Aberration Dmel\Df(2R)cn88b

General Information
Symbol	Dmel\Df(2R)cn88b	Species	D. melanogaster
Name	Deficiency (2R) cinnabar	FlyBase ID	FBab0002141
Feature type	chromosomal_deletion

Computed Breakpoints include	42A1-42A19;42E2-42E7
Deleted segment	42A1--42E7
Sequence coordinates
Member of large scale dataset(s)
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Aberration
Cytological Order
Progenitor
Mutagen
Class of aberration (relative to progenitor)	chromosomal_deletion (Pauli et al., 1995, Duffy et al., 1996, Harbecke and Lengyel, 1995, Lo and Frasch, 1998)
Breakpoints	42A1-42A19;42E1-42E7 (Lo and Frasch, 1998) 42A;42E (Pauli et al., 1995, Harbecke and Lengyel, 1995, Duffy et al., 1996)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data	EcR << bk1 << jing << vimar << bk2
Genetic mapping information
Comments
Comments on Cytology
	Limits of break 1 from polytene analysis (FBrf0102180) Left limit of break 2 from inclusion of vimar (FBrf0102180) Right limit of break 2 from polytene analysis (FBrf0102180)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	Adf1 (BDGP Project Members, 1994-1999) geminin (Spradling et al., 1999, BDGP Project Members, 1994-1999) jing (BDGP Project Members, 1994-1999) l(2)01289 (Spradling et al., 1999, BDGP Project Members, 1994-1999) l(2)04535b (Spradling et al., 1999, BDGP Project Members, 1994-1999) l(2)10521 (BDGP Project Members, 1994-1999) l(2)k04909b (BDGP Project Members, 1994-1999) Tdc1 (Cole et al., 2005) Tdc2 (Cole et al., 2005) ubl (Spradling et al., 1999, BDGP Project Members, 1994-1999) vimar (Lo and Frasch, 1998)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	Adf1 (DeZazzo et al., 2000) EcR (Spradling et al., 1999, BDGP Project Members, 1994-1999) Fatp (BDGP Project Members, 1994-1999) l(2)00329 (BDGP Project Members, 1994-1999) l(2)03055 (BDGP Project Members, 1994-1999) l(2)05315 (BDGP Project Members, 1994-1999) l(2)09851 (BDGP Project Members, 1994-1999) l(2)k00503 (BDGP Project Members, 1994-1999) l(2)k02520 (BDGP Project Members, 1994-1999) l(2)k03204 (Spradling et al., 1999, BDGP Project Members, 1994-1999) l(2)k09107 (BDGP Project Members, 1994-1999) l(2)k10613 (BDGP Project Members, 1994-1999) l(2)k14805 (Spradling et al., 1999, BDGP Project Members, 1994-1999) mbl (BDGP Project Members, 1994-1999) tai (BDGP Project Members, 1994-1999) vimar (Spradling et al., 1999, BDGP Project Members, 1994-1999) vlc (Spradling et al., 1999, BDGP Project Members, 1994-1999)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations	The Df(2R)cn88b chromosome does not act as a dominant suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{w^var}KR3-2", a stable "brown-red" variant of the P{3'WP-2,w^var}2Lt insertion). (Mason et al., 2004) Heterozygosity for Df(2R)cn88b results in 1.1% X chromosome nondisjunction and 0.7% fourth chromosome nondisjunction in In(1)FM7/X ; sv^spa-pol females. (Harris et al., 2003) Does not cause unconditional lethality in hybrid females when heterozygous with D.simulans chromosome. (Coyne et al., 1998) No second site non-complementing phenotype with zip^Ebr and zip^mhc-c6.1. (Halsell and Kiehart, 1998) Semi-lethality of the vimar^B6-2-30 mutation is complemented in combination with Df(2R)cn88b. (Lo and Frasch, 1998) Shows no maternal enhancement of dpp^hr4. (Nicholls and Gelbart, 1998) Dominantly causes tergite defects in less than 50% of run³ heterozygotes. (Duffy et al., 1996) Deficient embryos show a mutant midgut phenotype: anterior and posterior constrictions fail to form, though small invaginations are present at the appropriate sites. (Bilder and Scott, 1995) Homozygous embryos are very abnormal compared to wild-type. (Harbecke and Lengyel, 1995) Heterozygosity for this deletion has no effect on the mutant ovarian phenotype of ovo^D2. (Pauli et al., 1995)
Stocks ( 2 )
Bloomington	3134 Df(2R)cn88b, cn^*/CyO, P{sevRas1.V12}FK1
Kyoto	106872 Df(2R)cn88b, cn^*/CyO, P{sevRas1.V12}FK1
Notes on Origin
Discoverer
	Recovered as apparent cn double recombinants from test crosses of dysgenic-type males that were heterozygous for a maternally derived dp b cn bw second chromosome and paternally derived autosomes extracted from natural populations and capable of promoting male recombination.
Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	Df(2R)cn88b (Crest et al., 2007, Culi et al., 2006, Huang et al., 2004)
Name Synonym	Deficiency (2R) cinnabar
Secondary FlyBase IDs

References ( 26 )

Generate a list of	All references relating to this aberration ( 26 )

List References by type	Research paper ( 22 ) Personal communication to FlyBase ( 1 ) Abstract ( 1 ) FlyBase analysis ( 1 ) Book ( 1 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2011 Show research papers ...