Aberration Dmel\Df(2R)rl10a

General Information
Symbol	Dmel\Df(2R)rl10a	Species	D. melanogaster
Name	Deficiency (2R) rolled	FlyBase ID	FBab0002207
Feature type	chromosomal_deletion

Computed Breakpoints include	h38R-h41;h41-41A3
Deleted segment	h38R--41A3
Sequence coordinates
Recent Updates
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FB2012_01
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Aberration
Cytological Order
Progenitor
Mutagen
Class of aberration (relative to progenitor)	chromosomal_deletion (Pauli et al., 1995, Chandrashekaran and Sarla, 1993)
Breakpoints	41A;41A (Chandrashekaran and Sarla, 1993, Pauli et al., 1995)
Causes alleles	rl¹⁰ (Zhu et al., 2005) rl^10a (Lim et al., 1999, Peverali et al., 1996, Zhu et al., 2005, Rintelen et al., 2003, Begemann et al., 1995)
Carries alleles
Transposon Insertions
Formalized genetic data	bk1 << rl << bk2 << stw
Genetic mapping information
Comments
Comments on Cytology
	Left limit of break 1 from polytene analysis (FBrf0065355) Right limit of break 1 from inclusion of rl (FBrf0089778) Left limit of break 2 from inclusion of rl (FBrf0089778) Right limit of break 2 from polytene analysis (FBrf0065355)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	rl (Peverali et al., 1996)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	stmA (Chandrashekaran and Sarla, 1993)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations	Heterozygosity for this deletion has no effect on the mutant ovarian phenotype of ovo^D2. (Pauli et al., 1995) Ras85D^V12.sev; Df(2R)rl10a/+ flies have smooth eyes with a greatly reduced number of R7 cells, compared to Ras85D^V12.sev flies. Double mutants of rl¹ and Egfr^f11 or Df(2R)rl10a and Egfr^t1 show disruption of the longitudinal vein L4. (Brunner et al., 1994)
Stocks ( 2 )
Bloomington	742 Df(2R)rl10a, lt¹ rl^10a cn¹/In(2LR)bw^V1, ds^33k bw^V1
Kyoto	106058 Df(2R)rl10a, lt¹ rl^10a cn¹/In(2LR)bw^V1, ds^33k bw^V1
Notes on Origin
Discoverer

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

Synonyms & Secondary IDs ( 5 )
Reported As
Symbol Synonym	Df(2R)r110a (Ashton et al., 2001) Df(2R)rl10a Df(2R)rl^10a (Zhu et al., 2005, Rintelen et al., 2003, Lim et al., 1999, Chandrashekaran and Sarla, 1993, Diaz-Benjumea and Hafen, 1994, Biggs et al., 1994) rl^10a (Bergmann et al., 2002, Brunner et al., 1994)
Name Synonym	Deficiency (2R) rolled
Secondary FlyBase IDs

References ( 18 )
Research paper	Zhu et al., 2005, Genetics 170(2): 767--777 A screen for genes that influence fibroblast growth factor signal transduction in Drosophila. [FBrf0187664] Rintelen et al., 2003, Development 130(15): 3479--3490 The Drosophila dual-specificity ERK phosphatase DMKP3 cooperates with the ERK tyrosine phosphatase PTP-ER. [FBrf0160889] Bergmann et al., 2002, Dev. Cell 2(2): 159--170 Regulation of cell number by MAPK-dependent control of apoptosis: a mechanism for trophic survival signaling. [FBrf0144794] del Alamo et al., 2002, Development 129(8): 1975--1982 Spitz/EGFr signalling via the Ras/MAPK pathway mediates the induction of bract cells in Drosophila legs. [FBrf0146986] Ashton et al., 2001, Genetics 157(1): 283--294 Quantitative trait loci for the monoamine-related traits heart rate and headless behavior in Drosophila melanogaster. [FBrf0132335] Pasyukova et al., 2000, Genetics 156(3): 1129--1146 Deficiency mapping of quantitative trait loci affecting longevity in Drosophila melanogaster. [FBrf0131237] Lim et al., 1999, Genetics 153(2): 763--771 Genetic analysis of rolled, which encodes a Drosophila mitogen-activated protein kinase. [FBrf0111415] Peverali et al., 1996, EMBO J. 15(15): 3943--3950 Phosphorylation of Drosophila Jun by the MAP kinase rolled regulates photoreceptor differentiation. [FBrf0089778] Begemann et al., 1995, Development 121(1): 225--235 The Drosophila orphan nuclear receptor Seven-up requires the Ras pathway for its function in photoreceptor determination. [FBrf0076133] Pauli et al., 1995, Genetics 139(2): 713--732 Identification of regions interacting with ovo^D mutations: Potential new genes involved in germline sex determination or differentiation in Drosophila melanogaster. [FBrf0080317] Pauli et al., 1995, D. I. S. 76: 107--124 Dose dependent enhancers and suppressors of ovoD2. [FBrf0082455] Biggs et al., 1994, EMBO J. 13(7): 1628--1635 The Drosophila rolled locus encodes a MAP kinase required in the sevenless signal transduction pathway. [FBrf0068416] Brunner et al., 1994, Cell 76(5): 875--888 A gain-of-function mutation in Drosophila MAP kinase activates multiple receptor tyrosine kinase signaling pathways. [FBrf0068431] Diaz-Benjumea and Hafen, 1994, Development 120(3): 569--578 The sevenless signalling cassette mediates Drosophila EGF receptor function during epidermal development. [FBrf0072959] Chandrashekaran and Sarla, 1993, Genetica 90(1): 61--71 Phenotypes of lethal alleles of the recessive temperature sensitive paralytic mutant stambh A of Drosophila melanogaster suggest its neurogenic function. [FBrf0065355] Tano, 1966, Jpn J. Genet. 41: 299--308 Studies on the clustered recessive lethal genes on the second chromosome of Drosophila melanogaster. [FBrf0017985]
FlyBase analysis	FlyBase, 2007, En masse symbol-based assigment of Aberration Class with respect to wild type. En masse symbol-based assigment of Aberration Class with respect to wild type. [FBrf0191808]
Book	Lindsley and Zimm, 1992, The Genome of Drosophila melanogaster. The Genome of Drosophila melanogaster. [FBrf0066905]