Aberration Dmel\Df(2R)bw-HB132

General Information
Symbol	Dmel\Df(2R)bw-HB132	Species	D. melanogaster
Name		FlyBase ID	FBab0002067
Feature type	chromosomal_deletion
Also Known As	Df(2R)HB132

Computed Breakpoints include	59D11;59F6-59F8
Deleted segment	59D11--59F8
Sequence coordinates
Member of large scale dataset(s)
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Aberration
Cytological Order
Progenitor
Mutagen
Class of aberration (relative to progenitor)	chromosomal_deletion (Wharton et al., 1999, Bickel et al., 1996, Moore, 1997)
Breakpoints	59D5-59D11;59F6-59F8 (Bickel et al., 1996, Moore, 1997) 59D8-59D11;59F6-59F8 (Wharton et al., 1999)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data	ord << bk1 << bw << bk2
Genetic mapping information
Comments
Comments on Cytology
	Left limit of break 1 from non-inclusion of ord (FBrf0086327) Right limit of break 1 from polytene analysis (FBrf0086327) Limits of break 2 from polytene analysis (FBrf0086327)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	egl (Moore, 1997) l(2)60A-N (Wharton et al., 1999) l(2)60A-O (Wharton et al., 1999) mi (Moore, 1997)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	Frd (Moore, 1997) gbb (Wharton et al., 1999) kcc (Wharton et al., 1999) l(2)60A-A (Wharton et al., 1999) l(2)60A-B (Wharton et al., 1999) l(2)60A-D (Wharton et al., 1999) l(2)60A-E (Wharton et al., 1999) l(2)60A-F (Wharton et al., 1999) l(2)60Af (Wharton et al., 1999) l(2)60Ag (Wharton et al., 1999) l(2)60A-H (Wharton et al., 1999) l(2)60Ah (Wharton et al., 1999) l(2)60A-I (Wharton et al., 1999) l(2)60Ai (Wharton et al., 1999) l(2)60A-K (Wharton et al., 1999) l(2)60A-L (Wharton et al., 1999) l(2)60A-M (Wharton et al., 1999) l(2)vsp (Wharton et al., 1999) ord (Bickel et al., 1996, Moore, 1997) vir (Niessen et al., 2001)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations	Lethal in combination with Df(2R)bw-W4, Df(2R)bw-W3a or Df(2R)bw-W3b. (Watanabe et al., 2009) Inferred to overlap with: Df(2R)bw-WI3128. (Moore, 1997)
NOT in combination with other aberrations
Stocks ( 2 )
Bloomington	5225 Df(2R)bw-HB132, Frd^HB132/SM6a
Kyoto	108102 Df(2R)bw-HB132, Frd¹/SM6a
Notes on Origin
Discoverer
	Associated with: Frd^HB132. (Moore, 1997)
Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments
	The Df(2R)bw-HB132 chromosome may act as a dominant suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{w^var}KR3-2", a stable "brown-red" variant of the P{3'WP-2,w^var}2Lt insertion), but the eye colour phenotype in the presence of Df(2R)bw-HB132 overlaps the eye colour phenotype in a wild-type background so it cannot be unequivocally demonstrated that the deficiency chromosome uncovers a suppressor of telomeric silencing. In addition, any suppression is assumed to be a false positive result (the suppressor may not be within the bounds of the deficient region) because the 2L TAS array on the chromosome is reduced (as assayed by in situ hybridization) and it has previously been shown (FBrf0137248, FBrf0158986) that partial or complete deficiency of the 2L TAS array on the homologue suppresses silencing of brown-red variants of P{3'WP-2,w^var}2Lt. (Mason et al., 2004)
Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	Df(2R)bw-HB132 (Watanabe et al., 2009, Liu et al., 2007) Df(2R)HB132 (Ditch et al., 2005, Wharton et al., 1999, )
Name Synonym
Secondary FlyBase IDs
	FBab0028681
References ( 11 )
Research paper	Watanabe et al., 2009, Genetics 181(3): 1035--1043 Molecular spectrum of spontaneous de novo mutations in male and female germline cells of Drosophila melanogaster. [FBrf0207534] Liu et al., 2007, Genetics 176(2): 937--946 Mutations in cytochrome c oxidase subunit VIa cause neurodegeneration and motor dysfunction in Drosophila. [FBrf0202034] Ditch et al., 2005, Development 132(1): 155--164 Drosophila retained/dead ringer is necessary for neuronal pathfinding, female receptivity and repression of fruitless independent male courtship behaviors. [FBrf0187456] Mason et al., 2004, Genetics 168(3): 1353--1370 A deficiency screen for dominant suppressors of telomeric silencing in Drosophila. [FBrf0180277] Bradley et al., 2003, Dev. Biol. 257(2): 249--262 Posterior migration of the salivary gland requires an intact visceral mesoderm and integrin function. [FBrf0158855] Niessen et al., 2001, Genetics 157(2): 679--688 Molecular identification of virilizer, a gene required for the expression of the sex-determining gene Sex-lethal in Drosophila melanogaster. [FBrf0132340] Wharton et al., 1999, Genetics 152(2): 629--640 Genetic analysis of the bone morphogenetic protein-related gene, gbb, identifies multiple requirements during Drosophila development. [FBrf0109147] Bickel et al., 1996, EMBO J. 15(6): 1451--1459 Identification of ORD, a Drosophila protein essential for sister chromatid cohesion. [FBrf0086327]
Personal communication to FlyBase	Nothiger, 1994.12.23, Additional information for Df(2R)bw-S46 Additional information for Df(2R)bw-S46 [FBrf0075169]
FlyBase analysis	FlyBase, 2007, En masse symbol-based assigment of Aberration Class with respect to wild type. En masse symbol-based assigment of Aberration Class with respect to wild type. [FBrf0191808]
Thesis	Moore, 1997, Ph.D. Thesis, Massachusetts Institute of Technology, MA: 249pp The mechanism of chromosome segregation: genetics and cytology of the Drosophila mutants Dub, mei-S332 and ord. [FBrf0099407]