Aberration Dmel\Df(3L)fz-D21

General Information
Symbol	Dmel\Df(3L)fz-D21	Species	D. melanogaster
Name		FlyBase ID	FBab0002370
Feature type	chromosomal_deletion	Created / Updated	2006-08-22/2006-08-22

Formalized genetic data	Hsc70Cb << bk1 << D << shd << bk2 << gnu
Sequence coordinates
Deleted segment	70D2--70E8
Duplicated segment
Computed Breakpoints include	70D2;70E8
Breakpoints Inherited
Nature of the Aberration
Cytological Order
Progenitor
Mutagen	γ ray (Smyth and Belote, 1999)
Class of aberration (relative to progenitor)	chromosomal_deletion (Carpenter, 1994, Pauli et al., 1995, Nambu and Nambu, 1996, Harbecke and Lengyel, 1995, Landecker et al., 1994, Deak et al., 1997, Smyth and Belote, 1999)
Breakpoints	70D2;70E8 (Carpenter, 1994, Smyth and Belote, 1999) 70D3;70E3-70E8 (Landecker et al., 1994, Deak et al., 1997) 70D;71F (Pauli et al., 1995, Harbecke and Lengyel, 1995) 70D1-70D2;70E7 (Nambu and Nambu, 1996)
Causes alleles
Carries alleles
Transposon Insertions
Genetic mapping information
Comments
Comments on Cytology
	Left limit of break 1 from polytene analysis (FBrf0075380) Right limit of break 1 from inclusion of D (FBrf0075380) Limits of break 2 from polytene analysis (FBrf0075380)
Molecularly Mapped Breakpoints

Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	shd (Harbecke and Lengyel, 1995, Giesen et al., 2003) dlp (Kirkpatrick et al., 2004) Mpcp (BDGP Project Members, 1994-1999) HGTX (Broihier et al., 2004) fz (Freeman et al., 1986, Adler et al., 1994, Park et al., 1994) D (Carpenter, 1994, Nambu and Nambu, 1996, Burmester et al., 2000) l(3)70Da (Carpenter, 1994, Burmester et al., 2000) btl (Carpenter, 1994, Netter et al., 1998, Burmester et al., 2000) l(3)S072613a (Burmester et al., 2000)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	Prosβ2 (Smyth and Belote, 1999) gnu (Freeman et al., 1986, Tearle and Nusslein-Volhard, 1987) stwl (BDGP Project Members, 1994-1999) Hsc70Cb (BDGP Project Members, 1994-1999, Carpenter, 1994, Burmester et al., 2000) l(3)70Da (BDGP Project Members, 1994-1999) l(3)S027714 (Burmester et al., 2000) l(3)00421 (BDGP Project Members, 1994-1999) ome (Chihara et al., 2005)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments
	Does not delete P{lacW}endos^S067006 (Burmester et al., 2000)
Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations	Double mutants of fz²¹, fz²³ or Df(3L)fz-D21 with Df(3L)fz2 show variable embryonic segmentation defects ranging from a few extra denticles in the posterior part of some segments to complete replacement of naked cuticle with denticles. This phenotype is reminiscent of that for P{en1}wg^en11 loss of function. (Bhanot et al., 1999) Exhibit dominant suppression of Pc. (Carpenter, 1994) Heterozygosity for Df(3L)fz-D21 results in 1.1% X chromosome nondisjunction and 0.0% fourth chromosome nondisjunction in In(1)FM7/X ; sv^spa-pol females. (Harris et al., 2003) Heterozygosity for this deletion has no effect on the mutant ovarian phenotype of ovo^D2. (Pauli et al., 1995) No effect on the eye pigment phenotype of w^T81. (Netter et al., 1998) Shows dominant enhancement of dominant haltere phenotype caused by Ubx¹⁹⁵ and Ubx^9.22. (Burnette et al., 1999) Shows no maternal enhancement of dpp^hr4. (Nicholls and Gelbart, 1998) The Df(3L)fz-D21 chromosome does not act as a dominant suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{w^var}KR3-2", a stable "brown-red" variant of the P{3\'WP-2,w^var}2Lt insertion). (Mason et al., 2004)
Position Effect Variegation Data

Stocks ( 3 )
Bloomington	3123 Df(3L)fz-D21, th¹ st¹/TM6B, Tb¹
Kyoto	101591 Df(3L)fz-D21 / TM6B, e¹ Tb¹ ca¹ 106862 Df(3L)fz-D21, th¹ st¹/TM6B, Tb¹
Notes on Origin
Discoverer	Adler.

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments
	"70D2;70E8" was stated as revision. (Carpenter, 1994)
Synonyms & Secondary IDs ( 7 )
Reported As
Symbol Synonym	Df(3L)fz^D21 (Harris et al., 2003, Shimada et al., 2001, Taylor et al., 1998, Jones et al., 1996, Shimada et al., 2006) Df(3L)fz D21 (Kirkpatrick et al., 2004) Df(3L)fzD21 (Renault et al., 2003, Carrera et al., 1998, Pauli et al., 1995, Smith et al., 1993, Sullivan et al., 1993) Df(3L)fz-d21 (Tearle and Nusslein-Volhard, 1987) Df(3L)fz-D21 fz^D21 (Povelones et al., 2005, Ma et al., 2003, Rulifson et al., 2000, Usui et al., 1999, Bhanot et al., 1999, Adler et al., 1998, Adler et al., 1994, Park et al., 1994, Krasnow and Adler, 1994, Chae et al., 1999, Gao et al., 2000) fzD21 (Chihara et al., 2005)
Name Synonym
Secondary FlyBase IDs
	FBal0039358
References ( 47 )

Generate a list of	All references relating to this aberration ( 47 )

List References by type	Research paper ( 40 ) Supplementary material ( 1 ) Personal communication to FlyBase ( 1 ) FlyBase analysis ( 1 ) Stock list ( 2 ) Computer file ( 1 ) Book ( 1 )
Recent research papers ( 1 )
	Shimada et al., 2006, Dev. Cell 10(2): 209--222 Polarized transport of Frizzled along the planar microtubule arrays in Drosophila wing epithelium. [FBrf0190217] Show all research papers ...