Aberration Dmel\Df(2R)vg-C

General Information
Symbol	Dmel\Df(2R)vg-C	Species	D. melanogaster
Name	Deficiency (2R) vestigial-Carved	FlyBase ID	FBab0002234
Feature type	chromosomal_deletion

Computed Breakpoints include	49B2-49B3;49E2
Deleted segment	49B2--49E2
Map ( GBrowse )	Untitled Document
Sequence coordinates	2R:8,408,228..8,449,635 (Df(2R)vg-C:bk1) (Yamamoto et al., 2009.2.25) 2R:8,827,958..8,836,560 (Df(2R)vg-C:bk2) (Yamamoto et al., 2009.2.25)
Recent Updates
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FB2012_01
FB2011_10
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Nature of the Aberration
Cytological Order
Progenitor
Mutagen	X ray
Class of aberration (relative to progenitor)	chromosomal_deletion (Rabinow and Birchler, 1990, Pauli et al., 1995, Wu and Howe, 1995, Duffy et al., 1996, Zars and Hyde, 1996, Bownes and Roberts, 1981, Pennetta and Pauli, 1997, Harbecke and Lengyel, 1995, Mulligan et al., 1996, Price et al., 1997)
Breakpoints	49A4-49A13;49E7-49F1 (Pauli et al., 1995, Pennetta and Pauli, 1997) 49B1-49B8;49E2-49F2 (Wu and Howe, 1995, Zars and Hyde, 1996) 49B2-49B3;49E7-49F1 (Bownes and Roberts, 1981, Harbecke and Lengyel, 1995, Duffy et al., 1996, Mulligan et al., 1996, Price et al., 1997) 49B;49E (Rabinow and Birchler, 1990)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data	bk1 << stil << Mdr49 << bk2 << Psc
Genetic mapping information
Comments	Breakpoint(s) molecularly mapped (Wu et al., 1991)
Comments on Cytology
	The left Df(2R)vg-C breakpoint lies within CG8569, fra or CG30056 or in the region between CG8569 and CG30056, and lies in the range 2R:8408228..8449635 (R5) (predicted cytology: 49A10-B3). (Yamamoto et al., 2009.2.25) The right Df(2R)vg-C breakpoint lies within Mdr49 or CG3884 or in the region between Mdr49 and CG3884, and lies in the range 2R:8827958..8836560 (R5) (predicted cytology: 49E1-4). (Yamamoto et al., 2009.2.25) Uncovers the proximal, but not the distal, breakpoint of the In(2R)Arp1 inversion. (Brunk et al., 1991) Left limit of break 1 from polytene analysis (FBrf0036848) Right limit of break 1 from inclusion of stil (FBrf0089756) Left limit of break 2 from polytene analysis (FBrf0082794) Right limit of break 2 from non-inclusion of Psc (FBrf0043317)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	Aats-asp (Lasko and Pardue, 1988, Wu and Howe, 1995) Amph (Razzaq et al., 2001) bic (Lasko and Pardue, 1988) E(Egfr)B56 (Price et al., 1997) fra (Ratnaparkhi et al., 2002) Gα49B (Ratnaparkhi et al., 2002, Kain et al., 2008) l(2)49Dc (Lasko and Pardue, 1988, Wu and Howe, 1995) l(2)00434a (BDGP Project Members, 1994-1999) Mdr49 (Wu et al., 1991) ox (Castrillon et al., 1993) rdgE (Zars and Hyde, 1995, Zars and Hyde, 1996) sca (Rabinow and Birchler, 1990) Sin3A (Neufeld et al., 1998) stil (Mulligan et al., 1996, Pennetta and Pauli, 1997) Taz (Xu et al., 2006) vg (Lasko and Pardue, 1988, Rabinow and Birchler, 1990, Brunk et al., 1991, Wu and Howe, 1995)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	Cap-G (Lasko and Pardue, 1988) Dp (Lasko and Pardue, 1988) l(2)49Fa (Lasko and Pardue, 1988) l(2)49Fb (Lasko and Pardue, 1988) l(2)49Fg (Lasko and Pardue, 1988) l(2)49Fh (Lasko and Pardue, 1988) l(2)49Fj (Lasko and Pardue, 1988) l(2)49Fl (Lasko and Pardue, 1988) l(2)49Fm (Lasko and Pardue, 1988) l(2)49Fn (Lasko and Pardue, 1988) l(2)49Fo (Lasko and Pardue, 1988) lat (Lasko and Pardue, 1988) M(2)40c (Pasztor, 1976) mwr (Rasooly, 1996) Psc (Jurgens, 1985, Tearle and Nusslein-Volhard, 1987, Lasko and Pardue, 1988, BDGP Project Members, 1994-1999, Wu and Howe, 1995) seq (Brenman et al., 2001, Lasko and Pardue, 1988) shot (Prokop et al., 1998) Su(z)2 (Wu and Howe, 1995) Su(z)3 (Wu and Howe, 1995)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations	Fails to complement Df(2R)Amph-4A10. (Leventis et al., 2001) No effect on In(1)w^m4h position-effect variegation. (Wustmann et al., 1989)
NOT in combination with other aberrations	The Df(2R)vg-C chromosome does not act as a dominant suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{w^var}KR3-2", a stable "brown-red" variant of the P{3'WP-2,w^var}2Lt insertion). (Mason et al., 2004) Df(2R)vg-C/Df(2R)vg-C embryos exhibit thinner central nervous system commissures and extensive breaks in the axonal longitudinal tracts. (Ratnaparkhi et al., 2002) Does not cause unconditional lethality in hybrid females when heterozygous with D.simulans chromosome. (Coyne et al., 1998) Weak second site non-complementing phenotype with zip^Ebr and zip^mhc-c6.1: malformed phenotype penetrance 10-24%. (Halsell and Kiehart, 1998) Shows no maternal enhancement of dpp^hr4. (Nicholls and Gelbart, 1998) Enhances the phenotype of dominant ovo alleles. (Pennetta and Pauli, 1997) Complementation tests with E(Egfr)B56^B56 reveal defects in wing vein L2, L4 and L5. (Price et al., 1997) Dominantly causes tergite defects in less than 50% of run³ heterozygotes. (Duffy et al., 1996) Heterozygotes with rdgE¹ exhibit absence of a deep pseudopupil after 7 days in constant light. (Zars and Hyde, 1996) Heterozygosity for this deletion enhances the mutant ovarian phenotype of ovo^D2. (Pauli et al., 1995) Does not exhibit dominant flightlessness. (Cripps and Sparrow, 1989) homozygous lethal
Stocks ( 4 )
Bloomington	753 Df(2R)vg-C/In(2LR)Rev^B 754 Df(2R)vg-C/CyO, P{sevRas1.V12}FK1
Kyoto	106064 Df(2R)vg-C/In(2LR)Rev^B 108915 Df(2R)vg-C/CyO, P{sevRas1.V12}FK1
Notes on Origin
Discoverer	Demerec, 3 Mar. 1928.

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

Synonyms & Secondary IDs ( 11 )
Reported As
Symbol Synonym	Df(2R)vg^c (Wustmann et al., 1989) Df(2R)vg^C (Pennetta and Pauli, 1997, Zars and Hyde, 1996, Jurgens, 1985, Wu and Howe, 1995, Rabinow and Birchler, 1990, Rabinow et al., 1991, Brunk and Adler, 1990) df(2R)vg-C (Mathew et al., 2003) Df(2R)Vg-C (Brenman et al., 2001, Li et al., 2000) Df(2R)vg-c (Gildea et al., 2000) Df(2R)vgC (Renn et al., 1998, Pauli et al., 1995, Schupbach and Wieschaus, 1991, Schupbach and Wieschaus, 1989) Df(2R)vg-C (Xu et al., 2006, Crest et al., 2007, Yamamoto et al., 2009.2.25, Kain et al., 2008, Keuling et al., 2007) vg^C (Bownes and Roberts, 1981, Brunk et al., 1991) vg-C (Leventis et al., 2001) vgC (Gajewski et al., 1990)
Name Synonym	Deficiency (2R) vestigial-Carved
Secondary FlyBase IDs

References ( 67 )

Generate a list of	All references relating to this aberration ( 67 )

List References by type	Research paper ( 59 ) Review ( 1 ) Personal communication to FlyBase ( 1 ) Abstract ( 2 ) FlyBase analysis ( 1 ) Stock list ( 1 ) Computer file ( 1 ) Book ( 1 )
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