A Database of Drosophila Genes & Genomes

FB2008_07, released August 8, 2008
 

Aberration Dmel\Df(2R)trix

General Information
SymbolDmel\Df(2R)trixSpeciesD. melanogaster
NameDeficiency (2R) transformer intersexFlyBase IDFBab0002231
Feature typechromosomal_deletionCreated / Updated2006-08-22/2006-08-22
Formalized genetic data l(2)s3475 << bk1 << auk << bk2 << Sec61β
Sequence coordinates
Deleted segment51A2--51B6
Duplicated segment
Computed Breakpoints include [];51B6 51A2;51B6
Breakpoints Inherited  
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Cytological Order
Progenitor
Mutagen
Class of aberration (relative to progenitor)
Breakpoints
Causes alleles
Carries alleles
Transposon Insertions
Genetic mapping information
Comments
Breakpoint(s) molecularly mapped
hide Comments on Cytology
Left limit of break 1 from polytene analysis (FBrf0076124) Right limit of break 1 from inclusion of l(2)03563 (FBrf0067338) Limits of break 2 from polytene analysis (FBrf0049325)
 
Ref: Lindsley and Zimm, 1992
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DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
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Complementation Data
Completely deleted / disrupted
Molecular Data
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Complementation Data
Molecular Data
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Complementation Data
Molecular Data
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Complementation Data
Molecular Data
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In combination with other aberrations
NOT in combination with other aberrations
Deficient embryos show a mutant midgut phenotype: central and posterior constrictions absent.
Does not cause unconditional lethality in hybrid females when heterozygous with D.simulans chromosome.
Dominantly causes tergite defects in less than 50% of run3 heterozygotes.
Enhances the trx-G homeotic transformations of Df(3R)red1. Strongly enhances both the extra sex comb and abdominal segment transformation phenotypes of Pc4.
Hemizygosity strongly suppresses the phl::tor12D.hs.sev phenotype.
Heterozygosity for Df(2R)trix results in 2.2% X chromosome nondisjunction and 1.0% fourth chromosome nondisjunction in In(1)FM7/X ; svspa-pol females.
Heterozygosity for this deletion has no effect on the mutant ovarian phenotype of ovoD2.
Homozygous trix larvae show abdominal setal-belt phenotype in thorax.
 
Mutation does not affect the level of w expression in ph-plac+3 flies.
No second site non-complementing phenotype with zipEbr and zipmhc-c6.1.
Shows no maternal enhancement of dpphr4.
Suppressor of the dosage dependent (two or more copies of P{sev-svp1} or P{sev-svp2}) transformation of cone cells into R7 photoreceptors and at a lower frequency R7 cells into outer photoreceptors.
Df(2R)trix embryos from heterozygous mothers show segregation defects in anaphase and telophase as judged by the presence of chromatin bridges. These embryos show a higher level of "nuclear fallout", a process that removes nuclei with abnormal mitoses, than wild-type embryos. Fallout nuclei tend to be observed in pairs or clusters. There is no evidence of metaphase defects in these embryos and have a late telophase appearance.
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hide Stocks ( 3 )
Bloomington
Kyoto
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Discoverer
B.S. Baker.
 
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      The Df(2R)trix chromosome acts as a dominant weak suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{wvar}KR3-2", a stable "brown-red" variant of the P{3'WP-2,wvar}2Lt insertion), but this is a false positive result (the suppressor is not within the bounds of the deficient region) because the region of the deficiency is covered by one or more nonsuppressing deficiencies.
      hide Synonyms & Secondary IDs ( 8 )
      Reported As
      Symbol Synonym
      Df(2R)trix
      Name Synonym
      Deficiency (2R) transformer intersex
       
      Secondary FlyBase IDs
        hide References ( 76 )
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        hide Recent research papers ( 2 )
        Crest et al., 2007, Genetics 175(2): 567--584
        Onset of the DNA replication checkpoint in the early Drosophila embryo. [FBrf0194644]
        O'Dor et al., 2006, Dev. Biol. 290(2): 312--322
        Polycomb Group mutants exhibit mitotic defects in syncytial cell cycles of Drosophila embryos. [FBrf0190149]