bk1 << l(3)91Fa << Dl << bk2
Df(3R)Dl-X43/Df(3R)Exel6184 flies develop age-dependent abnormalities in the heart muscle throughout adult life, with increasingly disorganized myocardial myofibrils and gaps. With age, flies exhibit shorter diastolic intervals, resulting in increased heart rates and fewer asystoles, and produce a more regular heartbeat than wild-type controls.
Expressing Mmus\DmdDp116.UAS under the control of Scer\GAL4how-24B rescues the increased systolic diameter and reduced fractional shortening of the heart wall in Df(3R)Dl-X43/Df(3R)Exel6184 adult flies.
Throughout their adult life, Df(3R)Dl-X43/Df(3R)Exel6184 flies have a significantly wider diastolic and systolic diameter, accompanied by a reduced fractional shortening compared to controls, while single heterozygotes show increased diameter phenotypes without a reduction in fractional shortening.
Df(3R)Dl-X43/+ mutant third instar larval eye discs do not show disrupted neuronal projections from photoreceptor neurons to the brain optic lobes.
Transheterozygotes with sng- mutations are viable and phenotypically wild type.