Aberration Dmel\Df(3L)kto2

General Information
Symbol	Dmel\Df(3L)kto2	Species	D. melanogaster
Name	Deficiency (3L) kohtalo	FlyBase ID	FBab0002383
Feature type	chromosomal_deletion
Also Known As	Df(3L)kto², Df(3L)JK18, Df(2R)kto²

Computed Breakpoints include	76B1-76B2;76D5
Deleted segment	76B1--76D5
Sequence coordinates
Member of large scale dataset(s)
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Aberration
Cytological Order
Progenitor
Mutagen	P-element activity
Class of aberration (relative to progenitor)	chromosomal_deletion (Dorer et al., 1995, LaJeunesse and Shearn, 1995, Tsunoda and Salkoff, 1995, Hernandez et al., 1996)
Breakpoints	76B1-76B2;76D5 (Tsunoda and Salkoff, 1995, LaJeunesse and Shearn, 1995) 76B;76D (Dorer et al., 1995) [];76D5 (Hernandez et al., 1996)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data	bk1 << kto << bk2 << fln
Genetic mapping information
Comments
Comments on Cytology
	All limits from polytene analysis (FBrf0080459)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	asf1 (Zhu et al., 2005, Cooper et al., 2010) ash1 (Sen et al., 1998, Bantignies et al., 2000, LaJeunesse and Shearn, 1995, Veraksa and McGinnis, 1996, Gross and McGinnis, 1996, Tripoulas et al., 1996, Cooper et al., 2010) cyc (Rutila et al., 1998) Deaf1 (Veraksa and McGinnis, 1996, Gross and McGinnis, 1996, Cooper et al., 2010) Gyc76C (Zhu et al., 2005, Cook, 2008.12.1, Cooper et al., 2010) HLH106 (Cook, 2008.12.1, Cooper et al., 2010) kto (Veraksa et al., 2002, Zhu et al., 2005, Gross and McGinnis, 1996, Cooper et al., 2010) l(3)76BDd (Zhu et al., 2005, Cook, 2008.12.1, Cooper et al., 2010) l(3)76BDg (Szeged Stock Center, 1998-, Cook, 2008.12.1, Cooper et al., 2010) l(3)76BDh (Cook, 2008.12.1, Cooper et al., 2010) l(3)76BDj (Zhu et al., 2005, Cook, 2008.12.1, Cooper et al., 2010) l(3)76BDm (Zhu et al., 2005, Spradling et al., 1999, Cook, 2008.12.1, Cooper et al., 2010) l(3)76BDr (Zhu et al., 2005, Cooper et al., 2010) l(3)76BDt (Zhu et al., 2005, Cooper et al., 2010) l(3)S093411 (Szeged Stock Center, 1998-) l(3)S145709 (Szeged Stock Center, 1998-) Mi-2 (Kennison, 1995.6.21, Spradling et al., 1999, Cooper et al., 2010) Papss (Zhu et al., 2005, Cooper et al., 2010) pip (Sen et al., 1998, Cooper et al., 2010) Rab8 (Cook, 2008.12.1, Cooper et al., 2010, Zhu et al., 2005) serp (Zhu et al., 2005, Cook, 2008.12.1, Cooper et al., 2010) Su(Tpl) (Zhu et al., 2005, Dorer et al., 1995, Cooper et al., 2010) Su(z)12 (Birve et al., 1999, Zirin and Mann, 2004, Zhu et al., 2005, Cooper et al., 2010) Taf6 (Cooper et al., 2010) trc (Szeged Stock Center, 1998-, Geng et al., 2000, Veraksa et al., 2002, Zhu et al., 2005, Cooper et al., 2010) trpml (Cook, 2008.12.1, Cooper et al., 2010, Zhu et al., 2005) verm (Cook, 2008.12.1, Cooper et al., 2010)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	cp (Kennison, 2006.7.21) fang (Myat et al., 2005) fln (Hernandez et al., 1996) gim (Myat et al., 2005) gloin (Myat et al., 2005) l(3)ry119 (Kennison, 1993.7.1) Wow (Birchler et al., 1994)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations	Fails to complement Df(3L)fln1 and Df(3L)VW3. (Vigoreaux et al., 1998)
NOT in combination with other aberrations	Only the distal tip of the salivary gland turns in embryos homozygous for Df(3L)kto2 by stage 14. (Jattani et al., 2009) Df(3L)kto2 embryos show defects in tracheal cell migration. (Myat et al., 2005) Dominantly enhances the Kr^If-1/+ eye phenotype. (Carrera et al., 1998) No effect on the eye pigment phenotype of w^T81. (Netter et al., 1998) Homozygous lethal. Heterozygotes have longer locomotor rhythm periods than normal. (Rutila et al., 1998) Flies have a normal flight index. (Vigoreaux et al., 1998) Does not rescue the lethal phenotype of three doses of Tpl⁺. (Dorer et al., 1995) Mutation changes the level of w expression in ph-p^lac+3 flies; eye colour is darker. (Fauvarque et al., 1995) Only 13% of neurons in Df(3L)kto2 flies have a transient K⁺ current. (Tsunoda and Salkoff, 1995)
Stocks ( 3 )
Bloomington	3617 Df(3L)kto2/TM6B, Tb⁺
Kyoto	103295 Df(3L)kto2 / TM6B 107131 Df(3L)kto2/TM6B, Tb¹
Notes on Origin
Discoverer	Kennison, 1987.

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments
	The Df(3L)kto2 chromosome acts as a dominant weak suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{w^var}KR3-2", a stable "brown-red" variant of the P{3'WP-2,w^var}2Lt insertion), but this is a false positive result (the suppressor is not within the bounds of the deficient region) because the region of the deficiency is covered by one or more nonsuppressing deficiencies. (Mason et al., 2004)
Synonyms & Secondary IDs ( 9 )
Reported As
Symbol Synonym	Df(2R)kto² (Treisman, 2001, Mihaly et al., 1997) Df(3)TAF_II60 (Zhou et al., 1998) Df(3L)JK18 (Bantignies et al., 2000, Tsunoda and Salkoff, 1995, Tsunoda and Salkoff, 1995, LaJeunesse and Shearn, 1995, Tripoulas et al., 1996) Df(3L)KT02 (Zhou et al., 1998) Df(3L)kto (Birve et al., 1999) Df(3L)Kto2 (Feng et al., 2003) Df(3L)kto2 (Kennison, 2006.7.21, Goodliffe et al., 2007, Cook, 2008.12.1, Jattani et al., 2009, Aoyagi and Wassarman, 2001, Cooper et al., 2010) Df(3L)kto² (Lopez et al., 2001, Veraksa et al., 2002, Reedy et al., 2000, Netter et al., 1998, Hernandez et al., 1996, Fauvarque et al., 1995, Gross and McGinnis, 1996, Dorer et al., 1995)
Name Synonym	Deficiency (3L) kohtalo
Secondary FlyBase IDs

References ( 60 )

Generate a list of	All references relating to this aberration ( 60 )

List References by type	Research paper ( 50 ) Personal communication to FlyBase ( 4 ) Abstract ( 3 ) FlyBase analysis ( 1 ) Stock list ( 1 ) Book ( 1 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2011 Show research papers ...