FB2025_01 , released February 20, 2025
Aberration: Dmel\Df(2R)bw-S46
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General Information
Symbol
Df(2R)bw-S46
Species
D. melanogaster
Name
FlyBase ID
FBab0002070
Feature type
chromosomal_deletion
Also Known As
Df(2R)bwS46, Df(2R)bwS46, Df(2R)S246
Computed Breakpoints include

59D8-59D11;60A7

Features within 59D8--60A7
Sequence coordinates
Member of large scale dataset(s)
Nature of Aberration
Cytological Order
Progenitor
Mutagen
X ray
(Simpson, 1983)
Class of aberration (relative to wild type)
chromosomal_deletion
(FlyBase, 2007)
Class of aberration (relative to progenitor)
chromosomal_deletion
(Gellon et al., 1997, Prout et al., 1997, Wang et al., 1997, Bickel et al., 1996, Fryxell and Wood, 1995, Gunsalus et al., 1995, Harbecke and Lengyel, 1995, Pauli et al., 1995, Hilfiker and Nothiger, 1991)
Breakpoints

59D8-59D11;60A7

(Gellon et al., 1997, Prout et al., 1997, Wang et al., 1997, Duffy et al., 1996, Fryxell and Wood, 1995, Gunsalus et al., 1995, Harbecke and Lengyel, 1995, Pauli et al., 1995, Hilfiker and Nothiger, 1991)

59D5-59D11;60A7

(Bickel et al., 1996)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data

twi << bk1 << tak << eql << bk2 << Phm

Genetic mapping information
Comments
Comments on Cytology

Left limit of break 1 from polytene analysis (FBrf0055047) Right limit of break 1 from polytene analysis (FBrf0055047) Left limit of break 2 from inclusion of or (FBrf0064297) Right limit of break 2 from polytene analysis (FBrf0055047)

Sequence Crossreferences
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
Gene Deletion and Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted
apt
(Takasu-Ishikawa et al., 2001, Su et al., 1999, Eulenberg and Schuh, 1997, Gellon et al., 1997, BDGP Project Members, 1994-1999)
bgcn
(Schupbach and Wieschaus, 1991)
bw
(Moore, 1997)
Dcp-1
(Spradling et al., 1999, BDGP Project Members, 1994-1999)
egl
(Carpenter, 1994, Schupbach and Wieschaus, 1991)
eIF6
(Spradling et al., 1999, BDGP Project Members, 1994-1999)
eql
(Fryxell and Wood, 1995)
fs(2)ltoAHK35
(Schupbach and Wieschaus, 1991)
fs(2)ltoAPV63
(Schupbach and Wieschaus, 1991)
fs(2)ltoDC37
(Schupbach and Wieschaus, 1991)
fs(2)ltoHM11
(Schupbach and Wieschaus, 1991)
fs(2)ltoRM7
(Schupbach and Wieschaus, 1991)
gbb
(Wharton et al., 1999, Doctor et al., 1992)
ifm(2)RU4
(Nongthomba and Ramachandra, 1999)
kcc
(Wharton et al., 1999)
ken
(Spradling et al., 1999, BDGP Project Members, 1994-1999, Castrillon et al., 1993)
l(2)60A-A
(Wharton et al., 1999)
l(2)60A-B
(Wharton et al., 1999)
l(2)60A-D
(Wharton et al., 1999)
l(2)60A-E
(Wharton et al., 1999)
l(2)60A-F
(Wharton et al., 1999)
l(2)60Af
(Wharton et al., 1999)
l(2)60Ag
(Wharton et al., 1999)
l(2)60Ah
(Wharton et al., 1999)
l(2)60A-H
(Wharton et al., 1999)
l(2)60A-I
(Wharton et al., 1999)
l(2)60Ai
(Wharton et al., 1999)
l(2)60A-K
(Wharton et al., 1999)
l(2)60A-L
(Wharton et al., 1999)
l(2)60A-M
(Wharton et al., 1999)
l(2)60A-N
(Wharton et al., 1999)
l(2)60A-O
(Wharton et al., 1999)
l(2)k06608b
(BDGP Project Members, 1994-1999)
l(2)vsp
(Wharton et al., 1999, Reed, 1992)
mi
(Szuplewski et al., 2009, Moore, 1997, Schupbach and Wieschaus, 1991)
Mtpβ
(BDGP Project Members, 1994-1999)
or
(Moore, 1997, Reed, 1992)
ord
(Bickel et al., 1997, Moore, 1997, Bickel et al., 1996)
qui
(Schupbach and Wieschaus, 1991)
retn
(Spradling et al., 1999, BDGP Project Members, 1994-1999, Schupbach and Wieschaus, 1991)
SERCA
(Sanyal et al., 2005, Krishnan and Basole, 1999.4.2, Periz and Fortini, 1999, Spradling et al., 1999, BDGP Project Members, 1994-1999)
shu
(Munn and Steward, 2000, Schupbach and Wieschaus, 1991)
tak
(Prout et al., 1997)
vir
(Niessen et al., 2001, Nothiger, 1994.12.23, Hilfiker and Nothiger, 1991)
ytr
(Sinenko et al., 2004, BDGP Project Members, 1994-1999)
Partially deleted / disrupted
Molecular Data
Completely deleted
AIMP3
(Marygold et al., 2007)
eIF2Bδ
(Marygold et al., 2007)
eIF6
(Marygold et al., 2007)
Partially deleted
Genes NOT Deleted / Disrupted
Genes Duplicated
Complementation Data
Completely duplicated
kcc
(Hekmat-Scafe et al., 2006)
Partially duplicated
Molecular Data
Completely duplicated
Partially duplicated
Genes NOT Duplicated
Complementation Data
 
Molecular Data
 
Affected Genes Inferred by Location (0)
    If no genes are listed here, it may be because the affected region is very large. The JBrowse insert above may show an error for the same reason, and other FlyBase tools such as CytoSearch may also fail for large regions. You can contact FlyBase for more help.
    In these cases, there will be no "Export to Hitlist" button to the left.
    Phenotypic Data
    In combination with other aberrations

    Inferred to overlap with: Df(2R)WI213.

    (Moore, 1997)
    NOT in combination with other aberrations

    Shows no maternal enhancement of dpphr4.

    (Nicholls and Gelbart, 1998)

    Dominantly causes tergite defects in less than 50% of run3 heterozygotes.

    (Duffy et al., 1996)

    Mitotic clones cannot be generated.

    (Fryxell and Wood, 1995)

    Heterozygosity for this deletion has no effect on the mutant ovarian phenotype of ovoD2.

    (Pauli et al., 1995)
    Stocks (1)
    Notes on Origin
    Discoverer

    P. Simpson.

    (Simpson, 1983)
     
    Balancer / Genotype Variants of the Aberration
     
    Separable Components
     
    Other Comments
     

    The Df(2R)bw-S46 chromosome may act as a dominant suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{wvar}KR3-2", a stable "brown-red" variant of the P{3'WP-2,wvar}2Lt insertion), but the eye colour phenotype in the presence of Df(2R)bw-S46 overlaps the eye colour phenotype in a wild-type background so it cannot be unequivocally demonstrated that the deficiency chromosome uncovers a suppressor of telomeric silencing.

    (Mason et al., 2004)
    Synonyms and Secondary IDs (10)
    References (58)