Aberration Dmel\Df(3L)fz-M21

General Information
Symbol	Dmel\Df(3L)fz-M21	Species	D. melanogaster
Name		FlyBase ID	FBab0002373
Feature type	chromosomal_deletion
Also Known As	Df(3L)fzM21, Df(3L)fz^M21

Computed Breakpoints include	70D2;71E4-71E5
Deleted segment	70D2--71E5
Sequence coordinates
Member of large scale dataset(s)
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Aberration
Cytological Order
Progenitor
Mutagen	gamma ray (Smyth and Belote, 1999)
Class of aberration (relative to progenitor)	chromosomal_deletion (Carpenter, 1994, Pauli et al., 1995, Clark and McKearin, 1996, Coyne, 1996, Tear et al., 1996, Nambu and Nambu, 1996, Landecker et al., 1994, Smyth and Belote, 1999)
Breakpoints	70D2-70D3;70E4-70E5 (Clark and McKearin, 1996) 70D2-70D3;71E4-71E5 (Landecker et al., 1994, Pauli et al., 1995, Coyne, 1996, Tear et al., 1996, Nambu and Nambu, 1996) 70D2;71E (Carpenter, 1994) 70D3;71E5 (Smyth and Belote, 1999)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data	btl << bk1 << fz << gnu << bk2
Genetic mapping information
Comments
Comments on Cytology
	Limits of break 1 from polytene analysis (FBrf0075380) Limits of break 2 from polytene analysis (FBrf0076124)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	comm (Seeger, 1995.7.6, Tear et al., 1996) cp309 (Spradling et al., 1999, BDGP Project Members, 1994-1999) CrebA (Spradling et al., 1999, BDGP Project Members, 1994-1999) gnu (Tearle and Nusslein-Volhard, 1987) l(3)71EFa (Bloomington Drosophila Stock Center, 1999.6.23) l(3)j2A2 (Spradling et al., 1999, BDGP Project Members, 1994-1999) l(3)S119005 (Szeged Stock Center, 1998-) l(3)S137908 (Szeged Stock Center, 1998-) Mpcp (Spradling et al., 1999, BDGP Project Members, 1994-1999) ome (Chihara et al., 2005) Prosβ2 (Smyth and Belote, 1999) stwl (McKearin, 1998.8.4, Spradling et al., 1999, Clark and McKearin, 1996) Trl (Spradling et al., 1999, Brumby et al., 2004, BDGP Project Members, 1994-1999, Farkas et al., 1994)
Molecular Data
Completely deleted	Tollo (Kim et al., 2006)
Genes NOT Deleted / Disrupted
Complementation Data
	btl (Szeged Stock Center, 1998-, Burmester et al., 2000, Carpenter, 1994) cpo (BDGP Project Members, 1994-1999) D (Burmester et al., 2000, Carpenter, 1994, Nambu and Nambu, 1996, Carpenter, 1997.1.10) fang (Myat et al., 2005) gim (Myat et al., 2005) gloin (Myat et al., 2005) Hsc70Cb (Spradling et al., 1999, Burmester et al., 2000, BDGP Project Members, 1994-1999, Carpenter, 1994) l(3)00421 (BDGP Project Members, 1994-1999) l(3)j6C3 (BDGP Project Members, 1994-1999) l(3)s1754 (Spradling et al., 1999, BDGP Project Members, 1994-1999) l(3)S018405 (Szeged Stock Center, 1998-) l(3)S027707 (Szeged Stock Center, 1998-) l(3)S027714 (Burmester et al., 2000) l(3)S072613a (Burmester et al., 2000) Pex1 (Burmester et al., 2000, Carpenter, 1994)
Molecular Data
	Z600 (Grosshans et al., 2003)
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments
	Does not delete P{lacW}endos^S067006 (Burmester et al., 2000)
Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations	Df(3L)fz-M21 embryos show defects in tracheal cell migration. (Myat et al., 2005) The Df(3L)fz-M21 chromosome does not act as a dominant suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{w^var}KR3-2", a stable "brown-red" variant of the P{3'WP-2,w^var}2Lt insertion). (Mason et al., 2004) Shows dominant enhancement of dominant haltere phenotype caused by Ubx¹⁹⁵ and Ubx^9.22. (Burnette et al., 1999) Does not cause unconditional lethality in hybrid females when heterozygous with D.simulans chromosome. (Coyne et al., 1998) No second site non-complementing phenotype with zip^Ebr and zip^mhc-c6.1. (Halsell and Kiehart, 1998) Deficient embryos show an uninterpretable mutant midgut phenotype. (Bilder and Scott, 1995) Heterozygosity for this deletion has no effect on the mutant ovarian phenotype of ovo^D2. (Pauli et al., 1995) Trl hemizygous adult males show strong homeotic transformation of the sixth sternite into the fifth as shown by the presence of a bristles on the sixth sternite. (Farkas et al., 1994)
Stocks ( 5 )
Bloomington	3126 Df(3L)fz-M21, st¹/TM6 5461 Df(3L)fz-M21, th¹ st¹/TM6C, cu¹ Sb¹ ca¹; Ts(YSt;3Lt)ST1
Kyoto	106865 Df(3L)fz-M21, st¹/TM6 103293 Df(3L)fz-M21, th¹ st¹ / TM6 108253 Df(3L)fz-M21, th¹ st¹/TM6C, cu¹ Sb¹ ca¹; Ts(YSt;3Lt)ST1
Notes on Origin
Discoverer	Adler.

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments
	Used in D.melanogaster/D.simulans hybrids to map at least four non-overlapping regions on the D.simulans 3R that have effects on the species difference of cuticular hydrocarbon profile. (Coyne, 1996) "70D2;71E" was stated as revision. (Carpenter, 1994)
Synonyms & Secondary IDs ( 7 )
Reported As
Symbol Synonym	Df(3L)fz^M21 (McKearin, 1998.8.4, Tear et al., 1996) Df(3L)fz^m21 (Galewsky et al., 1999) Df(3L)fzM21 (Firth et al., 2000, Coyne, 1996, Bilder and Scott, 1995, Pauli et al., 1995, Farkas et al., 1994, Sullivan et al., 1993, Crest et al., 2007) Df(3L)fz-m21 (Tearle and Nusslein-Volhard, 1987) Df(3L)fz-M21 (Slack et al., 2006) Df(3L) fz-M21 (Kim et al., 2006) fzM21 (Chihara et al., 2005)
Name Synonym
Secondary FlyBase IDs

References ( 50 )

Generate a list of	All references relating to this aberration ( 50 )

List References by type	Research paper ( 38 ) Personal communication to FlyBase ( 6 ) Abstract ( 1 ) FlyBase analysis ( 1 ) Stock list ( 3 ) Book ( 1 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2011 Show research papers ...