Aberration Dmel\Df(2R)trix

General Information
Symbol	Dmel\Df(2R)trix	Species	D. melanogaster
Name	Deficiency (2R) transformer intersex	FlyBase ID	FBab0002231
Feature type	chromosomal_deletion	Created / Updated	2006-08-22/2006-08-22

Formalized genetic data	l(2)s3475 << bk1 << auk << bk2 << Sec61β
Sequence coordinates
Deleted segment	51A2--51B6
Duplicated segment
Computed Breakpoints include	[];51B6 51A2;51B6
Breakpoints Inherited
Nature of the Aberration
Cytological Order
Progenitor
Mutagen
Class of aberration (relative to progenitor)	chromosomal_deletion (Goralski et al., 1989, Rabinow et al., 1991, Smith et al., 1993, Kania et al., 1995, Pauli et al., 1995, Granadino et al., 1992, Duffy et al., 1996, Crozatier et al., 1996, Harbecke and Lengyel, 1995, Landecker et al., 1994, Prout et al., 1997, Nestoras et al., 1997, Salinas et al., 1998, Schupbach and Wieschaus, 1989)
Breakpoints	51A1-51A2;51B6 (Goralski et al., 1989, Schupbach and Wieschaus, 1989, Rabinow et al., 1991, Granadino et al., 1992, Smith et al., 1993, Pauli et al., 1995, Harbecke and Lengyel, 1995, Duffy et al., 1996, Prout et al., 1997) 51A2-51A4;51B6 (Landecker et al., 1994, Kania et al., 1995, Salinas et al., 1998) 51A1;51B6 (Crozatier et al., 1996) [];51B6 (Nestoras et al., 1997)
Causes alleles
Carries alleles
Transposon Insertions
Genetic mapping information
Comments	Breakpoint(s) molecularly mapped (Goralski et al., 1989)
Comments on Cytology
	Left limit of break 1 from polytene analysis (FBrf0076124) Right limit of break 1 from inclusion of l(2)03563 (FBrf0067338) Limits of break 2 from polytene analysis (FBrf0049325) Ref: Lindsley and Zimm, 1992 (Kania et al., 1995)
Molecularly Mapped Breakpoints

Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	L (Chern and Choi, 2002) ttv (BDGP Project Members, 1994-1999, Dickson et al., 1995, Bellaiche et al., 1998, Spradling et al., 1999, Schulze et al., 2005) LamC (Schulze et al., 2005) phyl (Begemann et al., 1995, Chang et al., 1995, Dickson et al., 1995, Dickson et al., 1996, Brumby et al., 2004) Tfb1 (Dickson et al., 1995) cpsf (Salinas et al., 1998) Asx (Simon et al., 1992, Landecker et al., 1994, Cheng et al., 1994, Soto et al., 1995, Bilder and Scott, 1995, Duffy et al., 1996, Sinclair et al., 1998, Salinas et al., 1998) tra2 (Goralski et al., 1989, Oliver et al., 1993, Mattox et al., 1996, Ryner et al., 1996) l(2)03563 (BDGP Project Members, 1994-1999, Spradling et al., 1999) l(2)k16805 (BDGP Project Members, 1994-1999, Spradling et al., 1999) l(2)k03906a (BDGP Project Members, 1994-1999) auk (Prout et al., 1997, Walsh and Brown, 1998)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	veg (BDGP Project Members, 1994-1999, Kania et al., 1995) kn (Nestoras et al., 1997) L (BDGP Project Members, 1994-1999, Spradling et al., 1999) Sec61β (BDGP Project Members, 1994-1999, Spradling et al., 1999) cg (BDGP Project Members, 1994-1999) Tfb1 (BDGP Project Members, 1994-1999, Spradling et al., 1999) fl(2)d (Granadino et al., 1992) seq (Brenman et al., 2001) boc (BDGP Project Members, 1994-1999, Spradling et al., 1999) mwr (Rasooly, 1996) l(2)k00803 (BDGP Project Members, 1994-1999) opa1-like (BDGP Project Members, 1994-1999, Spradling et al., 1999)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations	Deficient embryos show a mutant midgut phenotype: central and posterior constrictions absent. (Bilder and Scott, 1995) Does not cause unconditional lethality in hybrid females when heterozygous with D.simulans chromosome. (Coyne et al., 1998) Dominantly causes tergite defects in less than 50% of run³ heterozygotes. (Duffy et al., 1996) Enhances the trx-G homeotic transformations of Df(3R)red1. Strongly enhances both the extra sex comb and abdominal segment transformation phenotypes of Pc⁴. (Milne et al., 1999) Hemizygosity strongly suppresses the phl::tor^12D.hs.sev phenotype. (Dickson et al., 1996) Heterozygosity for Df(2R)trix results in 2.2% X chromosome nondisjunction and 1.0% fourth chromosome nondisjunction in In(1)FM7/X ; sv^spa-pol females. (Harris et al., 2003) Heterozygosity for this deletion has no effect on the mutant ovarian phenotype of ovo^D2. (Pauli et al., 1995) Homozygous trix larvae show abdominal setal-belt phenotype in thorax. Mutation does not affect the level of w expression in ph-p^lac+3 flies. (Fauvarque et al., 1995) No second site non-complementing phenotype with zip^Ebr and zip^mhc-c6.1. (Halsell and Kiehart, 1998) Shows no maternal enhancement of dpp^hr4. (Nicholls and Gelbart, 1998) Suppressor of the dosage dependent (two or more copies of P{sev-svp1} or P{sev-svp2}) transformation of cone cells into R7 photoreceptors and at a lower frequency R7 cells into outer photoreceptors. (Begemann et al., 1995) Df(2R)trix embryos from heterozygous mothers show segregation defects in anaphase and telophase as judged by the presence of chromatin bridges. These embryos show a higher level of "nuclear fallout", a process that removes nuclei with abnormal mitoses, than wild-type embryos. Fallout nuclei tend to be observed in pairs or clusters. There is no evidence of metaphase defects in these embryos and have a late telophase appearance. (O'Dor et al., 2006)
Position Effect Variegation Data

Stocks ( 3 )
Bloomington	1896 Df(2R)trix/CyO
Kyoto	106562 Df(2R)trix/CyO? 103286 Df(2R)trix / Cy^*
Notes on Origin
Discoverer	B.S. Baker.

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments
	The Df(2R)trix chromosome acts as a dominant weak suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{w^var}KR3-2", a stable "brown-red" variant of the P{3'WP-2,w^var}2Lt insertion), but this is a false positive result (the suppressor is not within the bounds of the deficient region) because the region of the deficiency is covered by one or more nonsuppressing deficiencies. (Mason et al., 2004)
Synonyms & Secondary IDs ( 8 )
Reported As
Symbol Synonym	Df(2)TRIX (Oliver et al., 1994, Oliver et al., 1993) Df(2R)Trix (Bielinska et al., 2005, Artero et al., 2003, The et al., 1999, Bellaiche et al., 1998, Crozatier et al., 1996, Simon et al., 1992) Df(2R)TRIX (Andrews and Oliver, 2002, Rabinow et al., 1991) Df(2R)trix (Crest et al., 2007) Df(trix) (O'Dor et al., 2006) DfTRIX (Pane et al., 2005, Waterbury et al., 2000) tra-2^Df (Waterbury et al., 2000)
Name Synonym	Deficiency (2R) transformer intersex
Secondary FlyBase IDs

References ( 76 )

Generate a list of	All references relating to this aberration ( 76 )

List References by type	Research paper ( 73 ) FlyBase analysis ( 1 ) Computer file ( 1 ) Book ( 1 )
Recent research papers ( 2 )
	Crest et al., 2007, Genetics 175(2): 567--584 Onset of the DNA replication checkpoint in the early Drosophila embryo. [FBrf0194644] O'Dor et al., 2006, Dev. Biol. 290(2): 312--322 Polycomb Group mutants exhibit mitotic defects in syncytial cell cycles of Drosophila embryos. [FBrf0190149] Show all research papers ...