Aberration Dmel\Df(2R)nap11

General Information
Symbol	Dmel\Df(2R)nap11	Species	D. melanogaster
Name		FlyBase ID	FBab0002186
Feature type	chromosomal_deletion
Also Known As	Df(2R)nap¹¹

Computed Breakpoints include	41E3-41E4;42A8-42A10
Deleted segment	41E3--42A10
Sequence coordinates
Member of large scale dataset(s)
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Aberration
Cytological Order
Progenitor
Mutagen
Class of aberration (relative to progenitor)	chromosomal_deletion (Kreber, 1994.3.17)
Breakpoints	41E3-41E4;42A7-42A10 (Kreber, 1994.3.17)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data	bk1 << mle << EcR << bk2 << l(2)42Bb
Genetic mapping information
Comments
Comments on Cytology
	Limits of break 1 from polytene analysis (FBrf0075275) Left limit of break 2 from inclusion of EcR (FBrf0091449) Right limit of break 2 from polytene analysis (FBrf0075275)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	ap (Gambetta and Mueller, 2009.8.18) EcR (Bender, 1996) kune (Gambetta and Mueller, 2009.8.18) l(2)42Aa (Roote and Ashburner, 2005.6) l(2)42Ab (Roote and Ashburner, 2005.6) l(2)42Ac (Roote and Ashburner, 2005.6) l(2)09851 (Gambetta and Mueller, 2009.8.18) l(2)NC136 (Gambetta and Mueller, 2009.8.18) laccase2 (Gambetta and Mueller, 2009.8.18) vlc (Gambetta and Mueller, 2009.8.18)
Molecular Data
Completely deleted	scaf (Rousset et al., 2010)
Genes NOT Deleted / Disrupted
Complementation Data
	l(2)42Bb (Bender, 1996) l(2)42Bc (Bender, 1996) l(2)42Bd (Bender, 1996) Nipped-A (Gambetta and Mueller, 2009.8.18) Nipped-B (Gambetta and Mueller, 2009.8.18) RpL38 (Gambetta and Mueller, 2009.8.18) sxc (Gambetta and Mueller, 2009.8.18, Gambetta et al., 2009)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations	Heterozygotes are viable and fertile. Heterozygous ovaries have a number of morphological defects; there are fewer terminal filament (TF) stacks at 24 hours after ecdysis to the third instar compared to control flies. There are more TF cells/stack at 24 hours after pupariation compared to control flies and the apical cell population is reduced, leading to a spiral orientation of TF stacks. Epithelial sheath cells often remain adherent to the ovarioles at 48 hours after pupariation. (Hodin and Riddiford, 1998)
Stocks ( 1 )
Bloomington	8884 Df(2R)nap11/In(2LR)Gla, wg^Gla-1
Notes on Origin
Discoverer

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	Df(2)nap11 (Tsai et al., 1999) Df(2R)nap11 (Gambetta et al., 2009, Gambetta and Mueller, 2009.8.18) Df(2R)nap¹¹ (Hodin and Riddiford, 1998, Kreber, 1994.3.17, Kernan et al., 1991) Δscaf (Rousset et al., 2010)
Name Synonym
Secondary FlyBase IDs

References ( 11 )
Research paper	Rousset et al., 2010, Development 137(13): 2177--2186 The Drosophila serine protease homologue Scarface regulates JNK signalling in a negative-feedback loop during epithelial morphogenesis. [FBrf0211045] Tsai et al., 1999, Mol. Cell 4(2): 175--186 SMRTER, a Drosophila nuclear receptor coregulator, reveals that EcR-mediated repression is critical for development. [FBrf0111507] Hodin and Riddiford, 1998, Dev. Genes Evol. 208(6): 304--317 The ecdysone receptor and ultraspiracle regulate the timing and progression of ovarian morphogenesis during Drosophila metamorphosis. [FBrf0104451] Bender et al., 1997, Cell 91(6): 777--788 Drosophila ecdysone receptor mutations reveal functional differences among receptor isoforms. [FBrf0099891] Bender, 1996, D. I. S. 77: 143 New lethal loci in the 42AB region of the Drosophila melanogaster 2nd chromosome. [FBrf0091449] Kernan et al., 1991, Cell 66: 949--959 nap^ts, a mutation affecting sodium channel activity in Drosophila, is an allele of mle, a regulator of X chromosome transcription. [FBrf0053404]
Supplementary material	Gambetta et al., 2009, Science 325(5936): Essential role of the glycosyltransferase sxc/Ogt in polycomb repression: Supporting Online Material. [FBrf0208740]
Personal communication to FlyBase	Gambetta and Mueller, 2009.8.18, Complementation behaviour of deficiencies and mutations in the sxc/Ogt region. Complementation behaviour of deficiencies and mutations in the sxc/Ogt region. [FBrf0208761] Roote and Ashburner, 2005.6, l(2)43A mutations. l(2)43A mutations. [FBrf0188639] Kreber, 1994.3.17, Df(2R)nap chromosomes. Df(2R)nap chromosomes. [FBrf0075275]
FlyBase analysis	FlyBase, 2007, En masse symbol-based assigment of Aberration Class with respect to wild type. En masse symbol-based assigment of Aberration Class with respect to wild type. [FBrf0191808]