 1993)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations	No effect on In(1)w^m4h position-effect variegation. (Wustmann et al., 1989)
NOT in combination with other aberrations	Heterozygosity for Df(2R)ST1 results in 1.9% X chromosome nondisjunction and 0.8% fourth chromosome nondisjunction in In(1)FM7/X ; sv^spa-pol females. (Harris et al., 2003) Homozygotes exhibit tracheal defects, with losses of the dorsal drunk, severely disrupted transverse connectives and absences of the visceral branch. (Sedaghat et al., 2002) Heterozygosity for this deletion has no effect on the mutant ovarian phenotype of ovo^D2. (Pauli et al., 1995) The ocelli are reduced in size. The number of anterior postalar bristles and ocellar bristles are reduced. The pattern of the interocellar microchaetae is disturbed. (Ashburner et al., 1981) Heterozygotes have small ocelli (Ashburner).
Stocks ( 3 )
Bloomington	1888 Df(2R)ST1, Adhⁿ⁵ pr¹ cn^*/CyO
Kyoto	106723 Df(2R)ST1, Adhⁿ⁵ pr¹ cn^/CyO 103285 Df(2R)ST1, Adhⁿ⁵ pr¹ cn^ / CyO
Notes on Origin
Discoverer	Tsubota. S.I. Tsubota. (Ashburner et al., 1981)
	The stock contains a second-site deletion uncovering l(2)gl. (Roegiers et al., 2009)
Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments
	The Df(2R)ST1 chromosome acts as a dominant weak suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{w^var}KR3-2", a stable "brown-red" variant of the P{3'WP-2,w^var}2Lt insertion), but this is a false positive result (the suppressor is not within the bounds of the deficient region) because the region of the deficiency is covered by one or more nonsuppressing deficiencies. (Mason et al., 2004) mistakenly interpreted as carrying a noc allele induced simultaneously (Ashburner et al., 1982) Mistakenly interpreted as carrying a noc allele induced simultaneously. (Ashburner et al., 1981, Gubb et al., 1985)
Synonyms & Secondary IDs ( 10 )
Reported As
Symbol Synonym	Df1888 (Cheyette et al., 1994) Df(2)ST1 (Eeken et al., 2001) Df(2R)1888 (Gajewski et al., 2003, Takeo et al., 2010) Df(2R)St1 (Harris et al., 2003, Sun et al., 2006) Df(2R)st1 (Sullivan et al., 1993) Df(2R)ST1 (Minakhina and Steward, 2006, Jordan et al., 2006, Crest et al., 2007, Rendina et al., 2010, Roegiers et al., 2009, Kleinhesselink et al., 2011, Twombly et al., 2009) Df(2R)ST1, noc³ (Ashburner et al., 1981, Gubb et al., 1985, Ashburner et al., 1982) Df(2R)STl (Chandrashekaran and Sarla, 1993) noc³ ST1 (Yamaguchi et al., 1999)
Name Synonym
Secondary FlyBase IDs
	FBal0013032
References ( 52 )

Generate a list of	All references relating to this aberration ( 52 )

List References by type	Research paper ( 46 ) Supplementary material ( 1 ) Personal communication to FlyBase ( 3 ) FlyBase analysis ( 1 ) Book ( 1 )
Recent research papers ( 1 )
	Kleinhesselink et al., 2011, Biochem. Genet. 49(5-6): 329--351 Regulation of hemocytes in Drosophila requires dappled cytochrome b5. [FBrf0214429] Show all research papers ...