Aberration Dmel\Df(2R)eve

General Information
Symbol	Dmel\Df(2R)eve	Species	D. melanogaster
Name	Deficiency (2R) even-skipped	FlyBase ID	FBab0002177
Feature type	chromosomal_deletion
Also Known As	Df(2R)eve^1.27, Df(2R)eve1.27, eve^1.27

Computed Breakpoints include	46C3-46C4;46C9-46C11
Deleted segment	46C3--46C11
Sequence coordinates
Member of large scale dataset(s)
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Aberration
Cytological Order
Progenitor
Mutagen
Class of aberration (relative to progenitor)	chromosomal_deletion (Schupbach and Wieschaus, 1991, Kania et al., 1995, Pauli et al., 1995, Duffy et al., 1996, Harbecke and Lengyel, 1995, Landecker et al., 1994)
Breakpoints	46C3-46C4;46C9-46C11 (Schupbach and Wieschaus, 1991, Landecker et al., 1994, Kania et al., 1995, Pauli et al., 1995, Harbecke and Lengyel, 1995, Duffy et al., 1996)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data	Mef2 << bk1 << l(2)46Cp << l(2)46Cd << bk2 << TER94
Genetic mapping information
Comments
Comments on Cytology
	Ref: Lindsley and Zimm, 1992 (Kania et al., 1995) Ref: Nusslein-Volhard et al., 1985, Cold Spring Harbor Symp. Quant. Biol. 50: 145--154. Proximal breakpoint is 40-45kb distal to Fmrf. (O'Brien et al., 1994) All limits from polytene analysis (FBrf0054123)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	Adam (Goldstein et al., 2001) eve (Goldstein et al., 2001, Tearle and Nusslein-Volhard, 1987, Goto et al., 1989, Morrissey et al., 1991, Smith et al., 1993, O'Brien et al., 1994, Harbecke and Lengyel, 1995, Ranganayakulu et al., 1995, Fujioka et al., 1995, Klingler et al., 1996) l(2)46Cd (O'Brien et al., 1994) l(2)46CDa (Goldstein et al., 2001) l(2)46Co (Ranganayakulu et al., 1995) l(2)46Cp (Ranganayakulu et al., 1995) ta (Bien-Willner et al., 1997)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	14-3-3ζ (Goldstein et al., 2001) cbx (BDGP Project Members, 1994-1999) Fmrf (Nambu et al., 1988, O'Brien et al., 1994) Hr46 (Goldstein et al., 2001) Jra (Goldstein et al., 2001) l(2)46Ca (O'Brien et al., 1994) l(2)46Cb (O'Brien et al., 1994) l(2)46CFn (Goldstein et al., 2001) l(2)46Ci (Goldstein et al., 2001) l(2)46Cj (Goldstein et al., 2001) l(2)46Ck (Goldstein et al., 2001) l(2)46Cl (Goldstein et al., 2001) l(2)46Cm (Goldstein et al., 2001) l(2)46Cn (Goldstein et al., 2001) l(2)46Da (O'Brien et al., 1994) l(2)46Db (O'Brien et al., 1994) l(2)46Dc (O'Brien et al., 1994) l(2)46Dd (O'Brien et al., 1994) l(2)46De (O'Brien et al., 1994) l(2)46DEa (Ranganayakulu et al., 1995) l(2)46DEb (Ranganayakulu et al., 1995) l(2)46DEc (Ranganayakulu et al., 1995) l(2)46DEd (Ranganayakulu et al., 1995) l(2)46Df (O'Brien et al., 1994) l(2)46Dg (O'Brien et al., 1994) l(2)46Dh (Goldstein et al., 2001) l(2)46Di (Goldstein et al., 2001) l(2)46Dj (Goldstein et al., 2001) l(2)46Ea (Goldstein et al., 2001) l(2)46Eb (Goldstein et al., 2001) l(2)46Ec (Goldstein et al., 2001) l(2)46Ed (Goldstein et al., 2001) l(2)46Eg (Goldstein et al., 2001) l(2)46Eh (Goldstein et al., 2001) l(2)46Ei (Goldstein et al., 2001) l(2)46Ej (Goldstein et al., 2001) l(2)46Fa (Goldstein et al., 2001) l(2)46Fb (Goldstein et al., 2001) l(2)gl (Mason et al., 2004) l(2)k05422a (BDGP Project Members, 1994-1999, Kania et al., 1995) l(2)k06408 (BDGP Project Members, 1994-1999) l(2)k07803 (BDGP Project Members, 1994-1999) Mef2 (Goldstein et al., 2001, Lilly et al., 1995, Ranganayakulu et al., 1995, Schulz et al., 1996) Syb (Goldstein et al., 2001) TER94 (Goldstein et al., 2001, BDGP Project Members, 1994-1999)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations	No effect on In(1)w^m4h position-effect variegation. (Wustmann et al., 1989)
NOT in combination with other aberrations	Mutant animals exhibit defects in axonal projections (Fujioka et al., 2003) Shows no maternal enhancement of dpp^hr4. (Nicholls and Gelbart, 1998) Dominantly causes tergite defects in less than 50% of run³ heterozygotes. (Duffy et al., 1996) Deficient embryos show an uninterpretable mutant midgut phenotype. (Bilder and Scott, 1995) Homozygous embryos do not complete head involution, tracheae are disconnected and salivary glands are bulgy. Formation and maintenance of the midgut epithelium is variable, and midgut constrictions do not form. (Harbecke and Lengyel, 1995) Heterozygosity for this deletion has no effect on the mutant ovarian phenotype of ovo^D2. (Pauli et al., 1995) Reduced ventral cord. (Smith et al., 1993)
Stocks ( 3 )
Bloomington	1545 Df(2R)eve, cn¹/CyO
Kyoto	106377 Df(2R)eve, cn¹/CyO 101375 CyO, Cy¹ dp^lv1 pr¹ cn² / Df(2R)eve, cn¹
Notes on Origin
Discoverer	Nusslein-Volhard.

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments
	The Df(2R)eve chromosome acts as a dominant moderate suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{w^var}KR3-2", a stable "brown-red" variant of the P{3'WP-2,w^var}2Lt insertion), but this is a false positive result (the suppressor is not within the bounds of the deficient region) because the region of the deficiency is covered by one or more nonsuppressing deficiencies. The suppressor maps to the tip of 2L rather than to the site of the deficiency. (Mason et al., 2004)
Synonyms & Secondary IDs ( 11 )
Reported As
Symbol Synonym	Df(2R)eve (Crest et al., 2007, Garces and Thor, 2006, Lacin et al., 2009, Zarin et al., 2012, Ludwig et al., 2011) Df(2R)eve1/27 (Klingler et al., 1996) Df(2R)eve1.27 (Gildea et al., 2000, Jackson and Berg, 1999, Tearle and Nusslein-Volhard, 1987, Harbecke and Lengyel, 1995, Duffy et al., 1996, Bilder and Scott, 1995, Schupbach and Wieschaus, 1991, Schupbach and Wieschaus, 1989, ) Df(2R)eve 1.27 (Carroll and Scott, 1986) Df(2R)eve^1.27 (Goldstein et al., 2001, Abrell et al., 2000, Sackerson et al., 1999, Park et al., 1998, Lawrence and Pick, 1998, Wustmann et al., 1989, Ingham and Gergen, 1988, Klingler and Gergen, 1993, Baumgartner and Noll, 1990, Nambu et al., 1988, Schulz et al., 1996, Small et al., 1996, Pritchard and Schubiger, 1996, Ranganayakulu et al., 1995, Lilly et al., 1995, Parkhurst and Ish-Horowicz, 1991, Coulter and Wieschaus, 1988, Tsai and Gergen, 1995, O'Brien et al., 1994, Gutjahr et al., 1993, Rabinow et al., 1991) Df(2R)evel.27 (Smith et al., 1993) Df(eve) (Fujioka et al., 1995) Df eve 1.27 (Lawrence and Johnston, 1989) Dfeve1.27 (Irvine and Wieschaus, 1994) eve^1.27 (Blankenship and Wieschaus, 2001, Frasch et al., 1988, Liang and Biggin, 1998, Morrissey et al., 1991)
Name Synonym	Deficiency (2R) even-skipped
Secondary FlyBase IDs

References ( 67 )

Generate a list of	All references relating to this aberration ( 67 )

List References by type	Research paper ( 62 ) Personal communication to FlyBase ( 1 ) Abstract ( 1 ) FlyBase analysis ( 1 ) Stock list ( 1 ) Book ( 1 )
Recent research papers ( 2 )
	Zarin et al., 2012, Development 139(10): 1798--1805 A GATA/homeodomain transcriptional code regulates axon guidance through the Unc-5 receptor. [FBrf0218039] Ludwig et al., 2011, PLoS Genet. 7(11): e1002364 Consequences of eukaryotic enhancer architecture for gene expression dynamics, development, and fitness. [FBrf0216746] Show all research papers ...