Aberration Dmel\Df(3L)Cat

General Information
Symbol	Dmel\Df(3L)Cat	Species	D. melanogaster
Name	Deficiency (3L) Catalase	FlyBase ID	FBab0002301
Feature type	chromosomal_deletion
Also Known As	Df(3L)Cat^DH104

Computed Breakpoints include	75C1-75C2;75F1
Deleted segment	75B4--75E2 (Estimated cytology)
Map ( GBrowse )	Untitled Document
Sequence coordinates	3L:18,033,789..18,078,763 (Df(3L)Cat:bk1) (Cook et al., 2010.2.12) 3L:18,833,555..18,834,991 (Df(3L)Cat:bk2) (Cook et al., 2010.2.12)
Member of large scale dataset(s)
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Aberration
Cytological Order
Progenitor
Mutagen	gamma ray
Class of aberration (relative to progenitor)	chromosomal_deletion (Mackay et al., 1986, Smith et al., 1993, Pauli et al., 1995, Duffy et al., 1996, Orr et al., 1996, Harbecke and Lengyel, 1995, Addison et al., 1995, Deak et al., 1997, Salzberg et al., 1997)
Breakpoints	75B8-75B11;75F1 (Addison et al., 1995) 75B8;75F1 (Mackay et al., 1986, Smith et al., 1993, Harbecke and Lengyel, 1995, Duffy et al., 1996) 75C1-75C2;75F1 (Pauli et al., 1995, Orr et al., 1996, Deak et al., 1997, Salzberg et al., 1997)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data	W << bk1 << not << l(3)03647 << bk2
Genetic mapping information
Comments
Comments on Cytology
	The left Df(3L)Cat breakpoint lies within CG32192 or to its right in the range 3L:18033789..18078763 (R5) (predicted cytology: 75B4-75B7) based on the following evidence. (Cook et al., 2010.2.12) The right Df(3L)Cat breakpoint lies within Indy and perhaps within CG32027 in the range 3L:18833555..18834991 (R5) (predicted cytology: 75E2) based on the following evidence. (Cook et al., 2010.2.12) Left limit of break 1 from polytene analysis (FBrf0080317) Right limit of break 1 from inclusion of rpr (FBrf0074787) Limits of break 2 from polytene analysis (FBrf0044501)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	ads (Addison et al., 1995) bora (Hutterer et al., 2006) Capr (Papoulas et al., 2010) Cat (Harshman et al., 1991, Wheeler et al., 1995, Orr et al., 1996) E(ftz)2828 (Kankel et al., 2004) ftz-f1 (Broadus et al., 1999, Spradling et al., 1999, Kankel et al., 2004) l(3)00864 (Spradling et al., 1999) l(3)03647 (Addison et al., 1995) l(3)S000625a (Szeged Stock Center, 1998-) l(3)S004021 (Szeged Stock Center, 1998-) l(3)S023825 (Szeged Stock Center, 1998-, Deak et al., 1997) l(3)S023837b (Deak et al., 1997) l(3)S027614b (Deak et al., 1997) l(3)S041315b (Deak et al., 1997) l(3)S041316a (Deak et al., 1997) l(3)S042806b (Deak et al., 1997) l(3)S042834a (Deak et al., 1997) l(3)S043005a (Deak et al., 1997) l(3)S048301a (Szeged Stock Center, 1998-, Deak et al., 1997) l(3)S049413b (Deak et al., 1997) l(3)S051701b (Deak et al., 1997) l(3)S056003b (Deak et al., 1997) l(3)S059706a (Deak et al., 1997) l(3)S061207 (Szeged Stock Center, 1998-, Deak et al., 1997) l(3)S073002a (Szeged Stock Center, 1998-, Deak et al., 1997) l(3)S088205 (Szeged Stock Center, 1998-) l(3)S095109 (Szeged Stock Center, 1998-) l(3)S116415 (Szeged Stock Center, 1998-, Deak et al., 1997) l(3)S119607b (Deak et al., 1997) l(3)S122407b (Deak et al., 1997) l(3)S122413a (Deak et al., 1997) l(3)S132214 (Deak et al., 1997) l(3)S132312 (Deak et al., 1997) l(3)S144607b (Szeged Stock Center, 1998-) l(3)S146604b (Deak et al., 1997) l(3)S146901 (Deak et al., 1997) l(3)S147402 (Deak et al., 1997) l(3)S147406a (Deak et al., 1997) l(3)S147410 (Deak et al., 1997) not (Martin et al., 1995, Addison et al., 1995) ripp (Giesen et al., 2003) rpr (White et al., 1994) W (Spradling, 1999.12.9)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	aos (Gaengel and Mlodzik, 2003) Eip75B (Spradling et al., 1999, BDGP Project Members, 1994-1999) ftz-f1 (BDGP Project Members, 1994-1999) l(3)j4E6 (Spradling et al., 1999) l(3)rL061 (Spradling et al., 1999) l(3)S000107 (Szeged Stock Center, 1998-) l(3)S001717 (Szeged Stock Center, 1998-) l(3)S017014a (Szeged Stock Center, 1998-) l(3)S024135 (Szeged Stock Center, 1998-) l(3)S044823 (Szeged Stock Center, 1998-) l(3)S097001 (Szeged Stock Center, 1998-) l(3)S102211 (Szeged Stock Center, 1998-) l(3)S136802 (Salzberg et al., 1997) l(3)S147006 (Szeged Stock Center, 1998-) nkd (Cox et al., 2000) Ten-m (Roote, 2003.11.4) tws (Szeged Stock Center, 1998-) W (BDGP Project Members, 1994-1999)
Molecular Data
	Rad9 (Vanrobays et al., 2010)
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments
	FlyBase curator comment: Df(3L)Cat stated to delete "l(3)00844" which is known to be an allele of Ten-m, Ten-m⁰⁰⁸⁴⁴. However Ten-m⁰⁰⁸⁴⁴ maps to 79E, so this seems unlikely. See Roote, 2003.11.28, personal communication to FlyBase for possible explanation of this. (Addison et al., 1995)
Phenotypic Data
In combination with other aberrations	Fails to complement Df(3L)Δ26, Df(3L)Δ32, Df(3L)Δ54, Df(3L)Δ215 and Df(3L)Δ3002. Lethal in combination with Df(3L)GR844^X22, Df(3L)GR844^X31 or Df(3L)GR844^X33. (Addison et al., 1995)
NOT in combination with other aberrations	The Df(3L)Cat chromosome does not act as a dominant suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{w^var}KR3-2", a stable "brown-red" variant of the P{3'WP-2,w^var}2Lt insertion). (Mason et al., 2004) Heterozygosity for Df(3L)Cat results in 14.5% X chromosome nondisjunction and 2.1% fourth chromosome nondisjunction in In(1)FM7/X ; sv^spa-pol females. (Harris et al., 2003) Does not cause unconditional lethality in hybrid females when heterozygous with D.simulans chromosome. (Coyne et al., 1998) Weak second site non-complementing phenotype with zip^Ebr and zip^mhc-c6.1: malformed phenotype penetrance 10-24%. (Halsell and Kiehart, 1998) Shows no maternal enhancement of dpp^hr4. (Nicholls and Gelbart, 1998) Dominantly causes tergite defects in less than 50% of run³ heterozygotes. (Duffy et al., 1996) Midgut development of mutant embryos is wild type. (Bilder and Scott, 1995) Homozygous embryos do not complete head involution, tracheae are disrupted, salivary glands are abnormal and there are holes in the epidermis. Midgut constrictions are incomplete and Malpighian tubules have a variable diameter along their length. (Harbecke and Lengyel, 1995) Heterozygosity for this deletion has no effect on the mutant ovarian phenotype of ovo^D2. (Pauli et al., 1995) Homozygotes show the full cell death defective phenotype. (White et al., 1994) Replication defective. (Smith et al., 1993) Recessive lethal. Exhibits gene dosage effect for catalase activity as a heterozygote. (Mackay and Bewley, 1989) Exerts a dosage effect for Cat activity. (Mackay et al., 1986) Deficiency heterozygotes show dosage effect for catalase activity.
Stocks ( 2 )
Bloomington	2990 Df(3L)Cat, kni^ri-1 Sb^sbd-1 e^*/TM3, Ser¹
Kyoto	107511 Df(3L)Cat, kni^ri-1 Sb^sbd-1 e^*/TM3, Ser¹
Notes on Origin
Discoverer

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

Synonyms & Secondary IDs ( 12 )
Reported As
Symbol Synonym	Cat (Provost et al., 2006) Cat^DH104 Df(3L)^CatDH104 (Fortier et al., 2003) Df(3L)cat (Gaengel and Mlodzik, 2003, Deak et al., 1997, Guichet et al., 1997) Df(3L)CAT (Giesen et al., 2003) Df(3L)Cat (Gao et al., 2011, Hutterer et al., 2006, Bejarano et al., 2008, Scott et al., 2007, Cook et al., 2010.2.12, Papoulas et al., 2010, Vanrobays et al., 2010) Df(3L)Cat^DH104 (Beckstead et al., 2001, Jiang et al., 2000, Broadus et al., 1999, Addison et al., 1995, Orr et al., 1996, White et al., 1994, Griswold et al., 1993, Harshman et al., 1991, Yamada et al., 2000, Rewitz et al., 2010) df(3L)Cat^DH104 (Wheeler et al., 1995) Df(3L)Cat^-DH104 (Mackay et al., 1986) Df(3L)Cat-DH104 (Mackay and Bewley, 1989, ) DH104 (Baldarelli et al., 1988)
Name Synonym	Deficiency (3L) Catalase
Secondary FlyBase IDs

References ( 64 )

Generate a list of	All references relating to this aberration ( 64 )

List References by type	Research paper ( 55 ) Supplementary material ( 1 ) Personal communication to FlyBase ( 4 ) Abstract ( 1 ) FlyBase analysis ( 1 ) Stock list ( 1 ) Book ( 1 )
Recent research papers ( 1 )
	Gao et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(12): 4932--4937 Paternal imprint essential for the inheritance of telomere identity in Drosophila. [FBrf0213318] Show all research papers ...