FlyBase Aberration Report: Dmel\Df(2R)vg-C

General Information

Symbol

Df(2R)vg-C

Species

D. melanogaster

Name

Deficiency (2R) vestigial-Carved

FlyBase ID

FBab0002234

Feature type

chromosomal_deletion

Also Known As

Df(2R)vg^c, Df(2R)vgC, vg-C, vg^C

Computed Breakpoints include

49B2-49B3;49E2

Features within 49B2--49E2

Genomic Maps

JBrowse

Sequence coordinates

2R:12,520,723..12,562,130 (Df(2R)vg-C:bk1)

(Yamamoto et al., 2009.2.25)

2R:12,940,453..12,949,055 (Df(2R)vg-C:bk2)

(Yamamoto et al., 2009.2.25)

Member of large scale dataset(s)

Nature of Aberration

Cytological Order

Progenitor

Mutagen

X ray

Class of aberration (relative to wild type)

chromosomal_deletion

(FlyBase, 2007)

Class of aberration (relative to progenitor)

chromosomal_deletion

(Pennetta and Pauli, 1997, Price et al., 1997, Duffy et al., 1996, Mulligan et al., 1996, Zars and Hyde, 1996, Harbecke and Lengyel, 1995, Pauli et al., 1995, Wu and Howe, 1995, Rabinow and Birchler, 1990, Bownes and Roberts, 1981)

Breakpoints

49B2-49B3;49E7-49F1

(Price et al., 1997, Duffy et al., 1996, Mulligan et al., 1996, Harbecke and Lengyel, 1995, Bownes and Roberts, 1981)

49B;49E

(Rabinow and Birchler, 1990)

49A4-49A13;49E7-49F1

(Pennetta and Pauli, 1997, Pauli et al., 1995)

49B1-49B8;49E2-49F2

(Zars and Hyde, 1996, Wu and Howe, 1995)

Causes alleles

Carries alleles

Transposon Insertions

Formalized genetic data

bk1 << stil << Mdr49 << bk2 << Psc

Genetic mapping information

Comments

This deletion removes a single ribosomal protein-coding gene (though other genes are also removed).

(Marygold et al., 2007)

Breakpoint(s) molecularly mapped

(Wu et al., 1991)

Comments on Cytology

The left Df(2R)vg-C breakpoint lies within CG8569, fra or CG30056 or in the region between CG8569 and CG30056, and lies in the range 2R:8408228..8449635 (R5) (predicted cytology: 49A10-B3).

(Yamamoto et al., 2009.2.25)

The right Df(2R)vg-C breakpoint lies within Mdr49 or CG3884 or in the region between Mdr49 and CG3884, and lies in the range 2R:8827958..8836560 (R5) (predicted cytology: 49E1-4).

(Yamamoto et al., 2009.2.25)

Uncovers the proximal, but not the distal, breakpoint of the In(2R)Arp1 inversion.

(Brunk et al., 1991)

Left limit of break 1 from polytene analysis (FBrf0036848) Right limit of break 1 from inclusion of stil (FBrf0089756) Left limit of break 2 from polytene analysis (FBrf0082794) Right limit of break 2 from non-inclusion of Psc (FBrf0043317)

Sequence Crossreferences

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

Gene Deletion and Duplication Data

Genes Deleted / Disrupted

Complementation Data

Completely deleted / disrupted

Partially deleted / disrupted

Molecular Data

Completely deleted

mRpL18

(Marygold et al., 2007)

Partially deleted

Genes NOT Deleted / Disrupted

Complementation Data

Molecular Data

Genes Duplicated

Complementation Data

Completely duplicated

Partially duplicated

Molecular Data

Completely duplicated

Partially duplicated

Genes NOT Duplicated

Complementation Data

Molecular Data

Affected Genes Inferred by Location (80)

Related Comments

Phenotypic Data

In combination with other aberrations

Fails to complement Df(2R)Amph-4A10.

(Leventis et al., 2001)

No effect on In(1)w^m4h position-effect variegation.

(Wustmann et al., 1989)

NOT in combination with other aberrations

Flies heterozygous for the deletion do not show a Minute bristle phenotype.

(Marygold et al., 2007)

The Df(2R)vg-C chromosome does not act as a dominant suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{w^var}KR3-2", a stable "brown-red" variant of the P{3'WP-2,w^var}2Lt insertion).

(Mason et al., 2004)

Df(2R)vg-C/Df(2R)vg-C embryos exhibit thinner central nervous system commissures and extensive breaks in the axonal longitudinal tracts.

(Ratnaparkhi et al., 2002)

Does not cause unconditional lethality in hybrid females when heterozygous with D.simulans chromosome.

(Coyne et al., 1998)

Weak second site non-complementing phenotype with zip^Ebr and zip^mhc-c6.1 : malformed phenotype penetrance 10-24%.

(Halsell and Kiehart, 1998)

Shows no maternal enhancement of dpp^hr4.

(Nicholls and Gelbart, 1998)

Enhances the phenotype of dominant ovo alleles.

(Pennetta and Pauli, 1997)

Complementation tests with E(Egfr)B56^B56 reveal defects in wing vein L2, L4 and L5.

(Price et al., 1997)

Dominantly causes tergite defects in less than 50% of run³ heterozygotes.

(Duffy et al., 1996)

Heterozygotes with rdgE¹ exhibit absence of a deep pseudopupil after 7 days in constant light.

(Zars and Hyde, 1996)

Heterozygosity for this deletion enhances the mutant ovarian phenotype of ovo^D2.

(Pauli et al., 1995)

Does not exhibit dominant flightlessness.

(Cripps and Sparrow, 1989)

homozygous lethal

Stocks (4)

Bloomington

753

Df(2R)vg-C/In(2LR)Rev^B

754

Df(2R)vg-C/CyO, P{sevRas1.V12}FK1

Kyoto

106064

Df(2R)vg-C/In(2LR)Rev^B

108915

Df(2R)vg-C/CyO, P{sevRas1.V12}FK1

Notes on Origin

Discoverer

Demerec, 3 Mar. 1928.

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

Synonyms and Secondary IDs (12)

Reported As

Symbol Synonym

Df(2R)^vg-C

(Muraoka et al., 2018)

Df(2R)Vg-C

(Brenman et al., 2001, Li et al., 2000)

Df(2R)vg-C

(Ribot et al., 2022, Tan et al., 2020, Kahsai and Cook, 2018, Clough et al., 2014, Galindo et al., 2014, Fernandes and Rao, 2011, Yamamoto et al., 2009.2.25, Kain et al., 2008, Crest et al., 2007, Keuling et al., 2007, Xu et al., 2006)

Df(2R)vg-c

(Gildea et al., 2000)

Df(2R)vg^C

(Pennetta and Pauli, 1997, Zars and Hyde, 1996, Wu and Howe, 1995, Rabinow et al., 1991, Brunk and Adler, 1990, Rabinow and Birchler, 1990, Jurgens, 1985)

Df(2R)vg^c

(Wustmann et al., 1989)

Df(2R)vgC

(Renn et al., 1998, Pauli et al., 1995, Schupbach and Wieschaus, 1991, Schupbach and Wieschaus, 1989)

df(2R)vg-C

(Mathew et al., 2003)

vg-C

(Yamada et al., 2023, Leventis et al., 2001)

vg^C

(Brunk et al., 1991, Bownes and Roberts, 1981)

vgC

(Gajewski et al., 1990)

Name Synonyms

Deficiency (2R) vestigial-Carved

Secondary FlyBase IDs

References (77)

Report Sections

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