Aberration Dmel\Df(3R)C4

General Information
Symbol	Dmel\Df(3R)C4	Species	D. melanogaster
Name		FlyBase ID	FBab0002502
Feature type	chromosomal_deletion
Also Known As	DfC4

Computed Breakpoints include	89E2-89E3;90A
Deleted segment	89E2--90A
Sequence coordinates
Member of large scale dataset(s)
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Aberration
Cytological Order
Progenitor	Abd-B^Mcp-1
Mutagen	X ray
Class of aberration (relative to progenitor)	chromosomal_deletion (Sokol et al., 1997, Pauli et al., 1995, Dickson et al., 1996, Harbecke and Lengyel, 1995)
Breakpoints	89E;90A (Pauli et al., 1995, Harbecke and Lengyel, 1995, Dickson et al., 1996, Sokol et al., 1997)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data	abd-A << bk1 << l(3)89Ej << cher << bk2
Genetic mapping information
Comments	Breakpoint(s) molecularly mapped (Karch et al., 1985) Proximal breakpoint 133.5-137 kb distal to the right breakpoint of In(3R)Cbx^rv1 (Karch et al., 1985).
Comments on Cytology
	Left limit of break 1 from non-inclusion of Ubx (FBrf0047928) Right limit of break 1 from inclusion of Abd-B (FBrf0047928) Limits of break 2 from polytene analysis (FBrf0080317)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	Abd-B (Jurgens, 1988, Celniker et al., 1989) cher (Li et al., 1999, Sokol and Cooley, 1999, Li, 1996.4.28, Sokol et al., 1997, Robinson et al., 1997) l(3)89Ek (Sanchez-Herrero, 1996.3.7) l(3)89El (Sanchez-Herrero, 1996.3.7) l(3)89Em (Sanchez-Herrero, 1998.8.30) l(3)89En (Sanchez-Herrero, 1998.8.30) l(3)06442 (Spradling et al., 1999, BDGP Project Members, 1994-1999) wheezy (Ghabrial et al., 2011)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	abd-A (Jurgens, 1988) CSN5 (Sanchez-Herrero, 1996.3.7) Dad (Spradling et al., 1999) E(br)420 (Ward et al., 2003) EfTuM (Spradling et al., 1999, BDGP Project Members, 1994-1999) l(3)89Bm (Sanchez-Herrero, 1996.3.7) l(3)89Bn (Sanchez-Herrero, 1996.3.7) l(3)89Bu (Sanchez-Herrero, 1998.8.30) l(3)89Ce (Sanchez-Herrero, 1996.3.7) l(3)89Cg (Sanchez-Herrero, 1998.8.30) l(3)89Ch (Sanchez-Herrero, 1998.8.30) l(3)89Ci (Sanchez-Herrero, 1998.8.30) l(3)89Dd (Sanchez-Herrero, 1998.8.30) l(3)89De (Sanchez-Herrero, 1998.8.30) l(3)89Df (Sanchez-Herrero, 1998.8.30) l(3)89Ea (Sanchez-Herrero, 1996.3.7) l(3)06658 (BDGP Project Members, 1994-1999) l(3)06664 (BDGP Project Members, 1994-1999) l(3)s2017 (BDGP Project Members, 1994-1999) Ubx (Jurgens, 1988)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments
	May uncover Abd-B. (Kuhn and Woods, 1982)
Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations	Does not cause unconditional lethality in hybrid females when heterozygous with D.simulans chromosome. (Coyne et al., 1998) No second site non-complementing phenotype with zip^Ebr and zip^mhc-c6.1. (Halsell and Kiehart, 1998) Shows no phenotype when heterozygous with 14-3-3ε^18A2, and no effect on phl::tor^12D.hs.sev when heterozygous with wild type. (Dickson et al., 1996) Deficient embryos show an uninterpretable mutant midgut phenotype. (Bilder and Scott, 1995) Homozygous embryos show abnormal gastrulation and cease development early in embryogenesis. (Harbecke and Lengyel, 1995) Heterozygosity for this deletion suppresses the mutant ovarian phenotype of ovo^D2. (Pauli et al., 1995) When in combination with salm mutations exhibit parasegments 10-13 resemble those in Abd-B^- embryos and parasegments 14 and 15 resemble those from salm;Df(3R)P9 embryos. (Jurgens, 1988) Sterile in heterozygotes and male heterozygotes have rotated genitalia. (Karch et al., 1985) is associated with slight reductions in Ubx and abd-A activity.
Stocks ( 3 )
Bloomington	3071 Df(3R)C4, p^*/Dp(3;3)P5, Sb¹
Kyoto	106820 Df(3R)C4, p^/Dp(3;3)P5, Sb¹ 103303 Df(3R)C4, p^ / Dp(3;3)P5, Sb¹
Notes on Origin
Discoverer	Crosby.

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments
	The Df(3R)C4 chromosome acts as a dominant weak suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{w^var}KR3-2", a stable "brown-red" variant of the P{3'WP-2,w^var}2Lt insertion), but this is a false positive result (the suppressor is not within the bounds of the deficient region) because the region of the deficiency is covered by one or more nonsuppressing deficiencies. (Mason et al., 2004)
Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	Df(3)C4 (Karch et al., 1990) Df(3R)C4 (Pilot et al., 2006, Gummalla et al., 2012, Ghabrial et al., 2011) DfC4 (Struhl and White, 1985, Sanchez-Herrero, 1996.3.7, Celniker et al., 1989, Sanchez-Herrero et al., 1985) Df-C4 (Kuhn and Woods, 1982)
Name Synonym
Secondary FlyBase IDs

References ( 43 )

Generate a list of	All references relating to this aberration ( 43 )

List References by type	Research paper ( 36 ) Personal communication to FlyBase ( 4 ) Abstract ( 1 ) FlyBase analysis ( 1 ) Book ( 1 )
Recent research papers ( 2 )
	Gummalla et al., 2012, PLoS Genet. 8(5): e1002720 abd-A Regulation by the iab-8 Noncoding RNA. [FBrf0218472] Ghabrial et al., 2011, PLoS Genet. 7(7): e1002087 A systematic screen for tube morphogenesis and branching genes in the Drosophila tracheal system. [FBrf0214368] Show all research papers ...