Aberration Dmel\Df(2R)X1

General Information
Symbol	Dmel\Df(2R)X1	Species	D. melanogaster
Name		FlyBase ID	FBab0002048
Feature type	chromosomal_deletion

Computed Breakpoints include	46C2;47A1
Deleted segment	46C2--47A1
Map ( GBrowse )	Untitled Document Error No matching regions found.
Sequence coordinates	2R:5,809,508..5,814,962 [-] (Df(2R)X1:bk1) (Lilly et al., 1995)
Member of large scale dataset(s)
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
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Nature of the Aberration
Cytological Order
Progenitor	P{Ddc⁺,Adh⁺}56.7A (O'Brien et al., 1994)
Mutagen	X ray (O'Brien et al., 1994, Bour et al., 1995)
Class of aberration (relative to progenitor)	chromosomal_deletion (Burg et al., 1993, O'Brien et al., 1994, Pauli et al., 1995, Rodriguez et al., 1996, Hou et al., 1997)
Breakpoints	46C;46E-46F (Pauli et al., 1995) 46C;46F (O'Brien et al., 1994, Hou et al., 1997) 46C;47A1 (Burg et al., 1993, Rodriguez et al., 1996)
Causes alleles	Mef2^X1 (Bour et al., 1995, Lilly et al., 1995, Vrailas-Mortimer et al., 2011)
Carries alleles
Transposon Insertions
Formalized genetic data	bk1 hits Mef2 << Syb << bk2
Genetic mapping information
Comments
Comments on Cytology
	Proximal breakpoint is 15-20kb distal to Fmrf. (O'Brien et al., 1994) Complementation data from unspecified deficiency chromosomes. (Goldstein et al., 1993) Left limit of break 1 from non-inclusion of Fmrf (FBrf0053296) Right limit of break 1 from inclusion of Mef2 (FBrf0078093) Limits of break 2 from polytene analysis (FBrf0058167)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	14-3-3ζ (Spradling et al., 1999, Goldstein et al., 2001, BDGP Project Members, 1994-1999, Carney et al., 1997) Adam (Spradling et al., 1999, Goldstein et al., 2001, BDGP Project Members, 1994-1999, Bour et al., 1995) EG162 (Ma et al., 2009) eve (Goldstein et al., 2001, O'Brien et al., 1994, Bour et al., 1995, Ranganayakulu et al., 1995) gl(2R)14-22 (Luschnig et al., 2004) Hdc (Burg et al., 1993) Hr46 (Goldstein et al., 1998, Spradling et al., 1999, Goldstein et al., 2001, BDGP Project Members, 1994-1999, Carney et al., 1997, Otte et al., 2009) Jra (Goldstein et al., 1998, Goldstein et al., 2001, Riesgo-Escovar and Hafen, 1997, Carney et al., 1997) l(2)46Cd (O'Brien et al., 1994) l(2)46CDa (Goldstein et al., 2001) l(2)46CFn (Goldstein et al., 2001) l(2)46Ci (Goldstein et al., 2001, Bour et al., 1995) l(2)46Cj (Goldstein et al., 2001, Bour et al., 1995) l(2)46Ck (Goldstein et al., 2001, Bour et al., 1995) l(2)46Cl (Goldstein et al., 2001, Bour et al., 1995) l(2)46Cm (Goldstein et al., 2001, Bour et al., 1995) l(2)46Cn (Goldstein et al., 2001, Bour et al., 1995) l(2)46Co (Ranganayakulu et al., 1995) l(2)46Cp (Ranganayakulu et al., 1995) l(2)46Da (O'Brien et al., 1994) l(2)46Db (O'Brien et al., 1994) l(2)46Dc (O'Brien et al., 1994) l(2)46Dd (O'Brien et al., 1994) l(2)46De (O'Brien et al., 1994) l(2)46DEa (Ranganayakulu et al., 1995) l(2)46DEb (Ranganayakulu et al., 1995) l(2)46DEc (Ranganayakulu et al., 1995) l(2)46DEd (Ranganayakulu et al., 1995) l(2)46Df (O'Brien et al., 1994) l(2)46Dg (O'Brien et al., 1994) l(2)46Dh (Goldstein et al., 2001) l(2)46Di (Goldstein et al., 2001) l(2)46Dj (Goldstein et al., 2001) l(2)46Ea (Goldstein et al., 2001, Carney et al., 1997) l(2)46Eb (Goldstein et al., 2001, Carney et al., 1997) l(2)46Ec (Goldstein et al., 2001, Carney et al., 1997) l(2)46Ed (Spradling et al., 1999, Goldstein et al., 2001, BDGP Project Members, 1994-1999, Carney et al., 1997) l(2)46Eg (Goldstein et al., 2001, Carney et al., 1997) l(2)46Eh (Goldstein et al., 2001, Carney et al., 1997) l(2)46Ei (Goldstein et al., 2001, Carney et al., 1997) l(2)46Ej (Goldstein et al., 2001, Carney et al., 1997) l(2)46Fa (Goldstein et al., 2001) l(2)46Fb (Goldstein et al., 2001, Carney et al., 1997) l(2)k03610 (Spradling et al., 1999, BDGP Project Members, 1994-1999) l(2)k04308 (Spradling et al., 1999, BDGP Project Members, 1994-1999) l(2)k08601 (Spradling et al., 1999, BDGP Project Members, 1994-1999) Mef2 (Goldstein et al., 1998, Goldstein et al., 2001, Bour et al., 1995, Bour et al., 1995, Lilly et al., 1995, Ranganayakulu et al., 1995) Pfk (Spradling et al., 1999, Goldstein et al., 2001, BDGP Project Members, 1994-1999) Syb (Goldstein et al., 1998, Spradling et al., 1999, Goldstein et al., 2001, Bhattacharya et al., 2002, BDGP Project Members, 1994-1999, Carney et al., 1997, Strub et al., 2008) TER94 (Spradling et al., 1999, Leon and McKearin, 1999, Goldstein et al., 2001, BDGP Project Members, 1994-1999, Bour et al., 1995) toto (Rodriguez et al., 1996)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	Ccs (BDGP Project Members, 1994-1999) dap (Spradling et al., 1999, BDGP Project Members, 1994-1999) Fmrf (O'Brien et al., 1991, O'Brien et al., 1994, Bour et al., 1995) Gαo (BDGP Project Members, 1994-1999) JhI-1 (Otte et al., 2009) l(2)46Ca (O'Brien et al., 1994) l(2)46Cb (O'Brien et al., 1994) l(2)47A3 (Otte et al., 2009) l(2)47A7 (Otte et al., 2009) l(2)47A9-5 (Otte et al., 2009) l(2)47A9-6 (Otte et al., 2009) l(2)k03111 (Spradling et al., 1999, BDGP Project Members, 1994-1999) l(2)k06204 (BDGP Project Members, 1994-1999) l(2)k06408 (BDGP Project Members, 1994-1999) l(2)k07237 (Spradling et al., 1999, BDGP Project Members, 1994-1999) l(2)k07803 (BDGP Project Members, 1994-1999) l(2)k08816 (BDGP Project Members, 1994-1999) lola (Otte et al., 2009) Mod(Prat:bw)2-1 (Malmanche and Clark, 2003) psq (Grillo et al., 2011) RanBPM (BDGP Project Members, 1994-1999, Spradling et al., 1999) raw (Liu et al., 1999) S (BDGP Project Members, 1994-1999) thr (Liu et al., 1999, BDGP Project Members, 1994-1999) whd (Strub et al., 2008)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations	Lethal in combination with Df(2R)12. (Bhattacharya et al., 2002)
NOT in combination with other aberrations	The Df(2R)X1 chromosome does not act as a dominant suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{w^var}KR3-2", a stable "brown-red" variant of the P{3'WP-2,w^var}2Lt insertion). (Mason et al., 2004) Heterozygosity for Df(2R)X1 results in 2.0% X chromosome nondisjunction and 0.0% fourth chromosome nondisjunction in In(1)FM7/X ; sv^spa-pol females. (Harris et al., 2003) Heterozygosity for this deletion has no effect on the mutant ovarian phenotype of ovo^D2. (Pauli et al., 1995)
Stocks ( 2 )
Bloomington	1702 Df(2R)X1, Mef2^X1/CyO, Adh^nB
Kyoto	106718 Df(2R)X1, Mef2^X1/CyO, Adh^nB
Notes on Origin
Discoverer

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments
	Complementation group identified in an EMS and DEB screen to isolate deficiencies that uncover Jra. (Goldstein et al., 1993)
Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	Df(2)X1 (Goldstein et al., 1998) DF(2R)X1 (Li and Li, 2003) Df(2R)X1 (Higashiyama et al., 2002, Strub et al., 2008, Ma et al., 2009, Otte et al., 2009, Grillo et al., 2011, Stein et al., 2010) l(2)46CFw unnamed (Goldstein et al., 1993) X-1 (Currie and Sullivan, 1994)
Name Synonym
Secondary FlyBase IDs
	FBgn0019705
References ( 49 )

Generate a list of	All references relating to this aberration ( 49 )

List References by type	Research paper ( 38 ) Supplementary material ( 1 ) Erratum ( 1 ) Personal communication to FlyBase ( 2 ) Abstract ( 6 ) FlyBase analysis ( 1 )
Recent research papers ( 2 )
	Grillo et al., 2011, Genetics 187(2): 513--521 Control of Germline torso Expression by the BTB/POZ Domain Protein Pipsqueak Is Required for Embryonic Terminal Patterning in Drosophila. [FBrf0213010] Vrailas-Mortimer et al., 2011, Dev. Cell 21(4): 783--795 A Muscle-Specific p38 MAPK/Mef2/MnSOD Pathway Regulates Stress, Motor Function, and Life Span in Drosophila. [FBrf0216446] Show all research papers ...

Aberration Dmel\Df(2R)X1

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