Aberration Dmel\Df(3L)BK10

General Information
Symbol	Dmel\Df(3L)BK10	Species	D. melanogaster
Name		FlyBase ID	FBab0002293
Feature type	chromosomal_deletion
Also Known As	BK10

Computed Breakpoints include	71C3;71E5
Deleted segment	71C3--71E5
Sequence coordinates
Member of large scale dataset(s)
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Aberration
Cytological Order
Progenitor	Dp(3;3)S2 (Leicht and Bonner, 1988)
Mutagen	X ray (Leicht and Bonner, 1988)
Class of aberration (relative to progenitor)	chromosomal_deletion (Leicht and Bonner, 1988, Pauli et al., 1995, Duffy et al., 1996, Tear et al., 1996, Andrew et al., 1997, Rose et al., 1997, Zhimulev et al., 1997.9.29, Zhimulev et al., 1998)
Breakpoints	71C1-71C2;71F4 (Rose et al., 1997) 71C1-71C2;71F4-71F5 (Leicht and Bonner, 1988, Tear et al., 1996) 71C1-72C2;71F4-71F5 (Andrew et al., 1997) 71C3;71E5 (Zhimulev et al., 1997.9.29, Zhimulev et al., 1998) 71C;71F (Pauli et al., 1995, Duffy et al., 1996)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data	bk1 << mrn << bk2 << brm
Genetic mapping information
Comments
Comments on Cytology
	All limits from polytene analysis (FBrf0098597)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	comm (Tear et al., 1996) CrebA (Andrew et al., 1997, Rose et al., 1997) dop (Galewsky and Schulz, 1992) fsl (Bucciarelli et al., 2003) mrn (Bloomington Drosophila Stock Center, 1999.6.23) Z600 (Grosshans and Wieschaus, 2000, Grosshans et al., 2003)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	Arl1 (Melendez et al., 1995) brm (Brumby et al., 2004, Melendez et al., 1995) DNApol-δ (Melendez et al., 1995) Hip14 (Melendez et al., 1995) l(3)72Ab (Melendez et al., 1995) l(3)72CDb (Melendez et al., 1995) l(3)72CDc (Melendez et al., 1995) mib1 (Melendez et al., 1995) Notum (Melendez et al., 1995) th (Melendez et al., 1995) Trl (Brumby et al., 2004)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations	Df(3L)BK10/Df(3L)ri-79c embryos show a failure to form a ventral furrow. The mesoderm primordium is internalised late. (Seher and Leptin, 2000) Df(3L)A5 complements Df(3L)Brd6 and Df(3L)Brd18 but not Df(3L)Brd20 or Df(3L)BK10. Df(3L)Q26 and Df(3L)A27 fail to complement Df(3L)Brd6, Df(3L)Brd18, Df(3L)Brd20 and Df(3L)BK10. (Melendez et al., 1995)
NOT in combination with other aberrations	88% of mutant embryos have an open ventral furrow phenotype. (Gawlinski et al., 2007) The Df(3L)BK10 chromosome does not act as a dominant suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{w^var}KR3-2", a stable "brown-red" variant of the P{3'WP-2,w^var}2Lt insertion). (Mason et al., 2004) The Df(3L)BK10 mutation induces premature mitosis in cells that form the ventral furrow. Among Df(3L)BK10 embryos, there is a small fraction containing patches of higher nuclear density which appear to be due to an extra (14th) cleavage division prior to cellularization. The nuclei/cells that divide only 13 times are more advanced than the nuclei that go through an additional mitosis and enter gastrulation later. (Grosshans et al., 2003) Heterozygosity for Df(3L)BK10 results in 0.4% X chromosome nondisjunction and 0.0% fourth chromosome nondisjunction in In(1)FM7/X ; sv^spa-pol females. (Harris et al., 2003) Homozygous mutants embryos show a failure to form a ventral furrow. The mesoderm primordium is internalised late. (Seher and Leptin, 2000) No second site non-complementing phenotype with zip^Ebr and zip^mhc-c6.1. (Halsell and Kiehart, 1998) The larval cuticle of homozygotes is weak, as seen by frequent holes at random positions in the exoskeleton. (Andrew et al., 1997) Dominantly causes tergite defects in less than 50% of run³ heterozygotes. (Duffy et al., 1996) Midgut development of mutant embryos is wild type. (Bilder and Scott, 1995) Heterozygosity for this deletion has no effect on the mutant ovarian phenotype of ovo^D2. (Pauli et al., 1995)
Stocks ( 2 )
Bloomington	2992 Df(3L)Ly, Df(3L)BK10, ru¹ sens^Ly-1 red¹ cv-c¹ Sb^sbd-1 sr¹ e¹/TM3, Sb¹
Kyoto	107513 Df(3L)Ly, Df(3L)BK10, ru¹ sens^Ly-1 red¹ cv-c¹ Sb^sbd-1 sr¹ e¹ / TM3, Sb¹
Notes on Origin
Discoverer

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments
	"71C3;71E5" was stated as revision. (Zhimulev et al., 1997.9.29, Zhimulev et al., 1998)
Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	BK10 (Yamaguchi et al., 2001, Yamaguchi et al., 1999) BL2992 (Wayne and McIntyre, 2002) Df(3L)BK10 (Crest et al., 2007, Matsuno et al., 2007, Gawlinski et al., 2007, Galewsky and Schulz, 1992) Df(3R)BK10 (Brumby et al., 2004) Df frs (Gawlinski et al., 2007) Dp(3;3)BK10
Name Synonym
Secondary FlyBase IDs

References ( 39 )

Generate a list of	All references relating to this aberration ( 39 )

List References by type	Research paper ( 34 ) Supplementary material ( 1 ) Personal communication to FlyBase ( 2 ) FlyBase analysis ( 1 ) Book ( 1 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2011 Show research papers ...