Aberration Dmel\Df(3R)Dl-FX3

General Information
Symbol	Dmel\Df(3R)Dl-FX3	Species	D. melanogaster
Name	Deficiency (3R) Delta	FlyBase ID	FBab0002537
Feature type	chromosomal_deletion	Created / Updated	2006-08-22/2006-08-22

Formalized genetic data	bk1 << l(3)91Fa << Dl << bk2
Sequence coordinates
Deleted segment	91F11--92A3
Duplicated segment
Computed Breakpoints include	91F11;92A3
Breakpoints Inherited
Nature of the Aberration
Cytological Order
Progenitor
Mutagen	X ray (Vassin and Campos-Ortega, 1987)
Class of aberration (relative to progenitor)	chromosomal_deletion (Vassin and Campos-Ortega, 1987)
Breakpoints	91F11;92A3 (Vassin and Campos-Ortega, 1987)
Causes alleles
Carries alleles
Transposon Insertions
Genetic mapping information
Comments
Comments on Cytology
	All limits from polytene analysis (FBrf0046377)
Molecularly Mapped Breakpoints

Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	nos (Forbes and Lehmann, 1998, Bhat, 1999) Dl (Vassin and Campos-Ortega, 1987, Cabrera, 1990, Campos-Ortega and Haenlin, 1992) l(3)91Fb (Vassin and Campos-Ortega, 1987) l(3)91Fe (Vassin and Campos-Ortega, 1987) l(3)92Aa (Vassin and Campos-Ortega, 1987) l(3)91Fa (Vassin and Campos-Ortega, 1987)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	S(CycE^JP)13S1 (Brumby et al., 2004)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations	Before delamination of the SI neuroblasts, medial, intermediate and lateral regions of the neuroectoderm can be detected in homozygous embryos. Only slight differences in cell size can be detected in the ventral neuroectoderm (VNE) compared to wild-type. However, morphological changes are visible in the basal regions of the VNE; in contrast to wild type, where only single basally enlarged cells can be detected, whole groups of cells become larger basally in homozygous embryos. The enlarged cells also do not shrink during stage 9 as occurs in wild-type embryos, rather more and more cells become enlarged until almost all cells of the VNE have increased in size and eventually become neuroblasts. (Stollewerk, 2000) Embryos exhibit few, if any, fused muscles. The unfused, birefringent fibres, have a random pattern of fine fibres apparently radiating out from small fragments of dorsal cuticle. The birefringent is clearly correlated with the expansion of the CNS and PNS, and the loss of epidermis and the degree to which myoblast fusion occurs. Where myoblast fusion fails conspicuous clusters of mesodermal cells are formed and if epidermal territories are expanded cells in these clusters may be recruited to fusion. (Bate et al., 1993) Fusion of tarsal segments: 2-4 tarsal segments fuse together forming a single segment without boundaries visible. (Vassin et al., 1985) Heterozygotes show a \'delta\' phenotype and confluence of wing veins 2 and 5. (Murata et al., 1996) Homozygotes die as embryos with an extreme embryonic neurogenic phenotype. (Lehmann et al., 1983) Homozygotes die as embryos. Surface of the CNS at 20 hours almost completely lacks investing cells. Islands of neural lamella and associated sheath cells are observed but no continuous barrier cell layer. There are few glial profiles among the abundant neuron cell bodies within the ganglion and among neurons in the neuropile. (Edwards et al., 1993) Mutant embryos show an overproduction of muscle founder cells. (Ruiz-Gomez et al., 2002) Post-transcriptional control of AS-C expression is suppressed, all cells expressing RNA accumulate protein. (Cabrera, 1990) Single cells from wild-type embryos transplanted into the ventral neurogenic region of Df(3R)Dl-FX3 host embryos give rise to neural cells. (Stuttem and Campos-Ortega, 1997) The expression of the Df(3R)Dl-FX3 phenotype is modified by the presence of ASC loss-of-function mutations. (Brand and Campos-Ortega, 1988)
Position Effect Variegation Data

Stocks ( 0 )

Notes on Origin
Discoverer

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

Synonyms & Secondary IDs ( 9 )
Reported As
Symbol Synonym	Df(3R)Dl^FX3 (Bhat, 1999, Martin-Bermudo et al., 1995, Jennings et al., 1994, Godt et al., 1991, Vassin and Campos-Ortega, 1987) Df(3R)Dl^Fx3 (Campos-Ortega, 1993, Giebel et al., 1997, Campos-Ortega, 1993, Campos-Ortega and Haenlin, 1992) Df(3R)DlFX3 (Vaessin and Campos-Ortega, 1987) Df(3R)Dl-FX3 Df(3R)FX3 (Brumby et al., 2004) Df(3R)Fx3 (Cabrera, 1990) Dl^FX3 (Johannes and Preiss, 2002, Ruiz-Gomez et al., 2002, Dunlop et al., 2000, Brennan et al., 1999, Brennan et al., 1999, Vassin et al., 1985, Rottgen et al., 1998, Murata et al., 1996, Edwards et al., 1993, Carmena et al., 1998, Brennan et al., 1997, Brand and Campos-Ortega, 1988, Bate et al., 1993, ) Dl^Fx3 (Stollewerk, 2000, Stuttem and Campos-Ortega, 1997)
Name Synonym	Deficiency (3R) Delta
Secondary FlyBase IDs
	FBal0029358
References ( 34 )

Generate a list of	All references relating to this aberration ( 34 )

List References by type	Research paper ( 29 ) Review ( 3 ) FlyBase analysis ( 1 ) Book ( 1 )
Recent research papers (0)
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