Aberration Dmel\Df(3R)E40

General Information
Symbol	Dmel\Df(3R)E40	Species	D. melanogaster
Name		FlyBase ID	FBab0002563
Feature type	chromosomal_deletion	Created / Updated	2006-08-22/2006-08-22

Formalized genetic data	rod << bk1 << Med << bk2
Sequence coordinates
Deleted segment	100C5--100F5
Duplicated segment
Computed Breakpoints include	100C5;100F1-100F5
Breakpoints Inherited
Nature of the Aberration
Cytological Order
Progenitor
Mutagen	PM hybrid dysgenesis (Locke et al., 1988)
Class of aberration (relative to progenitor)	chromosomal_deletion (Harbecke and Lengyel, 1995, Locke et al., 1988, Wisotzkey et al., 1998)
Breakpoints	100C5-100D1;100F1-100F5 (Locke et al., 1988) 100C5-100D1;100F (Harbecke and Lengyel, 1995) 100C5;100F1-100F5 (Wisotzkey et al., 1998)
Causes alleles
Carries alleles
Transposon Insertions
Genetic mapping information
Comments
Comments on Cytology
	Left limit of break 1 from polytene analysis (FBrf0048198) Right limit of break 1 from polytene analysis (citation unavailable) Limits of break 2 from polytene analysis (FBrf0048198) Right breakpoint is at the tip of 3R. (Locke et al., 1988)
Molecularly Mapped Breakpoints

Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	Med (Raftery et al., 1995, Raftery, 1995.4.6, Hudson et al., 1998, Wisotzkey et al., 1998, Das et al., 1998)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	rod (Wisotzkey et al., 1998)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations	Deficient embryos show a variably penetrant mutant midgut phenotype: central constriction absent. (Bilder and Scott, 1995) Homozygous embryos do not complete head involution or dorsal closure, and tracheae are not connected. Midgut constrictions are incomplete, Malpighian tubules have a variable diameter along their length and the hindgut is sometimes shorter than normal. (Harbecke and Lengyel, 1995) Homozygous lethal. (Locke et al., 1988) Strictly maternal enhancer of dpp^hr4 lethality. The lethal interaction is due to a loss of dorsal-most fates in the embryos, demonstrated by loss of amnioserosa cells. (Raftery et al., 1995)
Position Effect Variegation Data

Stocks ( 0 )

Notes on Origin
Discoverer

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	Df(3R)E40 (Takaesu et al., 2005) E40 (Locke et al., 1988)
Name Synonym
Secondary FlyBase IDs

References ( 13 )
Research paper	Takaesu et al., 2005, Development 132(21): 4883--4894 DNA-binding domain mutations in SMAD genes yield dominant-negative proteins or a neomorphic protein that can activate WG target genes in Drosophila. [FBrf0190324] Das et al., 1998, Development 125(8): 1519--1528 The Drosophila gene Medea demonstrates the requirement for different classes of Smads in dpp signaling. [FBrf0102615] Hudson et al., 1998, Development 125(8): 1407--1420 The Drosophila Medea gene is required downstream of dpp and encodes a functional homolog of human Smad4. [FBrf0102608] Wisotzkey et al., 1998, Development 125(8): 1433--1445 Medea is a Drosophila Smad4 homolog that is differentially required to potentiate DPP responses. [FBrf0102610] Yamamoto et al., 1996, Roux Arch. dev. Biol. 205(5-6): 215--224 Genetic interactions of pokkuri with seven in absentia, tramtrack and downstream components of the sevenless pathway in R7 photoreceptor induction in Drosophila melanogaster. [FBrf0086690] Bilder and Scott, 1995, Genetics 141(3): 1087--1100 Genomic regions required for morphogenesis of the Drosophila embryonic midgut. [FBrf0083777] Harbecke and Lengyel, 1995, Roux Arch. dev. Biol. 204(5): 308--329 Genes controlling posterior gut development in the Drosophila embryo. [FBrf0082073] Raftery et al., 1995, Genetics 139(1): 241--254 Genetic screens to identify elements of the decapentaplegic signaling pathway in Drosophila. [FBrf0079237] Bishop, 1992, Genetics 132: 1063--1069 Evidence for intrinsic differences in the formation of chromatin domains in Drosophila melanogaster. [FBrf0056200] Tartof et al., 1989, Dev. Genet. 10: 162--176 Towards an understanding of position effect variegation. [FBrf0049515] Locke et al., 1988, Genetics 120: 181--198 Dosage-dependent modifiers of position effect variegation in Drosophila and a mass action model that explains their effect. [FBrf0048198]
Personal communication to FlyBase	Raftery, 1995.4.6, [title not yet available] [title not yet available] [FBrf0086254]
FlyBase analysis	FlyBase, 2007, En masse symbol-based assigment of Aberration Class with respect to wild type. En masse symbol-based assigment of Aberration Class with respect to wild type. [FBrf0191808]