Aberration Dmel\Df(2R)vg-D

General Information
Symbol	Dmel\Df(2R)vg-D	Species	D. melanogaster
Name	Deficiency (2R) vestigial-Depilate	FlyBase ID	FBab0002235
Feature type	chromosomal_deletion
Also Known As	Df(2R)vg^D, vg^D, Df(2R)vgD

Computed Breakpoints include	49C1-49C2;49E6
Deleted segment	49C1--49E6
Sequence coordinates
Member of large scale dataset(s)
Recent Updates
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Nature of the Aberration
Cytological Order
Progenitor
Mutagen	spontaneous
Class of aberration (relative to progenitor)	chromosomal_deletion (Brunk and Adler, 1990, Rabinow and Birchler, 1990, Pauli et al., 1995, Wu and Howe, 1995, Zars and Hyde, 1996, Bownes and Roberts, 1981, Pennetta and Pauli, 1997, Price et al., 1997)
Breakpoints	49C1-49C2;49E2-49E6 (Bownes and Roberts, 1981, Schupbach and Wieschaus, 1989, Brunk and Adler, 1990, Pauli et al., 1995, Pennetta and Pauli, 1997) 49C1-49C2;49E4-49E5 (Price et al., 1997) 49C1-49D1;49E2-49F2 (Wu and Howe, 1995, Zars and Hyde, 1996) 49C;49E (Rabinow and Birchler, 1990) 49D3-49D4;50A2-50A3 (Rabinow et al., 1991)
Causes alleles	Psc^vgD (Simon et al., 1992, Lopez et al., 2001) Su(z)2^vgD (Wu and Howe, 1995, Brunk et al., 1991, Adler et al., 1989)
Carries alleles
Transposon Insertions
Formalized genetic data	rdgE << bk1 << E(Egfr)B56 << Su(z)2 << bk2 << Psc
Genetic mapping information
Comments	Breakpoint(s) molecularly mapped (Brunk and Adler, 1990)
Comments on Cytology
	Ref: FBrf0050577. (Wu and Howe, 1995) Limits of break 1 from polytene analysis (FBrf0036848) Left limit of break 2 from inclusion of Su(z)2 (FBrf0049524) Right limit of break 2 from polytene analysis (FBrf0036848)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	Aats-asp (Lasko and Pardue, 1988, Wu and Howe, 1995) bic (Tearle and Nusslein-Volhard, 1987, Lasko and Pardue, 1988) E(Egfr)B56 (Price et al., 1997) l(2)49Dc (Lasko and Pardue, 1988, Wu and Howe, 1995) Mdr49 (Wu et al., 1991, Wu and Howe, 1995) Psc (Jurgens, 1985, Tearle and Nusslein-Volhard, 1987, Lasko and Pardue, 1988, Adler et al., 1989, BDGP Project Members, 1994-1999, Wu and Howe, 1995) sca (Rabinow and Birchler, 1990) vg (Lasko and Pardue, 1988, Rabinow and Birchler, 1990, Brunk et al., 1991, Wu and Howe, 1995)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	Cap-G (Lasko and Pardue, 1988, Wu and Howe, 1995) Dp (Lasko and Pardue, 1988) l(2)49Fa (Lasko and Pardue, 1988, Wu and Howe, 1995) l(2)49Fb (Lasko and Pardue, 1988, Wu and Howe, 1995) l(2)49Fg (Lasko and Pardue, 1988, Wu and Howe, 1995) l(2)49Fh (Lasko and Pardue, 1988, Wu and Howe, 1995) l(2)49Fj (Lasko and Pardue, 1988) l(2)49Fl (Lasko and Pardue, 1988) l(2)49Fm (Lasko and Pardue, 1988) l(2)49Fn (Lasko and Pardue, 1988) l(2)49Fo (Lasko and Pardue, 1988) lat (Lasko and Pardue, 1988, Wu and Howe, 1995) mwr (Rasooly, 1996) rdgE (Zars and Hyde, 1995, Zars and Hyde, 1996) seq (Lasko and Pardue, 1988, Wu and Howe, 1995) shot (Prokop et al., 1998) Su(z)2 (Wu and Howe, 1995)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations	Lethal in combination with Df(2R)Su(z)2⁵. (Wu and Howe, 1995)
NOT in combination with other aberrations	The Df(2R)vg-D chromosome acts as a dominant weak suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{w^var}KR3-2", a stable "brown-red" variant of the P{3'WP-2,w^var}2Lt insertion). (Mason et al., 2004) Has no effect on the phenotype of dominant ovo alleles. (Pennetta and Pauli, 1997) Complementation tests with E(Egfr)B56^B56 reveal defects in wing vein L2, L4 and L5. (Price et al., 1997) Heterozygotes with rdgE¹ exhibit presense of a deep pseudopupil after 7 days in constant light. (Zars and Hyde, 1996) Heterozygosity for this deletion has no effect on the mutant ovarian phenotype of ovo^D2. (Pauli et al., 1995) Strong notum bristle loss phenotype. Phenotype enhanced after heat shock when in combination with Su(z)2^hs.PS. (Sharp et al., 1994) Macrochaetae on the dorsal thorax are lost or reduced in size, a loss or duplication of bristles on the femur and tibia and a reduction in the number of frontal and postorbital bristles on the head is evident. (Brunk et al., 1991) Greatly enhances dorsal dominant phenotype of dl mutant embryos. (Steward and Nusslein-Volhard, 1986) Heterozygotes have sparse hairs and bristles on the thorax. (Bownes and Roberts, 1981) Enhances BicD in heterozygotes (Mohler and Wieschaus, 1986, Genetics 112: 803-22) Df(2R)vg^D/+ flies show dominant flightlessness (Cripps and Sparrow, 1989, Dev. Genet. 10: 98-105) and loss of bristles on legs and anterior dorsal thorax (Morgan, et al., 1938) homozygous lethal
Stocks ( 3 )
Bloomington	434 Df(2R)vg-D, Psc^vgD Su(z)2^vgD/CyO, P{sevRas1.V12}FK1
Kyoto	105911 Df(2R)vg-D, Psc^vgD Su(z)2^vgD/SM5 101456 Df(2R)vg-D / SM5, al² Cy¹ lt^v cn² sp²
Notes on Origin
Discoverer	Bridges, 22 Jan. 1931.

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments
	Removes most of the Psc transcription unit. (Simon et al., 1992) Deletion ends within 20kb proximal to the distal break of In(2R)Arp1. (Brunk et al., 1991)
Synonyms & Secondary IDs ( 8 )
Reported As
Symbol Synonym	cvg^D (Sharp et al., 1994) Df(2)vgD (Culi et al., 2006) Df(2R)vg^D (Pennetta and Pauli, 1997, Zars and Hyde, 1996, Jurgens, 1985, Hu et al., 1995, Wu and Howe, 1995, Soto et al., 1995, Rabinow and Birchler, 1990, Adler et al., 1989, Rabinow et al., 1991, Schupbach and Wieschaus, 1991, Brand and Campos-Ortega, 1990, Schupbach and Wieschaus, 1989, Steward and Nusslein-Volhard, 1986, Brunk and Adler, 1990, Simon et al., 1992) Df(2R)vgD (Pauli et al., 1995, Lasko and Pardue, 1988, Jager et al., 2005) Df(2R)vg-D Df(2vgD) (Bejarano and Busturia, 2004) vg^D (Bownes and Roberts, 1981, Adler et al., 1991, Brunk et al., 1991, )
Name Synonym	Deficiency (2R) vestigial-Depilate
Secondary FlyBase IDs
	FBal0033091
References ( 42 )

Generate a list of	All references relating to this aberration ( 42 )

List References by type	Research paper ( 37 ) Personal communication to FlyBase ( 1 ) Abstract ( 1 ) FlyBase analysis ( 1 ) Stock list ( 1 ) Book ( 1 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2011 Show research papers ...