Aberration Dmel\Df(3L)rdgC-co2

General Information
Symbol	Dmel\Df(3L)rdgC-co2	Species	D. melanogaster
Name		FlyBase ID	FBab0002392
Feature type	chromosomal_deletion	Created / Updated	2006-08-22/2006-08-22

Formalized genetic data	Su(Tpl) << bk1 << polo << fbl << bk2 << l(3)j7C3
Sequence coordinates
Deleted segment	77A1--77D1
Duplicated segment
Computed Breakpoints include	77A1;77D1
Breakpoints Inherited
Nature of the Aberration
Cytological Order
Progenitor
Mutagen
Class of aberration (relative to progenitor)	chromosomal_deletion (Castrillon et al., 1993, Birchler et al., 1994, Pauli et al., 1995, Dorer et al., 1995, Roseman et al., 1995)
Breakpoints	77A1;77D1 (Castrillon et al., 1993, Pauli et al., 1995, Dorer et al., 1995, Roseman et al., 1995) 77A1;77D (Birchler et al., 1994)
Causes alleles
Carries alleles	cp¹ (Kennison, 2006.7.21)
Transposon Insertions
Genetic mapping information
Comments
Comments on Cytology
	All limits from polytene analysis (FBrf0064394) Previously reported to delete cp, however this was due to Df(3L)rdgC-co2 chromosome carrying cp[1]. cp[1] is separable from Df(3L)rdgC-co2 by recombination. (Kennison, 2006.7.21)
Molecularly Mapped Breakpoints

Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	eRF1 (BDGP Project Members, 1994-1999, Spradling et al., 1999, Lukinova et al., 1999, Collins, 2005) in (Adler et al., 1994, Lukinova et al., 1999) Psn (Ye et al., 1999, Lukinova et al., 1999) mRpL15 (Lukinova et al., 1999) trbl (Seher, 2000.3.3, Grosshans and Wieschaus, 2000, Mata et al., 2000) polo (BDGP Project Members, 1994-1999, Roseman et al., 1995, Herrmann et al., 1998, Szeged Stock Center, 1998-, Spradling et al., 1999, Lukinova et al., 1999) fbl (Castrillon et al., 1993, BDGP Project Members, 1994-1999, Spradling et al., 1999) l(3)77CDf (BDGP Project Members, 1994-1999, Spradling et al., 1999, Lukinova et al., 1999) l(3)S126014 (Szeged Stock Center, 1998-) l(3)77CDm (Lukinova et al., 1999) l(3)77ABd (Lukinova et al., 1999) l(3)77ABg (Lukinova et al., 1999) l(3)77CDj (Lukinova et al., 1999) l(3)77ABh (Lukinova et al., 1999) l(3)77ABf (Lukinova et al., 1999) flc (Lukinova et al., 1999) l(3)77CDl (Lukinova et al., 1999) l(3)77CDg (Lukinova et al., 1999) l(3)77CDe (Lukinova et al., 1999) l(3)77CDa (Lukinova et al., 1999) l(3)77ABj (Lukinova et al., 1999) l(3)77CDi (Lukinova et al., 1999) l(3)77CDh (Lukinova et al., 1999) l(3)77ABi (Lukinova et al., 1999) l(3)77CDd (Lukinova et al., 1999) l(3)77CDk (Lukinova et al., 1999) Snap (Lukinova et al., 1999) DNApol-α60 (BDGP Project Members, 1994-1999, Spradling et al., 1999, Lukinova et al., 1999, Chen et al., 2000)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	gig (Ito and Rubin, 1999) Su(Tpl) (Dorer et al., 1995) l(3)j7C3 (BDGP Project Members, 1994-1999) l(3)s2253 (BDGP Project Members, 1994-1999, Lukinova et al., 1999) l(3)S102702a (Szeged Stock Center, 1998-) Wow (Birchler et al., 1994) cp (Kennison, 2006.7.21)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments
	FlyBase curator comment: FBrf0123112 reported that Df(3L)rdgC-co2 deletes cp, however Kennison, 2006.7.21, personal communication to FlyBase, showed that Df(3L)rdgC-co2 is not deleted for cp, but in fact carries cp¹. (Lukinova et al., 1999)
Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations	Deficient embryos show an uninterpretable mutant midgut phenotype. (Bilder and Scott, 1995) Does not cause unconditional lethality in hybrid females when heterozygous with D.simulans chromosome. (Coyne et al., 1998) Heterozygosity for Df(3L)rdgC-co2 results in 2.3% X chromosome nondisjunction and 3.4% fourth chromosome nondisjunction in In(1)FM7/X ; sv^spa-pol females. (Harris et al., 2003) Heterozygosity for this deletion has no effect on the mutant ovarian phenotype of ovo^D2. (Pauli et al., 1995) Homozygous mutants embryos show a failure to form a ventral furrow. The mesoderm primordium is internalised late. (Seher and Leptin, 2000) Shows no maternal enhancement of dpp^hr4. (Nicholls and Gelbart, 1998) The Df(3L)rdgC-co2 chromosome does not act as a dominant suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{w^var}KR3-2", a stable "brown-red" variant of the P{3\'WP-2,w^var}2Lt insertion). (Mason et al., 2004) Weak second site non-complementing phenotype with zip^Ebr and zip^mhc-c6.1: malformed phenotype penetrance 10-24%. (Halsell and Kiehart, 1998)
Position Effect Variegation Data

Stocks ( 3 )
Kyoto	102297 Df(3L)rdgC-co2, th¹ st¹ in¹ kni^ri-1 p^p / TM6C, Sb¹ cu¹ e^s 106730 Df(3L)rdgC-co2, th¹ st¹ in¹ kni^ri-1 p^p/TM6C, cu¹ Sb¹ Tb¹ ca¹
Bloomington	2052 Df(3L)rdgC-co2, th¹ st¹ in¹ kni^ri-1 p^p/TM6C, cu¹ Sb¹ Tb¹ ca¹
Notes on Origin
Discoverer
	Induced on: marked third chromosome that carried the cp[1] allele. (Kennison, 2006.7.21)
Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

Synonyms & Secondary IDs ( 9 )
Reported As
Symbol Synonym	Df(3L)rdgC (Brumby et al., 2004, Harris et al., 2003, Firth et al., 2000, Ito and Rubin, 1999, Carrera et al., 1998, Dorer et al., 1995, Pauli et al., 1995, Birchler et al., 1994, Castrillon et al., 1993) Df(3L)rdgC^co2 (Seher and Leptin, 2000, Adler et al., 1994, Steele and O'Tousa, 1990) Df(3L)rdgC-cd (Jackson et al., 2005) Df(3L)rdgC-Ci2 (Spradling et al., 1999, ) Df(3L)rdgC-co (Grosshans and Wieschaus, 2000) Df(3L)rdgC-co2 (Clarke et al., 2005, Kennison, 2006.7.21, Crest et al., 2007, Babcock et al., 2004) Df(3L)rdgc-cos2 (Mirouse et al., 2006) rdgC (Yamaguchi et al., 2001) rdgC-co2 (Provost et al., 2006)
Name Synonym
Secondary FlyBase IDs

References ( 51 )

Generate a list of	All references relating to this aberration ( 51 )

List References by type	Research paper ( 46 ) Personal communication to FlyBase ( 2 ) FlyBase analysis ( 1 ) Computer file ( 2 )
Recent research papers ( 3 )
	Crest et al., 2007, Genetics 175(2): 567--584 Onset of the DNA replication checkpoint in the early Drosophila embryo. [FBrf0194644] Mirouse et al., 2006, Development 133(20): 4005--4013 Interaction between Polo and BicD proteins links oocyte determination and meiosis control in Drosophila. [FBrf0192446] Provost et al., 2006, Genetics 172(1): 207--219 Loss-of-function mutations in a glutathione S-transferase suppress the prune-Killer of prune lethal interaction. [FBrf0190760] Show all research papers ...