FlyBase Aberration Report: Dmel\Df(2R)vg135

General Information

Symbol

Df(2R)vg135

Species

D. melanogaster

Name

Deficiency (2R) vestigial

FlyBase ID

FBab0002246

Feature type

deficient_inversion

Also Known As

Df(2R)vg¹³⁵

Computed Breakpoints include

49A;49E1-49E2;47F4-47F18

Features within 49B2--49F1

Sequence coordinates

Member of large scale dataset(s)

Nature of Aberration

Cytological Order

Progenitor

Mutagen

gamma ray

(Lasko and Pardue, 1988)

Class of aberration (relative to wild type)

deficient_inversion

Class of aberration (relative to progenitor)

deficient_inversion

(Cook, 2003.1.20, Mulligan et al., 1996, Heiman and Beckingham, 1992)

chromosomal_deletion

(Pennetta and Pauli, 1997, Price et al., 1997, Duffy et al., 1996, Zars and Hyde, 1996, Harbecke and Lengyel, 1995, Kania et al., 1995, Pauli et al., 1995, Lee et al., 1994, Rabinow et al., 1991, Lasko and Pardue, 1988)

Breakpoints

48C-48D;49D

(Kania et al., 1995, Lee et al., 1994, Lasko and Pardue, 1988)

48D3;49D-49E

(Schupbach and Wieschaus, 1989)

48C-48D;49D1

(Price et al., 1997)

49B2-49B7;49E2-49F1;47F16-47F18

(Cook, 2003.1.20)

48D-48E;49D-49E

(Duffy et al., 1996, Rabinow et al., 1991)

49A-49B;49D-49E;47F4-48A

(Mulligan et al., 1996, Heiman and Beckingham, 1992)

49A;49D-49E

(Pennetta and Pauli, 1997, Pauli et al., 1995)

49A-49B;49D-49E

(Zars and Hyde, 1996, Harbecke and Lengyel, 1995)

Causes alleles

Carries alleles

Transposon Insertions

Formalized genetic data

Cam << bk1 << Gα49B << bk2 << Psc << nompA << bk3 << l(2)k06407

Genetic mapping information

Comments

This deletion removes a single ribosomal protein-coding gene (though other genes are also removed).

(Marygold et al., 2007)

Breakpoint(s) molecularly mapped

(Wu et al., 1991)

Comments on Cytology

Ref: Lindsley and Zimm, 1992

(Kania et al., 1995)

Left limit of break 1 from polytene analysis (FBrf0055685) Right limit of break 1 from polytene analysis (FBrf0082455) Right limit of break 2 from non-inclusion of Psc (FBrf0048224) Left limit of break 3 from polytene analysis (FBrf0055685)

Sequence Crossreferences

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

Gene Deletion and Duplication Data

Genes Deleted / Disrupted

Complementation Data

Completely deleted / disrupted

AspRS

(BDGP Project Members, 1994-1999, Lasko and Pardue, 1988)

bic

(BDGP Project Members, 1994-1999, Lasko and Pardue, 1988)

fdl

(Boquet et al., 2000)

fra

(Hummel et al., 1999)

Gαq

(Meyer et al., 2006, Zars and Hyde, 1996, Scott et al., 1995, Lee et al., 1994)

l(2)49Dc

(Lasko and Pardue, 1988)

l(2)k03003

(BDGP Project Members, 1994-1999)

l(2)k05722

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

l(2)k06407

(Pennetta and Pauli, 1997)

l(2)k17019a

(BDGP Project Members, 1994-1999)

Mdr49

(Wu et al., 1991)

Nacα

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

NAT1

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

qvr

(Humphreys et al., 1996)

rdgE

(Zars and Hyde, 1996, Zars and Hyde, 1995)

Sin3A

(Spradling et al., 1999, Neufeld et al., 1998, Pennetta and Pauli, 1997, BDGP Project Members, 1994-1999)

spt4

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

stil

(Pennetta and Pauli, 1997, Mulligan et al., 1996, Schupbach and Wieschaus, 1991)

unch

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

(Lasko and Pardue, 1988)

Partially deleted / disrupted

Molecular Data

Completely deleted

mRpL18

(Marygold et al., 2007)

Partially deleted

Genes NOT Deleted / Disrupted

Complementation Data

Cam

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Cap-G

(Lasko and Pardue, 1988)

CCT5

(BDGP Project Members, 1994-1999)

(Lasko and Pardue, 1988)

E(Egfr)B56

(Price et al., 1997)

eEF1α1

(BDGP Project Members, 1994-1999)

fdl

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

jeb

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

l(2)49Fa

(Lasko and Pardue, 1988)

l(2)49Fb

(Lasko and Pardue, 1988)

l(2)49Fg

(Lasko and Pardue, 1988)

l(2)49Fh

(Lasko and Pardue, 1988)

l(2)49Fj

(Lasko and Pardue, 1988)

l(2)49Fl

(Lasko and Pardue, 1988)

l(2)49Fm

(Lasko and Pardue, 1988)

l(2)49Fn

(Lasko and Pardue, 1988)

l(2)49Fo

(Lasko and Pardue, 1988)

l(2)06424

(BDGP Project Members, 1994-1999)

l(2)k03003

(Spradling et al., 1999)

l(2)k06612

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

l(2)k08317

(BDGP Project Members, 1994-1999)

l(2)k09328

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

l(2)rQ029

(BDGP Project Members, 1994-1999)

mam

(BDGP Project Members, 1994-1999)

Nnp-1

(BDGP Project Members, 1994-1999)

Orc3

(Lasko and Pardue, 1988)

pds5

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Psc

(Spradling et al., 1999, BDGP Project Members, 1994-1999, Lasko and Pardue, 1988)

seq

(Lasko and Pardue, 1988)

SmD3

(BDGP Project Members, 1994-1999)

Su(z)2

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

unch

(Kania et al., 1995)

ValRS

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

wst

(Ohsako and Yamamoto, 2011)

Molecular Data

Genes Duplicated

Complementation Data

Completely duplicated

Partially duplicated

Molecular Data

Completely duplicated

Partially duplicated

Genes NOT Duplicated

Complementation Data

Molecular Data

Affected Genes Inferred by Location (0)

If no genes are listed here, it may be because the affected region is very large. The JBrowse insert above may show an error for the same reason, and other FlyBase tools such as CytoSearch may also fail for large regions. You can contact FlyBase for more help.
In these cases, there will be no "Export to Hitlist" button to the left.

Related Comments

Fails to complement nompA mutants.

(Kernan et al., 1996)

Phenotypic Data

In combination with other aberrations

NOT in combination with other aberrations

Flies heterozygous for the deletion do not show a Minute bristle phenotype.

(Marygold et al., 2007)

Heterozygosity for Df(2R)vg135 results in 2.7% X chromosome nondisjunction and 1.9% fourth chromosome nondisjunction in In(1)FM7/X ; sv^spa-pol females.

(Harris et al., 2003)

Heterozygous adults show fusion of the β lobes in the central brain with intermediate penetrance.

(Boquet et al., 2000)

No second site non-complementing phenotype with zip^Ebr and zip^mhc-c6.1.

(Halsell and Kiehart, 1998)

Shows no maternal enhancement of dpp^hr4.

(Nicholls and Gelbart, 1998)

Enhances the phenotype of dominant ovo alleles.

(Pennetta and Pauli, 1997)

Dominantly causes tergite defects in less than 50% of run³ heterozygotes.

(Duffy et al., 1996)

Homozygous lethal. Heterozygotes with rdgE¹ exhibit absence of a deep pseudopupil after 7 days in constant light.

(Zars and Hyde, 1996)

Deficient embryos show a variably penetrant mutant midgut phenotype: incomplete constriction formation.

(Bilder and Scott, 1995)

Homozygous embryos show abnormal head epithelium differentiation.

(Harbecke and Lengyel, 1995)

Heterozygosity for this deletion enhances the mutant ovarian phenotype of ovo^D2.

(Pauli et al., 1995)

Homozygous lethal.

(Lee et al., 1994)

Does not exhibit dominant flightlessness.

(Cripps and Sparrow, 1989)

homozygous lethal

Stocks (3)

Bloomington

1642

Df(2R)vg135, nompA^vg135/CyO, S^* bw¹

Kyoto

106425

Df(2R)vg135, nompA^vg135/CyO, S^* bw¹

103287

Df(2R)vg135 / CyO, S¹ dpy^ov1 cn² bw¹

Notes on Origin

Discoverer

Associated with: nompA^vg135.

(Chung et al., 2001)

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

The Df(2R)vg135 chromosome may act as a dominant suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{w^var}KR3-2", a stable "brown-red" variant of the P{3'WP-2,w^var}2Lt insertion), but the eye colour phenotype in the presence of Df(2L)Prl overlaps the eye colour phenotype in a wild-type background so it cannot be unequivocally demonstrated that the deficiency chromosome uncovers a suppressor of telomeric silencing. In addition, the deficiency chromosome fails to complement lethal mutations of l(2)gl.

(Mason et al., 2004)

"49B2--7;49E2--F1;47F16--18" was stated as revision.

(Cook, 2003.1.20)

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

Df(2)vg135

(Frolov et al., 2000)

Df(2R)vg135

(Li et al., 2020, Tan et al., 2020, O'Donnell and Bashaw, 2013, Ohsako and Yamamoto, 2011, Elsaesser et al., 2010, Crest et al., 2007, Goodliffe et al., 2007, Meyer et al., 2006)

Df(2R)vg¹³⁵

(Pennetta and Pauli, 1997, Zars and Hyde, 1996, Lee et al., 1994, Rabinow et al., 1991)

FBab0024857

In(2R)vg135

(Chung et al., 2001)

In(2R)vg¹³⁵

(Ruan et al., 2017, Kernan et al., 1996)

Name Synonyms

Deficiency (2R) vestigial

Secondary FlyBase IDs

FBab0024398

References (60)

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