Aberration Dmel\Df(2R)vg-B

General Information
Symbol	Dmel\Df(2R)vg-B	Species	D. melanogaster
Name	Deficiency (2R) vestigial-Beaded	FlyBase ID	FBab0002233
Feature type	chromosomal_deletion	Created / Updated	2006-08-22/2006-08-22

Formalized genetic data	Nacα << bk1 << bic << sie << bk2 << drk
Sequence coordinates
Deleted segment	49D3--50A2
Duplicated segment
Computed Breakpoints include	49D3-49D4;50A2
Breakpoints Inherited
Nature of the Aberration
Cytological Order
Progenitor
Mutagen	spontaneous
Class of aberration (relative to progenitor)	chromosomal_deletion (Brunk and Adler, 1990, Rabinow et al., 1991, Rabinow and Birchler, 1990, Pauli et al., 1995, Bilder and Scott, 1995, Granadino et al., 1992, Bownes and Roberts, 1981, Harbecke and Lengyel, 1995, Mulligan et al., 1996, Abu-Issa and Cavicchi, 1996, Price et al., 1997)
Breakpoints	49D3-49D4;50A2-50A3 (Bownes and Roberts, 1981, Brunk and Adler, 1990, Abu-Issa and Cavicchi, 1996) 49D;50A (Rabinow and Birchler, 1990) 49C1-49C2;49E2-49E3 (Rabinow et al., 1991) 49D3-49D4;50A2-50A5 (Granadino et al., 1992) 49D3-49D4;49F15-50A3 (Pauli et al., 1995, Harbecke and Lengyel, 1995, Wu and Howe, 1995, Mulligan et al., 1996, Price et al., 1997)
Causes alleles
Carries alleles
Transposon Insertions
Genetic mapping information
Comments
Comments on Cytology
	Limits of break 1 from polytene analysis (FBrf0036848) Left limit of break 2 from polytene analysis (FBrf0036848) Right limit of break 2 from polytene analysis (citation unavailable) Uncovers the distal, but not the proximal, breakpoint of the In(2R)Arp1 inversion. (Brunk et al., 1991)
Molecularly Mapped Breakpoints

Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	Aats-val (BDGP Project Members, 1994-1999, Spradling et al., 1999) Dp (Lasko and Pardue, 1988, Hao et al., 1995, Royzman et al., 1997) lat (Lasko and Pardue, 1988, Boynton and Tully, 1992, Wu and Howe, 1995, Hao et al., 1995) bic (Tearle and Nusslein-Volhard, 1987, Lasko and Pardue, 1988, BDGP Project Members, 1994-1999, Spradling et al., 1999, Markesich et al., 2000) Aats-asp (Lasko and Pardue, 1988, BDGP Project Members, 1994-1999, Wu and Howe, 1995) vg (Lasko and Pardue, 1988, Rabinow and Birchler, 1990, Williams et al., 1990, Brunk et al., 1991, Staveley et al., 1995, Wu and Howe, 1995, Simmonds et al., 1997) Su(z)2 (BDGP Project Members, 1994-1999, Cheng et al., 1994, Wu and Howe, 1995, Spradling et al., 1999) Psc (Jurgens, 1985, Tearle and Nusslein-Volhard, 1987, Lasko and Pardue, 1988, Adler et al., 1989, Simon et al., 1992, BDGP Project Members, 1994-1999, Cheng et al., 1994, Harbecke and Lengyel, 1995, Wu and Howe, 1995, Spradling et al., 1999) Mdr49 (Wu and Howe, 1995) seq (Lasko and Pardue, 1988, Wu and Howe, 1995, Hao et al., 1995, Brenman et al., 2001) l(2)k09328 (BDGP Project Members, 1994-1999, Spradling et al., 1999) l(2)k05722 (BDGP Project Members, 1994-1999, Spradling et al., 1999) l(2)49Fa (Lasko and Pardue, 1988, Wu and Howe, 1995, Hao et al., 1995) l(2)49Fh (Lasko and Pardue, 1988, Wu and Howe, 1995, Hao et al., 1995) l(2)49Fb (Lasko and Pardue, 1988, Wu and Howe, 1995, Hao et al., 1995) l(2)49Fn (Lasko and Pardue, 1988) Su(z)3 (Wu and Howe, 1995) l(2)k17019a (BDGP Project Members, 1994-1999) l(2)49Fm (Lasko and Pardue, 1988, Hao et al., 1995) l(2)49Fj (Lasko and Pardue, 1988, Hao et al., 1995) l(2)49Dc (Lasko and Pardue, 1988, Wu and Howe, 1995) l(2)49Fl (Lasko and Pardue, 1988, Hao et al., 1995) l(2)49Fo (Lasko and Pardue, 1988, Hao et al., 1995) sie (Schupbach and Wieschaus, 1989, Schupbach and Wieschaus, 1991) l(2)49Fg (Lasko and Pardue, 1988, Wu and Howe, 1995, Hao et al., 1995) Cap-G (Lasko and Pardue, 1988, Wu and Howe, 1995, Hao et al., 1995, Dej et al., 2004)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	mam (BDGP Project Members, 1994-1999) shot (BDGP Project Members, 1994-1999, Prokop et al., 1998) fl(2)d (Granadino et al., 1992) drk (BDGP Project Members, 1994-1999, Heuer et al., 1995, Spradling et al., 1999) arr (BDGP Project Members, 1994-1999) stil (Mulligan et al., 1996) sca (Morgan et al., 1938) Sin3A (BDGP Project Members, 1994-1999, Spradling et al., 1999) NAT1 (BDGP Project Members, 1994-1999, Spradling et al., 1999) mwr (Rasooly, 1996) l(2)rQ029 (BDGP Project Members, 1994-1999) Go (Sturtevant, 1948) E(Egfr)B56 (Price et al., 1997) tum (Jones, 2005) Nacα (BDGP Project Members, 1994-1999, Spradling et al., 1999)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments
	Df(2R)CX1 fails to complement the P{lacW}Nrk^k14301 insertion line ("l(2)k14301"). (BDGP Project Members, 1994-1999)
Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations	Does not cause unconditional lethality in hybrid females when heterozygous with D.simulans chromosome. (Coyne et al., 1998) Does not exhibit dominant flightlessness. (Cripps and Sparrow, 1989) Dominant enhancer of nod^DTW. (Rasooly, 1995) Enhances BicD in heterozygotes (Mohler and Wieschaus, 1986) homozygous lethal Heterozygosity for this deletion has no effect on the mutant ovarian phenotype of ovo^D2. (Pauli et al., 1995) Heterozygous females produce embryos with defects in segmentation and head structure, and also a variable and occasionally very high proportion of undeveloped eggs. Bicaudal embryos are not seen. (Markesich et al., 2000) Homozygous embryos are very abnormal compared to wild-type. Differentiation of Malpighian tubule material is variable. (Harbecke and Lengyel, 1995) Homozygous lethal. Heterozygotes show occasional nicking of the wings. (Abu-Issa and Cavicchi, 1996) Midgut development of mutant embryos is wild type. (Bilder and Scott, 1995) Shows no maternal enhancement of dpp^hr4. (Nicholls and Gelbart, 1998)
Position Effect Variegation Data

Stocks ( 3 )
Bloomington	752 Df(2R)vg-B/SM5
Kyoto	106063 Df(2R)vg-B/SM5 101455 Df(2R)vg-B / SM5, al² Cy¹ lt^v cn² sp²
Notes on Origin
Discoverer	Bridges, 11 April 1928.

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments
	The Df(2R)vg-B chromosome may act as a dominant suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{w^var}KR3-2", a stable "brown-red" variant of the P{3'WP-2,w^var}2Lt insertion), but the eye colour phenotype in the presence of Df(2R)vg-B overlaps the eye colour phenotype in a wild-type background so it cannot be unequivocally demonstrated that the deficiency chromosome uncovers a suppressor of telomeric silencing. (Mason et al., 2004)
Synonyms & Secondary IDs ( 11 )
Reported As
Symbol Synonym	Df(2)vg^B (Saget et al., 1998) Df(2R)vg^B (Erhardt et al., 2003, Abrell et al., 2000, Hodgetts and O'Keefe, 2001, Sinclair et al., 1984, Wustmann et al., 1989, Abu-Issa and Cavicchi, 1996, Jurgens, 1985, Granadino et al., 1992, Williams et al., 1990, Wu and Howe, 1995, Staveley et al., 1995, Rabinow and Birchler, 1990, Rasooly, 1995, Adler et al., 1989, Rabinow et al., 1991, Schupbach and Wieschaus, 1991, Brunk and Adler, 1990, Schupbach and Wieschaus, 1989) Df(2R)vg^b (Tully et al., 1992) Df(2R)vgB (Jones, 2005, Renn et al., 1998, Hao et al., 1995, Pauli et al., 1995, Lasko and Pardue, 1988) Df(2R)Vg-B (Brenman et al., 2001) Df(2R)vg-B (Crest et al., 2007) Dfvg^B (Sturtevant, 1948) v^B (The Moscow Regional Drosophila melanogaster Stock Center, Dubna) vg^B (Bushey and Locke, 2004, Simmonds and Bell, 1998, Simmonds et al., 1997, Bownes and Roberts, 1981, Bazin et al., 1991, Adler et al., 1991, Bazin et al., 1993, Brunk et al., 1991) vgB (Markesich et al., 2000, Gajewski et al., 1990)
Name Synonym	Deficiency (2R) vestigial-Beaded
Secondary FlyBase IDs

References ( 75 )

Generate a list of	All references relating to this aberration ( 75 )

List References by type	Research paper ( 67 ) Abstract ( 3 ) FlyBase analysis ( 1 ) Stock list ( 2 ) Computer file ( 1 ) Book ( 1 )
Recent research papers ( 1 )
	Crest et al., 2007, Genetics 175(2): 567--584 Onset of the DNA replication checkpoint in the early Drosophila embryo. [FBrf0194644] Show all research papers ...