Aberration Dmel\Df(3L)brm11

General Information
Symbol	Dmel\Df(3L)brm11	Species	D. melanogaster
Name	Deficiency (3L) brahma	FlyBase ID	FBab0002363
Feature type	chromosomal_deletion
Also Known As	Df(3L)brm¹¹, Df(3)brm11, Df(3L) brm11

Computed Breakpoints include	72A3-72A4;72D1-72D5
Deleted segment	72A3--72D5
Sequence coordinates
Member of large scale dataset(s)
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Aberration
Cytological Order
Progenitor
Mutagen	P-element activity PM hybrid dysgenesis (Brizuela et al., 1994)
Class of aberration (relative to progenitor)	chromosomal_deletion (Brizuela et al., 1994, Zhimulev et al., 1997.9.29, Zhimulev et al., 1998)
Breakpoints	71F3-71F5;72D1-72D5 (Brizuela et al., 1994) 72A3-72A4;72C1 (Zhimulev et al., 1997.9.29, Zhimulev et al., 1998)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data	bk1 << l(3)72Ad << l(3)72CDe << bk2 << Taf4
Genetic mapping information
Comments
Comments on Cytology
	Pka-C3 gene lies within a 60kb region defined by the distal breakpoints of Df(3L)brm11 and Df(3L)st-f13. (Melendez and Kalderon, 1995) Limits of break 1 from polytene analysis (FBrf0098597) Limits of break 2 from polytene analysis (FBrf0072686)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	Arl1 (Brizuela et al., 1994, Melendez et al., 1995, Kennison, 2008.10.20, Cooper and Kennison, 2011) brm (Staehling-Hampton et al., 1999, Brumby et al., 2004, Tamkun et al., 1992, Brizuela et al., 1994, Melendez et al., 1995, Cooper and Kennison, 2011) DNApol-δ (Brizuela et al., 1994, Melendez et al., 1995, Cooper and Kennison, 2011) elgi (Von Stetina et al., 2008) Hip14 (Brizuela et al., 1994, Melendez et al., 1995, Ohyama et al., 2007, Cooper and Kennison, 2011) l(3)72Ab (Brizuela et al., 1994, Melendez et al., 1995, Cooper and Kennison, 2011) l(3)72CDb (Melendez et al., 1995) l(3)72CDc (Melendez et al., 1995, Cooper and Kennison, 2011) l(3)Me10 (Resino and Garcia-Bellido, 2004) mib1 (Melendez et al., 1995, Cooper and Kennison, 2011) Notum (Melendez et al., 1995, Cooper and Kennison, 2011) Pka-C3 (Melendez and Kalderon, 1995) sff (Baas et al., 2011) th (Cooper and Kennison, 2011, Melendez et al., 1995, Szeged Stock Center, 1998-, Wang et al., 1999, Colussi et al., 2000)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	fang (Myat et al., 2005) gim (Myat et al., 2005) gloin (Myat et al., 2005) l(3)72Dn (Kennison, 1995.6.21) l(3)S114709 (Szeged Stock Center, 1998-) Mbs (Szeged Stock Center, 1998-, BDGP Project Members, 1994-1999, Kennison, 1995.6.21) Taf4 (Sauer et al., 1996) Zn72D (Brumby et al., 2004)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations	Dominant scutellar bristle phenotype is increased in trans to Df(3L)A27 to around 48%. (Melendez et al., 1995) Df(3L)brm11/Df(3L)st-g24 lethal Df(3L)brm11/Df(3L)st-e4 viable Df(3L)brm11/Df(3L)st-b11 viable
NOT in combination with other aberrations	Df(3L)brm11 embryos show defects in tracheal cell migration. (Myat et al., 2005) Heterozygotes show transformation of haltere to wing and of segment A5 to A4. (Kankel et al., 2004) The Df(3L)brm11 chromosome does not act as a dominant suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{w^var}KR3-2", a stable "brown-red" variant of the P{3'WP-2,w^var}2Lt insertion). (Mason et al., 2004) Shows dominant enhancement of dominant haltere phenotype caused by Ubx¹⁹⁵ and Ubx^9.22. (Burnette et al., 1999) Dominantly enhances the Kr^If-1/+ eye phenotype. (Carrera et al., 1998) No second site non-complementing phenotype with zip^Ebr and zip^mhc-c6.1. (Halsell and Kiehart, 1998) Midgut development of mutant embryos is wild type. (Bilder and Scott, 1995) Adults heterozygous for Df(3L)brm11 or Df(3L)th102 have a high frequency of duplications of the anterior scutellar bristles (around 24%). (Melendez et al., 1995) Dominant suppressor of Pc⁴. (Brizuela et al., 1994)
Stocks ( 2 )
Bloomington	3640 Df(3L)brm11/TM6C, cu¹ Sb¹ ca¹
Kyoto	107149 Df(3L)brm11/TM6C, cu¹ Sb¹ ca¹
Notes on Origin
Discoverer	Kennison and Tamkun, 1987.

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments
	"72A3--4;72C1" was stated as revision. (Zhimulev et al., 1997.9.29, Zhimulev et al., 1998) Reduces the expression of homeotic genes. (Tamkun et al., 1992)
Synonyms & Secondary IDs ( 9 )
Reported As
Symbol Synonym	Df(3)brm11 (Resino and Garcia-Bellido, 2004, Wang et al., 2008) Df(3L)brm1 (Myat et al., 2005) DF(3L)brm11 (LaJeunesse et al., 2001) Df(3L) brm11 (Zhimulev et al., 1998, Zhimulev et al., 1997.9.29) Df(3L)brm11 (Pepple et al., 2007, Choi et al., 2006, Crest et al., 2007, Ohyama et al., 2007, Kennison, 2008.10.20, Weiss et al., 2012, Von Stetina et al., 2008, Cooper and Kennison, 2011, Popkova et al., 2012) Df(3L)brm¹¹ (Kankel et al., 2004, Gildea et al., 2000) Df(3R)brm11 (Brumby et al., 2004) Δbrm¹¹ (Baas et al., 2011)
Name Synonym	Deficiency (3L) brahma
Secondary FlyBase IDs

References ( 57 )

Generate a list of	All references relating to this aberration ( 57 )

List References by type	Research paper ( 49 ) Personal communication to FlyBase ( 4 ) Abstract ( 1 ) FlyBase analysis ( 1 ) Stock list ( 1 ) Book ( 1 )
Recent research papers ( 4 )
	Popkova et al., 2012, PLoS Genet. 8(12): e1003159 Polycomb controls gliogenesis by regulating the transient expression of the gcm/glide fate determinant. [FBrf0220515] Weiss et al., 2012, Genetics 190(2): 581--600 Huntingtin Aggregation Kinetics and Their Pathological Role in a Drosophila Huntington's Disease Model. [FBrf0217529] Baas et al., 2011, Development 138(3): 553--563 Sugar-free frosting, a homolog of SAD kinase, drives neural-specific glycan expression in the Drosophila embryo. [FBrf0212690] Cooper and Kennison, 2011, PLoS ONE 6(8): e23509 Molecular Genetic Analyses of Polytene Chromosome Region 72A-D in Drosophila melanogaster Reveal a Gene Desert in 72D. [FBrf0214748] Show all research papers ...