FlyBase Aberration Report: Dmel\Df(2R)en-SFX31

General Information

Symbol

Df(2R)en-SFX31

Species

D. melanogaster

Name

Deficiency (2R) engrailed

FlyBase ID

FBab0002175

Feature type

chromosomal_deletion

Also Known As

en^X31, en^SFX31, Df(2R)en^SFX31, Df(2R)enX31, enX31, Df(2R)en³¹, Df(2R)en^SF31

Computed Breakpoints include

48A1;48B5

Features within 48A1--48B5 Features within 47F13--48B4 (Estimated cytology)

Genomic Maps

JBrowse

Sequence coordinates

2R:11,445,082..11,445,082 (Df(2R)en-SFX31:bk1)

(Cheng et al., 2014)

2R:11,648,602..11,648,602 (Df(2R)en-SFX31:bk2)

(Cheng et al., 2014)

Member of large scale dataset(s)

Nature of Aberration

Cytological Order

Progenitor

Mutagen

X ray

(Karr et al., 1989, Kornberg, 1981)

Class of aberration (relative to wild type)

chromosomal_deletion

(FlyBase, 2007)

Class of aberration (relative to progenitor)

chromosomal_deletion

(Sinclair et al., 1998, Humphreys et al., 1996, Chase and Baker, 1995, Harbecke and Lengyel, 1995, Kornberg, 1981)

Breakpoints

48A;48B5

(Chase and Baker, 1995, Kornberg, 1981)

48A;48B

(Harbecke and Lengyel, 1995)

48A1;48B5-48B7

(Sinclair et al., 1998, Humphreys et al., 1996)

Causes alleles

Carries alleles

Transposon Insertions

Formalized genetic data

shn << bk1 << E(Pc) << obk << bk2

Genetic mapping information

Comments

Deletion of the entire en region.

(Drees et al., 1987)

Deletion extending from position -95 to +105, the mutation en¹ is arbitrarily designated as position 0.

(Kuner et al., 1985)

extends from coordinate -95 to +115 (Kuner et al., 1985)

Comments on Cytology

200kb deletion.

(Whiteley and Kassis, 1997)

Limits of break 1 from polytene analysis (FBrf0089694) Limits of break 2 from polytene analysis (FBrf0037248)

Sequence Crossreferences

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

Gene Deletion and Duplication Data

Genes Deleted / Disrupted

Complementation Data

Completely deleted / disrupted

Partially deleted / disrupted

Molecular Data

Completely deleted

Partially deleted

Genes NOT Deleted / Disrupted

Complementation Data

Molecular Data

Genes Duplicated

Complementation Data

Completely duplicated

Partially duplicated

Molecular Data

Completely duplicated

Partially duplicated

Genes NOT Duplicated

Complementation Data

Molecular Data

Affected Genes Inferred by Location (10)

Related Comments

Phenotypic Data

In combination with other aberrations

Loss of the anterior crossvein is seen in 41% of Df(2R)Pu-D17 Df(2R)en-SFX31 double heterozygous flies.

(Layalle et al., 2011)

91% of Df(2R)en^Δ530/Df(2R)en-SFX31 wings exhibit split veins in the posterior compartment.

(DeVido et al., 2008)

Inferred to overlap with: Df(2R)en^Delta530.

(DeVido et al., 2008)

Df(2L)NL Df(2R)en-SFX31 double mutant embryos lack antennal sense organs.

(Gallitano-Mendel and Finkelstein, 1998)

Suppresses position effect variegation (PEV) at the w locus caused by In(1)w^m4, PEV at the B locus caused by Dp(1;Y)Bar^SCV and PEV at the Sb locus caused by T(2;3)Sb^V.

(Sinclair et al., 1998)

NOT in combination with other aberrations

No wing phenotypes are seen in dpp^d6 heterozygotes.

(Layalle et al., 2011)

Df(2R)en-SFX31 mutant embryos display a highly disturbed ventral nerve cord architecture. The commissures are fused, or posterior commissures are thinner than normal or absent, suggesting that axons are either misrouted or missing. Longitudinal tracts are globally less affected than commissures in these mutants.

(Joly et al., 2007)

The gnathal lobes are reduced in mutant embryos.

(Rusch and Kaufman, 2000)

Agam\en^en-12A-5R fails to rescue the mutant phenotype. Agam\en^en-10B-5 rescue causes slight defects in the posterior compartments of the wings, both sexes are fertile.

(Whiteley and Kassis, 1997)

Homozygous lethal. When in combination with ci¹, ci³⁶ or ci⁵⁷ the ci phenotype is enhanced. en mutants can be ranked by strength regarding their ability to induce a ci phenotype: en¹ <= Df(2R)en30 <= en⁴ <= en^Enci <= Df(2R)en-SFX31 <= en⁵⁹.

(Locke and Hanna, 1996)

Homozygous embryos are very abnormal compared to wild-type.

(Harbecke and Lengyel, 1995)

ci^D expression is derepressed in the posterior compartments of embryos and imaginal discs.

(Eaton and Kornberg, 1990)

homozygous lethal

Stocks (2)

3373

107017

Notes on Origin

Discoverer

Kornberg.

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

The Df(2R)en-SFX31 chromosome acts as a dominant moderate suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{w^var}KR3-2", a stable "brown-red" variant of the P{3'WP-2,w^var}2Lt insertion), but this is a false positive result (the suppressor is not within the bounds of the deficient region) because the region of the deficiency is covered by a combination of nonsuppressing deficiencies and deficiencies with suppressors that map to the 2L tip.

(Mason et al., 2004)

Heterozygotes with en^Xho23 and en^Sac27 display wing vein abnormalities but heterozygotes with en^Xho25 fail to survive.

(Hama et al., 1990)

Synonyms and Secondary IDs (18)

Reported As

Symbol Synonym

DEf(2R)SFX31

(Joly et al., 2007)

Df(2R)en spx31

(Tanda, 1998.3.18)

Df(2R)en-SFX31

(Ruan et al., 2017, Casso et al., 2008, Srivastava et al., 2002)

Df(2R)en³¹

(Garrett-Engele et al., 2002, Chase and Baker, 1995)

Df(2R)en^SF31

(Hatini and DiNardo, 2001, Drees et al., 1987)

Df(2R)en^SFX31

(Fauvarque et al., 2001, Serrano et al., 1995, Lee et al., 1992, Williams et al., 1990, Poole and Kornberg, 1988)

Df(2R)en^SFX

(Locke and Hanna, 1996)

Df(2R)en^Sfx31

(Bhat and Schedl, 1997)

Df(2R)en^X31

(Soto et al., 1995)

Df(2R)enSFX31

(Harbecke and Lengyel, 1995)

Df(2R)enX31

(De et al., 2019, Cheng et al., 2014, DeVido et al., 2008, Whiteley and Kassis, 1997)

Df(3R)en-SFX

(Dworkin et al., 2001)

en^SF31

(Karr et al., 1989)

en^SFX31

(Gallitano-Mendel and Finkelstein, 1998, Maschat et al., 1998, Simmonds and Bell, 1998, Serrano et al., 1997, Ursuliak et al., 1997, Bejsovec and Wieschaus, 1993, Hama et al., 1990, Karr et al., 1989, Frasch and Levine, 1987, Kornberg, 1981)

en^X31

(Cheng et al., 2023, De et al., 2019, Layalle et al., 2011, Joly et al., 2007, Rusch and Kaufman, 2000, Bhojwani et al., 1995, Sturtevant and Bier, 1995, Eaton and Kornberg, 1990, Condie and Brower, 1989)

en^x31

(Karr et al., 1989)

enX31

(Cheng et al., 2014, Hirose et al., 2001, Yamaguchi et al., 1999)

Name Synonyms

Deficiency (2R) engrailed

Secondary FlyBase IDs

FBal0034509
FBal0031202

References (57)

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