FB2025_01 , released February 20, 2025
Aberration: Dmel\Df(2R)X1
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General Information
Symbol
Df(2R)X1
Species
D. melanogaster
Name
FlyBase ID
FBab0002048
Feature type
chromosomal_deletion
Computed Breakpoints include

46C2;47A1

Features within 46C2--47A1
Genomic Maps
Sequence coordinates
2R:9,922,003..9,927,457 [-] (Df(2R)X1:bk1)
(Lilly et al., 1995)
2R:10,249,435..10,307,030 (Df(2R)X1:bk2)
(Cook, 2016.2.8)
Member of large scale dataset(s)
Nature of Aberration
Cytological Order
Progenitor
P{Ddc+,Adh+}56.7A
(O'Brien et al., 1994)
Mutagen
X ray
(Bour et al., 1995, O'Brien et al., 1994)
Class of aberration (relative to wild type)
chromosomal_deletion
(FlyBase, 2007)
Class of aberration (relative to progenitor)
chromosomal_deletion
(Hou et al., 1997, Rodriguez et al., 1996, Pauli et al., 1995, O'Brien et al., 1994, Burg et al., 1993)
Breakpoints

46C;47A1

(Rodriguez et al., 1996, Burg et al., 1993)

46C;46F

(Hou et al., 1997, O'Brien et al., 1994)

46C;46E-46F

(Pauli et al., 1995)
Causes alleles
Mef2X1
(Vrailas-Mortimer et al., 2011, Bour et al., 1995, Lilly et al., 1995)
Carries alleles
Transposon Insertions
Formalized genetic data

bk1 hits Mef2 << Syb << bk2

Genetic mapping information
Comments

The 2R:10249435..10307030 release 6 coordinates of the right breakpoint are estimates. The left extent corresponds to the left end of Syb, which published results say is deleted. The right extent corresponds to the left end of JhI-1, which published results say is not deleted.

(Cook, 2016.2.8)

This deletion removes multiple ribosomal protein-coding genes (in addition to other genes).

(Marygold et al., 2007)
Comments on Cytology

Proximal breakpoint is 15-20kb distal to Fmrf.

(O'Brien et al., 1994)

Complementation data from unspecified deficiency chromosomes.

(Goldstein et al., 1993)

Left limit of break 1 from non-inclusion of Fmrf (FBrf0053296) Right limit of break 1 from inclusion of Mef2 (FBrf0078093) Limits of break 2 from polytene analysis (FBrf0058167)

Sequence Crossreferences
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
Gene Deletion and Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted
14-3-3ζ
(Goldstein et al., 2001, Spradling et al., 1999, Carney et al., 1997, BDGP Project Members, 1994-1999)
EG162
(Ma et al., 2009)
eIF3j
(Goldstein et al., 2001, Spradling et al., 1999, Bour et al., 1995, BDGP Project Members, 1994-1999)
eve
(Kahsai and Cook, 2018, Kahsai et al., 2016, Goldstein et al., 2001, Bour et al., 1995, Ranganayakulu et al., 1995, O'Brien et al., 1994)
gl(2R)14-22
(Luschnig et al., 2004)
Hdc
(Burg et al., 1993)
Hr3
(Otte et al., 2009, Goldstein et al., 2001, Spradling et al., 1999, Goldstein et al., 1998, Carney et al., 1997, BDGP Project Members, 1994-1999)
Jra
(Goldstein et al., 2001, Goldstein et al., 1998, Carney et al., 1997, Riesgo-Escovar and Hafen, 1997)
l(2)46Cd
(O'Brien et al., 1994)
l(2)46CDa
(Goldstein et al., 2001)
l(2)46CFn
(Goldstein et al., 2001)
l(2)46Ci
(Goldstein et al., 2001, Bour et al., 1995)
l(2)46Cj
(Goldstein et al., 2001, Bour et al., 1995)
l(2)46Ck
(Goldstein et al., 2001, Bour et al., 1995)
l(2)46Cl
(Goldstein et al., 2001, Bour et al., 1995)
l(2)46Cm
(Goldstein et al., 2001, Bour et al., 1995)
l(2)46Cn
(Goldstein et al., 2001, Bour et al., 1995)
l(2)46Co
(Ranganayakulu et al., 1995)
l(2)46Cp
(Ranganayakulu et al., 1995)
l(2)46Da
(O'Brien et al., 1994)
l(2)46Dc
(Kahsai and Cook, 2018, O'Brien et al., 1994)
l(2)46Dd
(Kahsai and Cook, 2018, O'Brien et al., 1994)
l(2)46De
(Kahsai and Cook, 2018, O'Brien et al., 1994)
l(2)46DEa
(Ranganayakulu et al., 1995)
l(2)46DEb
(Ranganayakulu et al., 1995)
l(2)46DEc
(Ranganayakulu et al., 1995)
l(2)46DEd
(Ranganayakulu et al., 1995)
l(2)46Df
(Kahsai and Cook, 2018, O'Brien et al., 1994)
l(2)46Dg
(O'Brien et al., 1994)
l(2)46Dh
(Goldstein et al., 2001)
l(2)46Di
(Goldstein et al., 2001)
l(2)46Dj
(Goldstein et al., 2001)
l(2)46Ea
(Goldstein et al., 2001, Carney et al., 1997)
l(2)46Eb
(Goldstein et al., 2001, Carney et al., 1997)
l(2)46Ec
(Goldstein et al., 2001, Carney et al., 1997)
l(2)46Ed
(Goldstein et al., 2001, Spradling et al., 1999, Carney et al., 1997, BDGP Project Members, 1994-1999)
l(2)46Eg
(Goldstein et al., 2001, Carney et al., 1997)
l(2)46Eh
(Goldstein et al., 2001, Carney et al., 1997)
l(2)46Ei
(Goldstein et al., 2001, Carney et al., 1997)
l(2)46Ej
(Goldstein et al., 2001, Carney et al., 1997)
l(2)46Fa
(Goldstein et al., 2001)
l(2)46Fb
(Goldstein et al., 2001, Carney et al., 1997)
l(2)k03610
(Spradling et al., 1999, BDGP Project Members, 1994-1999)
l(2)k04308
(Spradling et al., 1999, BDGP Project Members, 1994-1999)
l(2)k08601
(Kahsai et al., 2016, Spradling et al., 1999, BDGP Project Members, 1994-1999)
Mef2
(Goldstein et al., 2001, Goldstein et al., 1998, Bour et al., 1995, Bour et al., 1995, Lilly et al., 1995, Ranganayakulu et al., 1995)
Pfk
(Goldstein et al., 2001, Spradling et al., 1999, BDGP Project Members, 1994-1999)
Syb
(Strub et al., 2008, Bhattacharya et al., 2002, Goldstein et al., 2001, Spradling et al., 1999, Goldstein et al., 1998, Carney et al., 1997, BDGP Project Members, 1994-1999)
TER94
(Kahsai and Cook, 2018, Goldstein et al., 2001, Leon and McKearin, 1999, Spradling et al., 1999, Bour et al., 1995, BDGP Project Members, 1994-1999, O'Brien et al., 1994)
toto
(Rodriguez et al., 1996)
Partially deleted / disrupted
Molecular Data
Completely deleted
mRpL42
(Marygold et al., 2007)
RpLP0-like
(Marygold et al., 2007)
Partially deleted
Genes NOT Deleted / Disrupted
Genes Duplicated
Complementation Data
Completely duplicated
Partially duplicated
Molecular Data
Completely duplicated
Partially duplicated
Genes NOT Duplicated
Complementation Data
 
Molecular Data
 
Affected Genes Inferred by Location (72)
Phenotypic Data
In combination with other aberrations

Lethal in combination with Df(2R)12.

(Bhattacharya et al., 2002)
NOT in combination with other aberrations

Flies heterozygous for the deletion do not show a Minute bristle phenotype.

(Marygold et al., 2007)

The Df(2R)X1 chromosome does not act as a dominant suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{wvar}KR3-2", a stable "brown-red" variant of the P{3'WP-2,wvar}2Lt insertion).

(Mason et al., 2004)

Heterozygosity for Df(2R)X1 results in 2.0% X chromosome nondisjunction and 0.0% fourth chromosome nondisjunction in In(1)FM7/X ; svspa-pol females.

(Harris et al., 2003)

Heterozygosity for this deletion has no effect on the mutant ovarian phenotype of ovoD2.

(Pauli et al., 1995)
Stocks (2)
Notes on Origin
Discoverer
 
Balancer / Genotype Variants of the Aberration
 
Separable Components
 
Other Comments
 

Complementation group identified in an EMS and DEB screen to isolate deficiencies that uncover Jra.

(Goldstein et al., 1993)
Synonyms and Secondary IDs (9)
References (70)