Aberration Dmel\Df(2R)nap2

General Information
Symbol	Dmel\Df(2R)nap2	Species	D. melanogaster
Name		FlyBase ID	FBab0002188
Feature type	chromosomal_deletion
Also Known As	Df(2R)nap-2

Computed Breakpoints include	41F4-41F9;43A1
Deleted segment	41F4--43A1
Sequence coordinates
Member of large scale dataset(s)
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Aberration
Cytological Order
Progenitor
Mutagen	X ray (Gubb et al., 1999)
Class of aberration (relative to progenitor)	chromosomal_deletion (Ringo et al., 1991, Heitzler et al., 1993, Shtorch et al., 1995, Kreber, 1994.3.17, Gubb et al., 1999)
Breakpoints	41F4-41F9;43A1 (Ringo et al., 1991) 41F4-41F9;43A1-43A2 (Heitzler et al., 1993, Kreber, 1994.3.17, Shtorch et al., 1995, Gubb et al., 1999)
Causes alleles	pk^nap2 (Gubb et al., 1999)
Carries alleles
Transposon Insertions
Formalized genetic data	bk1 << ap << pk << bk2 << l(2)43Ba
Genetic mapping information
Comments
Comments on Cytology
	Limits of break 1 from polytene analysis (FBrf0053193) Left limit of break 2 from inclusion of nec (FBrf0058613) Right limit of break 2 from polytene analysis (FBrf0053193)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	Adf1 (BDGP Project Members, 1994-1999) ap (Ringo et al., 1991, Shtorch et al., 1995) BubR1 (Spradling et al., 1999, BDGP Project Members, 1994-1999, Basu et al., 1999) CG3267 (BDGP Project Members, 1994-1999) coro (Spradling et al., 1999, BDGP Project Members, 1994-1999) Eb1 (Spradling et al., 1999, Roote, 1996.12.3) EcR (Spradling et al., 1999, BDGP Project Members, 1994-1999) esg (BDGP Project Members, 1994-1999) geminin (Spradling et al., 1999, BDGP Project Members, 1994-1999) jing (Spradling et al., 1999, BDGP Project Members, 1994-1999) l(2)42Aa (Roote and Ashburner, 2005.6) l(2)42Ab (Roote and Ashburner, 2005.6) l(2)42Ac (Roote and Ashburner, 2005.6) l(2)01289 (Spradling et al., 1999, BDGP Project Members, 1994-1999) l(2)04535b (Spradling et al., 1999, BDGP Project Members, 1994-1999) l(2)09851 (Spradling et al., 1999, BDGP Project Members, 1994-1999) l(2)k03204 (Spradling et al., 1999, BDGP Project Members, 1994-1999) l(2)k09848 (Spradling et al., 1999, BDGP Project Members, 1994-1999) l(2)k14710 (Spradling et al., 1999, BDGP Project Members, 1994-1999) l(2)k14805 (Spradling et al., 1999, BDGP Project Members, 1994-1999) mle (Ringo et al., 1991) nec (Levashina et al., 1999, Green et al., 2000, Heitzler et al., 1993) pk (Gubb et al., 1999, Green et al., 2000, Heitzler et al., 1993) Src42A (Spradling et al., 1999, BDGP Project Members, 1994-1999) ubl (Spradling et al., 1999, BDGP Project Members, 1994-1999) vimar (Spradling et al., 1999, BDGP Project Members, 1994-1999) vlc (Spradling et al., 1999, BDGP Project Members, 1994-1999)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	blow (Heitzler et al., 1993) boca (Heitzler et al., 1993) cn (Heitzler et al., 1993) cos (Heitzler et al., 1993) dpa (Heitzler et al., 1993) Dscam (Heitzler et al., 1993) fs(2)43Ei (Heitzler et al., 1993) hum (Heitzler et al., 1993) l(2)43Ba (Heitzler et al., 1993) l(2)43Bb (Heitzler et al., 1993) l(2)43Bd (Heitzler et al., 1993, BDGP Project Members, 1994-1999) l(2)43Cb (Heitzler et al., 1993) l(2)43Cc (Heitzler et al., 1993) l(2)43Da (Heitzler et al., 1993) l(2)43Db (Heitzler et al., 1993) l(2)43Ef (Heitzler et al., 1993) l(2)43Eg (Heitzler et al., 1993) l(2)43Eh (Heitzler et al., 1993) l(2)00329 (BDGP Project Members, 1994-1999) l(2)05315 (BDGP Project Members, 1994-1999) l(2)k00503 (BDGP Project Members, 1994-1999) l(2)k02520 (BDGP Project Members, 1994-1999) ms(2)42D (Spradling et al., 1999, BDGP Project Members, 1994-1999) pwn (Heitzler et al., 1993) Rpt1 (Heitzler et al., 1993) scra (Heitzler et al., 1993) so (Heitzler et al., 1993) tai (BDGP Project Members, 1994-1999) tor (Heitzler et al., 1993) U2A (Heitzler et al., 1993)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations	Has no dominant effect on variegation of In(1)w^m4. (Green et al., 2000)
NOT in combination with other aberrations	Df(2R)sple-D2/Df(2R)nap2 mutants express amorphic pk and nec mutant phenotypes. (Green et al., 2000)
Stocks ( 2 )
Bloomington	6386 Df(2R)nap2, dp^v/CyO, P{sevRas1.V12}FK1
Kyoto	108763 Df(2R)nap2, dp^v/CyO
Notes on Origin
Discoverer

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	Df(2R)nap-2 (Green et al., 2000, Gubb et al., 1999, Shtorch et al., 1995, Heitzler et al., 1993) Df(2R)nap2 (Stork et al., 2008, Gohl et al., 2008) Df(2R)nap² (Kreber, 1994.3.17)
Name Synonym
Secondary FlyBase IDs

References ( 16 )
Research paper	Gohl et al., 2008, Genetics 178(1): 127--143 Enhancer blocking and transvection at the Drosophila apterous Locus. [FBrf0202942] Stork et al., 2008, J. Neurosci. 28(3): 587--597 Organization and function of the blood-brain barrier in Drosophila. [FBrf0202685] Green et al., 2000, Genetics 156(3): 1117--1127 The necrotic gene in Drosophila corresponds to one of a cluster of three serpin transcripts mapping at 43A1.2. [FBrf0131303] Basu et al., 1999, J. Cell Biol. 146(1): 13--28 Mutations in the essential spindle checkpoint gene bub1 cause chromosome missegregation and fail to block apoptosis in Drosophila. [FBrf0109303] Gubb et al., 1999, Genes Dev. 13(17): 2315--2327 The balance between isoforms of the prickle LIM domain protein is critical for planar polarity in Drosophila imaginal discs. [FBrf0111378] Levashina et al., 1999, Science 285(5435): 1917--1919 Constitutive activation of toll-mediated antifungal defense in serpin-deficient Drosophila. [FBrf0111411] Spradling et al., 1999, Genetics 153(1): 135--177 The Berkeley Drosophila genome project gene disruption project. Single P-element insertions mutating 25% of vital Drosophila genes. [FBrf0111489] Shtorch et al., 1995, Arch. Insect Biochem. Physiol. 30(2-3): 195--209 Genetic and molecular studies of apterous: A gene implicated in the juvenile hormone system of Drosophila. [FBrf0084370] Heitzler et al., 1993, Genetics 135(1): 105--115 Genetic and cytogenetic analysis of the 43A-E region containing the segment polarity gene costa and the cellular polarity genes prickle and spiny-legs in Drosophila melanogaster. [FBrf0058613] Ringo et al., 1992, Behav. Genet. 22: 469--487 Male sexual signaling is defective in mutants of the apterous gene of Drosophila melanogaster. [FBrf0055416] Ringo et al., 1991, Behav. Genet. 21(5): 453--469 Female sexual receptivity is defective in juvenile hormone-deficient mutants of the apterous gene of Drosophila melanogaster. [FBrf0053193]
Personal communication to FlyBase	Roote and Ashburner, 2005.6, l(2)43A mutations. l(2)43A mutations. [FBrf0188639] Roote, 1996.12.3, PZ01289 and PZ04524. PZ01289 and PZ04524. [FBrf0091336] BDGP Project Members, 1994-1999, BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project. (Computer file) BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project. (Computer file) [FBrf0067338] Kreber, 1994.3.17, Df(2R)nap chromosomes. Df(2R)nap chromosomes. [FBrf0075275]
FlyBase analysis	FlyBase, 2007, En masse symbol-based assigment of Aberration Class with respect to wild type. En masse symbol-based assigment of Aberration Class with respect to wild type. [FBrf0191808]