Aberration Dmel\Df(3L)h-i22

General Information
Symbol	Dmel\Df(3L)h-i22	Species	D. melanogaster
Name		FlyBase ID	FBab0002374
Feature type	chromosomal_deletion	Created / Updated	2006-08-22/2006-08-22

Formalized genetic data	bk1 << h << dally hits bk2 << l(3)s2383
Sequence coordinates
Deleted segment	66D10--66E2
Duplicated segment
Computed Breakpoints include	66D10;66E1-66E2
Breakpoints Inherited
Nature of the Aberration
Cytological Order
Progenitor
Mutagen	X ray (Hooper et al., 1989, Ingham et al., 1985, Tsuda et al., 1999)
Class of aberration (relative to progenitor)	chromosomal_deletion (Chorsky and Belote, 1994, Pauli et al., 1995, Nakato et al., 1995, Ingham et al., 1985, Duffy et al., 1996, Harbecke and Lengyel, 1995, Deak et al., 1997)
Breakpoints	66D9;66E1 (Ingham et al., 1985) 66D10;66D14 (Chorsky and Belote, 1994) 66D10-66D11;66E1-66E2 (Pauli et al., 1995, Harbecke and Lengyel, 1995, Duffy et al., 1996, Deak et al., 1997) 66D10;66E1-66E2 (Nakato et al., 1995)
Causes alleles	dallyⁱ²² (Tsuda et al., 1999) hⁱ²² (Ingham et al., 1985, Hooper et al., 1989, Myat and Andrew, 2002, Howard and Ingham, 1986, Fasano et al., 1988, Goto et al., 1989, Abu-Issa and Cavicchi, 1996)
Carries alleles
Transposon Insertions
Genetic mapping information
Comments	Breakpoint(s) molecularly mapped (Ish-Horowicz et al., 1985)
Comments on Cytology
	Left limit of break 1 from polytene analysis (FBrf0072831) Right limit of break 1 from inclusion of h (FBrf0042642) Left limit of break 2 from inclusion of dally (FBrf0110960) Right limit of break 2 from non-inclusion of dally (FBrf0110960) Ref: FBrf0042642. (Nakato et al., 1995)
Molecularly Mapped Breakpoints

Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	msn (BDGP Project Members, 1994-1999) mRpL12 (BDGP Project Members, 1994-1999) mfr (Smith, 2007) dally (BDGP Project Members, 1994-1999, Chorsky and Belote, 1994, Nakato et al., 1995, Spradling et al., 1999, Desbordes et al., 2005) Prm (BDGP Project Members, 1994-1999, Deak et al., 1997, Tsuda et al., 1999, Szeged Stock Center, 1998-, Spradling et al., 1999, Liu et al., 2003, Desbordes et al., 2005) SrpRβ (BDGP Project Members, 1994-1999, Spradling et al., 1999, Ring et al., 2000) Gug (BDGP Project Members, 1994-1999) foi (BDGP Project Members, 1994-1999, Spradling et al., 1999) h (Ingham et al., 1985, Howard and Ingham, 1986, BDGP Project Members, 1994-1999, Macias et al., 1994, Harbecke and Lengyel, 1995, Abu-Issa and Cavicchi, 1996, Long et al., 1996, Spradling et al., 1999) abd (Ingham et al., 1985, Long et al., 1996) l(3)j5B6 (BDGP Project Members, 1994-1999, Spradling et al., 1999) l(3)01629 (BDGP Project Members, 1994-1999, Spradling et al., 1999, Desbordes et al., 2005) l(3)06264 (BDGP Project Members, 1994-1999) l(3)S110013 (Szeged Stock Center, 1998-) l(3)S090001 (Szeged Stock Center, 1998-) l(3)S024020a (Szeged Stock Center, 1998-) l(3)S008418 (Deak et al., 1997, Szeged Stock Center, 1998-) l(3)S004209b (Szeged Stock Center, 1998-) l(3)S055009a (Deak et al., 1997) E(ftz)2955 (Kankel et al., 2004) l(3)S048412a (Deak et al., 1997) l(3)S062516b (Deak et al., 1997)
Partially deleted / disrupted	dally (Tsuda et al., 1999)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	mRpL12 (Tsuda et al., 1999, Spradling et al., 1999, Desbordes et al., 2005) Rdl (ffrench-Constant and Roush, 1991) Gug (Spradling et al., 1999) ergic53 (BDGP Project Members, 1994-1999) Sse (Jager et al., 2001) cpo (BDGP Project Members, 1994-1999) Clk (Allada et al., 1998) RpL14 (Saeboe-Larssen et al., 1997) l(3)06264 (Tsuda et al., 1999, Spradling et al., 1999) l(3)s2383 (BDGP Project Members, 1994-1999) l(3)L4222a (BDGP Project Members, 1994-1999, Spradling et al., 1999) jv (Ingham et al., 1985) gim (Myat et al., 2005) fang (Myat et al., 2005) mwh (Ingham et al., 1985) gloin (Myat et al., 2005) se (Ingham et al., 1985)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations	Deficient embryos show an uninterpretable mutant midgut phenotype. (Bilder and Scott, 1995) Does not cause unconditional lethality in hybrid females when heterozygous with D.simulans chromosome. (Coyne et al., 1998) Dominantly causes tergite defects in less than 50% of run³ heterozygotes. (Duffy et al., 1996) Heterozygosity for Df(3L)h-i22 results in 0.0% X chromosome nondisjunction and 0.0% fourth chromosome nondisjunction in In(1)FM7/X ; sv^spa-pol females. (Harris et al., 2003) Heterozygosity for this deletion has no effect on the mutant ovarian phenotype of ovo^D2. (Pauli et al., 1995) Heterozygotes with Df(3L)tra display a genitalia defective phenotype, all or parts of the genital disc derivatives are missing. (Chorsky and Belote, 1994) No second site non-complementing phenotype with zip^Ebr and zip^mhc-c6.1. (Halsell and Kiehart, 1998) Poor ventral cord organisation. (Smith et al., 1993) Shows no maternal enhancement of dpp^hr4. (Nicholls and Gelbart, 1998) Tracheal patterning and lumen size is disrupted in Df(3L)h-i22 embryos. (Myat et al., 2005) homozygous lethal
Position Effect Variegation Data

Stocks ( 2 )
Bloomington	3024 Df(3L)h-i22, hⁱ²² Ki¹ rn^roe-1 p^p/TM3, Ser¹
Kyoto	106787 Df(3L)h-i22, hⁱ²² Ki¹ rn^roe-1 p^p/TM3, Ser¹
Notes on Origin
Discoverer	Belote.

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

Synonyms & Secondary IDs ( 10 )
Reported As
Symbol Synonym	Df(3L)h,i22 (Nakato et al., 1995) Df(3L)h¹²² (Ingham and Gergen, 1988) Df(3L)hⁱ²² (Myat et al., 2005, Brumby et al., 2004, Myat and Andrew, 2002, Ring et al., 2000, Ingham and Gergen, 1988, Macias et al., 1994, Klingler and Gergen, 1993, Hooper et al., 1989, Howard and Ingham, 1986, Chorsky and Belote, 1994, Paroush et al., 1994, Gutjahr et al., 1993) Df(3L)hi22 (Kuhfittig et al., 2001) Df(3L)h-i22 (Crest et al., 2007, Smith, 2007) Df(3L)h-i22ry506 Df(3R)hⁱ²² (Baumgartner and Noll, 1990, Parkhurst and Ish-Horowicz, 1991) hⁱ²² (Ingham and Gergen, 1988) h-i22 (ffrench-Constant and Roush, 1991) unnamed (Abu-Issa and Cavicchi, 1996, Ingham et al., 1985)
Name Synonym
Secondary FlyBase IDs
	FBab0000007
References ( 59 )

Generate a list of	All references relating to this aberration ( 59 )

List References by type	Research paper ( 54 ) Personal communication to FlyBase ( 1 ) FlyBase analysis ( 1 ) Computer file ( 2 ) Book ( 1 )
Recent research papers ( 2 )
	Crest et al., 2007, Genetics 175(2): 567--584 Onset of the DNA replication checkpoint in the early Drosophila embryo. [FBrf0194644] Smith, 2007, BMC Dev. Biol. 7: 21 Complex regulation and multiple developmental functions of misfire, the Drosophila melanogaster ferlin gene. [FBrf0200139] Show all research papers ...