FlyBase Aberration Report: Dmel\Df(2R)trix

General Information

Symbol

Df(2R)trix

Species

D. melanogaster

Name

Deficiency (2R) transformer intersex

FlyBase ID

FBab0002231

Feature type

chromosomal_deletion

Also Known As

DfTRIX, Df(2)TRIX, Df(2R)^trix

Computed Breakpoints include

51A2;51B6

Features within 51A2--51B6

Sequence coordinates

Member of large scale dataset(s)

Nature of Aberration

Cytological Order

Progenitor

Mutagen

Class of aberration (relative to wild type)

chromosomal_deletion

(FlyBase, 2007)

Class of aberration (relative to progenitor)

chromosomal_deletion

(Salinas et al., 1998, Nestoras et al., 1997, Prout et al., 1997, Crozatier et al., 1996, Duffy et al., 1996, Harbecke and Lengyel, 1995, Kania et al., 1995, Pauli et al., 1995, Landecker et al., 1994, Smith et al., 1993, Granadino et al., 1992, Rabinow et al., 1991, Goralski et al., 1989, Schupbach and Wieschaus, 1989)

Breakpoints

51A1-51A2;51B6

(Prout et al., 1997, Duffy et al., 1996, Harbecke and Lengyel, 1995, Pauli et al., 1995, Smith et al., 1993, Granadino et al., 1992, Rabinow et al., 1991, Goralski et al., 1989, Schupbach and Wieschaus, 1989)

51A1;51B6

(Crozatier et al., 1996)

[];51B6

(Nestoras et al., 1997)

51A2-51A4;51B6

(Salinas et al., 1998, Kania et al., 1995, Landecker et al., 1994)

Causes alleles

Carries alleles

Transposon Insertions

Formalized genetic data

l(2)s3475 << bk1 << auk << bk2 << Sec61β

Genetic mapping information

Comments

Breakpoint(s) molecularly mapped

(Goralski et al., 1989)

Comments on Cytology

Ref: Lindsley and Zimm, 1992

(Kania et al., 1995)

Left limit of break 1 from polytene analysis (FBrf0076124) Right limit of break 1 from inclusion of l(2)03563 (FBrf0067338) Limits of break 2 from polytene analysis (FBrf0049325)

Sequence Crossreferences

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

Gene Deletion and Duplication Data

Genes Deleted / Disrupted

Complementation Data

Completely deleted / disrupted

Asx

(Halachmi et al., 2007, Salinas et al., 1998, Sinclair et al., 1998, Duffy et al., 1996, Bilder and Scott, 1995, Soto et al., 1995, Cheng et al., 1994, Landecker et al., 1994, Simon et al., 1992)

auk

(Walsh and Brown, 1998, Prout et al., 1997)

Cpsf160

(Salinas et al., 1998)

(Chern and Choi, 2002)

l(2)k03906b

(BDGP Project Members, 1994-1999)

l(2)k16805

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

LamC

(Schulze et al., 2005)

Oaz

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

phyl

(Brumby et al., 2004, Dickson et al., 1996, Begemann et al., 1995, Chang et al., 1995, Dickson et al., 1995)

Tfb1

(Dickson et al., 1995)

tra2

(Mattox et al., 1996, Ryner et al., 1996, Oliver et al., 1993, Goralski et al., 1989)

ttv

(Schulze et al., 2005, Spradling et al., 1999, Bellaiche et al., 1998, Dickson et al., 1995, BDGP Project Members, 1994-1999)

Partially deleted / disrupted

Molecular Data

Completely deleted

Partially deleted

Genes NOT Deleted / Disrupted

Complementation Data

Molecular Data

Genes Duplicated

Complementation Data

Completely duplicated

Partially duplicated

Molecular Data

Completely duplicated

Partially duplicated

Genes NOT Duplicated

Complementation Data

Molecular Data

Affected Genes Inferred by Location

Related Comments

Phenotypic Data

In combination with other aberrations

NOT in combination with other aberrations

Df(2R)trix embryos from heterozygous mothers show segregation defects in anaphase and telophase as judged by the presence of chromatin bridges. These embryos show a higher level of "nuclear fallout", a process that removes nuclei with abnormal mitoses, than wild-type embryos. Fallout nuclei tend to be observed in pairs or clusters. There is no evidence of metaphase defects in these embryos and have a late telophase appearance.

(O'Dor et al., 2006)

Heterozygosity for Df(2R)trix results in 2.2% X chromosome nondisjunction and 1.0% fourth chromosome nondisjunction in In(1)FM7/X ; sv^spa-pol females.

(Harris et al., 2003)

Enhances the trx-G homeotic transformations of Df(3R)red1. Strongly enhances both the extra sex comb and abdominal segment transformation phenotypes of Pc⁴.

(Milne et al., 1999)

Does not cause unconditional lethality in hybrid females when heterozygous with D.simulans chromosome.

(Coyne et al., 1998)

No second site non-complementing phenotype with zip^Ebr and zip^mhc-c6.1.

(Halsell and Kiehart, 1998)

Shows no maternal enhancement of dpp^hr4.

(Nicholls and Gelbart, 1998)

Hemizygosity strongly suppresses the phl::tor^12D.hs.sev phenotype.

(Dickson et al., 1996)

Dominantly causes tergite defects in less than 50% of run³ heterozygotes.

(Duffy et al., 1996)

Suppressor of the dosage dependent (two or more copies of P{sev-svp1} or P{sev-svp2}) transformation of cone cells into R7 photoreceptors and at a lower frequency R7 cells into outer photoreceptors.

(Begemann et al., 1995)

Deficient embryos show a mutant midgut phenotype: central and posterior constrictions absent.

(Bilder and Scott, 1995)

Mutation does not affect the level of w expression in ph-p^lac+3 flies.

(Fauvarque et al., 1995)

Heterozygosity for this deletion has no effect on the mutant ovarian phenotype of ovo^D2.

(Pauli et al., 1995)

Homozygous trix larvae show abdominal setal-belt phenotype in thorax.

Stocks (3)

1896

106562

103286

Notes on Origin

Discoverer

B.S. Baker.

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

The Df(2R)trix chromosome acts as a dominant weak suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{w^var}KR3-2", a stable "brown-red" variant of the P{3'WP-2,w^var}2Lt insertion), but this is a false positive result (the suppressor is not within the bounds of the deficient region) because the region of the deficiency is covered by one or more nonsuppressing deficiencies.

(Mason et al., 2004)

Synonyms and Secondary IDs (10)

Reported As

Symbol Synonym

Df(2)TRIX

(Oliver et al., 1994, Oliver et al., 1993)

Df(2L)trix

(Garner et al., 2018)

Df(2R)^trix

(Hudry et al., 2019, Hudry et al., 2016)

Df(2R)TRIX

(Andrews and Oliver, 2002, Rabinow et al., 1991)

Df(2R)Trix

(Bielinska et al., 2005, Artero et al., 2003, The et al., 1999, Bellaiche et al., 1998, Crozatier et al., 1996, Simon et al., 1992)

Df(2R)trix

(Martín et al., 2011, Sarno et al., 2011, Gurudatta et al., 2010, Ruiz and Sanchez, 2010, Sinclair et al., 2009, Crest et al., 2007, Halachmi et al., 2007)

Df(trix)

(O'Dor et al., 2006)

DfTRIX

(Pane et al., 2005, Waterbury et al., 2000)

tra-2^Df

(Waterbury et al., 2000)

Name Synonyms

Deficiency (2R) transformer intersex

Secondary FlyBase IDs

References (85)

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