Aberration Dmel\Df(2R)X3

General Information
Symbol	Dmel\Df(2R)X3	Species	D. melanogaster
Name		FlyBase ID	FBab0002049
Feature type	chromosomal_deletion

Computed Breakpoints include	46C1-46C2;46E1-46E2
Deleted segment	46C1--46E2
Sequence coordinates
Member of large scale dataset(s)
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Aberration
Cytological Order
Progenitor	P{Ddc⁺,Adh⁺}56.7A (O'Brien et al., 1994)
Mutagen	X ray (O'Brien et al., 1994, Bour et al., 1995)
Class of aberration (relative to progenitor)	chromosomal_deletion (Burg et al., 1993, Rodriguez et al., 1996)
Breakpoints	46C;46E1-46E2 (Burg et al., 1993, Rodriguez et al., 1996)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data	bk1 << l(2)46Ca << Jra << bk2 << l(2)46Ea
Genetic mapping information
Comments
Comments on Cytology
	Left limit of break 1 from polytene analysis (FBrf0058167) Right limit of break 1 from inclusion of Fmrf (FBrf0053296) Limits of break 2 from polytene analysis (FBrf0058167)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	Adam (Spradling et al., 1999, Goldstein et al., 2001, BDGP Project Members, 1994-1999, Bour et al., 1995) eve (Goldstein et al., 2001, O'Brien et al., 1994, Bour et al., 1995, Ranganayakulu et al., 1995) Fmrf (O'Brien et al., 1991, O'Brien et al., 1994, Bour et al., 1995) l(2)46Ca (O'Brien et al., 1994) l(2)46Cb (O'Brien et al., 1994) l(2)46Cd (O'Brien et al., 1994) l(2)46CDa (Goldstein et al., 2001) l(2)46CFn (Goldstein et al., 2001) l(2)46Ci (Goldstein et al., 2001, Bour et al., 1995) l(2)46Cj (Bour et al., 1995) l(2)46Ck (Goldstein et al., 2001, Bour et al., 1995) l(2)46Cl (Bour et al., 1995) l(2)46Cm (Bour et al., 1995) l(2)46Cn (Goldstein et al., 2001, Bour et al., 1995) l(2)46Co (Ranganayakulu et al., 1995) l(2)46Cp (Ranganayakulu et al., 1995) l(2)46Da (O'Brien et al., 1994) l(2)46Db (O'Brien et al., 1994) l(2)46Dc (O'Brien et al., 1994) l(2)46Dd (O'Brien et al., 1994) l(2)46De (O'Brien et al., 1994) l(2)46DEa (Ranganayakulu et al., 1995) l(2)46DEb (Ranganayakulu et al., 1995) l(2)46DEc (Ranganayakulu et al., 1995) l(2)46DEd (Ranganayakulu et al., 1995) l(2)46Df (O'Brien et al., 1994) l(2)46Dg (O'Brien et al., 1994) l(2)46Dh (Goldstein et al., 2001) l(2)46Di (Goldstein et al., 2001) l(2)46Dj (Goldstein et al., 2001) l(2)k06204 (BDGP Project Members, 1994-1999) l(2)k07803 (BDGP Project Members, 1994-1999) Mef2 (Goldstein et al., 2001, Bour et al., 1995, Ranganayakulu et al., 1995) sel (Stein et al., 2010) ta (Bien-Willner et al., 1997) TER94 (Spradling et al., 1999, Goldstein et al., 2001, BDGP Project Members, 1994-1999, Bour et al., 1995)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	14-3-3ζ (Spradling et al., 1999, Goldstein et al., 2001, BDGP Project Members, 1994-1999, Carney et al., 1997) dap (Spradling et al., 1999, BDGP Project Members, 1994-1999) Hdc (Burg et al., 1993) Hr46 (Goldstein et al., 2001, Carney et al., 1997) Jra (Goldstein et al., 2001, Carney et al., 1997) l(2)46Cj (Goldstein et al., 2001) l(2)46Cl (Goldstein et al., 2001) l(2)46Cm (Goldstein et al., 2001) l(2)46Ea (Goldstein et al., 2001, Carney et al., 1997) l(2)46Eb (Goldstein et al., 2001, Carney et al., 1997) l(2)46Ec (Goldstein et al., 2001, Carney et al., 1997) l(2)46Ed (Goldstein et al., 2001, Carney et al., 1997) l(2)46Eg (Goldstein et al., 2001, Carney et al., 1997) l(2)46Eh (Goldstein et al., 2001, Carney et al., 1997) l(2)46Ei (Goldstein et al., 2001, Carney et al., 1997) l(2)46Ej (Goldstein et al., 2001, Carney et al., 1997) l(2)46Fa (Goldstein et al., 2001) l(2)46Fb (Goldstein et al., 2001, Carney et al., 1997) l(2)k03111 (Spradling et al., 1999, BDGP Project Members, 1994-1999) l(2)k06408 (BDGP Project Members, 1994-1999) l(2)k07237 (Spradling et al., 1999, BDGP Project Members, 1994-1999) l(2)k08601 (Spradling et al., 1999, BDGP Project Members, 1994-1999) l(2)k08816 (BDGP Project Members, 1994-1999) psq (Grillo et al., 2011) Syb (Goldstein et al., 2001, Carney et al., 1997) toto (Rodriguez et al., 1996) Uba1 (Spradling et al., 1999, BDGP Project Members, 1994-1999)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations	The Df(2R)X3 chromosome does not act as a dominant suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{w^var}KR3-2", a stable "brown-red" variant of the P{3'WP-2,w^var}2Lt insertion). (Mason et al., 2004)
Stocks ( 2 )
Bloomington	1719 Df(2R)X3/CyO, Adh^nB
Kyoto	106468 Df(2R)X3/CyO, Adh^nB
Notes on Origin
Discoverer

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	Df(2R)X3 (Steinhauer et al., 2009, Grillo et al., 2011, Stein et al., 2010) X3 (Han et al., 2004)
Name Synonym
Secondary FlyBase IDs

References ( 18 )
Research paper	Grillo et al., 2011, Genetics 187(2): 513--521 Control of Germline torso Expression by the BTB/POZ Domain Protein Pipsqueak Is Required for Embryonic Terminal Patterning in Drosophila. [FBrf0213010] Stein et al., 2010, Curr. Biol. 20(21): 1953--1958 Localization and Activation of the Drosophila Protease Easter Require the ER-Resident Saposin-like Protein Seele. [FBrf0212238] Steinhauer et al., 2009, Mol. Biol. Cell 20(24): 5224--5235 Drosophila Lysophospholipid Acyltransferases Are Specifically Required for Germ Cell Development. [FBrf0209500] Han et al., 2004, J. Neurochem. 90(1): 129--141 Drosophila uses two distinct neuropeptide amidating enzymes, dPAL1 and dPAL2. [FBrf0179240] Harbison et al., 2004, Genetics 166(4): 1807--1823 Quantitative trait loci affecting starvation resistance in Drosophila melanogaster. [FBrf0174696] Mason et al., 2004, Genetics 168(3): 1353--1370 A deficiency screen for dominant suppressors of telomeric silencing in Drosophila. [FBrf0180277] Goldstein et al., 2001, Mol. Genet. Genomics 266(4): 695--700 A genetic analysis of the cytological region 46C-F containing the Drosophila melanogaster homolog of the jun proto-oncogene. [FBrf0145131] Spradling et al., 1999, Genetics 153(1): 135--177 The Berkeley Drosophila genome project gene disruption project. Single P-element insertions mutating 25% of vital Drosophila genes. [FBrf0111489] Bien-Willner et al., 1997, D. I. S. 80: 103--104 The 'nw^PZry+' mutation of Drosophila melanogaster proves to be an allele of tapered. [FBrf0098437] Carney et al., 1997, Proc. Natl. Acad. Sci. U.S.A. 94(22): 12024--12029 DHR3, an ecdysone-inducible early-late gene encoding a Drosophila nuclear receptor, is required for embryogenesis. [FBrf0098753] Rodriguez et al., 1996, Genetics 143(2): 929--940 Identification of immune system and responses genes, and novel mutations causing melanotic tumor formation in Drosophila melanogaster. [FBrf0087676] Bour et al., 1995, Genes Dev. 9(6): 730--741 Drosophila MEF2, a transcription factor that is essential for myogenesis. [FBrf0079902] Ranganayakulu et al., 1995, Dev. Biol. 171(1): 169--181 A series of mutations in the D-MEF2 transcription factor reveal multiple functions in larval and adult myogenesis in Drosophila. [FBrf0084289] O'Brien et al., 1994, Genetics 137(1): 121--137 A genetic and molecular analysis of the 46C chromosomal region surrounding the FMRFamide neuropeptide gene of Drosophila melanogaster. [FBrf0074052] Burg et al., 1993, EMBO J. 12(3): 911--919 Genetic and molecular identification of a Drosophila histidine decarboxylase gene required in photoreceptor transmitter synthesis. [FBrf0058167]
Personal communication to FlyBase	BDGP Project Members, 1994-1999, BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project. (Computer file) BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project. (Computer file) [FBrf0067338]
Abstract	O'Brien et al., 1991, Greenspan, Palka, 1991: 83 A genetic analysis of the FMRFamide gene in Drosophila. [FBrf0053296]
FlyBase analysis	FlyBase, 2007, En masse symbol-based assigment of Aberration Class with respect to wild type. En masse symbol-based assigment of Aberration Class with respect to wild type. [FBrf0191808]