Aberration Dmel\Df(2R)trix
| General Information | |||
|---|---|---|---|
| Symbol | Dmel\Df(2R)trix | Species | D. melanogaster |
| Name | Deficiency (2R) transformer intersex | FlyBase ID | FBab0002231 |
| Feature type | chromosomal_deletion | ||
| Also Known As | DfTRIX, Df(2)TRIX | ||
| Computed Breakpoints include | 51A2;51B6 | ||
| Deleted segment | 51A2--51B6 | ||
| Sequence coordinates | |||
| Member of large scale dataset(s) | |||
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| Description |
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| FB2013_03 | |||
| FB2013_02 | |||
| All updates | Click here to see a list of all updates to this record from FB2010_08 and on. | ||
Nature of the Aberration
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| Cytological Order | |||
| Progenitor | |||
| Mutagen | |||
| Class of aberration (relative to progenitor) | (Goralski et al., 1989, Rabinow et al., 1991, Smith et al., 1993, Kania et al., 1995, Pauli et al., 1995, Granadino et al., 1992, Duffy et al., 1996, Crozatier et al., 1996, Harbecke and Lengyel, 1995, Landecker et al., 1994, Prout et al., 1997, Nestoras et al., 1997, Salinas et al., 1998, Schupbach and Wieschaus, 1989) | ||
| Breakpoints | 51A1-51A2;51B6 51A1;51B6 51A2-51A4;51B6 [];51B6 | ||
| Causes alleles | |||
| Carries alleles | |||
| Transposon Insertions | |||
| Formalized genetic data | l(2)s3475 << bk1 << auk << bk2 << Sec61β | ||
| Genetic mapping information | |||
| Comments | Breakpoint(s) molecularly mapped | ||
Comments on Cytology
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Ref: Lindsley and Zimm, 1992 Left limit of break 1 from polytene analysis (FBrf0076124) Right limit of break 1 from inclusion of l(2)03563 (FBrf0067338) Limits of break 2 from polytene analysis (FBrf0049325) | |||
Sequence Crossreferences
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EMBL / GenBank | DNA sequence Protein sequence Name | ||
Gene Deletion & Duplication Data
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Genes Deleted / Disrupted
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| Complementation Data | |||
| Completely deleted / disrupted | |||
| Molecular Data | |||
Genes NOT Deleted / Disrupted
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| Complementation Data | |||
| Molecular Data | |||
Genes Duplicated
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| Complementation Data | |||
| Molecular Data | |||
Genes NOT Duplicated
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| Complementation Data | |||
| Molecular Data | |||
Related Comments
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Phenotypic Data
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| In combination with other aberrations | |||
| NOT in combination with other aberrations | Df(2R)trix embryos from heterozygous mothers show segregation defects in anaphase and telophase as judged by the presence of chromatin bridges. These embryos show a higher level of "nuclear fallout", a process that removes nuclei with abnormal mitoses, than wild-type embryos. Fallout nuclei tend to be observed in pairs or clusters. There is no evidence of metaphase defects in these embryos and have a late telophase appearance. Heterozygosity for Df(2R)trix results in 2.2% X chromosome nondisjunction and 1.0% fourth chromosome nondisjunction in In(1)FM7/X ; svspa-pol females. Enhances the trx-G homeotic transformations of Df(3R)red1. Strongly enhances both the extra sex comb and abdominal segment transformation phenotypes of Pc4. Does not cause unconditional lethality in hybrid females when heterozygous with D.simulans chromosome. No second site non-complementing phenotype with zipEbr and zipmhc-c6.1. Shows no maternal enhancement of dpphr4. Hemizygosity strongly suppresses the phl::tor12D.hs.sev phenotype. Dominantly causes tergite defects in less than 50% of run3 heterozygotes. Suppressor of the dosage dependent (two or more copies of P{sev-svp1} or P{sev-svp2}) transformation of cone cells into R7 photoreceptors and at a lower frequency R7 cells into outer photoreceptors. Deficient embryos show a mutant midgut phenotype: central and posterior constrictions absent. Heterozygosity for this deletion has no effect on the mutant ovarian phenotype of ovoD2. Homozygous trix larvae show abdominal setal-belt phenotype in thorax. | ||
Stocks
( 3 ) | |||
| Bloomington | 1896 | ||
| Kyoto | 106562 103286 | ||
Notes on Origin
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| Discoverer | B.S. Baker. | ||
Balancer / Genotype Variants of the Aberration
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Separable Components
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Other Comments
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The Df(2R)trix chromosome acts as a dominant weak suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{wvar}KR3-2", a stable "brown-red" variant of the P{3'WP-2,wvar}2Lt insertion), but this is a false positive result (the suppressor is not within the bounds of the deficient region) because the region of the deficiency is covered by one or more nonsuppressing deficiencies. | |||
Synonyms & Secondary IDs
( 8 ) | |||
| Reported As | |||
| Symbol Synonym | Df(2)TRIX Df(2R)Trix Df(2R)TRIX Df(2R)trix Df(trix) DfTRIX tra-2Df | ||
| Name Synonym | Deficiency (2R) transformer intersex | ||
| Secondary FlyBase IDs | |||
References
( 81 ) | |||
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Recent research papers ( 1 ) | |||
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Recent Updates